ACETAMINOPHEN

First approved in 1950

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H9NO2
Molecular Weight	151.1626
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)NC1=CC=C(O)C=C1

InChI

InChIKey=RZVAJINKPMORJF-UHFFFAOYSA-N

InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

HIDE SMILES / InChI

Molecular Formula	C8H9NO2
Molecular Weight	151.1626
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019872Orig1s044lbl.pdf

Acetaminophen, also known as paracetamol, is commonly used for its analgesic and antipyretic effects. Its therapeutic effects are similar to salicylates, but it lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects. Acetaminophen (USAN) or Paracetamol (INN) is a widely used analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. It is a major ingredient in numerous cold and flu medications and many prescription analgesics. It is extremely safe in standard doses, but because of its wide availability, deliberate or accidental overdoses are not uncommon. Acetaminophen, unlike other common analgesics such as aspirin and ibuprofen, has no anti-inflammatory properties or effects on platelet function, and it is not a member of the class of drugs known as non-steroidal anti-inflammatory drugs or NSAIDs. At therapeutic doses, acetaminophen does not irritate the lining of the stomach nor affect blood coagulation, kidney function, or the fetal ductus arteriosus (as NSAIDs can). Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. Acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells, which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works. The antipyretic properties of acetaminophen are likely due to direct effects on the heat-regulating centers of the hypothalamus resulting in peripheral vasodilation, sweating and hence heat dissipation.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cyclooxygenase 89 Target ID: CHEMBL2094253 Sources: https://www.ncbi.nlm.nih.gov/pubmed/?term=15662292	Inhibitor 8146

Conditions

Condition	Modality	Highest Phase	Product
Arthritis 89 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019872Orig1s044lbl.pdf	Palliative	Approved 8307	TYLENOL Approved Use Uses temporarily relieves minor aches and pains due to: minor pain of arthritis, muscular aches, backache, premenstrual abd menstrual cramps, the common cold, headache, toochache; temporary reduce fever Launch Date 7.5798721E11
Backache 16 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019872Orig1s044lbl.pdf	Palliative	Approved 8307	TYLENOL Approved Use Uses temporarily relieves minor aches and pains due to: minor pain of arthritis, muscular aches, backache, premenstrual abd menstrual cramps, the common cold, headache, toochache; temporary reduce fever Launch Date 7.5790077E11
Common cold 59 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019872Orig1s044lbl.pdf	Palliative	Approved 8307	TYLENOL Approved Use Uses temporarily relieves minor aches and pains due to: minor pain of arthritis, muscular aches, backache, premenstrual abd menstrual cramps, the common cold, headache, toochache; temporary reduce fever Launch Date 7.5790077E11
Fever 22 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019872Orig1s044lbl.pdf	Palliative	Approved 8307	TYLENOL Approved Use Uses temporarily relieves minor aches and pains due to: minor pain of arthritis, muscular aches, backache, premenstrual abd menstrual cramps, the common cold, headache, toochache; temporary reduce fever Launch Date 7.5790077E11
Headache 47 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019872Orig1s044lbl.pdf	Palliative	Approved 8307	TYLENOL Approved Use Uses temporarily relieves minor aches and pains due to: minor pain of arthritis, muscular aches, backache, premenstrual abd menstrual cramps, the common cold, headache, toochache; temporary reduce fever Launch Date 7.5790077E11

C_max

Value	Dose	Co-administered	Analyte	Population
28 μg/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/204767s000lbl.pdf	1000 mg single, intravenous dose: 1000 mg route of administration: Intravenous experiment type: SINGLE co-administered:		ACETAMINOPHEN plasma	Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
43 μg × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/204767s000lbl.pdf	1000 mg single, intravenous dose: 1000 mg route of administration: Intravenous experiment type: SINGLE co-administered:		ACETAMINOPHEN plasma	Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
2.4 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/204767s000lbl.pdf	1000 mg single, intravenous dose: 1000 mg route of administration: Intravenous experiment type: SINGLE co-administered:		ACETAMINOPHEN plasma	Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1670	substrate 985	substrate 1168

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
UGT1A6 107 UGT2B15 64 hOCT1 10	CYP1A1 344 CYP1A2 1013 CYP2A6 510 CYP2B6 648 CYP2C19 955 CYP2E1 633 UGT1A1 417 UGT1A3 421 UGT1A4 345 UGT1A6 306 UGT1A7 235 UGT1A8 282 UGT1A9 378 UGT1A10 289 UGT2B4 248 UGT2B7 387 UGT2B15 202 UGT2B17 212 SULT2A1 24 SULT1A3/4 4 SULT1E1 17

Drug as perpetrator

Target	Modality	Activity
hOCT1 10	inhibitor 3185 Sources: https://pubmed.ncbi.nlm.nih.gov/12388633/ Page: -	no
UGT1A6 139	inhibitor 3185 Sources: https://pubs.acs.org/doi/10.1021/tx050317i Page: -	yes [Ki 2300 uM]
UGT2B15 64	inhibitor 3185 Sources: https://pubs.acs.org/doi/10.1021/tx050317i Page: -	yes [Ki 5300 uM]

Drug as victim

Target	Modality	Activity
CYP3A4 1670	substrate 3264 Sources: https://www.tandfonline.com/doi/pdf/10.1080/00498250802512830?needAccess=true Page: 6.0	major
CYP2A6 510	substrate 3264 Sources: https://www.tandfonline.com/doi/pdf/10.1080/00498250802512830?needAccess=true Page: 6.0	no
CYP2B6 648	substrate 3264 Sources: https://www.tandfonline.com/doi/pdf/10.1080/00498250802512830?needAccess=true Page: 6.0	no
UGT1A3 421	substrate 3264 Sources: https://pubs.acs.org/doi/10.1021/tx050317i Page: -	no
UGT1A4 345	substrate 3264 Sources: https://pubs.acs.org/doi/10.1021/tx050317i Page: -	no
UGT2B17 212	substrate 3264 Sources: https://pubs.acs.org/doi/10.1021/tx050317i Page: -	no
UGT2B4 248	substrate 3264 Sources: https://pubs.acs.org/doi/10.1021/tx050317i Page: -	no
SULT1A3/4 4	substrate 3264 Sources: https://pubmed.ncbi.nlm.nih.gov/18232020/ Page: -	yes [Km 1500 uM]
SULT1E1 17	substrate 3264 Sources: https://pubmed.ncbi.nlm.nih.gov/18232020/ Page: -	yes [Km 1900 uM]
UGT2B15 202	substrate 3264 Sources: https://pubs.acs.org/doi/10.1021/tx050317i Page: -	yes [Km 2300 uM]
SULT2A1 24	substrate 3264 Sources: https://pubmed.ncbi.nlm.nih.gov/18232020/ Page: -	yes [Km 3700 uM]
UGT1A6 306	substrate 3264 Sources: https://pubs.acs.org/doi/10.1021/tx050317i Page: -	yes [Km 4000 uM]
UGT1A1 417	substrate 3264 Sources: https://pubs.acs.org/doi/10.1021/tx050317i Page: -	yes [Km 5500 uM]
CYP1A1 344	substrate 3264 Sources: https://www.tandfonline.com/doi/pdf/10.1080/00498250802512830?needAccess=true Page: 6.0	yes
CYP1A2 1013	substrate 3264 Sources: https://www.tandfonline.com/doi/pdf/10.1080/00498250802512830?needAccess=true Page: 6.0	yes
CYP2C19 955	substrate 3264 Sources: https://www.tandfonline.com/doi/pdf/10.1080/00498250802512830?needAccess=true Page: 6.0	yes
CYP2C9 985	substrate 3264 Sources: https://www.tandfonline.com/doi/pdf/10.1080/00498250802512830?needAccess=true Page: 6.0	yes
CYP2D6 1168	substrate 3264 Sources: https://www.tandfonline.com/doi/pdf/10.1080/00498250802512830?needAccess=true Page: 6.0	yes
CYP2E1 633	substrate 3264 Sources: https://www.tandfonline.com/doi/pdf/10.1080/00498250802512830?needAccess=true Page: 6.0	yes
UGT1A10 289	substrate 3264 Sources: https://pubs.acs.org/doi/10.1021/tx050317i Page: -	yes
UGT1A7 235	substrate 3264 Sources: https://pubs.acs.org/doi/10.1021/tx050317i Page: -	yes
UGT1A8 282	substrate 3264 Sources: https://pubs.acs.org/doi/10.1021/tx050317i Page: -	yes
UGT1A9 378	substrate 3264 Sources: https://pubs.acs.org/doi/10.1021/tx050317i Page: -	yes
UGT2B7 387	substrate 3264 Sources: https://pubs.acs.org/doi/10.1021/tx050317i Page: -	yes

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B1-00018	http://www.3bsc.com/index/pro_info.php?id=20230
AA Blocks	AA0033T3	http://www.aablocks.com/goods/Goods/detail?id=AA0033T3
AHH Chemical co.,ltd	MT-46428	http://www.ahhchemical.com/product/MT-46428.html
AHH Chemical co.,ltd	NP-1212	http://www.ahhchemical.com/product/NP-1212.html
AHH Chemical co.,ltd	NP-1228	http://www.ahhchemical.com/product/NP-1228.html
AK Scientific, Inc. (AKSCI)	H865	http://www.aksci.com/item_detail.php?cat=H865
Aaron Chemicals	AR0034KV	http://www.aaronchem.com/103-90-2
AbMole Bioscience	M3301	http://www.abmole.com/products/acetaminophen.html
Acadechem	ACDS-017269	http://www.acadechemical.com/product/91968
Accela ChemBio Inc	SY001162	http://www.accelachem.com/cn/search.html?keyword=SY001162&attname=GoodsCode
Achemica	ACMC-20989w	http://www.achemica.com/prodinfo/?id=118918
Achemo Scientific Limited	AC-22304	http://www.achemo.com/search/?Keyword=103-90-2
Achemtek	0104-010324	http://www.achemtek.com/103-90-2
Acros Organics	AC102330051	https://www.fishersci.com/shop/products/4-acetamidophenol-98-acros-organics-3/AC102330051
Acros Organics	AC102330010	https://www.fishersci.com/shop/products/4-acetamidophenol-98-acros-organics/AC102330010
Acros Organics	AC102330050	https://www.fishersci.com/shop/products/4-acetamidophenol-98-acros-organics/AC102330050
Acros Organics	AC102332500	https://www.fishersci.com/shop/products/4-acetamidophenol-98-acros-organics/AC102332500
Adooq BioScience	A10030	https://www.adooq.com/acetaminophen.html
Alfa Aesar	A11240	https://www.alfa.com/en/catalog/A11240/
Alfa Chemistry	AP103902	https://reagents.alfa-chemistry.com/product/acetaminophen-cas-103-90-2-966.html
Alfa Chemistry	AP103902-A	https://reagents.alfa-chemistry.com/product/acetaminophen-cas-103-90-2-967.html
Alfa Chemistry	103-90-2	https://www.alfa-chemistry.com/4-acetamidophenol-cas-103-90-2-item-289305.htm
Alfa Chemistry	ACM103902-1	https://www.alfa-chemistry.com/4-acetamidophenol-cas-103-90-2-item-289305.htm
Alichem	19146428	http://www.alichem.com/en/products/103-90-2.html
Allbio Pharm Co., Ltd	AD12245	http://www.allbiopharm.com/product/n/AD12245
Alsachim	1261	http://www.alsachim.com/product-C1609-glo.bal-view.html
Ambinter	Amb1209347	http://www.ambinter.com/reference/1209347
Anward	ANW-14994	http://www.anward.com/pro_result/17980
Aurora Fine Chemicals LLC	A00.157.692	http://online.aurorafinechemicals.com/info?ID=A00.157.692
Avantor Inc	200000-000	https://us.vwr.com/store/product/7513585/paracetamol
Avantor Inc	200010-144	https://us.vwr.com/store/product/7513585/paracetamol
Avantor Inc	101094-036	https://us.vwr.com/store/product/7889321/acetaminophen
BOC Sciences	360769-21-7	https://isotope.bocsci.com/product/n-4-hydroxyphenyl-acetamide-13c2-15n-cas-360769-21-7-344677.html
BOC Sciences	60902-28-5	https://www.bocsci.com/acetaminophen-d3-cas-60902-28-5-item-466045.html
BOC Sciences	64315-36-2	https://www.bocsci.com/acetaminophen-d4-cas-64315-36-2-item-212493.html
BioChemPartner	BCP23431	http://www.biochempartner.com/103-90-2-BCP23431
BioCrick	BCC5269	http://www.biocrick.com/Acetaminophen-BCC5269.html
BioSynth	J-001064	https://www.biosynth.com/en/products/all-products/products/J-001064.html
BioSynth	J-514275	https://www.biosynth.com/en/products/all-products/products/J-514275.html
Boerchem	BC204766	http://www.boerchem.com/?product_34471.html
Capot Chemical	17726	http://www.capotchem.com/en/17726.htm
Capot Chemical	PubChem17726	http://www.capotchem.com/en/17726.htm
Chem Scene	CS-2819	http://www.chemscene.com/103-90-2.html
ChemMol	1202927	http://www.chemmol.com/chemmol/1202927.html
ChemMol	44001940	http://www.chemmol.com/chemmol/44001940.html
ChemMol	49417442	http://www.chemmol.com/chemmol/49417442.html
ChemMol	98000234	http://www.chemmol.com/chemmol/98000234.html
ChemMol	99163344	http://www.chemmol.com/chemmol/99163344.html
Chemchart	cc-acetaminophen	http://chemchart.com/acetaminophen-detail.html
Chemenu	CM116796	http://www.chemenu.com/products/CM116796
Chemspace	CSSB00000184395	https://chem-space.com/CSSB00000184395
China MainChem Co., Ltd	103-90-2	https://www.mainchem.com/product/paracetamol/
Clearsynth	CS-O-30999	https://www.clearsynth.com/en/CSO30999.html
Clearsynth	CS-T-46981	https://www.clearsynth.com/en/CST46981.html
DC Chemicals	DC9900	http://www.dcchemicals.com/product_show-Acetaminophen.html
Finetech	FT-0661041	http://www.finetechnology-ind.com/prod/detail/pub/60902-28-5.html
Finetech	FT-0661042	http://www.finetechnology-ind.com/prod/detail/pub/64315-36-2.html
Finetech	FT-0658035	http://www.finetechnology-ind.com/product/All%20product%20List/103-90-2.html
Glentham Life Sciences	GK4314	http://www.glentham.com/products/product/GK4314/
Hairui	HR124390	http://www.hairuichem.com/en/product/103-90-2.html
LGC Standards	DRE-C15846000	https://www.lgcstandards.com/US/en/p/DRE-C15846000
LGC Standards	LGCAMP0042.00-01	https://www.lgcstandards.com/US/en/p/LGCAMP0042.00-01
LGC Standards	LGCFOR0042.00	https://www.lgcstandards.com/US/en/p/LGCFOR0042.00
LGC Standards	MM0042.00-0250	https://www.lgcstandards.com/US/en/p/MM0042.00-0250
Lab Network	LN00195030	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00195030
Matrix Scientific	139844	https://www.matrixscientific.com/139844.html
MedChem Express	HY-66005	https://www.medchemexpress.com/acetaminophen.html
Oakwood	5037	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=2289&ExtHyperLink=1
Otava	125160280	https://search.otavachemicals.com/#!/search?query=0125160280&type=code&base=dbb
Parchem	11769	http://www.parchem.com/chemical-supplier-distributor/Acetaminophen-001769.aspx
Renno Tech	RP21489	http://www.rennotech.com/product_show.asp?id=27206
Sigma-Aldrich	A-064_CERILLIAN	https://www.sigmaaldrich.com/catalog/product/cerillian/a064?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	A2794_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/a2794?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	A3035_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/a3035?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	A5000_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/a5000?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	1003009_USP	https://www.sigmaaldrich.com/catalog/product/usp/1003009?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S001612	http://www.sinfoobiotech.com/product/1005010
Smolecule	S516952	http://www.smolecule.com/products/s516952
TCI (Tokyo Chemical Industry)	H0190	http://www.tcichemicals.com/eshop/en/us/commodity/H0190/index.html
THE BioTek	bt-257085	https://www.thebiotek.com/product/inhibitors/bt-257085
Tocris	1706	https://www.tocris.com/products/acetaminophen_1706
VladaChem	VL160812	https://www.vladachem.com/product.php?products=103-90-2
VladaChem	VL276129-250G	https://www.vladachem.com/product.php?products=103-90-2
Yuhao Chemical	RT12770	http://www.chemyuhao.com/103-90-2.html
abcr GmbH	AB113247	http://www.abcr.com/shop/en/AB113247
eNovation Chemicals	D516853	http://www.enovationchem.com/productDetails.asp?productID=D516853
iChemical	EBD5728	http://www.ichemical.com/products/103-90-2.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
mcule	MCULE-3844920617	https://mcule.com/MCULE-3844920617/

PubMed

Title	Date	PubMed
Massive hemolysis caused by acetaminophen. Positive determination by direct Coombs test.	1976 Dec 13	1036573
Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.	1979 Feb 10	104998
An experimental study on the disorders of hepatic hemodynamics and changes of plasma histamine in dogs with fulminant hepatic failure.	1998	10806799
Isolated acute renal failure due to paracetamol intoxication in an alcoholic patient.	1999	10529635
Paracetamol-induced fulminant hepatic failure in a child after 5 days of therapeutic doses.	1999	10447915
Early metabolic acidosis and coma after acetaminophen ingestion.	1999 Apr	10092726
Assay to detect inhibitory substances in serum of patients with acute liver failure.	1999 Feb	10212046
Modifying effects of a mixture of acetaminophen, aspirin, dipyrone and ethenzamide on a multiorgan initiation model and its carcinogenicity in male F344 rats.	1999 Jan 8	10077225
Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice.	1999 Jul	10445756
Risk factors for acetaminophen and nimesulide intolerance in patients with NSAID-induced skin disorders.	1999 Jun	10400483
Characteristics and risk factors of acetaminophen-induced hepatitis in Taiwan.	1999 Jun	10389295
Enhancement of low density lipoprotein catabolism by non-steroidal anti-inflammatory drugs in cultured HepG2 cells.	1999 May 21	10395027
Accidental paracetamol overdosing and fulminant hepatic failure in children.	1999 Nov 1	10615340
Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells.	1999 Sep	10454517
[Does TNF-alpha contribute to liver disease physiopathology?].	2000	10975018
The potential of acetaminophen as a prodrug in gene-directed enzyme prodrug therapy.	2000 Apr	10811468
The hepatic inflammatory response after acetaminophen overdose: role of neutrophils.	2000 Apr	10774834
Time to onset of analgesia and analgesic efficacy of effervescent acetaminophen 1000 mg compared to tablet acetaminophen 1000 mg in postoperative dental pain: a single-dose, double-blind, randomized, placebo-controlled study.	2000 Apr	10761164
Acetaminophen controlled-release sprinkles versus acetaminophen immediate-release elixir in febrile children.	2000 Apr	10761163
Leukotriene receptor antagonists may prevent NSAID-induced exacerbations in patients with chronic urticaria.	2000 Aug	10982225
Acetaminophen produces cataract in DBA2 mice by Ah receptor-independent induction of CYP1A2.	2000 Aug	10977129
Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis.	2000 Aug	10932156
Hepatocellular response to chemical stress in CD-1 mice: induction of early genes and gamma-glutamylcysteine synthetase.	2000 Aug	10915739
Acetaminophen inhibits iNOS gene expression in RAW 264.7 macrophages: differential regulation of NF-kappaB by acetaminophen and salicylates.	2000 Jun 16	10860828
Energy expenditure in acetaminophen-induced fulminant hepatic failure.	2000 Mar	10752809
N-acetylcysteine in acute hepatic failure (non-paracetamol-induced).	2000 May-Jun	10919033
Mechanism of action of acetaminophen: is there a cyclooxygenase 3?	2000 Oct	11113024
Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure.	2000 Oct	11006363
Effects of acetaminophen administration to patients in intensive care.	2000 Sep	11089781
A prospective study of gastric mucosal ischaemia in paracetamol-induced acute liver failure.	2000 Sep	11089752
Transcriptional activation of heme oxygenase-1 and its functional significance in acetaminophen-induced hepatitis and hepatocellular injury in the rat.	2000 Sep	11019995
p-Aminophenol-induced liver toxicity: tentative evidence of a role for acetaminophen.	2001	11170313
Urine drug screens in overdose patients do not contribute to immediate clinical management.	2001 Feb	11206043
Stroke severity determines body temperature in acute stroke.	2001 Feb	11157175
Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media.	2001 Feb 10	11159657
Clinical trial of an air-circulating cooling blanket for fever control in critically ill neurologic patients.	2001 Feb 13	11171891
[About paracetamol again].	2001 Feb 18	11243017
ABC of diseases of liver, pancreas, and biliary system. Other causes of parenchymal liver disease.	2001 Feb 3	11157536
Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches.	2001 Jan	11215692
A comparison of the effect of nitroparacetamol and paracetamol on liver injury.	2001 Jan	11156555
Treatment with paracetamol in infants.	2001 Jan	11152028
Gastric emptying in diabetic gastroparetic dogs: ffects of SK-951,a novel prokinetic agent.	2001 Jan	11150919
Safety of childhood acetaminophen overdose.	2001 Jan	11145785
Treatment of acetaminophen ingestion with a superactivated charcoal-cola mixture.	2001 Jan	11145772
Causes of Alzheimer's disease: paracetamol (acetaminophen) today? Amphetamines tomorrow?	2001 Jan	11133268
Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg.	2001 Jan 10	11231885
[Dexketoprofen-trometamol and tramadol in acute lumbago].	2001 Jan 11	11217678
Unexpected and pronounced antinociceptive synergy between spinal acetaminophen (paracetamol) and phentolamine.	2001 Jan 26	11165231
Experimental and theoretical microdialysis studies of in situ metabolism.	2001 Mar	11237334
A comparison of ropivacaine and bupivacaine for cervical plexus block.	2001 Mar	11226108

Patents

Sample Use Guides

In Vivo Use Guide

2 caplets every 8 hours with water; don't take more than 6 caplets in 24 hours

Route of Administration: Oral

In Vitro Use Guide

A time- and concentration-dependent decrease in intracellular GSH occurred in freshly isolated type II pneumocytes and alveolar macrophages exposed to subtoxic (

Substance Class	Chemical Created by `admin` on `Sun Dec 18 19:19:58 UTC 2022` Edited by `admin` on `Sun Dec 18 19:19:58 UTC 2022`
Record UNII	362O9ITL9D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACETAMINOPHEN

Official Name

English

ACETAMINOPHEN COMPONENT OF MEDIGESIC PLUS

Common Name

English

NORCET COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF ROXICET

Common Name

English

ACETAMINOPHEN COMPONENT OF TALACEN

Common Name

English

ACETAMINOPHEN [VANDF]

Common Name

English

PHENAPHEN

Common Name

English

NSC-109028

Code

English

DURADYNE DHC COMPONENT ACETAMINOPHEN

Common Name

English

TRIAPRIN COMPONENT ACETAMINOPHEN

Common Name

English

PERCOCET COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF DURADYNE DHC

Common Name

English

ACETAMINOPHEN COMPONENT OF BANCAP

Common Name

English

ACETAMINOPHEN [INCI]

Common Name

English

PARACETAMOLUM [WHO-IP LATIN]

Common Name

English

TRIAD COMPONENT ACETAMINOPHEN

Common Name

English

ESGIC COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF SYNALGOS-DC-A

Common Name

English

DHC PLUS COMPONENT ACETAMINOPHEN

Common Name

English

PARACETAMOL [WHO-IP]

Common Name

English

PERFALGAN

Brand Name

English

ACETAMINOPHEN [ORANGE BOOK]

Common Name

English

ACETAMINOPHEN COMPONENT OF LORTAB

Common Name

English

LORCET-HD COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMIDE, N-(4-HYDROXYPHENYL)-

Systematic Name

English

DAFALGAN

Brand Name

English

ACETAMINOPHEN COMPONENT OF FIORICET

Common Name

English

SEDAPAP COMPONENT ACETAMINOPHEN

Common Name

English

OFIRMEV

Brand Name

English

MEDIGESIC PLUS COMPONENT ACETAMINOPHEN

Common Name

English

DRIXORAL PLUS COMPONENT ACETAMINOPHEN

Common Name

English

P-HYDROXY-ACETANILID

Common Name

English

PARACETAMOL [MART.]

Common Name

English

4'-HYDROXYACETANILIDE

Systematic Name

English

VICODIN COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN [USP IMPURITY]

Common Name

English

ACETAMINOPHEN COMPONENT OF BUCET

Common Name

English

EFFERALGAN

Brand Name

English

ZYDONE COMPONENT ACETAMINOPHEN

Common Name

English

NORCO COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN [MI]

Common Name

English

FEMCET COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF OXYCET

Common Name

English

PARACETAMOL [EP MONOGRAPH]

Common Name

English

ALLAY COMPONENT ACETAMINOPHEN

Common Name

English

BIOCETAMOL

Common Name

English

ACETAMINOPHEN COMPONENT OF DHC PLUS

Common Name

English

ACETAMINOPHEN COMPONENT OF ROXILOX

Common Name

English

PARACETAMOL [IARC]

Common Name

English

ACETAMINOPHEN COMPONENT OF NORCO

Common Name

English

LORTAB COMPONENT ACETAMINOPHEN

Common Name

English

NEOPAP

Brand Name

English

ACETAMINOPHEN COMPONENT OF DOLENE AP-65

Common Name

English

ANEXSIA COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF VICODIN

Common Name

English

ACETAMINOPHEN COMPONENT OF WYGESIC

Common Name

English

FIORICET COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN [JAN]

Common Name

English

ACETAMINOPHEN [USP-RS]

Common Name

English

ACETAMINOPHEN COMPONENT OF EXCEDRIN

Common Name

English

CODRIX COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN [USP MONOGRAPH]

Common Name

English

PHRENILIN COMPONENT ACETAMINOPHEN

Common Name

English

HY-PHEN COMPONENT ACETAMINOPHEN

Common Name

English

TYCOLET COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF TYCOLET

Common Name

English

PARACETAMOL

Official Name

English

ACETAMINOPHEN COMPONENT OF CO-GESIC

Common Name

English

BUCET COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF NORCET

Common Name

English

TENCON COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF LORCET-HD

Common Name

English

ACETAMINOPHEN [HSDB]

Common Name

English

ROXICET COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF TENCON

Common Name

English

TREZIX COMPONENT ACETAMINOPHEN

Brand Name

English

EXCEDRIN COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF CODRIX

Common Name

English

paracetamol [INN]

Common Name

English

ACETAMINOPHEN COMPONENT OF ALLAY

Common Name

English

TYLENOL

Brand Name

English

ACETAMINOPHEN COMPONENT OF HY-PHEN

Common Name

English

DARVOCET COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF TYLOX

Common Name

English

XARTEMIS COMPONENT ACETAMINOPHEN

Brand Name

English

ACETAMINOPHEN COMPONENT OF TRIAD

Common Name

English

NSC-3991

Code

English

ACETAMINOPHEN COMPONENT OF SEDAPAP

Common Name

English

ULTRACET COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF XARTEMIS

Brand Name

English

ANOQUAN COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF ULTRACET

Common Name

English

N-ACETYL-P-AMINOPHENOL

Common Name

English

ACETAMINOPHEN COMPONENT OF ANOQUAN

Common Name

English

ROXILOX COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF BUTAPAP

Common Name

English

ACETAMINOPHEN COMPONENT OF BANCAP HC

Common Name

English

ACETAMINOPHEN COMPONENT OF PERCOCET

Common Name

English

ACETAMINOPHEN COMPONENT OF DARVOCET

Common Name

English

ACETAMINOPHEN COMPONENT OF ANEXSIA

Common Name

English

BUTAPAP COMPONENT ACETAMINOPHEN

Common Name

English

BANCAP HC COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF ZYDONE

Common Name

English

Paracetamol [WHO-DD]

Common Name

English

ACETAMINOPHEN COMPONENT OF TRIAPRIN

Common Name

English

DOLIPRANE

Common Name

English

BANCAP COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF DRIXORAL PLUS

Common Name

English

TYLOX COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF ESGIC

Common Name

English

CO-GESIC COMPONENT ACETAMINOPHEN

Common Name

English

VERMIDON

Common Name

English

OXYCET COMPONENT ACETAMINOPHEN

Common Name

English

ACEPHEN

Brand Name

English

ACETAMINOPHEN COMPONENT OF PHRENILIN

Common Name

English

WYGESIC COMPONENT ACETAMINOPHEN

Common Name

English

INJECTAPAP

Brand Name

English

SYNALGOS-DC-A COMPONENT ACETAMINOPHEN

Common Name

English

TALACEN COMPONENT ACETAMINOPHEN

Common Name

English

DOLENE AP-65 COMPONENT ACETAMINOPHEN

Common Name

English

ACETAMINOPHEN COMPONENT OF FEMCET

Common Name

English

PANADOL

Brand Name

English

Classification Tree Code System Code

WHO-ATC

N02AJ17

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

CFR

21 CFR 341.40

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

WHO-VATC

QN02BE71

Created by admin on Sun Dec 18 19:20:06 UTC 2022 , Edited by admin on Sun Dec 18 19:20:06 UTC 2022

NCI_THESAURUS

C2356

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

WHO-ESSENTIAL MEDICINES LIST

7.1

Created by admin on Sun Dec 18 19:20:06 UTC 2022 , Edited by admin on Sun Dec 18 19:20:06 UTC 2022

WHO-VATC

QN02BE01

Created by admin on Sun Dec 18 19:20:06 UTC 2022 , Edited by admin on Sun Dec 18 19:20:06 UTC 2022

WHO-ATC

N02AJ06

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

CFR

21 CFR 862.3030

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

WHO-ATC

N02BE71

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

CFR

21 CFR 310.201

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

EPA PESTICIDE CODE

606318

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

WHO-VATC

QN02BE51

Created by admin on Sun Dec 18 19:20:06 UTC 2022 , Edited by admin on Sun Dec 18 19:20:06 UTC 2022

LOINC

75071-1

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

WHO-ATC

N02BE51

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

WHO-ATC

N02BE01

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

WHO-ATC

N02AJ13

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

WHO-ESSENTIAL MEDICINES LIST

2.1

Created by admin on Sun Dec 18 19:20:06 UTC 2022 , Edited by admin on Sun Dec 18 19:20:06 UTC 2022

LIVERTOX

NBK548162

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

WHO-ATC

N02AJ01

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

Code System Code Type Description

RS_ITEM_NUM

1003009

Created by admin on Sun Dec 18 19:20:06 UTC 2022 , Edited by admin on Sun Dec 18 19:20:06 UTC 2022

PRIMARY

EVMPD

SUB09611MIG

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

EPA CompTox

DTXSID2020006

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

DAILYMED

362O9ITL9D

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

PUBCHEM

1983

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

DRUG BANK

DB00316

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

WIKIPEDIA

PARACETAMOL

Created by admin on Sun Dec 18 19:20:06 UTC 2022 , Edited by admin on Sun Dec 18 19:20:06 UTC 2022

PRIMARY

CAS

8055-08-1

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

SUPERSEDED

LACTMED

Acetaminophen

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

MERCK INDEX

M1317

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

Merck Index

WHO INTERNATIONAL PHARMACOPEIA

ACETAMINOPHEN

Created by admin on Sun Dec 18 19:20:06 UTC 2022 , Edited by admin on Sun Dec 18 19:20:06 UTC 2022

PRIMARY

Description: A white, crystalline powder; odourless. Solubility: Sparingly soluble in water; freely soluble in ethanol (~750 g/l) TS and acetone R; practically insoluble in ether R. Category: Analgesic; antipyretic. Storage: Paracetamol should be kept in a tightly closed container, protected from light. Definition: Paracetamol contains not less than 98.5% and not more than 101.0% of C8H9NO2, calculated with reference to thedried substance.

INN

626

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

NSC

109028

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

ECHA (EC/EINECS)

203-157-5

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

FDA UNII

362O9ITL9D

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

ChEMBL

CHEMBL112

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

DRUG CENTRAL

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

RXCUI

161

Created by admin on Sun Dec 18 19:20:06 UTC 2022 , Edited by admin on Sun Dec 18 19:20:06 UTC 2022

PRIMARY

RxNorm

HSDB

3001

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

CHEBI

46195

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

NSC

3991

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

MESH

D000082

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

CAS

103-90-2

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

IUPHAR

5239

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

NCI_THESAURUS

C198

Created by admin on Sun Dec 18 19:20:05 UTC 2022 , Edited by admin on Sun Dec 18 19:20:05 UTC 2022

PRIMARY

Related Record Type Details


					805SU96HKF

CYTOCHROME P450 3A5

METABOLIC ENZYME -> SUBSTRATE


					VK4SQL11C0

CYTOCHROME P450 1A2

METABOLIC ENZYME -> SUBSTRATE


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					WVH4R62LA6

POTASSIUM 4-ACETAMIDOPHENOLATE

SALT/SOLVATE -> PARENT

Amount:


					R17Q1X3RGX

ARYLAMINE N-ACETYLTRANSFERASE 2

METABOLIC ENZYME -> SUBSTRATE


					03BYF220B6

CYTOCHROME P450 2E1

METABOLIC ENZYME -> SUBSTRATE

Comments:

Enzyme responsible for the bulk of NAPQI formation

Interaction Type:

MAJOR


					V9E6HW6ZAG

4-HYDROXYACETANILIDE SODIUM

SALT/SOLVATE -> PARENT

Amount:


					362O9ITL9D

ACETAMINOPHEN

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (UV)

Qualification:

USP

Amount:

Related Record Type Details


					58IFB293JI

VORINOSTAT

PARENT -> METABOLITE

Amount:


					ER0CTH01H9

PHENACETIN

PARENT -> METABOLITE ACTIVE

Comments:

Percent of dose excreted in urine as metabolite.

Interaction Type:

AMOUNT ADMINISTERED

Qualification:

URINE

Amount:


					R86SEU3G6U

ACETAMINOPHEN MERCAPTURATE

METABOLITE INACTIVE -> PARENT

Qualification:

URINE

Amount:


					S6002H6J9F

ACETAMINOPHEN SULFATE

METABOLITE INACTIVE -> PARENT

Interaction Type:

MAJOR

Qualification:

URINE

Amount:


					6Q2X58Y8BP

3-CYSTEINYLACETAMINOPHEN

METABOLITE INACTIVE -> PARENT

Qualification:

URINE

Amount:


					T3YTW02XCU

3-GLUTATHIONYLACETAMINOPHEN

METABOLITE -> PARENT

Amount:


					8BE7G9R76X

ACETAMINOPHEN GLUCURONIDE

METABOLITE INACTIVE -> PARENT

Interaction Type:

MAJOR

Qualification:

URINE

Amount:


					XVJ94H0U21

AM-404

METABOLITE ACTIVE -> PARENT


					IX22A3NJLN

3-HYDROXYACETAMINOPHEN

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

PLASMA


					SP86R356CC

ACETANILIDE

PARENT -> METABOLITE ACTIVE

Comments:

Percent of dose excreted in urine as metabolite 60-80

Qualification:

URINE

Amount:


					57DZD477I1

3-METHYL-THIOACETAMINOPHEN GLUCURONIDE

METABOLITE -> PARENT

Qualification:

URINE


					R7P8FRP05V

P-AMINOPHENOL

METABOLITE ACTIVE -> PARENT

Comments:

May be substrate for formation of AM-404

Interaction Type:

MINOR

Amount:


					G6S9BN13TI

ACETIMIDOQUINONE

METABOLITE TOXIC -> PARENT

Comments:

Metabolite produced hepatic necrosis in man.

Interaction Type:

AMOUNT EXCRETED

Qualification:

URINE

Amount:

Related Record Type Details


					GT5H6Q4HYA

PHENOL, 4,4'-IMINOBIS-

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

Amount:


					G1L3HT4CMH

HYDROXYACETOPHENONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

Amount:


					BFG1TY61BG

DIACETAMATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

Amount:


					4AS8989RNI

O-HYDROXYACETANILIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

Amount:


					3UMW7AU2LD

ACETAMINOPHEN DIMER

IMPURITY -> PARENT

Amount:


					3E533Z76W0

2'-HYDROXYACETOPHENONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

Amount:


					E11430J0W2

4-ACETYLAMINO-2-CHLOROPHENOL

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

Amount:


					SP86R356CC

ACETANILIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

Amount:


					R7P8FRP05V

P-AMINOPHENOL

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					6I0LI34G5J

P-CHLOROACETANILIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (TLC)

Qualification:

USP

Amount:


					FQB3AM10WC

4'-HYDROXYACETOPHENONE OXIME

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

Amount:


					I729P6N0P7

PARAPROPAMOL

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					LT12J9ECA9

4,4'-OXYBIS(ACETANILIDE)

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

Amount:

Related Record Type Details


					362O9ITL9D

ACETAMINOPHEN

ACTIVE MOIETY

Name	Property Type	Parameters
Tmax	PHARMACOKINETIC

ORAL BIOAVAILABILITY	PHARMACOKINETIC

MAXIMUM TOLERATED DOSE	TOXICITY	IV, LESS THAN 50 Kg
MAXIMUM TOLERATED DOSE	TOXICITY

Tmax	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC

RENAL CLEARANCE	PHARMACOKINETIC

MAXIMUM TOLERATED DOSE	TOXICITY

MAXIMUM TOLERATED DOSE	TOXICITY

Details

SMILES

InChI

DescriptionSources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019872Orig1s044lbl.pdf

CNS Activity

Originator

Approval Year

Targets

Conditions

Approved Use

Launch Date

Approved Use

Launch Date

Approved Use

Launch Date

Approved Use

Launch Date

Approved Use

Launch Date

Cmax

AUC

T1/2

Overview

OverviewOther

Drug as perpetrator​

Drug as victim

Sourcing

PubMed

Patents

Sample Use Guides

Description
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019872Orig1s044lbl.pdf

C_max

T_1/2

Drug as perpetrator