U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C8H9NO2
Molecular Weight 151.1626
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ACETAMINOPHEN

SMILES

CC(=O)NC1=CC=C(O)C=C1

InChI

InChIKey=RZVAJINKPMORJF-UHFFFAOYSA-N
InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

HIDE SMILES / InChI

Molecular Formula C8H9NO2
Molecular Weight 151.1626
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Acetaminophen, also known as paracetamol, is commonly used for its analgesic and antipyretic effects. Its therapeutic effects are similar to salicylates, but it lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects. Acetaminophen (USAN) or Paracetamol (INN) is a widely used analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. It is a major ingredient in numerous cold and flu medications and many prescription analgesics. It is extremely safe in standard doses, but because of its wide availability, deliberate or accidental overdoses are not uncommon. Acetaminophen, unlike other common analgesics such as aspirin and ibuprofen, has no anti-inflammatory properties or effects on platelet function, and it is not a member of the class of drugs known as non-steroidal anti-inflammatory drugs or NSAIDs. At therapeutic doses, acetaminophen does not irritate the lining of the stomach nor affect blood coagulation, kidney function, or the fetal ductus arteriosus (as NSAIDs can). Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. Acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells, which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works. The antipyretic properties of acetaminophen are likely due to direct effects on the heat-regulating centers of the hypothalamus resulting in peripheral vasodilation, sweating and hence heat dissipation.

CNS Activity

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
TYLENOL
Palliative
TYLENOL
Palliative
TYLENOL
Palliative
TYLENOL
Palliative
TYLENOL
PubMed

PubMed

TitleDatePubMed
The degradation of paracetamol (4-hydroxyacetanilide) and other substituted acetanilides by a Penicillium species.
1975
Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.
1979 Feb 10
An experimental study on the disorders of hepatic hemodynamics and changes of plasma histamine in dogs with fulminant hepatic failure.
1998
Isolated acute renal failure due to paracetamol intoxication in an alcoholic patient.
1999
Paracetamol-induced fulminant hepatic failure in a child after 5 days of therapeutic doses.
1999
Early metabolic acidosis and coma after acetaminophen ingestion.
1999 Apr
Severe hypophosphataemia in paracetamol-induced oliguric renal failure.
1999 Aug
Assay to detect inhibitory substances in serum of patients with acute liver failure.
1999 Feb
Modifying effects of a mixture of acetaminophen, aspirin, dipyrone and ethenzamide on a multiorgan initiation model and its carcinogenicity in male F344 rats.
1999 Jan 8
Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice.
1999 Jul
Acetaminophen (paracetamol) levels in human tears.
1999 Oct
Clinical use of a bioartificial liver in the treatment of acetaminophen-induced fulminant hepatic failure.
1999 Oct
Regular use of analgesics is a risk factor for renal cell carcinoma.
1999 Oct
Micellar electrokinetic capillary chromatography as a powerful tool for pharmacological investigations without sample pretreatment: a precise technique providing cost advantages and limits of detection to the low nanomolar range.
1999 Sep
Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells.
1999 Sep
Acetaminophen controlled-release sprinkles versus acetaminophen immediate-release elixir in febrile children.
2000 Apr
Hepatocellular response to chemical stress in CD-1 mice: induction of early genes and gamma-glutamylcysteine synthetase.
2000 Aug
Long-chain hydroxydicarboxylic aciduria, carnitine depletion and acetaminophen exposure.
2000 Mar
Energy expenditure in acetaminophen-induced fulminant hepatic failure.
2000 Mar
Effect of chronic analgesic exposure on the central serotonin system: a possible mechanism of analgesic abuse headache.
2000 May
Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: relationship between UGT1A1 promoter genotype and variability in a liver bank.
2000 Nov
Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure.
2000 Oct
Transient neurologic symptoms after epidural analgesia in a five-year-old child.
2000 Oct
Transcriptional activation of heme oxygenase-1 and its functional significance in acetaminophen-induced hepatitis and hepatocellular injury in the rat.
2000 Sep
Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations.
2001
p-Aminophenol-induced liver toxicity: tentative evidence of a role for acetaminophen.
2001
Preparation of rapidly disintegrating tablet using new types of microcrystalline cellulose (PH-M series) and low substituted-hydroxypropylcellulose or spherical sugar granules by direct compression method.
2001 Feb
Effect of coadministered drugs and ethanol on the binding of therapeutic drugs to human serum in vitro.
2001 Feb
A novel pH-sensitive membrane from chitosan--TEOS IPN; preparation and its drug permeation characteristics.
2001 Feb
Stroke severity determines body temperature in acute stroke.
2001 Feb
Clinical trial of an air-circulating cooling blanket for fever control in critically ill neurologic patients.
2001 Feb 13
[About paracetamol again].
2001 Feb 18
The role of acetaminophen in the management of patients with osteoarthritis.
2001 Feb 19
ABC of diseases of liver, pancreas, and biliary system. Other causes of parenchymal liver disease.
2001 Feb 3
NSAID impairment of orthodontic tooth movement.
2001 Jan
Separation of cold medicine ingredients by capillary electrophoresis.
2001 Jan
The dark side of a 'detoxification' mechanism.
2001 Jan
A comparison of the effect of nitroparacetamol and paracetamol on liver injury.
2001 Jan
Safety of childhood acetaminophen overdose.
2001 Jan
Effects of rectally administered paracetamol on infants delivered by vacuum extraction.
2001 Jan
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes.
2001 Jan
Causes of Alzheimer's disease: paracetamol (acetaminophen) today? Amphetamines tomorrow?
2001 Jan
Prevention of acetaminophen-induced liver toxicity by 2(R,S)-n-propylthiazolidine-4(R)-carboxylic acid in mice.
2001 Jan 15
Allergic reactions due to ibuprofen in children.
2001 Jan-Feb
Pharmacokinetics of oral diclofenac and acetaminophen in children after surgery.
2001 Mar
Patents

Sample Use Guides

In Vivo Use Guide
2 caplets every 8 hours with water; don't take more than 6 caplets in 24 hours
Route of Administration: Oral
In Vitro Use Guide
A time- and concentration-dependent decrease in intracellular GSH occurred in freshly isolated type II pneumocytes and alveolar macrophages exposed to subtoxic (
Substance Class Chemical
Created
by admin
on Mon Oct 21 21:06:46 UTC 2019
Edited
by admin
on Mon Oct 21 21:06:46 UTC 2019
Record UNII
362O9ITL9D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ACETAMINOPHEN
HSDB   INCI   MI   ORANGE BOOK   USP   USP-RS   VANDF  
INCI  
Official Name English
ACETAMINOPHEN COMPONENT OF MEDIGESIC PLUS
Common Name English
NORCET COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF ROXICET
Common Name English
ACETAMINOPHEN [USP]
Common Name English
ACETAMINOPHEN COMPONENT OF TALACEN
Common Name English
ACETAMINOPHEN [VANDF]
Common Name English
PHENAPHEN
Common Name English
NSC-109028
Code English
DURADYNE DHC COMPONENT ACETAMINOPHEN
Common Name English
TRIAPRIN COMPONENT ACETAMINOPHEN
Common Name English
PERCOCET COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF DURADYNE DHC
Common Name English
ACETAMINOPHEN COMPONENT OF BANCAP
Common Name English
ACETAMINOPHEN [INCI]
Common Name English
PARACETAMOLUM [WHO-IP LATIN]
Common Name English
TRIAD COMPONENT ACETAMINOPHEN
Common Name English
ESGIC COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF SYNALGOS-DC-A
Common Name English
DHC PLUS COMPONENT ACETAMINOPHEN
Common Name English
PARACETAMOL [WHO-IP]
Common Name English
PERFALGAN
Brand Name English
ACETAMINOPHEN [ORANGE BOOK]
Common Name English
ACETAMINOPHEN COMPONENT OF LORTAB
Common Name English
LORCET-HD COMPONENT ACETAMINOPHEN
Common Name English
ACETAMIDE, N-(4-HYDROXYPHENYL)-
Systematic Name English
DAFALGAN
Brand Name English
ACETAMINOPHEN COMPONENT OF FIORICET
Common Name English
SEDAPAP COMPONENT ACETAMINOPHEN
Common Name English
OFIRMEV
Brand Name English
MEDIGESIC PLUS COMPONENT ACETAMINOPHEN
Common Name English
DRIXORAL PLUS COMPONENT ACETAMINOPHEN
Common Name English
P-HYDROXY-ACETANILID
Common Name English
PARACETAMOL [MART.]
Common Name English
4'-HYDROXYACETANILIDE
Systematic Name English
VICODIN COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF BUCET
Common Name English
EFFERALGAN
Brand Name English
ZYDONE COMPONENT ACETAMINOPHEN
Common Name English
NORCO COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN [MI]
Common Name English
FEMCET COMPONENT ACETAMINOPHEN
Common Name English
APAP
Common Name English
ACETAMINOPHEN COMPONENT OF OXYCET
Common Name English
ALLAY COMPONENT ACETAMINOPHEN
Common Name English
BIOCETAMOL
Common Name English
ACETAMINOPHEN COMPONENT OF DHC PLUS
Common Name English
ACETAMINOPHEN COMPONENT OF ROXILOX
Common Name English
PARACETAMOL [IARC]
Common Name English
ACETAMINOPHEN COMPONENT OF NORCO
Common Name English
LORTAB COMPONENT ACETAMINOPHEN
Common Name English
NEOPAP
Brand Name English
ACETAMINOPHEN COMPONENT OF DOLENE AP-65
Common Name English
ANEXSIA COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF VICODIN
Common Name English
ACETAMINOPHEN COMPONENT OF WYGESIC
Common Name English
FIORICET COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN [JAN]
Common Name English
ACETAMINOPHEN [USP-RS]
Common Name English
ACETAMINOPHEN COMPONENT OF EXCEDRIN
Common Name English
CODRIX COMPONENT ACETAMINOPHEN
Common Name English
PHRENILIN COMPONENT ACETAMINOPHEN
Common Name English
HY-PHEN COMPONENT ACETAMINOPHEN
Common Name English
TYCOLET COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF TYCOLET
Common Name English
PARACETAMOL
EP   INN   MART.   WHO-DD   WHO-IP  
INN  
Official Name English
ACETAMINOPHEN COMPONENT OF CO-GESIC
Common Name English
BUCET COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF NORCET
Common Name English
TENCON COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF LORCET-HD
Common Name English
ACETAMINOPHEN [HSDB]
Common Name English
ROXICET COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF TENCON
Common Name English
TREZIX COMPONENT ACETAMINOPHEN
Brand Name English
EXCEDRIN COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF CODRIX
Common Name English
PARACETAMOL [INN]
Common Name English
ACETAMINOPHEN COMPONENT OF ALLAY
Common Name English
TYLENOL
Brand Name English
ACETAMINOPHEN COMPONENT OF HY-PHEN
Common Name English
DARVOCET COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF TYLOX
Common Name English
XARTEMIS COMPONENT ACETAMINOPHEN
Brand Name English
ACETAMINOPHEN COMPONENT OF TRIAD
Common Name English
NSC-3991
Code English
ACETAMINOPHEN COMPONENT OF SEDAPAP
Common Name English
ULTRACET COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF XARTEMIS
Brand Name English
ANOQUAN COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF ULTRACET
Common Name English
N-ACETYL-P-AMINOPHENOL
Common Name English
ACETAMINOPHEN COMPONENT OF ANOQUAN
Common Name English
ROXILOX COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF BUTAPAP
Common Name English
ACETAMINOPHEN COMPONENT OF BANCAP HC
Common Name English
ACETAMINOPHEN COMPONENT OF PERCOCET
Common Name English
ACETAMINOPHEN COMPONENT OF DARVOCET
Common Name English
ACETAMINOPHEN COMPONENT OF ANEXSIA
Common Name English
BUTAPAP COMPONENT ACETAMINOPHEN
Common Name English
BANCAP HC COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF ZYDONE
Common Name English
ACETAMINOPHEN COMPONENT OF TRIAPRIN
Common Name English
DOLIPRANE
Common Name English
PARACETAMOL [EP]
Common Name English
BANCAP COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF DRIXORAL PLUS
Common Name English
TYLOX COMPONENT ACETAMINOPHEN
Common Name English
ACETAMINOPHEN COMPONENT OF ESGIC
Common Name English
CO-GESIC COMPONENT ACETAMINOPHEN
Common Name English
VERMIDON
Common Name English
OXYCET COMPONENT ACETAMINOPHEN
Common Name English
ACEPHEN
Brand Name English
ACETAMINOPHEN COMPONENT OF PHRENILIN
Common Name English
WYGESIC COMPONENT ACETAMINOPHEN
Common Name English
INJECTAPAP
Brand Name English
SYNALGOS-DC-A COMPONENT ACETAMINOPHEN
Common Name English
TALACEN COMPONENT ACETAMINOPHEN
Common Name English
DOLENE AP-65 COMPONENT ACETAMINOPHEN
Common Name English
PARACETAMOL [WHO-DD]
Common Name English
ACETAMINOPHEN COMPONENT OF FEMCET
Common Name English
PANADOL
Brand Name English
Classification Tree Code System Code
WHO-ATC N02AJ17
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
CFR 21 CFR 341.40
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
WHO-VATC QN02BE71
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
NCI_THESAURUS C2356
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
WHO-ESSENTIAL MEDICINES LIST 7.1
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
WHO-VATC QN02BE01
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
WHO-ATC N02AJ06
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
CFR 21 CFR 862.3030
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
WHO-ATC N02BE71
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
CFR 21 CFR 310.201
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
EPA PESTICIDE CODE 606318
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
WHO-VATC QN02BE51
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
WHO-ATC N02BE51
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
WHO-ATC N02BE01
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
WHO-ATC N02AJ13
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
WHO-ESSENTIAL MEDICINES LIST 2.1
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
LIVERTOX 8
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
WHO-ATC N02AJ01
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
Code System Code Type Description
EVMPD
SUB09611MIG
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY
EPA CompTox
103-90-2
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY
PUBCHEM
1983
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY
DRUG BANK
DB00316
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY
WIKIPEDIA
PARACETAMOL
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY
LACTMED
103-90-2
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY
MERCK INDEX
M1317
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY Merck Index
WHO INTERNATIONAL PHARMACOPEIA
ACETAMINOPHEN
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY Description: A white, crystalline powder; odourless. Solubility: Sparingly soluble in water; freely soluble in ethanol (~750 g/l) TS and acetone R; practically insoluble in ether R. Category: Analgesic; antipyretic. Storage: Paracetamol should be kept in a tightly closed container, protected from light. Definition: Paracetamol contains not less than 98.5% and not more than 101.0% of C8H9NO2, calculated with reference to thedried substance.
INN
626
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY
ECHA (EC/EINECS)
203-157-5
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY
CAS
8055-08-1
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
SUPERCEDED
ChEMBL
CHEMBL112
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY
RXCUI
161
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY RxNorm
HSDB
103-90-2
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY
MESH
D000082
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY
CAS
103-90-2
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY
IUPHAR
5239
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY
NCI_THESAURUS
C198
Created by admin on Mon Oct 21 21:06:46 UTC 2019 , Edited by admin on Mon Oct 21 21:06:46 UTC 2019
PRIMARY
Related Record Type Details
METABOLIC ENZYME -> SUBSTRATE
BINDER->LIGAND
BINDING
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (UV)
USP
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
Related Record Type Details
PARENT -> METABOLITE
PARENT -> METABOLITE ACTIVE
Percent of dose excreted in urine as metabolite.
AMOUNT ADMINISTERED
URINE
PARENT -> METABOLITE ACTIVE
Percent of dose excreted in urine as metabolite 60-80
URINE
METABOLITE INACTIVE -> PARENT
URINE
METABOLITE INACTIVE -> PARENT
MAJOR
URINE
METABOLITE INACTIVE -> PARENT
URINE
METABOLITE INACTIVE -> PARENT
MAJOR
URINE
METABOLITE ACTIVE -> PARENT
METABOLITE -> PARENT
MINOR
PLASMA
METABOLITE TOXIC -> PARENT
Metabolite produced hepatic necrosis in man.
AMOUNT EXCRETED
URINE
Related Record Type Details
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (TLC)
USP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC
ORAL BIOAVAILABILITY PHARMACOKINETIC
MAXIMUM TOLERATED DOSE TOXICITY IV, LESS THAN 50 Kg

MAXIMUM TOLERATED DOSE TOXICITY
Tmax PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC
RENAL CLEARANCE
MAXIMUM TOLERATED DOSE TOXICITY
MAXIMUM TOLERATED DOSE TOXICITY