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Details

Stereochemistry ACHIRAL
Molecular Formula C6H7NO
Molecular Weight 109.1259
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of P-AMINOPHENOL

SMILES

NC1=CC=C(O)C=C1

InChI

InChIKey=PLIKAWJENQZMHA-UHFFFAOYSA-N
InChI=1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2

HIDE SMILES / InChI
Molecular Formula C6H7NO
Molecular Weight 109.1259
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

p-Aminophenol is an active metabolite of paracetamol. p-Aminophenol is conjugated with arachidonic acid by fatty acid amide hydrolase to form AM404. AM404 exerts effect through cannabinoid receptors. p- Aminophenol is a nephrotoxic metabolite of paracetamol and phenacetin. It causes acute renal proximal tubular necrosis after administration to rats. p-Aminophenol may cause skin sensitization, dermatitis. p-Aminophenol is a synthetic dye used in hair coloring.

Approval Year

2013
596

Targets

Primary TargetPharmacologyConditionPotency
Arylamine N-acetyltransferase 1
3
Substrate
661
Arylamine N-acetyltransferase 1
3
Substrate
661

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Patents

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2
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2
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4
JP4820369B2
6
JPH01174526A
2
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2
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2
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2
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2
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2
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2
JPH0269448A
2
JPH03112946A
4
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4
JPH03177419A
2
JPH04108824A
2
JPH04154860A
2
JPH0496924A
2
JPH05156007A
2
JPH05170902A
3
JPH05174621A
2
JPH05221937A
2
JPH0551450A
2
JPH06219999A
2
JPH06228303A
2
US3079435 A
2

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Concentrations of p-aminophenol from 1 to 100 μg/ml produced significant (p < 0.05) loss of mouse cortical neuron viability at 24 hr compared to the controls.
Substance Class Chemical
Record UNII
R7P8FRP05V
Record Status Validated (UNII)
Record Version
NIH
NCATS
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