Details
Stereochemistry | ACHIRAL |
Molecular Formula | C6H7NO.ClH |
Molecular Weight | 145.587 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NC1=CC=C(O)C=C1
InChI
InChIKey=RVGOBWDGAVAVPJ-UHFFFAOYSA-N
InChI=1S/C6H7NO.ClH/c7-5-1-3-6(8)4-2-5;/h1-4,8H,7H2;1H
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C6H7NO |
Molecular Weight | 109.1259 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
p-Aminophenol is an active metabolite of paracetamol. p-Aminophenol is conjugated with arachidonic acid by fatty acid amide hydrolase to form AM404. AM404 exerts effect through cannabinoid receptors. p- Aminophenol is a nephrotoxic metabolite of paracetamol and phenacetin. It causes acute renal proximal tubular necrosis after administration to rats. p-Aminophenol may cause skin sensitization, dermatitis. p-Aminophenol is a synthetic dye used in hair coloring.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL5101 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10692486 |
|||
Target ID: CHEMBL5101 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10692486 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
PubMed
Title | Date | PubMed |
---|---|---|
The degradation of paracetamol (4-hydroxyacetanilide) and other substituted acetanilides by a Penicillium species. | 1975 |
|
Biotransformation of hydroxylaminobenzene and aminophenol by Pseudomonas putida 2NP8 cells grown in the presence of 3-nitrophenol. | 2000 Jun |
|
Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants. | 2000 Oct |
|
Isolation and characterization of a pseudomonas strain that degrades 4-acetamidophenol and 4-aminophenol. | 2001 |
|
p-Aminophenol-induced liver toxicity: tentative evidence of a role for acetaminophen. | 2001 |
|
Metabolism of (R)- and (S)-3-(phenylamino)propane-1,2-diol in C57BL/6- and A/J-strain mice. Identification of new metabolites with potential toxicological significance to the toxic oil syndrome. | 2001 Aug |
|
Patch testing by additional series of allergens: results of further experiences. | 2001 Dec |
|
Potentiation of antitumor immunity by antibody-directed enzyme prodrug therapy. | 2001 Dec 15 |
|
Quantitative analysis of analgoantipyretics in dosage form using planar chromatography. | 2001 Mar |
|
Study of a novel cationic calix[4]arene used a selectivity modifier in capillary electrophoresis with electrochemical detection. | 2001 Mar 2 |
|
Effects of alternative carbon sources on biological transformation of nitrophenols. | 2002 |
|
Synthesis and beta 1-, beta 2-adrenergic receptor binding studies of 4-acylamino-substituted phenoxypropanolamine and 5-acylamino-substituted naphthyloxypropanolamine derivatives. | 2002 |
|
An in-vitro study of the effects of various disinfectants on prosthetic and surface materials. | 2002 Apr |
|
Liver regeneration is an angiogenesis- associated phenomenon. | 2002 Dec |
|
Cytokinin oxidase/cytokinin dehydrogenase assay: optimized procedures and applications. | 2002 Jul 1 |
|
NMR and Bayesian regularized neural network regression for impurity determination of 4-aminophenol. | 2002 Jul 1 |
|
[Research into simultaneous spectrophotometric determination of components in cough syrup by principal component regression method]. | 2002 Jun |
|
Anti-tumour activity and toxicity of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in mice. | 2002 May 20 |
|
Deviceless decoupled electrochemical detection of catecholamines in capillary electrophoresis using gold microband array electrodes. | 2002 Nov |
|
Biological activity of p-methylaminophenol, an essential structural component of N-(4-hydroxyphenyl)retinamide, fenretinide. | 2002 Nov |
|
Rapid and quantitative determination of metabolites from multiple cytochrome P450 probe substrates by gradient liquid chromatography-electrospray ionization-ion trap mass spectrometry. | 2002 Nov 25 |
|
Immobilizing a single pybox ligand onto a library of solid supports. | 2003 |
|
The use of thermal lensing for the determination of pyrogens. | 2003 Apr |
|
Sorption and diffusion of phenols onto well-defined ordered nanoporous monolithic silicas. | 2003 Apr 1 |
|
Generation of ligand conformations in continuum solvent consistent with protein active site topology: application to thrombin. | 2003 Apr 10 |
|
Metalloantimalarials: targeting of P. falciparum strains with novel iron(III) and gallium(III) complexes of an amine phenol ligand. | 2003 Apr 7 |
|
Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry. | 2003 Dec 25 |
|
Synthesis of 11C-amides using [11C]carbon monoxide and in situ activated amines by palladium-mediated carboxaminations. | 2003 Feb 7 |
|
A capillary-based amperometric flow immunoassay for 2,4,6-trichlorophenol. | 2003 Jan |
|
Synthesis, characterization, and molecular structure of a gallium(III) complex of an amine-phenol ligand with activity against chloroquine-sensitive Plasmodium falciparum strains. | 2003 Jan 15 |
|
Dlf complexes with uniform coordination geometry: structural and magnetic properties of an LnNi2 core supported by a heptadentate amine phenol ligand. | 2003 Mar 10 |
|
Poly(ethyleneglycol) column for the determination of acetaminophen, phenylephrine and chlorpheniramine in pharmaceutical formulations. | 2003 Mar 5 |
|
A potential biomarker of kidney damage identified by proteomics: preliminary findings. | 2003 May-Aug |
|
Spectrophotometric determination of paracetamol with microwave assisted alkaline hydrolysis. | 2004 Jul |
|
Hair dye contact allergy: quantitative exposure assessment of selected products and clinical cases. | 2004 Jun |
|
Bead-based immunoassays with microelectrode detection. | 2004 Jun |
|
Toxic effects of aminophenols on aquatic life using the zebrafish embryo test and the comet assay. | 2004 Oct |
|
Microchip capillary electrophoresis with a boron-doped diamond electrochemical detector for analysis of aromatic amines. | 2004 Sep |
|
Pharmacophore based synthesis of 3-chloroquinoxaline-2-carboxamides as serotonin3 (5-HT3) receptor antagonist. | 2004 Sep |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21771276
Concentrations of p-aminophenol from 1 to 100 μg/ml produced significant (p < 0.05) loss of mouse cortical neuron viability at 24 hr compared to the controls.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:52:50 GMT 2023
by
admin
on
Fri Dec 15 18:52:50 GMT 2023
|
Record UNII |
IWL2N22RFY
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Official Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
2151
Created by
admin on Fri Dec 15 18:52:50 GMT 2023 , Edited by admin on Fri Dec 15 18:52:50 GMT 2023
|
PRIMARY | |||
|
C026729
Created by
admin on Fri Dec 15 18:52:50 GMT 2023 , Edited by admin on Fri Dec 15 18:52:50 GMT 2023
|
PRIMARY | |||
|
5828
Created by
admin on Fri Dec 15 18:52:50 GMT 2023 , Edited by admin on Fri Dec 15 18:52:50 GMT 2023
|
PRIMARY | |||
|
IWL2N22RFY
Created by
admin on Fri Dec 15 18:52:50 GMT 2023 , Edited by admin on Fri Dec 15 18:52:50 GMT 2023
|
PRIMARY | |||
|
DTXSID6058760
Created by
admin on Fri Dec 15 18:52:50 GMT 2023 , Edited by admin on Fri Dec 15 18:52:50 GMT 2023
|
PRIMARY | |||
|
DBSALT002745
Created by
admin on Fri Dec 15 18:52:50 GMT 2023 , Edited by admin on Fri Dec 15 18:52:50 GMT 2023
|
PRIMARY | |||
|
200-122-6
Created by
admin on Fri Dec 15 18:52:50 GMT 2023 , Edited by admin on Fri Dec 15 18:52:50 GMT 2023
|
PRIMARY | |||
|
51-78-5
Created by
admin on Fri Dec 15 18:52:50 GMT 2023 , Edited by admin on Fri Dec 15 18:52:50 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
PARENT -> SALT/SOLVATE |