Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H9NO5S |
| Molecular Weight | 231.226 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)NC1=CC=C(OS(O)(=O)=O)C=C1
InChI
InChIKey=IGTYILLPRJOVFY-UHFFFAOYSA-N
InChI=1S/C8H9NO5S/c1-6(10)9-7-2-4-8(5-3-7)14-15(11,12)13/h2-5H,1H3,(H,9,10)(H,11,12,13)
| Molecular Formula | C8H9NO5S |
| Molecular Weight | 231.226 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Caco-2 cell monolayers as a tool to study simultaneous phase II metabolism and metabolite efflux of indomethacin, paracetamol and 1-naphthol. | 2010-01-04 |
|
| Alteration in metabolism and toxicity of acetaminophen upon repeated administration in rats. | 2009-10 |
|
| Simultaneous RP-HPLC determination of sotalol, metoprolol, alpha-hydroxymetoprolol, paracetamol and its glucuronide and sulfate metabolites in human urine. | 2009-06 |
|
| Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice. | 2009-05 |
|
| Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation. | 2009-01 |
|
| Development of an HPLC-MS/MS method for the selective determination of paracetamol metabolites in mouse urine. | 2008-03-01 |
|
| Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases. | 2007-09 |
|
| Effects of combined UDP-glucuronosyltransferase (UGT) 1A1*28 and 1A6*2 on paracetamol pharmacokinetics in beta-thalassemia/HbE. | 2007 |
|
| A pharmacokinetic study of paracetamol in Thai beta-thalassemia/HbE patients. | 2006-09 |
|
| Spectrophotometric determination of paracetamol in urine with tetrahydroxycalix[4]arene as a coupling reagent and preconcentration with triton X-114 using cloud point extraction. | 2006-06 |
|
| Intra- and interindividual variability of glucuronidation of paracetamol during repeated administration of propacetamol in neonates. | 2005-09 |
|
| Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1. | 2005-08 |
|
| Effect of taurine on biliary excretion and metabolism of acetaminophen in male hamsters. | 2004-11 |
|
| The quantification of paracetamol, paracetamol glucuronide and paracetamol sulphate in plasma and urine using a single high-performance liquid chromatography assay. | 2004-02-18 |
|
| Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites. | 2003-09 |
|
| Paracetamol and metabolite pharmacokinetics in infants. | 2003-07 |
|
| The effects of phytoestrogenic isoflavones on the formation and disposition of paracetamol sulfate in the isolated perfused rat liver. | 2003-05 |
|
| Effect of nizatidine on paracetamol and its metabolites in human plasma. | 2002-06 |
|
| Application of 4-hydroxyantipyrine and acetaminophen O-sulfate as biodistribution promoter. | 2001-12 |
|
| Role of ATP and glycogen reserves in both paracetamol sulfation and glucuronidation by cultured precision-cut rat liver slices. | 2001-12 |
|
| Cisapride raises the bioavailability of paracetamol by inhibiting its glucuronidation in man. | 2001-07 |
|
| Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen. | 2001-06-15 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:55:44 GMT 2025
by
admin
on
Mon Mar 31 18:55:44 GMT 2025
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| Record UNII |
S6002H6J9F
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| Record Status |
Validated (UNII)
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| Record Version |
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| Code System | Code | Type | Description | ||
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C045667
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S6002H6J9F
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83939
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10066-90-7
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DTXSID70143433
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32635
Created by
admin on Mon Mar 31 18:55:44 GMT 2025 , Edited by admin on Mon Mar 31 18:55:44 GMT 2025
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| Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
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| Related Record | Type | Details | ||
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PARENT -> METABOLITE |
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PARENT -> METABOLITE INACTIVE |
Major metabolite in infants and young children glucuronide is major metabolite in adults.
MAJOR
URINE
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