VORINOSTAT

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H20N2O3
Molecular Weight	264.3202
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1

InChI

InChIKey=WAEXFXRVDQXREF-UHFFFAOYSA-N

InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)

HIDE SMILES / InChI

Molecular Formula	C14H20N2O3
Molecular Weight	264.3202
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.drugbank.ca/drugs/DB02546
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021991s002lbl.pdf

Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL). Vorinostat inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC50< 86 nM). These enzymes catalyze the removal of acetyl groups from the lysine residues of histones proteins. In some cancer cells, there is an overexpression of HDACs, or an aberrant recruitment of HDACs to oncogenic transcription factors causing hypoacetylation of core nucleosomal histones. By inhibiting histone deacetylase, vorinostat causes the accumulation of acetylated histones and induces cell cycle arrest and/or apoptosis of some transformed cells. The mechanism of the antineoplastic effect of vorinostat has not been fully characterized. Vorinostat is used for the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies. Vorinostat is marketed under the name Zolinza by Merck for the treatment of cutaneous manifestations in patients with cutaneous T cell lymphoma (CTCL) when the disease persists, gets worse, or comes back during or after two systemic therapies.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Plasmodium falciparum 3D7 6 Target ID: CHEMBL2366922 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26199860	Inhibitor 8146	0.12 µM [IC50]
NCI-H661 1 Target ID: CHEMBL1075544 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25953722	Inhibitor 8146	0.13 µM [IC50]
Histone deacetylase 1 51 Target ID: CHEMBL325 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25953722	Inhibitor 8146	0.15 µM [IC50]
Histone deacetylase 2 37 Target ID: CHEMBL1937 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25953722	Inhibitor 8146	0.28 µM [IC50]
Histone deacetylase 8 17 Target ID: CHEMBL3192 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25953722	Inhibitor 8146	1.68 µM [IC50]
Histone deacetylase 3 35 Target ID: CHEMBL1829 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19410459	Inhibitor 8146	57.0 nM [IC50]
Histone deacetylase 6 27 Target ID: CHEMBL1865 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25734520	Inhibitor 8146	1.0 µM [EC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cutaneous T-cell lymphoma 8 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021991s002lbl.pdf	Primary		Approved 8307	Zolinza Approved Use Treatment of cutaneous manifestations in patients with cutaneous T cell lymphoma (CTCL) who have progressive, persistent or recurrent disease on or following two systemic therapies. Launch Date 1.16000634E12

C_max

Value	Dose	Analyte	Population
1.2 μM DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021991s002lbl.pdf	400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered:	VORINOSTAT plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: HIGH-FAT
0.83 uM Clinical Trial https://clinicaltrials.gov/ct2/show/NCT00771472	400 mg single, oral dose: 400 mg route of administration: oral experiment type: single co-administered:	VORINOSTAT plasma	Homo sapiens population: unhealthy age: sex: food status:
1.17 uM Clinical Trial https://clinicaltrials.gov/ct2/show/NCT00771472	400 mg 1 times / day steady, oral dose: 400 mg route of administration: oral experiment type: steady co-administered:	VORINOSTAT plasma	Homo sapiens population: unhealthy age: sex: food status:

AUC

Value	Dose	Analyte	Population
5.5 μM × h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021991s002lbl.pdf	400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered:	VORINOSTAT plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: HIGH-FAT
4.59 uM*h Clinical Trial https://clinicaltrials.gov/ct2/show/NCT00771472	400 mg single, oral dose: 400 mg route of administration: oral experiment type: single co-administered:	VORINOSTAT plasma	Homo sapiens population: unhealthy age: sex: food status:
5.59 uM*h Clinical Trial https://clinicaltrials.gov/ct2/show/NCT00771472	400 mg 1 times / day steady, oral dose: 400 mg route of administration: oral experiment type: steady co-administered:	VORINOSTAT plasma	Homo sapiens population: unhealthy age: sex: food status:

T_1/2

Value	Dose	Analyte	Population
2 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021991s002lbl.pdf	400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered:	VORINOSTAT plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: HIGH-FAT
1.94 h Clinical Trial https://clinicaltrials.gov/ct2/show/NCT00771472	400 mg single, oral dose: 400 mg route of administration: oral experiment type: single co-administered:	VORINOSTAT plasma	Homo sapiens population: unhealthy age: sex: food status:
2.3 h Clinical Trial https://clinicaltrials.gov/ct2/show/NCT00771472	400 mg 1 times / day steady, oral dose: 400 mg route of administration: oral experiment type: steady co-administered:	VORINOSTAT plasma	Homo sapiens population: unhealthy age: sex: food status:

F_unbound

Value	Dose	Co-administered	Analyte	Population
29% DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021991s002lbl.pdf	400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered:		VORINOSTAT plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: HIGH-FAT

Doses

Dose	Population	Adverse events
250 mg 2 times / day multiple, oral Dose: 250 mg, 2 times / day Route: oral Route: multiple Dose: 250 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/18297527	unhealthy, 63 years (range: 38 - 74 years) n = 5 Health Status: unhealthy Condition: advanced multiple myeloma Age Group: 63 years (range: 38 - 74 years) Population Size: 5 Sources: https://pubmed.ncbi.nlm.nih.gov/18297527	DLT: Fatigue... Dose limiting toxicities: Fatigue (grade 3, 1 patient) Sources: https://pubmed.ncbi.nlm.nih.gov/18297527
300 mg 2 times / day multiple, oral (starting) Highest studied dose Dose: 300 mg, 2 times / day Route: oral Route: multiple Dose: 300 mg, 2 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021991lbl.pdf https://pubmed.ncbi.nlm.nih.gov/16960145	unhealthy, 69 years (range: 26.0 - 80.0 years) n = 12 Health Status: unhealthy Condition: cutaneous Tcell lymphoma Age Group: 69 years (range: 26.0 - 80.0 years) Sex: M+F Population Size: 12 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021991lbl.pdf https://pubmed.ncbi.nlm.nih.gov/16960145	Disc. AE: Thrombocytopenia, Anemia... Other AEs: Hypotension, Sepsis... AEs leading to discontinuation/dose reduction: Thrombocytopenia (grade 3-4, 8%) Anemia (grade 3-4, 17%) Deep vein thrombosis (grade 3-4, 25%) Pyrexia (grade 3-4, 25%) Pulmonary embolism (grade 3-4, 17%) Other AEs: Hypotension (grade 3-4, 17%) Sepsis (grade 3-4, 8%) Fatigue (all grades, 27%) Diarrhea (11%) Nausea (8%) Dysgeusia (11%) Weight loss (3%) Vomiting (11%) Anorexia (3%) Blood creatinine increased (8%) Dehydration (5%) Anemia (5%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021991lbl.pdf https://pubmed.ncbi.nlm.nih.gov/16960145

AEs

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 1532 inducer 753 supressor 21	inhibitor 1695 inducer 372	inhibitor 1789	inhibitor 1570

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP 107 P-gp 1401 CYP1A2 1463 CYP2B6 770 CYP2C8 869 CYP2C19 1410	CYP 252 P-gp 1491 UGT1A1 417 UGT1A3 421 UGT1A7 235 UGT1A8 282 UGT1A9 378 UGT2B7 387 UGT2B17 212	CYP1A2 671 CYP2B6 521 CYP2C19 283

Drug as perpetrator

Target	Modality	Activity	Clinical evidence
P-gp 1588	inhibitor 3185 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 4, 6, 27	inconclusive	no (co-administration study) Comment: vorinostat has no inhibitory effect on the tranport of vinblastine Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 4, 6, 27
CYP2C19 1484	inhibitor 3185 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 6, 25, 26	no [IC50 79.8 uM]
CYP1A2 1620	inhibitor 3185 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 6, 25, 26	no [IC50 >100 uM]
CYP2B6 946	inhibitor 3185 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 6, 25, 26	no [IC50 >100 uM]
CYP2C8 923	inhibitor 3185 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 6, 25, 26	no [IC50 >100 uM]
CYP2C9 1747	inhibitor 3185 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 6, 25, 26	no [IC50 >100 uM]
CYP2D6 1826	inhibitor 3185 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 6, 25, 26	no [IC50 >100 uM]
CYP3A4 1857	inhibitor 3185 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 6, 25, 26	no [IC50 >100 uM]
CYP 143	inhibitor 3185 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021991s009lbl.pdf Page: 9.0	no
CYP1A2 1620	inducer 1515 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 25.0	yes
CYP2B6 946	inducer 1515 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 26.0	yes
CYP2C19 1484	inducer 1515 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 26.0	yes
CYP2C9 1747	inducer 1515 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 26.0	yes
CYP3A4 1857	inducer 1515 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 26.0	yes
CYP3A4 1857	supressor 149 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_PharmR.pdf Page: 37.0	yes

Drug as victim

Target	Modality	Activity
P-gp 1491	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 4, 6, 27	inconclusive
CYP 252	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 6.0	no
UGT1A1 417	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 3.0	yes
UGT1A3 421	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 3.0	yes
UGT1A7 235	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 3.0	yes
UGT1A8 282	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 3.0	yes
UGT1A9 378	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 4.0	yes
UGT2B17 212	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 4.0	yes
UGT2B7 387	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_ClinPharmR.pdf Page: 4.0	yes

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 1603	inhibitor 1584 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021991s000_Zolinza_PharmR.pdf Page: 31.0

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:45716	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:45716
ChemicalBook	CB3506806	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB3506806
MolPort	MolPort-003-850-293	https://www.molport.com/shop/molecule-link/MolPort-003-850-293
Selleck Chemicals	Vorinostat-(SAHA)	http://www.selleckchem.com/products/Vorinostat-(SAHA).html
ZINC	ZINC000001543873	http://zinc15.docking.org/substances/ZINC000001543873
eMolecules	1989084	https://www.emolecules.com/cgi-bin/more?vid=1989084

PubMed

Title	Date	PubMed
Histone deacetylase inhibitors up-regulate the expression of tight junction proteins.	2004 Dec	15634758
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.	2004 Dec 1	15574791
Proteasome inhibition sensitizes non-small cell lung cancer to histone deacetylase inhibitor-induced apoptosis through the generation of reactive oxygen species.	2004 Nov	15514602
High turbulence liquid chromatography online extraction and tandem mass spectrometry for the simultaneous determination of suberoylanilide hydroxamic acid and its two metabolites in human serum.	2005	15945019
Histone deacetylase inhibitors in programmed cell death and cancer therapy.	2005 Apr	15738652
Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change.	2005 Apr	15625278
Suberoylanilide hydroxamic acid combined with gemcitabine enhances apoptosis in non-small cell lung cancer.	2005 Aug	16153448
Synergistic apoptosis induction by proteasome and histone deacetylase inhibitors is dependent on protein synthesis.	2005 Aug	16133866
Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines.	2005 Aug	16093438
It's about time: scheduling alters effect of histone deacetylase inhibitors on camptothecin-treated cells.	2005 Aug 1	16061681
Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelin.	2005 Dec	16123169
Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates.	2005 Feb 24	15715470
Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines.	2005 Jan	15661398
The histone deacetylase inhibitor suberoylanilide hydroxamic acid down-regulates expression levels of Bcr-abl, c-Myc and HDAC3 in chronic myeloid leukemia cell lines.	2005 Jan	15583844
Identification of a potent non-hydroxamate histone deacetylase inhibitor by mechanism-based drug design.	2005 Jan 17	15603949
Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma.	2005 Jul	16026644
Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation.	2005 Jul	15964800
Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines.	2005 Jul	15930892
Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent.	2005 Jul 1	15927839
A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells.	2005 Jul 28	16033284
The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells.	2005 Jun	15754201
Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer.	2005 Jun 10	15897550
Drug insight: Histone deacetylase inhibitors--development of the new targeted anticancer agent suberoylanilide hydroxamic acid.	2005 Mar	16264908
4-Hydroxybenzoyl derivative from the aqueous extract of the hydroid Campanularia sp.	2005 Mar	15787459
Histone deacetylase inhibitors interact synergistically with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in carcinoma cell lines.	2005 Mar	15744585
Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells.	2005 Mar 1	15713371
[Histone deacetylase inhibitors as a new generation of anti-cancer agents].	2005 Mar 11	15928589
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species.	2005 Mar 15	15781658
Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo.	2005 May	15857402
Modulation of radiation response by histone deacetylase inhibition.	2005 May 1	15850925
The role of histone acetylation in SMN gene expression.	2005 May 1	15772088
Novel histone deacetylase inhibitors in the treatment of thyroid cancer.	2005 May 15	15897598
Selective induction of apoptosis by histone deacetylase inhibitor SAHA in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action.	2005 Nov	16297208
Suberoylanilide hydroxamic acid enhances gap junctional intercellular communication via acetylation of histone containing connexin 43 gene locus.	2005 Nov 1	16266998
Crystal structure of a bacterial class 2 histone deacetylase homologue.	2005 Nov 18	16242151
Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.	2005 Oct	16121216
Early clinical data and potential clinical utility of novel histone deacetylase inhibitors in prostate cancer.	2005 Sep	16197607
Synergistic interactions between MEK1/2 and histone deacetylase inhibitors in BCR/ABL+ human leukemia cells.	2005 Sep	16015388
Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2.	2005 Sep 1	16144943
Induction of polyploidy by histone deacetylase inhibitor: a pathway for antitumor effects.	2005 Sep 1	16140952
Histone deacetylase inhibitors suppress the induction of c-Jun and its target genes including COX-2.	2005 Sep 23	15994313
Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene silencing of thioredoxin-binding protein-2.	2006 Apr 6	16314839
Histone deacetylase inhibitors reduce VEGF production and induce growth suppression and apoptosis in human mantle cell lymphoma.	2006 Jan	16343270
SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells.	2006 Jan	16328054
5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation.	2006 Jan	16043219
Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies.	2006 Jan 1	16330674
SAHA-sensitized prostate cancer cells to TNFalpha-related apoptosis-inducing ligand (TRAIL): mechanisms leading to synergistic apoptosis.	2006 Jul 1	16450389
Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells.	2006 Mar	16465382
Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation.	2006 Mar 3	16377638
Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases.	2006 May 15	16434199

Patents

Sample Use Guides

In Vivo Use Guide

400 mg orally once daily with food. If patient is intolerant to therapy, the dose may be reduced to 300 mg orally once daily with food. If necessary, the dose may be further reduced to 300 mg once daily with food for 5 consecutive days each week.

Route of Administration: Oral

In Vitro Use Guide

Concentrations of vorinostat higher than 0.5 uM significantly inhibited the upregulated gene expression of MMP-1 and MMP-13 induced by IL-1β, whereas 0.1 uM vorinostat showed no obvious effect. Conversely, 0.5 uM vorinostat or higher concentration increased the TIMP-1 expression.

Substance Class	Chemical Created by `admin` on `Sun Dec 18 17:32:28 UTC 2022` Edited by `admin` on `Sun Dec 18 17:32:28 UTC 2022`
Record UNII	58IFB293JI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

VORINOSTAT

Official Name

English

VORINOSTAT [MI]

Common Name

English

NSC-759852

Code

English

VORINOSTAT [ORANGE BOOK]

Common Name

English

NSC-701852

Code

English

N-HYDROXY-N'-PHENYLOCTANEDIAMIDE

Systematic Name

English

NSC-748799

Code

English

ZOLINZA

Brand Name

English

MK0683

Code

English

VORINOSTAT [MART.]

Common Name

English

MK-0683

Code

English

VORINOSTAT [USAN]

Common Name

English

OCTANEDIAMIDE, N-HYDROXY-N'-PHENYL-

Systematic Name

English

vorinostat [INN]

Common Name

English

Vorinostat [WHO-DD]

Common Name

English

SUBEROYLANILIDE HYDROXAMIC ACID

Common Name

English

VORINOSTAT [JAN]

Common Name

English

VORINOSTAT [VANDF]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

177203