U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
139594
Substance Class Protein
Created
by admin
on Sat Dec 16 12:55:16 GMT 2023
Edited
by admin
on Sat Dec 16 12:55:16 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
O037NFL7YQ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HISTONE DEACETYLASE 1
Common Name English
HD1
Common Name English
HDAC1
Common Name English
RPD3L1
Common Name English
Code System Code Type Description
PHAROS
Q13547
Created by admin on Sat Dec 16 12:55:18 GMT 2023 , Edited by admin on Sat Dec 16 12:55:18 GMT 2023
PRIMARY
FDA UNII
O037NFL7YQ
Created by admin on Sat Dec 16 12:55:18 GMT 2023 , Edited by admin on Sat Dec 16 12:55:18 GMT 2023
PRIMARY
UNIPROT
Q13547
Created by admin on Sat Dec 16 12:55:18 GMT 2023 , Edited by admin on Sat Dec 16 12:55:18 GMT 2023
PRIMARY
Related Record Type Details
Structure of RICOLINOSTAT
WEAK INHIBITOR->TARGET
IC50
Structure of 5-(1-(4-(TERT-BUTYL)BENZYL)-1H-PYRAZOL-3-YL)-NHYDROXYPENTANAMIDE
INHIBITOR -> TARGET
Structure of PURINOSTAT
INHIBITOR -> TARGET
IN-VIVO
Structure of TUCIDINOSTAT
INHIBITOR -> TARGET
IC50
Structure of TACEDINALINE
INHIBITOR -> TARGET
IC50
Structure of TINOSTAMUSTINE
INHIBITOR -> TARGET
Structure of MOCETINOSTAT
INHIBITOR -> TARGET
Potent HDAC inhibitor with most potency for HDAC1 in a cell-free assay.
INHIBITOR
IC50
Structure of DACINOSTAT
INHIBITOR -> TARGET
Structure of APICIDIN
INHIBITOR -> TARGET
Structure of NANATINOSTAT
INHIBITOR -> TARGET
Structure of Zabadinostat
INHIBITOR -> TARGET
Structure of REC-2282
INHIBITOR -> TARGET
IC50
Structure of ENTINOSTAT
INHIBITOR -> TARGET
Enzymatic Inhibition
IC50
Structure of FR-135313
INHIBITOR -> TARGET
Structure of DOMATINOSTAT
INHIBITOR -> TARGET
4SC-202 is a selective class I HDAC inhibitor and also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.
INHIBITOR
IC50
Structure of BELINOSTAT
LIGAND->TARGET
Structure of BG-45
INHIBITOR -> TARGET
Structure of IVALTINOSTAT
INHIBITOR -> TARGET
Structure of N-HYDROXY-5-(1-(4-NITROBENZYL)-1H-PYRAZOL-3-YL)PENTANAMIDE
INHIBITOR -> TARGET
Structure of 5-(1-(4-BROMOBENZYL)-1H-PYRAZOL-3-YL)-NHYDROXYPENTANAMIDE
INHIBITOR -> TARGET
Structure of CITARINOSTAT
INHIBITOR -> TARGET
Structure of ROMIDEPSIN
INHIBITOR -> TARGET
Potent HDAC1 inhibitor in a cell-free assay.
INHIBITOR
IC50
Structure of PANOBINOSTAT
INHIBITOR -> TARGET
A PAN HDAC INHIBITOR.
IC50
Structure of PRACINOSTAT
INHIBITOR -> TARGET
Structure of QUISINOSTAT
INHIBITOR -> TARGET
Structure of FIMEPINOSTAT
INHIBITOR -> TARGET
CUDC-907 is a dual PI3K.ALPHA. and HDAC1 inhibitor. Phase 1.
INHIBITOR
IC50
Structure of OCID-4681
INHIBITOR -> TARGET
Structure of N-HYDROXY-3-(3-(PHENETHYLSULFAMOYL)PHENYL)ACRYLAMIDE
INHIBITOR -> TARGET
Structure of N-HYDROXY-5-(1-(4-(TRIFLUOROMETHYL)BENZYL)-1H-PYRAZOL-3-YL)PENTANAMIDE
INHIBITOR -> TARGET
Structure of VALPROIC ACID
INHIBITOR -> TARGET
Structure of VORINOSTAT
INHIBITOR -> TARGET
Structure of ABEXINOSTAT
INHIBITOR -> TARGET
Abexinostat (PCI-24781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 NM. Phase 1/2.
INHIBITOR
Ki
Structure of REMETINOSTAT
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966