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Details

Stereochemistry ACHIRAL
Molecular Formula C23H24N8O4S
Molecular Weight 508.553
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FIMEPINOSTAT

SMILES

COC1=CC=C(C=N1)C2=NC(N3CCOCC3)=C4SC(CN(C)C5=NC=C(C=N5)C(=O)NO)=CC4=N2

InChI

InChIKey=JOWXJLIFIIOYMS-UHFFFAOYSA-N
InChI=1S/C23H24N8O4S/c1-30(23-25-11-15(12-26-23)22(32)29-33)13-16-9-17-19(36-16)21(31-5-7-35-8-6-31)28-20(27-17)14-3-4-18(34-2)24-10-14/h3-4,9-12,33H,5-8,13H2,1-2H3,(H,29,32)

HIDE SMILES / InChI

Molecular Formula C23H24N8O4S
Molecular Weight 508.553
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

CUDC-907 is a small molecule inhibitor of histone deacetylase and PI3 kinase developed by Curis. It is investigated in clinical trials for the treatment of relapsed or refractory lymphomas, thyroid cancer, multiple myeloma, breast cancer and other malignancies.

Originator

Approval Year

TargetsConditions
PubMed

PubMed

TitleDatePubMed
Cancer network disruption by a single molecule inhibitor targeting both histone deacetylase activity and phosphatidylinositol 3-kinase signaling.
2012 Aug 1
Patents

Sample Use Guides

In Vivo Use Guide
The recommended dose for phase 2 clinical trial is 60 mg on the 5/2 dosing schedule.
Route of Administration: Oral
In Vitro Use Guide
Human cancer cell lines were purchased from American Type Culture Collection (Manassas, VA) and plated at densities of 5,000 to 10,000 per well in 96-well flat-bottomed plates with the recommended culture medium. The cells were then incubated with compounds at various concentrations for 72 hours in culture medium supplemented with 0.5% (v/v) FBS. Growth inhibition was assessed by assay of cellular ATP content using the Perkin-Elmer ATPlite kit. CUDC-907 inhibits the growth of cell lines with IC50 of 10-100 nM.
Substance Class Chemical
Created
by admin
on Tue Oct 22 02:00:01 UTC 2019
Edited
by admin
on Tue Oct 22 02:00:01 UTC 2019
Record UNII
3S9RX35S5X
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FIMEPINOSTAT
USAN   INN  
Official Name English
N-HYDROXY-2-(((2-(6-METHOXYPYRIDIN-3-YL)-4-(MORPHOLIN-4-YL)THIENO(3,2-D)PYRIMIDIN-6-YL)METHYL)(METHYL)AMINO)PYRIMIDINE-5-CARBOXAMIDE
Systematic Name English
FIMEPINOSTAT [USAN]
Common Name English
FIMEPINOSTAT [INN]
Common Name English
CUDC 907 [WHO-DD]
Common Name English
5-PYRIMIDINECARBOXAMIDE, N-HYDROXY-2-(((2-(6-METHOXY-3-PYRIDINYL)-4-(4-MORPHOLINYL)THIENO(3,2-D)PYRIMIDIN-6-YL)METHYL)METHYLAMINO)-
Systematic Name English
PI3K/HDAC INHIBITOR CUDC-907
Common Name English
CUDC907
Code English
CUDC-907
Code English
Classification Tree Code System Code
NCI_THESAURUS C129825
Created by admin on Tue Oct 22 02:00:01 UTC 2019 , Edited by admin on Tue Oct 22 02:00:01 UTC 2019
NCI_THESAURUS C1404
Created by admin on Tue Oct 22 02:00:01 UTC 2019 , Edited by admin on Tue Oct 22 02:00:01 UTC 2019
NCI_THESAURUS C1946
Created by admin on Tue Oct 22 02:00:01 UTC 2019 , Edited by admin on Tue Oct 22 02:00:01 UTC 2019
FDA ORPHAN DRUG 467814
Created by admin on Tue Oct 22 02:00:01 UTC 2019 , Edited by admin on Tue Oct 22 02:00:01 UTC 2019
FDA ORPHAN DRUG 482415
Created by admin on Tue Oct 22 02:00:01 UTC 2019 , Edited by admin on Tue Oct 22 02:00:01 UTC 2019
Code System Code Type Description
EPA CompTox
1339928-25-4
Created by admin on Tue Oct 22 02:00:01 UTC 2019 , Edited by admin on Tue Oct 22 02:00:01 UTC 2019
PRIMARY
INN
10504
Created by admin on Tue Oct 22 02:00:01 UTC 2019 , Edited by admin on Tue Oct 22 02:00:01 UTC 2019
PRIMARY
CAS
1339928-25-4
Created by admin on Tue Oct 22 02:00:01 UTC 2019 , Edited by admin on Tue Oct 22 02:00:01 UTC 2019
PRIMARY
PUBCHEM
54575456
Created by admin on Tue Oct 22 02:00:01 UTC 2019 , Edited by admin on Tue Oct 22 02:00:01 UTC 2019
PRIMARY
ChEMBL
CHEMBL3545052
Created by admin on Tue Oct 22 02:00:01 UTC 2019 , Edited by admin on Tue Oct 22 02:00:01 UTC 2019
PRIMARY
NCI_THESAURUS
C104008
Created by admin on Tue Oct 22 02:00:01 UTC 2019 , Edited by admin on Tue Oct 22 02:00:01 UTC 2019
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
SALT/SOLVATE -> PARENT
TARGET -> INHIBITOR
TARGET -> INHIBITOR
CUDC-907 is a dual PI3K.ALPHA. and HDAC1 inhibitor. Phase 1.
INHIBITOR
IC50
TARGET -> INHIBITOR
CUDC-907 is a dual PI3K.ALPHA. and HDAC2 inhibitor. Phase 1.
INHIBITOR
IC50
TARGET -> INHIBITOR
CUDC-907 is a dual PI3K.ALPHA. and HDAC3 inhibitor. Phase 1.
INDUCER
IC50
TARGET -> INHIBITOR
CUDC-907 is a dual PI3K.ALPHA. and HDAC10 inhibitor. Phase 1.
INHIBITOR
IC50
Related Record Type Details
ACTIVE MOIETY