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Approval Year

Substance Class Protein
Created
by admin
on Sun Dec 18 09:21:32 UTC 2022
Edited
by admin
on Sun Dec 18 09:21:32 UTC 2022
Protein Sub Type
Sequence Type COMPLETE
Record UNII
JQ83GG8LT2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
Common Name English
PI3-KINASE SUBUNIT ALPHA
Common Name English
PTDINS-3-KINASE SUBUNIT ALPHA
Common Name English
PHOSPHOINOSITIDE-3-KINASE CATALYTIC ALPHA POLYPEPTIDE
Common Name English
PI3K-ALPHA
Common Name English
PIK3CA
Common Name English
Code System Code Type Description
DRUG BANK
DB14954
Created by admin on Sun Dec 18 09:21:36 UTC 2022 , Edited by admin on Sun Dec 18 09:21:36 UTC 2022
PRIMARY
FDA UNII
JQ83GG8LT2
Created by admin on Sun Dec 18 09:21:36 UTC 2022 , Edited by admin on Sun Dec 18 09:21:36 UTC 2022
PRIMARY
Related Record Type Details
NON-INHIBITOR->OFF TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
selective for alpha isoform, and leads to degradation of mutant p110 alpha PI3K subunit.
Ki
INHIBITOR -> TARGET
WEAK INHIBITOR->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
PARENT->INNOVATOR
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
COMPETITIVE INHIBITOR
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR
IC50
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Highly selective PI3K? inhibitor when tested at 1 ?M in a broad kinase panel (344 assays). >1000-fold selective over the members of class 2 (PI3K-C2?, PI3K-C2?), class 3 (hVPS34), and class 4 (PI3K?, PI4K?) groups of the PI3K family, PI3K-related (DNA-PK, mTOR) kinase family.
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Selective, oral bioavailable PI3K? isoform inhibitor s more than 100-fold selective than other class I PI3K isoforms and mTOR as well as a high degree of selectivity against a large panel of protein kinases with potential antitumor activity.
IC50
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL