Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 12:10:53 UTC 2023
by
admin
on
Sat Dec 16 12:10:53 UTC 2023
|
| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
JQ83GG8LT2
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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DB14954
Created by
admin on Sat Dec 16 12:10:56 UTC 2023 , Edited by admin on Sat Dec 16 12:10:56 UTC 2023
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PRIMARY | |||
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JQ83GG8LT2
Created by
admin on Sat Dec 16 12:10:56 UTC 2023 , Edited by admin on Sat Dec 16 12:10:56 UTC 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
INHIBITOR -> TARGET |
Selective, oral bioavailable PI3Kα isoform inhibitor s more than 100-fold selective than other class I
PI3K isoforms and mTOR as well as a high degree of selectivity against a large panel of protein kinases with potential antitumor activity.
IC50
|
||
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INHIBITOR -> TARGET |
selective for alpha isoform, and leads to degradation of mutant p110 alpha PI3K subunit.
Ki
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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NON-INHIBITOR->OFF TARGET |
IC50
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WEAK INHIBITOR->TARGET | |||
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INHIBITOR -> TARGET |
IC50
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||
|
INHIBITOR -> TARGET |
INHIBITOR
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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PARENT->INNOVATOR | |||
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
Ki
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INHIBITOR -> TARGET |
IC50
|
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|
INHIBITOR -> TARGET |
STX-478 is a second-generation, allosteric, mutant-selective, PI3Kα small molecule inhibitor
ALLOSTERIC
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MUTANT->PARENT |
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INHIBITOR -> TARGET |
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MUTANT->PARENT |
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INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET |
IC50
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|
INHIBITOR -> TARGET |
ADP-Glo
IC50
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|
INHIBITOR -> TARGET |
IC50
|
||
|
|
INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET | |||
|
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INHIBITOR -> TARGET |
IC50
|
||
|
INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET |
|
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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|
INHIBITOR -> TARGET |
INHIBITOR
IC50
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INHIBITOR -> TARGET |
Ki
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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|
INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET |
COMPETITIVE INHIBITOR
|
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|
INHIBITOR -> TARGET |
Highly selective PI3Kα inhibitor when tested at 1 μM in a broad kinase panel (344 assays). >1000-fold selective over the members of
class 2 (PI3K-C2α, PI3K-C2β), class 3 (hVPS34), and class 4 (PI3Kα, PI4Kβ) groups of the PI3K family, PI3K-related (DNA-PK, mTOR) kinase family.
Ki
|
||
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INHIBITOR -> TARGET |
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
|