U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 18:34:32 GMT 2025
Edited
by admin
on Tue Apr 01 18:34:32 GMT 2025
Protein Type ENZYME
Protein Sub Type PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE|KINASE
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
JQ83GG8LT2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
Common Name English
PHOSPHOINOSITIDE-3-KINASE CATALYTIC ALPHA POLYPEPTIDE
Preferred Name English
PI3-KINASE SUBUNIT ALPHA
Common Name English
PTDINS-3-KINASE SUBUNIT ALPHA
Common Name English
PI3K-ALPHA
Common Name English
PIK3CA
Common Name English
PI3K?
Common Name English
Code System Code Type Description
DRUG BANK
DB14954
Created by admin on Tue Apr 01 18:34:32 GMT 2025 , Edited by admin on Tue Apr 01 18:34:32 GMT 2025
PRIMARY
FDA UNII
JQ83GG8LT2
Created by admin on Tue Apr 01 18:34:32 GMT 2025 , Edited by admin on Tue Apr 01 18:34:32 GMT 2025
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
selective for alpha isoform, and leads to degradation of mutant p110 alpha PI3K subunit.
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
WEAK INHIBITOR->TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR
IC50
SUBSTRATE -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
PARENT->INNOVATOR
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
STX-478 is a second-generation, allosteric, mutant-selective, PI3K? small molecule inhibitor
ALLOSTERIC
MUTANT->PARENT
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Allosteric PI3K? inhibitor
ALLOSTERIC
IC50
MUTANT->PARENT
INHIBITOR -> TARGET
ADP-Glo
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
WEAK INHIBITOR->OFF TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR
IC50
NON-INHIBITOR->OFF TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Highly selective PI3K? inhibitor when tested at 1 ?M in a broad kinase panel (344 assays). >1000-fold selective over the members of class 2 (PI3K-C2?, PI3K-C2?), class 3 (hVPS34), and class 4 (PI3K?, PI4K?) groups of the PI3K family, PI3K-related (DNA-PK, mTOR) kinase family.
Ki
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL