Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H26N8O5 |
| Molecular Weight | 494.5031 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C2N=C(NC(=O)C3=CN=C(N)N=C3)N4CCN=C4C2=CC=C1OCCCN5CCOCC5=O
InChI
InChIKey=MRKMXPSMJSHTCR-UHFFFAOYSA-N
InChI=1S/C23H26N8O5/c1-34-19-16(36-9-2-6-30-8-10-35-13-17(30)32)4-3-15-18(19)28-23(31-7-5-25-20(15)31)29-21(33)14-11-26-22(24)27-12-14/h3-4,11-12H,2,5-10,13H2,1H3,(H2,24,26,27)(H,28,29,33)
| Molecular Formula | C23H26N8O5 |
| Molecular Weight | 494.5031 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 14:21:04 GMT 2023
by
admin
on
Sat Dec 16 14:21:04 GMT 2023
|
| Record UNII |
UD5QDA5GMW
|
| Record Status |
Validated (UNII)
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| Record Version |
|
-
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UD5QDA5GMW
Created by
admin on Sat Dec 16 14:21:04 GMT 2023 , Edited by admin on Sat Dec 16 14:21:04 GMT 2023
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2132943-79-2
Created by
admin on Sat Dec 16 14:21:04 GMT 2023 , Edited by admin on Sat Dec 16 14:21:04 GMT 2023
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PARENT -> METABOLITE ACTIVE |
(OXIDATION BY CYP3A4), The six healthy male volunteers received a single i.v. infusion of 12 mg copanlisib (2.76 MBq (14C)copanlisib) in a total volume of 40 mL as a 1-h infusion in the morning, 1-h after a light breakfast. 5 Caucasians and 1 Asian with an age 54.8 +/- 5.2 yeas (mean +/- SD, range: 47-61 years) and a BMI of 24.8 kg/m^2. Non-smokers and reported at the most light alcohol use.
AMOUNT EXCRETED
FECAL; PLASMA; URINE
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