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Details

Stereochemistry ACHIRAL
Molecular Formula C23H26N8O5
Molecular Weight 494.5031
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BAY-84-5975

SMILES

COC1=C2N=C(NC(=O)C3=CN=C(N)N=C3)N4CCN=C4C2=CC=C1OCCCN5CCOCC5=O

InChI

InChIKey=MRKMXPSMJSHTCR-UHFFFAOYSA-N
InChI=1S/C23H26N8O5/c1-34-19-16(36-9-2-6-30-8-10-35-13-17(30)32)4-3-15-18(19)28-23(31-7-5-25-20(15)31)29-21(33)14-11-26-22(24)27-12-14/h3-4,11-12H,2,5-10,13H2,1H3,(H2,24,26,27)(H,28,29,33)

HIDE SMILES / InChI

Molecular Formula C23H26N8O5
Molecular Weight 494.5031
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Approval Year

Substance Class Chemical
Created
by admin
on Sat Dec 16 14:21:04 UTC 2023
Edited
by admin
on Sat Dec 16 14:21:04 UTC 2023
Record UNII
UD5QDA5GMW
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BAY-84-5975
Code English
5-PYRIMIDINECARBOXAMIDE, 2-AMINO-N-(2,3-DIHYDRO-7-METHOXY-8-(3-(3-OXO-4-MORPHOLINYL)PROPOXY)IMIDAZO(1,2-C)QUINAZOLIN-5-YL)-
Systematic Name English
COPANLISIB METABOLITE M1
Common Name English
Code System Code Type Description
FDA UNII
UD5QDA5GMW
Created by admin on Sat Dec 16 14:21:04 UTC 2023 , Edited by admin on Sat Dec 16 14:21:04 UTC 2023
PRIMARY
CAS
2132943-79-2
Created by admin on Sat Dec 16 14:21:04 UTC 2023 , Edited by admin on Sat Dec 16 14:21:04 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> METABOLITE ACTIVE
(OXIDATION BY CYP3A4), The six healthy male volunteers received a single i.v. infusion of 12 mg copanlisib (2.76 MBq (14C)copanlisib) in a total volume of 40 mL as a 1-h infusion in the morning, 1-h after a light breakfast. 5 Caucasians and 1 Asian with an age 54.8 +/- 5.2 yeas (mean +/- SD, range: 47-61 years) and a BMI of 24.8 kg/m^2. Non-smokers and reported at the most light alcohol use.
AMOUNT EXCRETED
FECAL; PLASMA; URINE