U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 14:27:46 GMT 2023
Edited
by admin
on Sat Dec 16 14:27:46 GMT 2023
Protein Type ENZYME
Protein Sub Type DEACETYLASE
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
7YNS2RVD5Q
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HISTONE DEACETYLASE 3
Common Name English
HDAC3
Common Name English
Code System Code Type Description
UNIPROT
O15379
Created by admin on Sat Dec 16 14:27:48 GMT 2023 , Edited by admin on Sat Dec 16 14:27:48 GMT 2023
PRIMARY
FDA UNII
7YNS2RVD5Q
Created by admin on Sat Dec 16 14:27:48 GMT 2023 , Edited by admin on Sat Dec 16 14:27:48 GMT 2023
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR -> TARGET
CUDC-907 is a dual PI3K.ALPHA. and HDAC3 inhibitor. Phase 1.
INDUCER
IC50
INHIBITOR -> TARGET
4SC-202 is a selective class I HDAC inhibitor and also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.
INHIBITOR
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
WEAK INHIBITOR->TARGET
Strongly inhibits HDAC3 in cell-free assays. Phase 3.
INHIBITOR
IC50
WEAK INHIBITOR->TARGET
IC50
INHIBITOR -> TARGET
Enzymatic Inhibition
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IN-VIVO
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
Abexinostat (PCI-24781) is a modestly potent inhibitor to HDAC3. Phase 1/2.
INHIBITOR
MODERATE
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Mocetinostat (MGCD0103) is a potent HDAC inhibitor with a 2- to 10- fold selectivity against HDAC3. Phase 2.
INHIBITOR
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL