HISTONE DEACETYLASE 3

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 14:27:46 UTC 2023` Edited by `admin` on `Sat Dec 16 14:27:46 UTC 2023`
Protein Type	ENZYME
Protein Sub Type	DEACETYLASE
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	7YNS2RVD5Q
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

HISTONE DEACETYLASE 3

Common Name

English

HDAC3

Common Name

English

Code System Code Type Description

UNIPROT

O15379

Created by admin on Sat Dec 16 14:27:48 UTC 2023 , Edited by admin on Sat Dec 16 14:27:48 UTC 2023

PRIMARY

FDA UNII

7YNS2RVD5Q

Created by admin on Sat Dec 16 14:27:48 UTC 2023 , Edited by admin on Sat Dec 16 14:27:48 UTC 2023

PRIMARY

Related Record Type Details


					W797AY1743

NBM-T-BMX-OS 01

INHIBITOR -> TARGET


					3S9RX35S5X

INHIBITOR -> TARGET

Comments:

CUDC-907 is a dual PI3K.ALPHA. and HDAC3 inhibitor. Phase 1.

Interaction Type:

INDUCER

Qualification:

IC50

Amount:


					264ARM7UXX

INHIBITOR -> TARGET

Comments:

4SC-202 is a selective class I HDAC inhibitor and also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:


					YLL2FM0TXX

N-HYDROXY-3-(3-(PHENETHYLSULFAMOYL)PHENYL)ACRYLAMIDE

INHIBITOR -> TARGET


					9BJ85K1J8S

INHIBITOR -> TARGET

Amount:


					1ZNY4FKK9H

WEAK INHIBITOR->TARGET

Comments:

Strongly inhibits HDAC3 in cell-free assays. Phase 3.

Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:


					WKT909C62B

WEAK INHIBITOR->TARGET

Qualification:

IC50

Amount:


					1ZNY4FKK9H

INHIBITOR -> TARGET

Comments:

Enzymatic Inhibition

Qualification:

IC50

Amount:


					4I8MLM7L2H

INHIBITOR -> TARGET


					9647FM7Y3Z

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					614OI1Z5WI

INHIBITOR -> TARGET

Amount:


					FTV8V4AYQ8

INHIBITOR -> TARGET

Interaction Type:

IN-VIVO

Amount:


					87CIC980Y0

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					IYO470654U

INHIBITOR -> TARGET

Comments:

Abexinostat (PCI-24781) is a modestly potent inhibitor to HDAC3. Phase 1/2.

Interaction Type:

INHIBITOR

Qualification:

MODERATE


					441P620G3P

INHIBITOR -> TARGET


					58IFB293JI

INHIBITOR -> TARGET


					12P6IK4ZUX

BG-45

INHIBITOR -> TARGET


					A6GWB8T96J

INHIBITOR -> TARGET

Comments:

Mocetinostat (MGCD0103) is a potent HDAC inhibitor with a 2- to 10- fold selectivity against HDAC3. Phase 2.

Interaction Type:

INHIBITOR


					37NT056AT4

INHIBITOR -> TARGET

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL