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Details

Stereochemistry ACHIRAL
Molecular Formula C16H21NO6
Molecular Weight 323.341
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of REMETINOSTAT

SMILES

COC(=O)C1=CC=C(OC(=O)CCCCCCC(=O)NO)C=C1

InChI

InChIKey=XDZAHHULFQIBFE-UHFFFAOYSA-N
InChI=1S/C16H21NO6/c1-22-16(20)12-8-10-13(11-9-12)23-15(19)7-5-3-2-4-6-14(18)17-21/h8-11,21H,2-7H2,1H3,(H,17,18)

HIDE SMILES / InChI

Molecular Formula C16H21NO6
Molecular Weight 323.341
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

METHYLPARABEN SUBEROHYDROXAMIC ACID PHENYL ESTER (more known as Remetinostat), a histone deacetylase (HDAC) inhibitor, was developed for the treatment of cutaneous T cell lymphoma (CTCL). This drug is participating in phase II clinical trial to evaluate the efficacy, safety, and tolerability to skin lesions in patients with early-stage cutaneous T-cell lymphoma. In May 2019 was announced the positive results from phase II trial of remetinostat in basal cell carcinoma (BCC) patients. Initial results suggest that remetinostat gel offers a potentially effective and well-tolerated, non-surgical intervention for the treatment of localized BCCs. The unique design of remetinostat enables topical application, making it active only in the skin. As soon as it reaches the blood stream, it is degraded, avoiding the side effects associated with other HDAC inhibitors. Besides, remetinostat was studied as the treatment of plaque psoriasis; however, this study was discontinued.

Approval Year

Sample Use Guides

0.5 or 1.0% SHAPE Gelled Solution once daily
Route of Administration: Topical
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:56:01 GMT 2023
Edited
by admin
on Sat Dec 16 17:56:01 GMT 2023
Record UNII
37NT056AT4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
REMETINOSTAT
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
BENZOIC ACID, 4-((8-(HYDROXYAMINO)-1,8-DIOXOOCTYL)OXY)-, METHYL ESTER
Systematic Name English
REMETINOSTAT [USAN]
Common Name English
remetinostat [INN]
Common Name English
Methyl 4-{[8-(hydroxyamino)-8-oxooctanoyl]oxy}benzoate
Systematic Name English
SHP-141
Code English
Remetinostat [WHO-DD]
Common Name English
NSC-748492
Code English
METHYLPARABEN SUBEROHYDROXAMIC ACID PHENYL ESTER
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1946
Created by admin on Sat Dec 16 17:56:02 GMT 2023 , Edited by admin on Sat Dec 16 17:56:02 GMT 2023
FDA ORPHAN DRUG 292109
Created by admin on Sat Dec 16 17:56:02 GMT 2023 , Edited by admin on Sat Dec 16 17:56:02 GMT 2023
NCI_THESAURUS C129825
Created by admin on Sat Dec 16 17:56:02 GMT 2023 , Edited by admin on Sat Dec 16 17:56:02 GMT 2023
Code System Code Type Description
NSC
748492
Created by admin on Sat Dec 16 17:56:02 GMT 2023 , Edited by admin on Sat Dec 16 17:56:02 GMT 2023
PRIMARY
EPA CompTox
DTXSID20647779
Created by admin on Sat Dec 16 17:56:02 GMT 2023 , Edited by admin on Sat Dec 16 17:56:02 GMT 2023
PRIMARY
USAN
CD-94
Created by admin on Sat Dec 16 17:56:02 GMT 2023 , Edited by admin on Sat Dec 16 17:56:02 GMT 2023
PRIMARY
PUBCHEM
24875489
Created by admin on Sat Dec 16 17:56:02 GMT 2023 , Edited by admin on Sat Dec 16 17:56:02 GMT 2023
PRIMARY
CAS
946150-57-8
Created by admin on Sat Dec 16 17:56:02 GMT 2023 , Edited by admin on Sat Dec 16 17:56:02 GMT 2023
PRIMARY
NCI_THESAURUS
C97513
Created by admin on Sat Dec 16 17:56:02 GMT 2023 , Edited by admin on Sat Dec 16 17:56:02 GMT 2023
PRIMARY
FDA UNII
37NT056AT4
Created by admin on Sat Dec 16 17:56:02 GMT 2023 , Edited by admin on Sat Dec 16 17:56:02 GMT 2023
PRIMARY
SMS_ID
100000174649
Created by admin on Sat Dec 16 17:56:02 GMT 2023 , Edited by admin on Sat Dec 16 17:56:02 GMT 2023
PRIMARY
DRUG BANK
DB14869
Created by admin on Sat Dec 16 17:56:02 GMT 2023 , Edited by admin on Sat Dec 16 17:56:02 GMT 2023
PRIMARY
ChEMBL
CHEMBL3707219
Created by admin on Sat Dec 16 17:56:02 GMT 2023 , Edited by admin on Sat Dec 16 17:56:02 GMT 2023
PRIMARY
INN
10310
Created by admin on Sat Dec 16 17:56:02 GMT 2023 , Edited by admin on Sat Dec 16 17:56:02 GMT 2023
PRIMARY
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TARGET -> INHIBITOR
TARGET -> INHIBITOR
TARGET -> INHIBITOR
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METABOLITE INACTIVE -> PARENT
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ACTIVE MOIETY