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Details

Stereochemistry ACHIRAL
Molecular Formula C24H27N5O3
Molecular Weight 433.5029
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RICOLINOSTAT

SMILES

ONC(=O)CCCCCCNC(=O)C1=CN=C(N=C1)N(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=QGZYDVAGYRLSKP-UHFFFAOYSA-N
InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30)

HIDE SMILES / InChI

Molecular Formula C24H27N5O3
Molecular Weight 433.5029
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Ricolinostat is a selective inhibitor of HDAC6 with IC50 value of 4.7 nM. Ricolinostat demonstrated good anti-proliferative activity on different cell lines and clinical models of cancer. The drug is being tested in phase I/II for the treatment of multiple myeloma and lymphoid malignancies and in phase I in patients with breast cancer, gynecological cancer, cholangiocarcinoma, recurrent chronic lymphoid leukemia.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
4.7 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Development and therapeutic implications of selective histone deacetylase 6 inhibitors.
2013 Aug 22
Patents

Patents

Sample Use Guides

Lymphoid Malignancies: Patients take 160 mg for 28 consecutive days on a 28-day treatment cycle. Multiple myeloma: Patients take 40-240 mg once daily to 160 mg twice daily
Route of Administration: Oral
MCF-7, MDA-MB-436, MDA-MB-231, T47D, SUM-190, IBC-3, SUM-149 cell lines were treated with increasing concentrations of ricolinostat (1, 2.5, 5 uM) to test drug-induced apoptosis.
Substance Class Chemical
Created
by admin
on Sat Dec 16 04:48:52 UTC 2023
Edited
by admin
on Sat Dec 16 04:48:52 UTC 2023
Record UNII
WKT909C62B
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RICOLINOSTAT
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
ricolinostat [INN]
Common Name English
5-PYRIMIDINECARBOXAMIDE, 2-(DIPHENYLAMINO)-N-(7-(HYDROXYAMINO)-7-OXOHEPTYL)-
Systematic Name English
Ricolinostat [WHO-DD]
Common Name English
ACY-1215
Code English
RICOLINOSTAT [USAN]
Common Name English
2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide
Systematic Name English
ACY-63
Code English
Classification Tree Code System Code
NCI_THESAURUS C1946
Created by admin on Sat Dec 16 04:48:52 UTC 2023 , Edited by admin on Sat Dec 16 04:48:52 UTC 2023
Code System Code Type Description
INN
9801
Created by admin on Sat Dec 16 04:48:52 UTC 2023 , Edited by admin on Sat Dec 16 04:48:52 UTC 2023
PRIMARY
PUBCHEM
53340666
Created by admin on Sat Dec 16 04:48:52 UTC 2023 , Edited by admin on Sat Dec 16 04:48:52 UTC 2023
PRIMARY
FDA UNII
WKT909C62B
Created by admin on Sat Dec 16 04:48:52 UTC 2023 , Edited by admin on Sat Dec 16 04:48:52 UTC 2023
PRIMARY
EPA CompTox
DTXSID40157148
Created by admin on Sat Dec 16 04:48:52 UTC 2023 , Edited by admin on Sat Dec 16 04:48:52 UTC 2023
PRIMARY
SMS_ID
100000167118
Created by admin on Sat Dec 16 04:48:52 UTC 2023 , Edited by admin on Sat Dec 16 04:48:52 UTC 2023
PRIMARY
USAN
ZZ-154
Created by admin on Sat Dec 16 04:48:52 UTC 2023 , Edited by admin on Sat Dec 16 04:48:52 UTC 2023
PRIMARY
NCI_THESAURUS
C96431
Created by admin on Sat Dec 16 04:48:52 UTC 2023 , Edited by admin on Sat Dec 16 04:48:52 UTC 2023
PRIMARY
EVMPD
SUB181488
Created by admin on Sat Dec 16 04:48:52 UTC 2023 , Edited by admin on Sat Dec 16 04:48:52 UTC 2023
PRIMARY
CAS
1316214-52-4
Created by admin on Sat Dec 16 04:48:52 UTC 2023 , Edited by admin on Sat Dec 16 04:48:52 UTC 2023
PRIMARY
DRUG BANK
DB12376
Created by admin on Sat Dec 16 04:48:52 UTC 2023 , Edited by admin on Sat Dec 16 04:48:52 UTC 2023
PRIMARY
ChEMBL
CHEMBL2364628
Created by admin on Sat Dec 16 04:48:52 UTC 2023 , Edited by admin on Sat Dec 16 04:48:52 UTC 2023
PRIMARY
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