Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 12:19:15 UTC 2023
by
admin
on
Sat Dec 16 12:19:15 UTC 2023
|
| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
X6HV7Q6XP4
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
Q9UBN7
Created by
admin on Sat Dec 16 12:19:17 UTC 2023 , Edited by admin on Sat Dec 16 12:19:17 UTC 2023
|
PRIMARY | |||
|
X6HV7Q6XP4
Created by
admin on Sat Dec 16 12:19:17 UTC 2023 , Edited by admin on Sat Dec 16 12:19:17 UTC 2023
|
PRIMARY |
| Linkage Type | Residue Index | |||
|---|---|---|---|---|
| COORDINATION COMPOUND | 1_1133 | 1_1136 | 1_1153 | 1_1160 |
| COORDINATION COMPOUND | 1_1113 | 1_1115 | 1_1183 | 1_1186 |
| COORDINATION COMPOUND | 1_1145 | 1_1148 | 1_1164 | 1_1170 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR -> TARGET |
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NON-INHIBITOR->TARGET |
Mocetinostat (MGCD0103) is a potent HDAC inhibitor with no activity to HDAC6. Phase 2.
INHIBITOR
NOT CLINICALLY SIGNIFICANT
|
||
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|
INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
IC50
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||
|
INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
Polarize macrophages to the anti-tumoral M1 phenotype.
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET |
|
||
|
INHIBITOR -> TARGET |
Abexinostat (PCI-24781) is a modestly potent inhibitor to HDA6. Phase 1/2.
INHIBITOR
MODERATE
|
||
|
INHIBITOR -> TARGET |
IC50
|
||
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INHIBITOR -> TARGET |
IC50
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|
INHIBITOR -> TARGET |
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|
INHIBITOR -> TARGET |
Tubastatin A HCl is a potent and selective HDAC6 inhibitor in a cell-free assay.
INHIBITOR
IC50
|
||
|
INHIBITOR -> TARGET |
IN-VIVO
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|
WEAK INHIBITOR->TARGET |
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|
INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET |
PRECLINICAL
IC50
|
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|
|
INHIBITOR -> TARGET | |||
|
INHIBITOR -> TARGET |
IC50
|
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
|