U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 18:57:49 GMT 2025
Edited
by admin
on Tue Apr 01 18:57:49 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
X6HV7Q6XP4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HISTONE DEACETYLASE 6
Common Name English
HDAC-6
Preferred Name English
HDAC6
Common Name English
Code System Code Type Description
UNIPROT
Q9UBN7
Created by admin on Tue Apr 01 18:57:49 GMT 2025 , Edited by admin on Tue Apr 01 18:57:49 GMT 2025
PRIMARY
FDA UNII
X6HV7Q6XP4
Created by admin on Tue Apr 01 18:57:49 GMT 2025 , Edited by admin on Tue Apr 01 18:57:49 GMT 2025
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
Pan HDAC inhibitor
INHIBITOR -> TARGET
WEAK INHIBITOR->TARGET
IC50
INHIBITOR -> TARGET
NON-INHIBITOR->OFF TARGET
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Polarize macrophages to the anti-tumoral M1 phenotype.
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Selectivity greater than 4,000~43,000-fold over other HDAC isoforms.
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
NON-INHIBITOR->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IN-VIVO
WEAK INHIBITOR->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
PRECLINICAL
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_1016] [1_1021] [1_1027] [1_1031] [1_1034] [1_1040] SITE_SPECIFIC THREONINE PHOSPHATE 3L4WX7B1EI
AMINO_ACID_SUBSTITUTION [1_1145] [1_1148] [1_1164] [1_1170] SITE_SPECIFIC C2H2-TYPE ZINC FINGER A0G4UYZ9B5
AMINO_ACID_SUBSTITUTION [1_1113] [1_1115] [1_1183] [1_1186] SITE_SPECIFIC C3H1-TYPE ZINC FINGER JKX41V9FYM
AMINO ACID SUBSTITUTION [1_22] [1_1035] SITE_SPECIFIC DEXFOSFOSERINE VI4F0K069V
AMINO_ACID_SUBSTITUTION [1_1133] [1_1136] [1_1153] [1_1160] SITE_SPECIFIC C3H1-TYPE ZINC FINGER JKX41V9FYM
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL