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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Mon Mar 31 23:09:03 GMT 2025
Edited
by admin
on Mon Mar 31 23:09:03 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
0RFO7VC96N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HUGT1A1
Preferred Name English
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1
Common Name English
UDP-GLUCURONOSYLTRANSFERASE 1A1
Common Name English
UDP-GLUCURONOSYLTRANSFERASE 1-1
Systematic Name English
UGT-1A1
Common Name English
HUMAN URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1
Systematic Name English
UGT1A1
Common Name English
Code System Code Type Description
CAS
400706-63-0
Created by admin on Mon Mar 31 23:09:03 GMT 2025 , Edited by admin on Mon Mar 31 23:09:03 GMT 2025
PRIMARY
UNIPROT
P22309
Created by admin on Mon Mar 31 23:09:03 GMT 2025 , Edited by admin on Mon Mar 31 23:09:03 GMT 2025
PRIMARY
WIKIPEDIA
UDP GLUCURONOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1
Created by admin on Mon Mar 31 23:09:03 GMT 2025 , Edited by admin on Mon Mar 31 23:09:03 GMT 2025
PRIMARY
FDA UNII
0RFO7VC96N
Created by admin on Mon Mar 31 23:09:03 GMT 2025 , Edited by admin on Mon Mar 31 23:09:03 GMT 2025
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_77
N 1_270
N 1_322
Related Record Type Details
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Structure of SELUMETINIB
SUBSTRATE -> METABOLIC ENZYME
Structure of INDACATEROL
SUBSTRATE -> METABOLIC ENZYME
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Structure of DEFERASIROX
SUBSTRATE -> METABOLIC ENZYME
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Structure of Raltegravir
SUBSTRATE -> METABOLIC ENZYME
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Structure of MOTESANIB
SUBSTRATE -> METABOLIC ENZYME
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Structure of TRIHYDROXYCHALCONE
SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
Structure of BILIRUBIN
SUBSTRATE -> METABOLIC ENZYME
Structure of VERINURAD
SUBSTRATE -> METABOLIC ENZYME
Structure of ESTRADIOL
SUBSTRATE -> METABOLIC ENZYME
Structure of LASOFOXIFENE
SUBSTRATE -> METABOLIC ENZYME
Structure of LENACAPAVIR
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of TECOVIRIMAT
SUBSTRATE -> METABOLIC ENZYME
Structure of PONESIMOD
SUBSTRATE -> METABOLIC ENZYME
Structure of DOLUTEGRAVIR
SUBSTRATE -> METABOLIC ENZYME
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Structure of 2-(3-FLUOROPHENYL)-5-HYDROXY-6-METHOXY-4(1H)-QUINOLINONE
INHIBITOR -> METABOLIC ENZYME
Structure of Febuxostat
SUBSTRATE -> METABOLIC ENZYME
Structure of CP-544439
SUBSTRATE -> METABOLIC ENZYME
Structure of Lumateperone
SUBSTRATE -> METABOLIC ENZYME
Structure of SELICICLIB
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of BELINOSTAT
SUBSTRATE -> METABOLIC ENZYME
Structure of REGORAFENIB ANHYDROUS
INHIBITOR -> METABOLIC ENZYME
SN-38 is metabolized by UGT1A1, it appears that regorafenib inhibits UGT1A1 in humans. The mean AUC of irinotecan and SN-38 increased by 28% and 44%, respectively, when irinotecan was administered five days after the last of seven daily doses of regorafenib.
Structure of Vericiguat
SUBSTRATE -> METABOLIC ENZYME
Structure of PASIREOTIDE
NON-SUBSTRATE -> METABOLIC ENZYME
in vitro study results indicate that pasireotide is not a substrate, inhibitor, or inducer for metabolic isozymes including UGT1A1 particularly at the proposed dosing range.
Structure of BAZEDOXIFENE
SUBSTRATE -> METABOLIC ENZYME
Structure of ENCORAFENIB
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of EDARAVONE
SUBSTRATE -> METABOLIC ENZYME
Structure of DAROLUTAMIDE
SUBSTRATE -> METABOLIC ENZYME
Structure of Nintedanib
SUBSTRATE -> METABOLIC ENZYME
Structure of TAMATINIB
INHIBITOR -> METABOLIC ENZYME
Structure of ALISERTIB
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of IDELALISIB
INHIBITOR -> METABOLIC ENZYME
INN VITRO
Structure of TRICLOCARBAN
SUBSTRATE -> METABOLIC ENZYME
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INHIBITOR -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
Structure of RALOXIFENE
SUBSTRATE -> METABOLIC ENZYME
Structure of SCUTELLARIN
SUBSTRATE -> METABOLIC ENZYME
Structure of PANOBINOSTAT
SUBSTRATE -> METABOLIC ENZYME
IN VITRO
Structure of PITAVASTATIN
SUBSTRATE -> METABOLIC ENZYME
Structure of TAFAMIDIS
SUBSTRATE -> METABOLIC ENZYME
Structure of DELAFLOXACIN
SUBSTRATE -> METABOLIC ENZYME
Structure of ORANTINIB
SUBSTRATE -> METABOLIC ENZYME
Structure of OLODATEROL
SUBSTRATE -> METABOLIC ENZYME
Structure of PEXIDARTINIB
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of 2,3,7-TRICHLORODIBENZO-P-DIOXIN
SUBSTRATE -> METABOLIC ENZYME
Structure of Ertugliflozin
INHIBITOR -> METABOLIC ENZYME
Structure of Binimetinib
INHIBITOR -> METABOLIC ENZYME
MINOR
IC50
Structure of Bictegravir
SUBSTRATE -> METABOLIC ENZYME
Structure of Desloratadine
SUBSTRATE -> METABOLIC ENZYME
Structure of CABOTEGRAVIR
SUBSTRATE -> METABOLIC ENZYME
Structure of PRADIGASTAT
SUBSTRATE -> METABOLIC ENZYME
Structure of Eltrombopag
SUBSTRATE -> METABOLIC ENZYME
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INHIBITOR -> METABOLIC ENZYME
Inhibits at clinically relevant concentrations.
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL
NIH
NCATS
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