U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Thu Jul 06 15:49:12 UTC 2023
Edited
by admin
on Thu Jul 06 15:49:12 UTC 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
0RFO7VC96N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1
Common Name English
UDP-GLUCURONOSYLTRANSFERASE 1A1
Common Name English
HUGT1A1
Common Name English
UDP-GLUCURONOSYLTRANSFERASE 1-1
Systematic Name English
UGT-1A1
Common Name English
HUMAN URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1
Systematic Name English
UGT1A1
Common Name English
Code System Code Type Description
CAS
400706-63-0
Created by admin on Thu Jul 06 15:49:16 UTC 2023 , Edited by admin on Thu Jul 06 15:49:16 UTC 2023
PRIMARY
UNIPROT
P22309
Created by admin on Thu Jul 06 15:49:16 UTC 2023 , Edited by admin on Thu Jul 06 15:49:16 UTC 2023
PRIMARY
WIKIPEDIA
UDP GLUCURONOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1
Created by admin on Thu Jul 06 15:49:16 UTC 2023 , Edited by admin on Thu Jul 06 15:49:16 UTC 2023
PRIMARY
FDA UNII
0RFO7VC96N
Created by admin on Thu Jul 06 15:49:16 UTC 2023 , Edited by admin on Thu Jul 06 15:49:16 UTC 2023
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_77
N 1_270
N 1_322
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SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
EXPRESSED PROTEIN->VECTOR
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SN-38 is metabolized by UGT1A1, it appears that regorafenib inhibits UGT1A1 in humans. The mean AUC of irinotecan and SN-38 increased by 28% and 44%, respectively, when irinotecan was administered five days after the last of seven daily doses of regorafenib.
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in vitro study results indicate that pasireotide is not a substrate, inhibitor, or inducer for metabolic isozymes including UGT1A1 particularly at the proposed dosing range.
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INN VITRO
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SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
IN VITRO
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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MINOR
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SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
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Inhibits at clinically relevant concentrations.
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL