U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
139594
Substance Class Protein
Created
by admin
on Sat Dec 16 09:18:01 UTC 2023
Edited
by admin
on Sat Dec 16 09:18:01 UTC 2023
Protein Type ENZYME
Protein Sub Type CYTOCHROME P450
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
805SU96HKF
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYTOCHROME P450 3A5
Common Name English
CYTOCHROME P450-PCN3
Common Name English
CYTOCHROME P 450 3A5
Common Name English
CYTOCHROME P450 HLP2
Common Name English
HUMAN CYTOCHROME P450 3A5
Common Name English
CYP3A5
Common Name English
Code System Code Type Description
UNIPROT
P20815
Created by admin on Sat Dec 16 09:18:06 UTC 2023 , Edited by admin on Sat Dec 16 09:18:06 UTC 2023
PRIMARY
FDA UNII
805SU96HKF
Created by admin on Sat Dec 16 09:18:06 UTC 2023 , Edited by admin on Sat Dec 16 09:18:06 UTC 2023
PRIMARY
CAS
336874-97-6
Created by admin on Sat Dec 16 09:18:06 UTC 2023 , Edited by admin on Sat Dec 16 09:18:06 UTC 2023
PRIMARY
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Structure of OSILODROSTAT
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Structure of LASOFOXIFENE
SUBSTRATE -> METABOLIC ENZYME
Structure of PIMECROLIMUS
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Structure of NIFEDIPINE
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Structure of LORLATINIB
SUBSTRATE -> METABOLIC ENZYME
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Structure of RIFAMPIN
INDUCER -> METABOLIC ENZYME
Structure of LUSUTROMBOPAG
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Structure of LEMBOREXANT
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of OTENABANT
SUBSTRATE -> METABOLIC ENZYME
TROGLITAZONE
INDUCER -> METABOLIC ENZYME
Structure of CARBAMAZEPINE
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IC50
Structure of PRASTERONE
SUBSTRATE -> METABOLIC ENZYME
Structure of ALVESPIMYCIN
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of PONESIMOD
SUBSTRATE -> METABOLIC ENZYME
Structure of QUINIDINE
SUBSTRATE -> METABOLIC ENZYME
Structure of FLUOXETINE
SUBSTRATE -> METABOLIC ENZYME
Structure of HYDROCORTISONE
SUBSTRATE -> METABOLIC ENZYME
Structure of TEMSIROLIMUS
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of DIAZEPAM
SUBSTRATE -> METABOLIC ENZYME
Structure of EPIANDROSTERONE
SUBSTRATE -> METABOLIC ENZYME
Structure of IRINOTECAN
SUBSTRATE -> METABOLIC ENZYME
Structure of TEZACAFTOR
SUBSTRATE -> METABOLIC ENZYME
Structure of ATAZANAVIR
SUBSTRATE -> METABOLIC ENZYME
Structure of ABT-384
SUBSTRATE -> METABOLIC ENZYME
Structure of 20(S)-GINSENOSIDE RH2
SUBSTRATE -> METABOLIC ENZYME
Structure of ALLITINIB
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of EXEMESTANE
SUBSTRATE -> METABOLIC ENZYME
Structure of PARATHION
SUBSTRATE -> METABOLIC ENZYME
Structure of RIFAPENTINE
INDUCER -> METABOLIC ENZYME
Structure of TROLEANDOMYCIN
INDUCER -> METABOLIC ENZYME
Structure of DIETHYLTOLUAMIDE
SUBSTRATE -> METABOLIC ENZYME
Structure of NORENDOXIFEN
INHIBITOR -> METABOLIC ENZYME
Structure of PRALSETINIB
INHIBITOR -> METABOLIC ENZYME
TIME-DEPENDENT INHIBITION
Structure of ELEXACAFTOR
SUBSTRATE -> METABOLIC ENZYME
Structure of RIVOCERANIB
SUBSTRATE -> METABOLIC ENZYME
Structure of SELUMETINIB
SUBSTRATE -> METABOLIC ENZYME
Structure of CJ-13610
SUBSTRATE -> METABOLIC ENZYME
Structure of EBASTINE
SUBSTRATE -> METABOLIC ENZYME
Structure of ALFENTANIL
SUBSTRATE -> METABOLIC ENZYME
Structure of ENZALUTAMIDE
INHIBITOR -> METABOLIC ENZYME
Structure of RIVOGLITAZONE
SUBSTRATE -> METABOLIC ENZYME
Structure of LOVASTATIN
SUBSTRATE -> METABOLIC ENZYME
Structure of TERFENADINE
SUBSTRATE -> METABOLIC ENZYME
Structure of TRIAZOLAM
SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
Structure of E-NORENDOXIFEN
INHIBITOR -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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MAJOR
Structure of VERINURAD
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of EVATANEPAG
SUBSTRATE -> METABOLIC ENZYME
Structure of AXITINIB
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of ARTEMETHER
SUBSTRATE -> METABOLIC ENZYME
Structure of EZLOPITANT
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of MIDAZOLAM
SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
Structure of PARITAPREVIR
SUBSTRATE -> METABOLIC ENZYME
Structure of ESAXERENONE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of ELETRIPTAN
SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
Structure of IXABEPILONE
SUBSTRATE -> METABOLIC ENZYME
Structure of ACETAMINOPHEN
SUBSTRATE -> METABOLIC ENZYME
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INDUCER -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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NON-SUBSTRATE -> METABOLIC ENZYME
Structure of DEXAMETHASONE
INDUCER -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
Structure of CARBAMAZEPINE
SUBSTRATE -> METABOLIC ENZYME
Structure of SULFINPYRAZONE
INDUCER -> METABOLIC ENZYME
Structure of ISAVUCONAZOLE
INDUCER -> METABOLIC ENZYME
Structure of ARTEMOTIL
SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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HUMAN LIVER
TISSUE EXPRESSION -> PARENT
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SUBSTRATE -> METABOLIC ENZYME
Structure of TESTOSTERONE
SUBSTRATE -> METABOLIC ENZYME
Structure of LONAFARNIB
SUBSTRATE -> METABOLIC ENZYME
Structure of RIFABUTIN
INDUCER -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of VARDENAFIL
SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
MINOR
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SUBSTRATE -> METABOLIC ENZYME
MAJOR
HUMAN TYPE I COLLAGEN (LUNG)
TISSUE EXPRESSION -> PARENT
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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INDUCER -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
Related Record Type Details
Structure of TENAPANOR
PARENT -> IMPURITY
Tenapanor is a substrate of CYP3A4 and CYP3A5; however, none of the CYP enzymes was found to be responsible for ≥25% of its overall elimination.
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
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