CYTOCHROME P450 3A5

Approval Year

Substance Class	Protein
Protein Type	ENZYME
Protein Sub Type	CYTOCHROME P450
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	805SU96HKF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CYTOCHROME P450 3A5

Common Name

English

CYTOCHROME P450-PCN3

Common Name

English

CYTOCHROME P 450 3A5

Common Name

English

CYTOCHROME P450 HLP2

Common Name

English

HUMAN CYTOCHROME P450 3A5

Common Name

English

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Code System

Code

Type

Description

UNIPROT

P20815

PRIMARY

FDA UNII

805SU96HKF

PRIMARY

CAS

336874-97-6

PRIMARY

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Subunit 0

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Type

Details


					0GEI24LG0J

CHENODIOL

SUBSTRATE -> METABOLIC ENZYME

Interaction Type:

MINOR


					5B2546MB5Z

ELAGOLIX

INHIBITOR -> TARGET

Qualification:

Ki

Amount:

74 MICROMOLAR (average)


					VZI5B1W380

OXCARBAZEPINE

INDUCER -> METABOLIC ENZYME

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

Ki

Amount:

[<279] MICROMOLAR (limits)


					5YL4IQ1078

OSILODROSTAT

INHIBITOR -> METABOLIC ENZYME

Interaction Type:

WEAK INHIBITION


					337G83N988

LASOFOXIFENE

SUBSTRATE -> METABOLIC ENZYME

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Related Record

Type

Details


					WYD79216A6

TENAPANOR

PARENT -> IMPURITY

Comments:

Tenapanor is a substrate of CYP3A4 and CYP3A5; however, none of the CYP enzymes was found to be responsible for ≥25% of its overall elimination.

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 57100 Da (average)
Molecular Formula	CHEMICAL	ESTIMATED C2650H4168O735N666S18Fe

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