RIVOGLITAZONE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H19N3O4S
Molecular Weight	397.4494
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of RIVOGLITAZONE

Structure Search

SMILES

Cn1c2cc(ccc2nc1COc3ccc(cc3)CC4C(=NC(=O)S4)O)OC

InChI

InChIKey=XMSXOLDPMGMWTH-UHFFFAOYSA-N

InChI=1S/C20H19N3O4S/c1-23-16-10-14(26-2)7-8-15(16)21-18(23)11-27-13-5-3-12(4-6-13)9-17-19(24)22-20(25)28-17/h3-8,10,17H,9,11H2,1-2H3,(H,22,24,25)

HIDE SMILES / InChI

Molecular Formula	C20H19N3O4S
Molecular Weight	397.4494
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.jstage.jst.go.jp/article/jphs/advpub/0/advpub_09084FP/_pdf/-char/en | https://clinicaltrials.gov/ct2/show/NCT00571519 | https://clinicaltrials.gov/ct2/show/NCT00143520 | https://patents.google.com/patent/US8017633B2/en

Rivoglitazone hydrochloride (CS-011) is a thiazolidinedione-derivative peroxisome proliferator–activated receptor (PPAR)-γ agonist. It has been developed as potential treatment in type 2 diabetes mellitus and was shown to decrease plasma glucose and triglyceride levels in a dose-dependent manner in animals. Phase II and III clinical studies have assessed the efficacy and safety of rivoglitazone hydrochloride in patients with type 2 diabetes mellitus.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Drug evaluation: rivoglitazone, a new oral therapy for the treatment of type 2 diabetes.	2007 Apr	17458185
A randomized-controlled trial to investigate the effects of rivoglitazone, a novel PPAR gamma agonist on glucose-lipid control in type 2 diabetes.	2011 Sep	21492364

Patents

Patents

Substance Class	Chemical Created by `admin` on `Sat Jun 26 00:04:50 UTC 2021` Edited by `admin` on `Sat Jun 26 00:04:50 UTC 2021`
Record UNII	3A3N0634Q6
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

RIVOGLITAZONE

Official Name

English

R-106056

Code

English

DE-101

Code

English

5-(4-(6-METHOXY-1-METHYL-1H-BENZIMIDAZOL-2-YLMETHOXY)BENZYL)THIAZOLIDIN-2,4-DIONE

Systematic Name

English

RIVOGLITAZONE [WHO-DD]

Common Name

English

RIVOGLITAZONE [INN]

Common Name

English

2,4-THIAZOLIDINEDIONE, 5-((4-((6-METHOXY-1-METHYL-1H-BENZIMIDAZOL-2-YL)METHOXY)PHENYL)METHYL)-

Systematic Name

English

RIVOGLITAZONE [USAN]

Common Name

English

CS-011

Common Name

English

(+/-)-5-(P-((6-METHOXY-1-METHYL-2-BENZIMIDAZOLYL)METHOXY)BENZYL)-2,4-THIAZOLIDINEDIONE

Common Name

English

R 106056

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C98241

Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021

Code System Code Type Description

EVMPD

SUB129557

Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021

PRIMARY

WIKIPEDIA

RIVOGLITAZONE

Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021

PRIMARY

MESH

C521549

Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021

PRIMARY

CAS

185428-18-6

Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021

PRIMARY

NCI_THESAURUS

C72841

Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021

PRIMARY

DRUG BANK

DB09200

Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021

PRIMARY

INN

8081

Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021

PRIMARY

FDA UNII

3A3N0634Q6

Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021

PRIMARY

PUBCHEM

3055168

Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021

PRIMARY

ChEMBL

CHEMBL2104753

Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021

PRIMARY

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ACTIVE MOIETY