U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C20H19N3O4S
Molecular Weight 397.4494
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RIVOGLITAZONE

SMILES

Cn1c2cc(ccc2nc1COc3ccc(cc3)CC4C(=NC(=O)S4)O)OC

InChI

InChIKey=XMSXOLDPMGMWTH-UHFFFAOYSA-N
InChI=1S/C20H19N3O4S/c1-23-16-10-14(26-2)7-8-15(16)21-18(23)11-27-13-5-3-12(4-6-13)9-17-19(24)22-20(25)28-17/h3-8,10,17H,9,11H2,1-2H3,(H,22,24,25)

HIDE SMILES / InChI

Molecular Formula C20H19N3O4S
Molecular Weight 397.4494
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Rivoglitazone hydrochloride (CS-011) is a thiazolidinedione-derivative peroxisome proliferator–activated receptor (PPAR)-γ agonist. It has been developed as potential treatment in type 2 diabetes mellitus and was shown to decrease plasma glucose and triglyceride levels in a dose-dependent manner in animals. Phase II and III clinical studies have assessed the efficacy and safety of rivoglitazone hydrochloride in patients with type 2 diabetes mellitus.

Approval Year

PubMed

PubMed

TitleDatePubMed
Drug evaluation: rivoglitazone, a new oral therapy for the treatment of type 2 diabetes.
2007 Apr
A randomized-controlled trial to investigate the effects of rivoglitazone, a novel PPAR gamma agonist on glucose-lipid control in type 2 diabetes.
2011 Sep
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 00:04:50 UTC 2021
Edited
by admin
on Sat Jun 26 00:04:50 UTC 2021
Record UNII
3A3N0634Q6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RIVOGLITAZONE
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
R-106056
Code English
DE-101
Code English
5-(4-(6-METHOXY-1-METHYL-1H-BENZIMIDAZOL-2-YLMETHOXY)BENZYL)THIAZOLIDIN-2,4-DIONE
Systematic Name English
RIVOGLITAZONE [WHO-DD]
Common Name English
RIVOGLITAZONE [INN]
Common Name English
2,4-THIAZOLIDINEDIONE, 5-((4-((6-METHOXY-1-METHYL-1H-BENZIMIDAZOL-2-YL)METHOXY)PHENYL)METHYL)-
Systematic Name English
RIVOGLITAZONE [USAN]
Common Name English
CS-011
Common Name English
(+/-)-5-(P-((6-METHOXY-1-METHYL-2-BENZIMIDAZOLYL)METHOXY)BENZYL)-2,4-THIAZOLIDINEDIONE
Common Name English
R 106056
Code English
Classification Tree Code System Code
NCI_THESAURUS C98241
Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021
Code System Code Type Description
EVMPD
SUB129557
Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021
PRIMARY
WIKIPEDIA
RIVOGLITAZONE
Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021
PRIMARY
MESH
C521549
Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021
PRIMARY
CAS
185428-18-6
Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021
PRIMARY
NCI_THESAURUS
C72841
Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021
PRIMARY
DRUG BANK
DB09200
Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021
PRIMARY
INN
8081
Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021
PRIMARY
FDA UNII
3A3N0634Q6
Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021
PRIMARY
PUBCHEM
3055168
Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021
PRIMARY
ChEMBL
CHEMBL2104753
Created by admin on Sat Jun 26 00:04:51 UTC 2021 , Edited by admin on Sat Jun 26 00:04:51 UTC 2021
PRIMARY
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