Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sun Dec 18 15:46:50 UTC 2022
by
admin
on
Sun Dec 18 15:46:50 UTC 2022
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| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
2PDN1S3FVX
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
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2PDN1S3FVX
Created by
admin on Sun Dec 18 15:46:54 UTC 2022 , Edited by admin on Sun Dec 18 15:46:54 UTC 2022
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PRIMARY | |||
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Q07869
Created by
admin on Sun Dec 18 15:46:54 UTC 2022 , Edited by admin on Sun Dec 18 15:46:54 UTC 2022
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PRIMARY |
| Linkage Type | Residue Index | |||
|---|---|---|---|---|
| COORDINATION COMPOUND | 1_139 | 1_143 | 1_153 | 1_156 |
| COORDINATION COMPOUND | 1_102 | 1_105 | 1_119 | 1_122 |
| Related Record | Type | Details | ||
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AGONIST -> TARGET | |||
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ACTIVATOR -> TARGET | |||
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ACTIVATOR -> TARGET | |||
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AGONIST -> TARGET |
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INHIBITOR -> TARGET |
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WEAK AGONIST->TARGET |
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AGONIST -> TARGET |
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INHIBITOR -> TARGET | |||
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WEAK AGONIST->TARGET |
EC50
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AGONIST -> TARGET |
SELECTIVE
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AGONIST -> TARGET | |||
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AGONIST -> TARGET |
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AGONIST -> TARGET | |||
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AGONIST -> TARGET |
Tesaglitazar is a novel dual-acting peroxisome proliferator-activated receptor alpha and gamma agonist.
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AGONIST -> TARGET |
EC50
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ACTIVATOR -> TARGET | |||
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AGONIST -> TARGET | |||
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AGONIST -> TARGET | |||
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INHIBITOR -> TARGET |
INHIBITOR
EC50
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AGONIST -> TARGET |
Ki=7.1 micromolar (Supplementary Fig. S5; http://clincancerres.aacrjournals.org/content/22/10/2508.figures-only)
IN-VITRO
IC50
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ACTIVATOR -> TARGET | |||
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AGONIST -> TARGET |
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AGONIST -> TARGET |
AGONIST
EC50
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AGONIST -> TARGET |
The PPAR? potency and selectivity of 3 were further confirmed by testing it in cotransfection assays in HepG2 cells using full length human PPAR? and PPAR? receptors..
EC50
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
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