PEMAGLITAZAR

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H17F3O3S
Molecular Weight	370.386
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(SCC[C@H](OC2=CC=C(C=C2)C(F)(F)F)C(O)=O)C=CC=C1

InChI

InChIKey=YDTVNTDYQGJBOX-HNNXBMFYSA-N

InChI=1S/C18H17F3O3S/c1-12-4-2-3-5-16(12)25-11-10-15(17(22)23)24-14-8-6-13(7-9-14)18(19,20)21/h2-9,15H,10-11H2,1H3,(H,22,23)/t15-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C18H17F3O3S
Molecular Weight	370.386
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.who.int/medicines/services/inn/StemBook_2018.pdf

Pemaglitazar was developed as a dual peroxisome proliferator-activated receptors alpha and gamma (PPAR- α,γ) agonist. Information about the further development of this drug is not available.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Peroxisome proliferator-activated receptor alpha 62 Target ID: Q07869 Gene ID: 5465.0 Gene Symbol: PPARA Target Organism: Homo sapiens (Human) Sources: https://www.who.int/medicines/services/inn/StemBook_2018.pdf \| https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C87621	Agonist 2678
Peroxisome proliferator-activated receptor gamma 111 Target ID: P37231\|\|\|Q15179 Gene ID: 5468.0 Gene Symbol: PPARG Target Organism: Homo sapiens (Human) Sources: https://www.who.int/medicines/services/inn/StemBook_2018.pdf \| https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C87621	Agonist 2678

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:13:20 UTC 2023` Edited by `admin` on `Fri Dec 15 17:13:20 UTC 2023`
Record UNII	5MSR134WO2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PEMAGLITAZAR

Official Name

English

pemaglitazar [INN]

Common Name

English

(2S)-4-((2-METHYLPHENYL)SULFANYL)-2-(4-(TRIFLUOROMETHYL)PHENOXY)BUTANOIC ACID

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C98233