OXEGLITAZAR

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H22O4
Molecular Weight	314.3756
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(OCC(C)(C)C=C2\C=C\C(C)=C\C(O)=O)C=C1

InChI

InChIKey=FVGXANXBVWECQE-BYWGDBCOSA-N

InChI=1S/C19H22O4/c1-13(9-18(20)21)5-6-14-11-19(2,3)12-23-17-8-7-15(22-4)10-16(14)17/h5-11H,12H2,1-4H3,(H,20,21)/b6-5+,13-9+

HIDE SMILES / InChI

Molecular Formula	C19H22O4
Molecular Weight	314.3756
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	2
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19442711 | https://www.ncbi.nlm.nih.gov/pubmed/30060458 | https://adisinsight.springer.com/drugs/800019059

Oxeglitazar (also known as EMD 336340 or LM 4156), an orally administered poorly water-soluble dual peroxisome proliferator-activated receptor α/γ agonist. This drug was used in the treatment of type II diabetes mellitus and metabolic syndrome. In addition, oxeglitazar participated in phase I trials for the gout treatment; however, this study was halted. Information about the further development of this drug is not available.

Originator

Approval Year

PubMed

Title	Date	PubMed
Comparison of solid dispersions produced by supercritical antisolvent and spray-freezing technologies.	2009 Jul 30	19442711
Application of mixtures of polymeric carriers for dissolution enhancement of oxeglitazar using hot-melt extrusion.	2012 Dec 15	23073606

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:48:26 UTC 2023` Edited by `admin` on `Sat Dec 16 15:48:26 UTC 2023`
Record UNII	LKX634SL5X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OXEGLITAZAR

Official Name

English

oxeglitazar [INN]

Common Name

English

(2E,4E)-5-(7-METHOXY-3,3-DIMETHYL-2,3-DIHYDRO-1-BENZOXEPIN-5-YL)-3-METHYLPENTA-2,4-DIENOIC ACID

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C98233