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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H23F3O5S
Molecular Weight 444.465
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SELADELPAR

SMILES

CCO[C@H](COC1=CC=C(C=C1)C(F)(F)F)CSC2=CC=C(OCC(O)=O)C(C)=C2

InChI

InChIKey=JWHYSEDOYMYMNM-QGZVFWFLSA-N
InChI=1S/C21H23F3O5S/c1-3-27-17(11-28-16-6-4-15(5-7-16)21(22,23)24)13-30-18-8-9-19(14(2)10-18)29-12-20(25)26/h4-10,17H,3,11-13H2,1-2H3,(H,25,26)/t17-/m1/s1

HIDE SMILES / InChI
Molecular Formula C21H23F3O5S
Molecular Weight 444.465
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

MBX-8025 (Seladelpar) is an agonist of peroxisome proliferator-activated receptor delta. MBX-8025 improves insulin sensitivity and reverses dyslipidemia and hepatic storage of lipotoxic lipids to improve nonalcoholic steatohepatitis pathology in atherogenic diet-fed obese diabetic mice. MBX-8025 improves lipoprotein subfractions associated with atherogenic dyslipidemia. CymaBay Therapeutics is developing MBX-8025 for the treatment of patients with the autoimmune liver disease, primary biliary cholangitis and nonalcoholic steatohepatitis.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Peroxisome proliferator-activated receptor delta
29
Target ID: Q03181|||Q9BUD4
Gene ID: 5467.0
Gene Symbol: PPARD
Target Organism: Homo sapiens (Human)
Agonist
2678
 2.0 nM [EC50]
PubMed

PubMed

TitleDatePubMed
MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin.
2011 Sep

Sample Use Guides

In Vivo Use Guide
Phase 2 study to evaluate the safety and efficacy of MBX-8025 2 mg, 5 mg, and 10 mg over 52 weeks of treatment
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:51:02 GMT 2023
Edited
by admin
on Fri Dec 15 15:51:02 GMT 2023
Record UNII
7C00L34NB9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SELADELPAR
INN   WHO-DD  
INN  
Official Name English
MBX-8025
Code English
seladelpar [INN]
Common Name English
ACETIC ACID, 2-(4-(((2R)-2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)THIO)-2-METHYLPHENOXY)-
Systematic Name English
SELADELPAR [USAN]
Common Name English
(+)-MBX-8025
Code English
Seladelpar [WHO-DD]
Common Name English
(4-(((2R)-2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)SULFANYL)-2-METHYLPHENOXY)ACETIC ACID PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) AGONIST,ANTIHYPERLIPIDAEMIC
Common Name English
((4-(((2R)-2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)THIO)-2-METHYLPHENYL)OXY)ACETIC ACID
Systematic Name English
RWJ-800025
Code English
ACETIC ACID, (4-(((2R)-2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)THIO)-2-METHYLPHENOXY)-
Systematic Name English
ACETIC ACID, (4-(((2R)-2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)THIO)-2-METHYLPHENOXY)- ((4-(((2R)-2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)THIO)-2-METHYLPHENYL)OXY)ACETIC ACID
Systematic Name English
(R)-2-(4-((2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)-THIO)-2-METHYLPHENOXY)ACETIC ACID
Systematic Name English
Classification Tree Code System Code
EU-Orphan Drug EU/3/17/1930
Created by admin on Fri Dec 15 15:51:02 GMT 2023 , Edited by admin on Fri Dec 15 15:51:02 GMT 2023
Code System Code Type Description
WIKIPEDIA
Seladelpar
Created by admin on Fri Dec 15 15:51:02 GMT 2023 , Edited by admin on Fri Dec 15 15:51:02 GMT 2023
PRIMARY
NCI_THESAURUS
C167015
Created by admin on Fri Dec 15 15:51:02 GMT 2023 , Edited by admin on Fri Dec 15 15:51:02 GMT 2023
PRIMARY
ChEMBL
CHEMBL3545019
Created by admin on Fri Dec 15 15:51:02 GMT 2023 , Edited by admin on Fri Dec 15 15:51:02 GMT 2023
PRIMARY
SMS_ID
100000177208
Created by admin on Fri Dec 15 15:51:02 GMT 2023 , Edited by admin on Fri Dec 15 15:51:02 GMT 2023
PRIMARY
EPA CompTox
DTXSID001045332
Created by admin on Fri Dec 15 15:51:02 GMT 2023 , Edited by admin on Fri Dec 15 15:51:02 GMT 2023
PRIMARY
USAN
EF-45
Created by admin on Fri Dec 15 15:51:02 GMT 2023 , Edited by admin on Fri Dec 15 15:51:02 GMT 2023
PRIMARY
FDA UNII
7C00L34NB9
Created by admin on Fri Dec 15 15:51:02 GMT 2023 , Edited by admin on Fri Dec 15 15:51:02 GMT 2023
PRIMARY
CAS
851528-79-5
Created by admin on Fri Dec 15 15:51:02 GMT 2023 , Edited by admin on Fri Dec 15 15:51:02 GMT 2023
PRIMARY
INN
10340
Created by admin on Fri Dec 15 15:51:02 GMT 2023 , Edited by admin on Fri Dec 15 15:51:02 GMT 2023
PRIMARY
DRUG BANK
DB12390
Created by admin on Fri Dec 15 15:51:02 GMT 2023 , Edited by admin on Fri Dec 15 15:51:02 GMT 2023
PRIMARY
PUBCHEM
11236126
Created by admin on Fri Dec 15 15:51:02 GMT 2023 , Edited by admin on Fri Dec 15 15:51:02 GMT 2023
PRIMARY
Related Record Type Details
PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA
TARGET->WEAK AGONIST
EC50
CYTOCHROME P450 2C9
METABOLIC ENZYME -> SUBSTRATE
Structure of SELADELPAR LYSINE ANHYDROUS
SALT/SOLVATE -> PARENT
PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA
TARGET -> AGONIST
SELECTIVE
EC50
Structure of SELADELPAR LYSINE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of SELADELPAR
ACTIVE MOIETY
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