| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H24O4S |
| Molecular Weight | 384.489 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CSC1=CC=C(C=C1)C(=O)\C=C\C2=CC(C)=C(OC(C)(C)C(O)=O)C(C)=C2
InChI
InChIKey=AFLFKFHDSCQHOL-IZZDOVSWSA-N
InChI=1S/C22H24O4S/c1-14-12-16(13-15(2)20(14)26-22(3,4)21(24)25)6-11-19(23)17-7-9-18(27-5)10-8-17/h6-13H,1-5H3,(H,24,25)/b11-6+
| Molecular Formula | C22H24O4S |
| Molecular Weight | 384.489 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α and peroxisome proliferator-activated receptor-δ. GFT505 has an active
metabolite, GFT1007, and both have potent agonist activity
for PPAR-a and to a lesser extent for PPAR-d. Elafibranor improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation. Elafibranor (GFT505) reverses nonalcoholic steatohepatitis (NASH) to prevent fibrosis progression. With an outstanding safety and tolerance profile, elafibranor provides NASH patients with needed cardio-protective benefits. Elafibranor is currently being evaluated in the clinical Phase 3 study RESOLVE-IT. The safety profile of GFT505 from the completed clinical
trials appears satisfactory with no indication of PPAR-g agonist
effects such as edema or body weight gain.
Originator
Approval Year
Doses
AEs
Sourcing
Sample Use Guides
Nonalcoholic Steatohepatitis (NASH) With Fibrosis :Coated tablets dosed at 120mg Elafibranor; oral administration; one tablet per day before breakfast with a glass of water.
Route of Administration:
Oral
