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Details

Stereochemistry ABSOLUTE
Molecular Formula C30H30N2O7
Molecular Weight 530.5684
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PELIGLITAZAR

SMILES

COC1=CC=C(OC(=O)N(CC(O)=O)[C@@H](C)C2=CC=C(OCCC3=C(C)OC(=N3)C4=CC=CC=C4)C=C2)C=C1

InChI

InChIKey=CUADMYMMZWFUCY-FQEVSTJZSA-N
InChI=1S/C30H30N2O7/c1-20(32(19-28(33)34)30(35)39-26-15-13-24(36-3)14-16-26)22-9-11-25(12-10-22)37-18-17-27-21(2)38-29(31-27)23-7-5-4-6-8-23/h4-16,20H,17-19H2,1-3H3,(H,33,34)/t20-/m0/s1

HIDE SMILES / InChI
Molecular Formula C30H30N2O7
Molecular Weight 530.5684
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Peliglitazar (also known as BMS 426707-01), a dual α/γ peroxisome proliferator-activated receptor agonist, has been studied in phase I/II clinical trial in patients with type 2 diabetes mellitus. However, this study was discontinued.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
An active film-coating approach to enhance chemical stability of a potent drug molecule.
2012 Mar-Apr
Patents

Patents

20030069275
1
20030087935
1
20030096846
1
20040147560
1
20040171644
1
20050119311
1

Sample Use Guides

In Vivo Use Guide
10 healthy male subjects with and without bile collection (groups 1 and 2) after a single 10-mg oral dose
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 16:52:31 UTC 2023
Edited
by admin
on Sat Dec 16 16:52:31 UTC 2023
Record UNII
D26ZN076H1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PELIGLITAZAR
INN   USAN  
USAN   INN  
Official Name English
[[(4-Methoxyphenoxy)carbonyl][(1S)-1-[4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]phenyl]ethyl]amino]acetic acid
Systematic Name English
PELIGLITAZAR [USAN]
Common Name English
BMS-426707-1
Code English
peliglitazar [INN]
Common Name English
GLYCINE, N-((4-METHOXYPHENOXY)CARBONYL)-N-((1S)-1-(4-(2-(5-METHYL-2-PHENYL-4-OXAZOLYL)ETHOXY)PHENYL)ETHYL)-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C98233
Created by admin on Sat Dec 16 16:52:34 UTC 2023 , Edited by admin on Sat Dec 16 16:52:34 UTC 2023
Code System Code Type Description
INN
8579
Created by admin on Sat Dec 16 16:52:34 UTC 2023 , Edited by admin on Sat Dec 16 16:52:34 UTC 2023
PRIMARY
FDA UNII
D26ZN076H1
Created by admin on Sat Dec 16 16:52:34 UTC 2023 , Edited by admin on Sat Dec 16 16:52:34 UTC 2023
PRIMARY
USAN
QQ-26
Created by admin on Sat Dec 16 16:52:34 UTC 2023 , Edited by admin on Sat Dec 16 16:52:34 UTC 2023
PRIMARY
MESH
C557782
Created by admin on Sat Dec 16 16:52:34 UTC 2023 , Edited by admin on Sat Dec 16 16:52:34 UTC 2023
PRIMARY
ChEMBL
CHEMBL2104978
Created by admin on Sat Dec 16 16:52:34 UTC 2023 , Edited by admin on Sat Dec 16 16:52:34 UTC 2023
PRIMARY
SMS_ID
300000034318
Created by admin on Sat Dec 16 16:52:34 UTC 2023 , Edited by admin on Sat Dec 16 16:52:34 UTC 2023
PRIMARY
PUBCHEM
6451147
Created by admin on Sat Dec 16 16:52:34 UTC 2023 , Edited by admin on Sat Dec 16 16:52:34 UTC 2023
PRIMARY
EPA CompTox
DTXSID20186830
Created by admin on Sat Dec 16 16:52:34 UTC 2023 , Edited by admin on Sat Dec 16 16:52:34 UTC 2023
PRIMARY
CAS
331744-64-0
Created by admin on Sat Dec 16 16:52:34 UTC 2023 , Edited by admin on Sat Dec 16 16:52:34 UTC 2023
PRIMARY
NCI_THESAURUS
C98154
Created by admin on Sat Dec 16 16:52:34 UTC 2023 , Edited by admin on Sat Dec 16 16:52:34 UTC 2023
PRIMARY
Related Record Type Details
PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
TARGET -> AGONIST
PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA
TARGET -> AGONIST
Structure of PELIGLITAZAR
EXCRETED UNCHANGED
Parent compound in urine was also a minor component.
TRACE
URINE
Structure of PELIGLITAZAR
EXCRETED UNCHANGED
Unchanged drug in feces accounted for approximately 47% of the dose in group 1 and 18.4% in group 2.
FECAL
Related Record Type Details
Structure of 9-HYDROXY PELIGLITAZAR
METABOLITE -> PARENT
TRACE
URINE
Structure of 2-(((1S)-1-(4-HYDROXYPHENYL)ETHYL)-(4-METHOXYPHENOXY)CARBONYL-AMINO)ACETIC ACID
METABOLITE -> PARENT
4.38% of dose in group 1 and 1.79% of the dose in group 2
MAJOR
FECAL
Structure of 12-HYDROXY PELIGLITAZAR
METABOLITE -> PARENT
6.66% of dose in group 1 and 2.15% of the dose in group 2
FECAL
Structure of 2-(((1S)-1-(4-HYDROXYPHENYL)ETHYL)-(4-METHOXYPHENOXY)CARBONYL-AMINO)ACETIC ACID
METABOLITE -> PARENT
PLASMA; URINE
Structure of 12-HYDROXY O-DEMETHYL PELIGLITAZAR
METABOLITE -> PARENT
TRACE
URINE
Structure of 12-HYDROXY O-DEMETHYL PELIGLITAZAR
METABOLITE -> PARENT
6.13% of dose in group 1 and 2.33% of the dose in group 2
FECAL
Structure of 17-HYDROXY PELIGLITAZAR
METABOLITE -> PARENT
TRACE
URINE
Structure of O-DEMETHYL PELIGLITAZAR ACYL-BETA-D-GLUCURONIDE
METABOLITE -> PARENT
TRACE
URINE
Structure of 5-METHYL-2-PHENYL-4-OXAZOLEACETIC ACID
METABOLITE -> PARENT
MINOR
FECAL; URINE
Structure of 9-HYDROXY O-DEMETHYL PELIGLITAZAR
METABOLITE -> PARENT
TRACE
URINE
Structure of PELIGLITAZAR ACYL-BETA-D-GLUCURONIDE
METABOLITE -> PARENT
MAJOR
PLASMA
Structure of 17-HYDROXY PELIGLITAZAR
METABOLITE -> PARENT
0.88% of dose in group 1 and 0.90% of the dose in group 2
FECAL
Structure of 12-HYDROXY PELIGLITAZAR
METABOLITE -> PARENT
TRACE
URINE
Structure of PELIGLITAZAR ACYL-BETA-D-GLUCURONIDE
METABOLITE -> PARENT
MINOR
URINE
Structure of 9-HYDROXY O-DEMETHYL PELIGLITAZAR
METABOLITE -> PARENT
1.23% of dose in group 1
MINOR
FECAL
Structure of O-DEMETHYL PELIGLITAZAR
METABOLITE -> PARENT
14.6% of dose in group 1 and 4.66% of the dose in group 2
FECAL
Structure of OXAZOLE RING-OPENED PELIGLITAZAR
METABOLITE -> PARENT
5.52% of dose in group 1 and 1.63% of the dose in group 2
FECAL
Structure of 9-HYDROXY PELIGLITAZAR
METABOLITE -> PARENT
1.58% of dose in group 1
FECAL
Related Record Type Details
Structure of PELIGLITAZAR
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC SINGLE DOSE

ORAL ADMINISTRATION

Biological Half-life PHARMACOKINETIC ORAL ADMINISTRATION

SINGLE DOSE

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