U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Thu Jul 06 12:30:55 UTC 2023
Edited
by admin
on Thu Jul 06 12:30:55 UTC 2023
Protein Type ENZYME
Protein Sub Type CYTOCHROME P450
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
081I12ZA58
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYTOCHROME P450 2C19
Common Name English
HUMAN CYTOCHROME P450 2C19
Common Name English
CYTOCHROME P 450 2C19
Common Name English
CYP2C19
Common Name English
Code System Code Type Description
UNIPROT
P33261
Created by admin on Thu Jul 06 12:31:05 UTC 2023 , Edited by admin on Thu Jul 06 12:31:05 UTC 2023
PRIMARY
CAS
391962-06-4
Created by admin on Thu Jul 06 12:31:05 UTC 2023 , Edited by admin on Thu Jul 06 12:31:05 UTC 2023
ALTERNATIVE
CAS
330589-90-7
Created by admin on Thu Jul 06 12:31:05 UTC 2023 , Edited by admin on Thu Jul 06 12:31:05 UTC 2023
PRIMARY
FDA UNII
081I12ZA58
Created by admin on Thu Jul 06 12:31:05 UTC 2023 , Edited by admin on Thu Jul 06 12:31:05 UTC 2023
PRIMARY
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INHIBITOR -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
MINOR
NON-SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
MINOR
INHIBITOR -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
Metabolized by CYP3A4 (0 to 70%), CYP2C19 (0‐20%), and FMO3 (0‐33%) in vitro.
INHIBITOR -> METABOLIC ENZYME
IC50
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> METABOLIC ENZYME
Inhibits at clinically relevant concentrations.
SUBSTRATE -> METABOLIC ENZYME
MINOR
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
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SUBSTRATE -> METABOLIC ENZYME
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MODERATE
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> TARGET
MINOR
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
MAJOR
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
MAJOR
INDUCER -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> METABOLIC ENZYME
WEAK
IC50
INHIBITOR -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> METABOLIC ENZYME
POTENT
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL