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Approval Year

Unknown
139594
Substance Class Protein
Created
by admin
on Sat Dec 16 06:58:38 GMT 2023
Edited
by admin
on Sat Dec 16 06:58:38 GMT 2023
Protein Type ENZYME
Protein Sub Type CYTOCHROME P450
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
081I12ZA58
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYTOCHROME P450 2C19
Common Name English
HUMAN CYTOCHROME P450 2C19
Common Name English
CYTOCHROME P 450 2C19
Common Name English
CYP2C19
Common Name English
Code System Code Type Description
UNIPROT
P33261
Created by admin on Sat Dec 16 06:58:49 GMT 2023 , Edited by admin on Sat Dec 16 06:58:49 GMT 2023
PRIMARY
CAS
391962-06-4
Created by admin on Sat Dec 16 06:58:49 GMT 2023 , Edited by admin on Sat Dec 16 06:58:49 GMT 2023
ALTERNATIVE
CAS
330589-90-7
Created by admin on Sat Dec 16 06:58:49 GMT 2023 , Edited by admin on Sat Dec 16 06:58:49 GMT 2023
PRIMARY
FDA UNII
081I12ZA58
Created by admin on Sat Dec 16 06:58:49 GMT 2023 , Edited by admin on Sat Dec 16 06:58:49 GMT 2023
PRIMARY
Related Record Type Details
Structure of TICLOPIDINE
SUBSTRATE -> METABOLIC ENZYME
Structure of FLUNITRAZEPAM
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of REGORAFENIB ANHYDROUS
INHIBITOR -> METABOLIC ENZYME
Ki
Structure of TRIHYDROXYCHALCONE
SUBSTRATE -> METABOLIC ENZYME
Structure of AMITRIPTYLINE
SUBSTRATE -> METABOLIC ENZYME
Structure of SERATRODAST
SUBSTRATE -> METABOLIC ENZYME
Structure of NORTILIDINE
SUBSTRATE -> METABOLIC ENZYME
Structure of UAB-30
SUBSTRATE -> METABOLIC ENZYME
HUMAN LIVER
TISSUE EXPRESSION -> PARENT
Structure of CLOBAZAM
SUBSTRATE -> METABOLIC ENZYME
Structure of ENZALUTAMIDE
INHIBITOR -> METABOLIC ENZYME
Structure of TRAMADOL
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of BRANEBRUTINIB
INHIBITOR -> METABOLIC ENZYME
Structure of OXCARBAZEPINE
INHIBITOR -> METABOLIC ENZYME
Ki
Structure of BIIB021
SUBSTRATE -> METABOLIC ENZYME
Structure of PARATHION-METHYL
SUBSTRATE -> METABOLIC ENZYME
Structure of DIAZEPAM
SUBSTRATE -> METABOLIC ENZYME
Structure of BOCIDELPAR
INHIBITOR -> METABOLIC ENZYME
Structure of VILAZODONE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of Lacosamide
SUBSTRATE -> METABOLIC ENZYME
Structure of LURASIDONE
INHIBITOR -> METABOLIC ENZYME
MODERATE
Structure of ZIMLOVISERTIB
NON-INHIBITOR -> METABOLIC ENZYME
Structure of RILPIVIRINE
SUBSTRATE -> METABOLIC ENZYME
Structure of AMBRISENTAN
SUBSTRATE -> METABOLIC ENZYME
Structure of SOLIFENACIN
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of SKF-8742
INHIBITOR -> METABOLIC ENZYME
Structure of ALDUMASTAT
NON-SUBSTRATE -> METABOLIC ENZYME
Structure of ZANUBRUTINIB
INDUCER -> METABOLIC ENZYME
Zanubrutinib is a weak inducer of CYP3A4 and CYP2C19 in vivo.
WEAK
Structure of UMBRALISIB
INHIBITOR -> METABOLIC ENZYME
Structure of ENCORAFENIB
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of FORMOTEROL
SUBSTRATE -> METABOLIC ENZYME
Structure of ANETHOLTRITHION
SUBSTRATE -> METABOLIC ENZYME
Structure of SELUMETINIB
SUBSTRATE -> METABOLIC ENZYME
Structure of ELAGOLIX
INDUCER -> TARGET
Structure of ARTEMETHER
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of E-NORENDOXIFEN
INHIBITOR -> METABOLIC ENZYME
Structure of BEROTRALSTAT
INHIBITOR -> METABOLIC ENZYME
WEAK
Structure of LONAFARNIB
SUBSTRATE -> METABOLIC ENZYME
IN VITRO
Structure of PARATHION
SUBSTRATE -> METABOLIC ENZYME
Structure of MAVOGLURANT
SUBSTRATE -> METABOLIC ENZYME
Structure of LEMBOREXANT
INHIBITOR -> METABOLIC ENZYME
REVERSIBLE INHIBITION
IC50
Structure of ZOLPIDEM
SUBSTRATE -> METABOLIC ENZYME
Structure of TIMOLOL ANHYDROUS
SUBSTRATE -> METABOLIC ENZYME
Structure of MIDOMAFETAMINE
SUBSTRATE -> METABOLIC ENZYME
Structure of METHADONE
SUBSTRATE -> METABOLIC ENZYME
CYP2C19 preferentially metabolized (R)-methadone,
Structure of OTESECONAZOLE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of MDE
MDE
SUBSTRATE -> METABOLIC ENZYME
Structure of STIRIPENTOL
INHIBITOR -> METABOLIC ENZYME
Structure of TERIFLUNOMIDE
NON-SUBSTRATE -> METABOLIC ENZYME
Structure of ETHINYL ESTRADIOL
SUBSTRATE -> METABOLIC ENZYME
Structure of RUCAPARIB
INHIBITOR -> METABOLIC ENZYME
REVERSIBLE
Structure of IXAZOMIB
SUBSTRATE -> METABOLIC ENZYME
At higher than clinical concentrations, ixazomib was metabolized by multiple CYP isoforms with estimated relative contributions of 3A4 (42%), 1A2 (26%), 2B6 (16%), 2C8 (6%), 2D6 (5%), 2C19 (5%) and 2C9 (< 1%).
Structure of PEXIDARTINIB
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of CHLORPYRIFOS
SUBSTRATE -> METABOLIC ENZYME
Structure of CENOBAMATE
SUBSTRATE -> METABOLIC ENZYME
Structure of IOFETAMINE
SUBSTRATE -> METABOLIC ENZYME
Structure of MOMELOTINIB
SUBSTRATE -> METABOLIC ENZYME
Structure of Zolunicant, (-)-
SUBSTRATE -> METABOLIC ENZYME
Structure of APREPITANT
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of DIPHENHYDRAMINE
SUBSTRATE -> METABOLIC ENZYME
CYP1A2, CYP2C9, and CYP2C19 are involved in the metabolism of diphenhydramine as low-affinity P450 isozymes.
Structure of RIFAMPIN
INDUCER -> METABOLIC ENZYME
POTENT
Structure of PROGUANIL
SUBSTRATE -> METABOLIC ENZYME
Structure of RITONAVIR
INDUCER -> METABOLIC ENZYME
POTENT
Structure of TECOVIRIMAT
INHIBITOR -> METABOLIC ENZYME
MINOR
Structure of NELFINAVIR
SUBSTRATE -> METABOLIC ENZYME
Structure of SIMEPREVIR
INHIBITOR -> METABOLIC ENZYME
WEAK
IC50
Structure of 3-ISOXAZOLECARBOXAMIDE, N-(2,4-DICHLOROPHENYL)-5-METHYL-
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of VILAZODONE
INHIBITOR -> METABOLIC ENZYME
In vitro studies have shown that vilazodone is a moderate inhibitor of CYP2C19 and CYP2D6
Structure of SIMEPREVIR
SUBSTRATE -> METABOLIC ENZYME
Structure of CANNABIDIOL
INHIBITOR -> METABOLIC ENZYME
Responsible for a drug interaction with clobazam. Mean increase in clozabam and N-desmethylclozabam levels was 60% and 500%, respectively, after 4 weeks of concomitant therapy.
Structure of PRETOMANID
INHIBITOR -> METABOLIC ENZYME
Pretomanid is a weak time-dependent inhibitor of CYP2C8 and CYP2C19.
TIME-DEPENDENT INHIBITION
Structure of Desloratadine
NON-INHIBITOR -> METABOLIC ENZYME
Structure of LICOFELONE
SUBSTRATE -> METABOLIC ENZYME
Structure of METHOXYCHLOR
SUBSTRATE -> METABOLIC ENZYME
Structure of ALVAMELINE
SUBSTRATE -> METABOLIC ENZYME
Structure of CAPSAICIN
SUBSTRATE -> METABOLIC ENZYME
Structure of LORLATINIB
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of CARBAMAZEPINE
INDUCER -> METABOLIC ENZYME
POTENT
Structure of FIDAXOMICIN
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of PHENYTOIN
INDUCER -> METABOLIC ENZYME
POTENT
Structure of RIFAMYCIN
INHIBITOR -> METABOLIC ENZYME
Rifamycin is an inhibitor of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4/5 in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose clinically relevant inhibition of these enzymes in vivo is unlikely.
Structure of CANNABIDIOL
SUBSTRATE -> METABOLIC ENZYME
Structure of MACITENTAN
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of IDELALISIB
INHIBITOR -> METABOLIC ENZYME
IN VITRO
Structure of OSILODROSTAT
INHIBITOR -> METABOLIC ENZYME
TIME-DEPENDENT INHIBITION
Ki
Structure of BUPIVACAINE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of FLUCONAZOLE
INHIBITOR -> METABOLIC ENZYME
Structure of LYS-006
NON-INHIBITOR -> METABOLIC ENZYME
IC50
Structure of FLUOXETINE
SUBSTRATE -> METABOLIC ENZYME
Structure of VORICONAZOLE
SUBSTRATE -> METABOLIC ENZYME
IN VITRO
Structure of ILAPRAZOLE
SUBSTRATE -> METABOLIC ENZYME
Structure of SUVOREXANT
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of TRICLABENDAZOLE
SUBSTRATE -> METABOLIC ENZYME
Structure of KB-0742
NON-INHIBITOR -> METABOLIC ENZYME
IC50
Structure of RHINACANTHIN C
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of NOMIFENSINE
SUBSTRATE -> METABOLIC ENZYME
Structure of HEXOBARBITAL
SUBSTRATE -> METABOLIC ENZYME
Structure of TOFACITINIB
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of ELAGOLIX
INHIBITOR -> TARGET
Ki
Structure of APALUTAMIDE
INDUCER -> METABOLIC ENZYME
Structure of OMEPRAZOLE
INHIBITOR -> METABOLIC ENZYME
Structure of VELIPARIB
SUBSTRATE -> METABOLIC ENZYME
Structure of IMIPRAMINE
SUBSTRATE -> METABOLIC ENZYME
Structure of TRICLABENDAZOLE SULFONE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of Roflumilast
SUBSTRATE -> METABOLIC ENZYME
Structure of NE-100 FREE BASE
SUBSTRATE -> METABOLIC ENZYME
Structure of TASIMELTEON
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of ENASIDENIB
SUBSTRATE -> METABOLIC ENZYME
Structure of OSPEMIFENE
SUBSTRATE -> METABOLIC ENZYME
Ospemifene is primarily metabolized by CYP3A4, 2C9, and 2C19 responsible for approximately 40 to 50%, ~25%, and ~25%, respectively, of its clearance.
MAJOR
Structure of LOFEXIDINE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of GABAPENTIN ENACARBIL
NON-SUBSTRATE -> METABOLIC ENZYME
Structure of OXYMETAZOLINE
SUBSTRATE -> METABOLIC ENZYME
Structure of OLICERIDINE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of CENOBAMATE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of MDMC
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of Binimetinib
SUBSTRATE -> METABOLIC ENZYME
Structure of ESCITALOPRAM
SUBSTRATE -> METABOLIC ENZYME
Structure of FLURBIPROFEN
INDUCER -> METABOLIC ENZYME
Structure of NORENDOXIFEN
INHIBITOR -> METABOLIC ENZYME
Structure of ENAVOGLIFLOZIN
SUBSTRATE -> METABOLIC ENZYME
Structure of OTESECONAZOLE
INDUCER -> METABOLIC ENZYME
mRNA levels in at least 2 hepatocyte cultures. Up 10 micromolar OTESECONAZOLE
Structure of TILIDINE
SUBSTRATE -> METABOLIC ENZYME
Structure of VORICONAZOLE
INHIBITOR -> METABOLIC ENZYME
Structure of REMIBRUTINIB
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of LOMITAPIDE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of FERROQUINE
SUBSTRATE -> METABOLIC ENZYME
Structure of PF-06835919
NON-INHIBITOR -> METABOLIC ENZYME
IC50
Structure of OSU-6162
SUBSTRATE -> METABOLIC ENZYME
Structure of LORCASERIN
SUBSTRATE -> METABOLIC ENZYME
Structure of PROPRANOLOL
SUBSTRATE -> METABOLIC ENZYME
Structure of SKF-26754A
INHIBITOR -> METABOLIC ENZYME
Structure of TRICLABENDAZOLE SULFOXIDE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of MEPERIDINE
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of CYCLOHEXANAMINE, N-(2-ETHOXYETHYL)-1-PHENYL-
SUBSTRATE -> METABOLIC ENZYME
Structure of U-48800
SUBSTRATE -> METABOLIC ENZYME
Structure of TICLOPIDINE
INHIBITOR -> METABOLIC ENZYME
Structure of VERUBECESTAT
NON-INHIBITOR -> METABOLIC ENZYME
Structure of PROADIFEN
INHIBITOR -> METABOLIC ENZYME
SELECTIVE
Structure of GS-563117
INHIBITOR -> METABOLIC ENZYME
Structure of COBICISTAT
NON-INHIBITOR -> METABOLIC ENZYME
Structure of CHLORAMPHENICOL
INHIBITOR -> METABOLIC ENZYME
MIXED INHIBITION
MAJOR
Ki
Structure of PANOBINOSTAT
INHIBITOR -> METABOLIC ENZYME
Structure of BMS-823778 FREE BASE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of MICONAZOLE
INHIBITOR -> METABOLIC ENZYME
Structure of CYCLOHEXANAMINE, N-(3-ETHOXYPROPYL)-1-PHENYL-
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of DIETHYLTOLUAMIDE
SUBSTRATE -> METABOLIC ENZYME
Structure of PANTOPRAZOLE
SUBSTRATE -> METABOLIC ENZYME
Structure of OSPEMIFENE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of ATOMOXETINE
SUBSTRATE -> METABOLIC ENZYME
Structure of .ALPHA.-PYRROLIDINOPENTIOPHENONE
SUBSTRATE -> METABOLIC ENZYME
Structure of 2,4-DICHLOROANILINE
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of OMEPRAZOLE
SUBSTRATE -> METABOLIC ENZYME
Structure of ISAVUCONAZOLE
INHIBITOR -> METABOLIC ENZYME
Structure of LESINURAD
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of CYCLOPHOSPHAMIDE ANHYDROUS
SUBSTRATE -> METABOLIC ENZYME
Structure of PANOBINOSTAT
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of RAMELTEON
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of MECLIZINE
NON-SUBSTRATE -> METABOLIC ENZYME
Structure of TOFACITINIB
NON-INHIBITOR -> METABOLIC ENZYME
Structure of ALVESPIMYCIN
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of BRIVARACETAM
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of 1-(((4-((7-METHOXY-6-(SULFOOXY)-4-QUINOLINYL)OXY)PHENYL)AMINO)CARBONYL)CYCLOPROPANECARBOXYLIC ACID
SUBSTRATE -> METABOLIC ENZYME
Structure of PF-5212377
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of SEBETRALSTAT
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of FLUVOXAMINE
INHIBITOR -> METABOLIC ENZYME
POTENT
Structure of RABEPRAZOLE SODIUM
SUBSTRATE -> METABOLIC ENZYME
Structure of FEDRATINIB
SUBSTRATE -> METABOLIC ENZYME
Metabolized by CYP3A4 (0 to 70%), CYP2C19 (0‐20%), and FMO3 (0‐33%) in vitro.
Structure of SELICICLIB
INHIBITOR -> METABOLIC ENZYME
IC50
Structure of MEPHENYTOIN, (+)-
SUBSTRATE -> METABOLIC ENZYME
Structure of 4'-METHYL-.ALPHA.-PYRROLIDINOBUTIOPHENONE
SUBSTRATE -> METABOLIC ENZYME
Structure of VALDECOXIB
SUBSTRATE -> METABOLIC ENZYME
Structure of Belumosudil
INHIBITOR -> METABOLIC ENZYME
Inhibits at clinically relevant concentrations.
Structure of DRONABINOL
SUBSTRATE -> METABOLIC ENZYME
MINOR
Structure of N-(2-METHOXYETHYL)-1-PHENYLCYCLOHEXANAMINE
SUBSTRATE -> METABOLIC ENZYME
Structure of WARFARIN, (R)-
SUBSTRATE -> METABOLIC ENZYME
Structure of VOXELOTOR
SUBSTRATE -> METABOLIC ENZYME
In vitro metabolism studies involving recombinant enzymes indicated that CYP3A4, CYP1A1, CYP3A5, CYP2C9, CYP2C19 and CYP2B6 were responsible for the oxidative metabolism of voxelotor.
Structure of PHENYTOIN
SUBSTRATE -> METABOLIC ENZYME
Structure of ENZALUTAMIDE
INDUCER -> METABOLIC ENZYME
Therefore, co-administration of enzalutamide with CYP3A4, 2C9, and 2C19 substrates with a narrow therapeutic index should be avoided.
MODERATE
Structure of N-(3-METHOXYPROPYL)-1-PHENYLCYCLOHEXANAMINE
SUBSTRATE -> METABOLIC ENZYME
Structure of LUSUTROMBOPAG
INHIBITOR -> TARGET
MINOR
Structure of LANSOPRAZOLE
SUBSTRATE -> METABOLIC ENZYME
Structure of SELEGILINE
SUBSTRATE -> METABOLIC ENZYME
MAJOR
Structure of ETRAVIRINE
SUBSTRATE -> METABOLIC ENZYME
Structure of LONAFARNIB
INHIBITOR -> METABOLIC ENZYME
Structure of DIMPYLATE
SUBSTRATE -> METABOLIC ENZYME
Structure of RIVOGLITAZONE
SUBSTRATE -> METABOLIC ENZYME
Structure of ETORICOXIB
SUBSTRATE -> METABOLIC ENZYME
Structure of ABROCITINIB
SUBSTRATE -> METABOLIC ENZYME
Structure of DELAVIRDINE
INDUCER -> METABOLIC ENZYME
Structure of TOPIRAMATE
INHIBITOR -> METABOLIC ENZYME
Structure of BORTEZOMIB
SUBSTRATE -> METABOLIC ENZYME
Structure of GILTERITINIB
INHIBITOR -> METABOLIC ENZYME
WEAK
IC50
Structure of Desloratadine
SUBSTRATE -> METABOLIC ENZYME
Structure of ISONIAZID
INHIBITOR -> METABOLIC ENZYME
POTENT
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
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