U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C6H7N3O
Molecular Weight 137.1395
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ISONIAZID

SMILES

c1cnccc1C(=O)NN

InChI

InChIKey=QRXWMOHMRWLFEY-UHFFFAOYSA-N
InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)

HIDE SMILES / InChI

Molecular Formula C6H7N3O
Molecular Weight 137.1395
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Isoniazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically M. tuberculosis, M. bovis and M. kansasii. Isoniazid is recommended for all forms of tuberculosis in which organisms are susceptible. Isoniazid is a prodrug and must be activated by bacterial catalase. Isoniazid inhibits InhA, the enoyl reductase from Mycobacterium tuberculosis, by forming a covalent adduct with the NAD cofactor. The most frequent adverse reactions to isoniazid are those affecting the nervous system and the liver.

CNS Activity

Curator's Comment:: Isoniazid easily crosses the blood-brain barrier.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
0.75 nM [Ki]
Target ID: P9WIE4|||Q50553
Gene ID: NA
Gene Symbol: katG
Target Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Isoniazid

Approved Use

all forms of tuberculos in which organisms are susceptible. However, active tuberculosis must be treated with multiple concomitant antituberculosis medications to prevent the emergence of drug resistance. Also is recommended as preventive therapy

Launch Date

27302400000
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
8.7 mg/L
15 mg/kg bw 2 times / week multiple, oral
dose: 15 mg/kg bw
route of administration: Oral
experiment type: MULTIPLE
co-administered:
ISONIAZID plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
7.7 mg/L
15 mg/kg 2 times / week multiple, oral
dose: 15 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
ISONIAZID plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
2.1 mg/L
5 mg/kg bw 1 times / day multiple, oral
dose: 5 mg/kg bw
route of administration: Oral
experiment type: MULTIPLE
co-administered:
ISONIAZID plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
2.8 mg/L
5 μg/kg bw 1 times / day multiple, oral
dose: 5 μg/kg bw
route of administration: Oral
experiment type: MULTIPLE
co-administered:
ISONIAZID plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
16.6 mg/L
15 mg/kg bw 2 times / week multiple, oral
dose: 15 mg/kg bw
route of administration: Oral
experiment type: MULTIPLE
co-administered:
ISONIAZID plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
3.1 mg/L
5 mg/kg bw 1 times / day multiple, oral
dose: 5 mg/kg bw
route of administration: Oral
experiment type: MULTIPLE
co-administered:
ISONIAZID plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
37.81 mg × h/L
15 mg/kg bw 2 times / week multiple, oral
dose: 15 mg/kg bw
route of administration: Oral
experiment type: MULTIPLE
co-administered:
ISONIAZID plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
53.17 mg × h/L
15 mg/kg 2 times / week multiple, oral
dose: 15 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
ISONIAZID plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
6.96 mg × h/L
5 mg/kg bw 1 times / day multiple, oral
dose: 5 mg/kg bw
route of administration: Oral
experiment type: MULTIPLE
co-administered:
ISONIAZID plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
9.71 mg × h/L
5 μg/kg bw 1 times / day multiple, oral
dose: 5 μg/kg bw
route of administration: Oral
experiment type: MULTIPLE
co-administered:
ISONIAZID plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
71.52 mg × h/L
15 mg/kg bw 2 times / week multiple, oral
dose: 15 mg/kg bw
route of administration: Oral
experiment type: MULTIPLE
co-administered:
ISONIAZID plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
11.06 ng × h/L
5 mg/kg bw 1 times / day multiple, oral
dose: 5 mg/kg bw
route of administration: Oral
experiment type: MULTIPLE
co-administered:
ISONIAZID plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
86%
unknown, unknown
ISONIAZID plasma
Homo sapiens
population: UNHEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
20 g single, oral
Overdose
Dose: 20 g
Route: oral
Route: single
Dose: 20 g
Sources:
healthy, 16
Health Status: healthy
Age Group: 16
Sex: F
Sources:
Disc. AE: Nausea, Vomiting...
AEs leading to
discontinuation/dose reduction:
Nausea
Vomiting
Grand mal seizure
Lethargy
Coma
Sources:
20 g single, oral
Overdose
Dose: 20 g
Route: oral
Route: single
Dose: 20 g
Sources:
healthy, 16
Health Status: healthy
Age Group: 16
Sex: F
Sources:
Disc. AE: Nystagmus, Hyperreflexia...
AEs leading to
discontinuation/dose reduction:
Nystagmus
Hyperreflexia
Sources:
112 mg/kg single, oral
Overdose
Dose: 112 mg/kg
Route: oral
Route: single
Dose: 112 mg/kg
Sources:
unhealthy, 17
Health Status: unhealthy
Age Group: 17
Sex: M
Sources:
Disc. AE: Lethargy, Seizures...
AEs leading to
discontinuation/dose reduction:
Lethargy
Seizures
Coma
Tachycardia
Sources:
25 g single, oral
Overdose
Dose: 25 g
Route: oral
Route: single
Dose: 25 g
Sources:
healthy, 20
Health Status: healthy
Age Group: 20
Sex: F
Sources:
Disc. AE: Generalized tonic-clonic seizure...
AEs leading to
discontinuation/dose reduction:
Generalized tonic-clonic seizure
Sources:
900 mg 1 times / week multiple, oral
Recommended
Dose: 900 mg, 1 times / week
Route: oral
Route: multiple
Dose: 900 mg, 1 times / week
Sources:
unhealthy, 25–47
Health Status: unhealthy
Age Group: 25–47
Sex: M+F
Sources:
Disc. AE: Hepatotoxicity, Hypersensitivity...
AEs leading to
discontinuation/dose reduction:
Hepatotoxicity (0.3%)
Hypersensitivity (2.9%)
Sources:
3000 mg single, oral
Overdose
Dose: 3000 mg
Route: oral
Route: single
Dose: 3000 mg
Sources:
healthy, 7
Health Status: healthy
Age Group: 7
Sex: M
Sources:
Disc. AE: Seizures, Metabolic acidosis...
AEs leading to
discontinuation/dose reduction:
Seizures (severe)
Metabolic acidosis
Coma
Oliguria
Sources:
900 mg 3 times / week multiple, oral
Recommended
Dose: 900 mg, 3 times / week
Route: oral
Route: multiple
Dose: 900 mg, 3 times / week
Sources:
unhealthy
Disc. AE: Hepatitis...
AEs leading to
discontinuation/dose reduction:
Hepatitis (grade 5)
Sources:
AEs

AEs

AESignificanceDosePopulation
Coma Disc. AE
20 g single, oral
Overdose
Dose: 20 g
Route: oral
Route: single
Dose: 20 g
Sources:
healthy, 16
Health Status: healthy
Age Group: 16
Sex: F
Sources:
Grand mal seizure Disc. AE
20 g single, oral
Overdose
Dose: 20 g
Route: oral
Route: single
Dose: 20 g
Sources:
healthy, 16
Health Status: healthy
Age Group: 16
Sex: F
Sources:
Lethargy Disc. AE
20 g single, oral
Overdose
Dose: 20 g
Route: oral
Route: single
Dose: 20 g
Sources:
healthy, 16
Health Status: healthy
Age Group: 16
Sex: F
Sources:
Nausea Disc. AE
20 g single, oral
Overdose
Dose: 20 g
Route: oral
Route: single
Dose: 20 g
Sources:
healthy, 16
Health Status: healthy
Age Group: 16
Sex: F
Sources:
Vomiting Disc. AE
20 g single, oral
Overdose
Dose: 20 g
Route: oral
Route: single
Dose: 20 g
Sources:
healthy, 16
Health Status: healthy
Age Group: 16
Sex: F
Sources:
Hyperreflexia Disc. AE
20 g single, oral
Overdose
Dose: 20 g
Route: oral
Route: single
Dose: 20 g
Sources:
healthy, 16
Health Status: healthy
Age Group: 16
Sex: F
Sources:
Nystagmus Disc. AE
20 g single, oral
Overdose
Dose: 20 g
Route: oral
Route: single
Dose: 20 g
Sources:
healthy, 16
Health Status: healthy
Age Group: 16
Sex: F
Sources:
Coma Disc. AE
112 mg/kg single, oral
Overdose
Dose: 112 mg/kg
Route: oral
Route: single
Dose: 112 mg/kg
Sources:
unhealthy, 17
Health Status: unhealthy
Age Group: 17
Sex: M
Sources:
Lethargy Disc. AE
112 mg/kg single, oral
Overdose
Dose: 112 mg/kg
Route: oral
Route: single
Dose: 112 mg/kg
Sources:
unhealthy, 17
Health Status: unhealthy
Age Group: 17
Sex: M
Sources:
Seizures Disc. AE
112 mg/kg single, oral
Overdose
Dose: 112 mg/kg
Route: oral
Route: single
Dose: 112 mg/kg
Sources:
unhealthy, 17
Health Status: unhealthy
Age Group: 17
Sex: M
Sources:
Tachycardia Disc. AE
112 mg/kg single, oral
Overdose
Dose: 112 mg/kg
Route: oral
Route: single
Dose: 112 mg/kg
Sources:
unhealthy, 17
Health Status: unhealthy
Age Group: 17
Sex: M
Sources:
Generalized tonic-clonic seizure Disc. AE
25 g single, oral
Overdose
Dose: 25 g
Route: oral
Route: single
Dose: 25 g
Sources:
healthy, 20
Health Status: healthy
Age Group: 20
Sex: F
Sources:
Hepatotoxicity 0.3%
Disc. AE
900 mg 1 times / week multiple, oral
Recommended
Dose: 900 mg, 1 times / week
Route: oral
Route: multiple
Dose: 900 mg, 1 times / week
Sources:
unhealthy, 25–47
Health Status: unhealthy
Age Group: 25–47
Sex: M+F
Sources:
Hypersensitivity 2.9%
Disc. AE
900 mg 1 times / week multiple, oral
Recommended
Dose: 900 mg, 1 times / week
Route: oral
Route: multiple
Dose: 900 mg, 1 times / week
Sources:
unhealthy, 25–47
Health Status: unhealthy
Age Group: 25–47
Sex: M+F
Sources:
Coma Disc. AE
3000 mg single, oral
Overdose
Dose: 3000 mg
Route: oral
Route: single
Dose: 3000 mg
Sources:
healthy, 7
Health Status: healthy
Age Group: 7
Sex: M
Sources:
Metabolic acidosis Disc. AE
3000 mg single, oral
Overdose
Dose: 3000 mg
Route: oral
Route: single
Dose: 3000 mg
Sources:
healthy, 7
Health Status: healthy
Age Group: 7
Sex: M
Sources:
Oliguria Disc. AE
3000 mg single, oral
Overdose
Dose: 3000 mg
Route: oral
Route: single
Dose: 3000 mg
Sources:
healthy, 7
Health Status: healthy
Age Group: 7
Sex: M
Sources:
Seizures severe
Disc. AE
3000 mg single, oral
Overdose
Dose: 3000 mg
Route: oral
Route: single
Dose: 3000 mg
Sources:
healthy, 7
Health Status: healthy
Age Group: 7
Sex: M
Sources:
Hepatitis grade 5
Disc. AE
900 mg 3 times / week multiple, oral
Recommended
Dose: 900 mg, 3 times / week
Route: oral
Route: multiple
Dose: 900 mg, 3 times / week
Sources:
unhealthy
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Isoniazid-associated hepatitis--serum enzyme determinations and histologic features.
1975 May
Antituberculosis activity of certain antifungal and antihelmintic drugs.
1999
Antimycobacterial activity of new ortho-, meta- and para-toluidine derivatives.
1999 Nov-Dec
Drug-induced lupus nephritis in HIV infection.
1999 Oct
New pyrrole derivatives as antimycobacterial agents analogs of BM212.
1999 Oct 18
A multicentre study of the early bactericidal activity of anti-tuberculosis drugs.
2000 Jun
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis.
2000 Jun 2
Increased incidence of peripheral neuropathy with co-administration of stavudine and isoniazid in HIV-infected individuals.
2000 Mar 31
Leucocytoclastic vasculitis and indinavir.
2000 Nov
On-column amperometric detection of ofloxacin and pasiniazid in urine by capillary electrophoresis with an improved fractured joint and small detection cell.
2001 Apr
Ion interaction reagent reversed-phase high-performance liquid chromatography determination of anti-tuberculosis drugs and metabolites in biological fluids.
2001 Apr 25
Facial granulomatous diseases: a study of four cases tested for the presence of Mycobacterium tuberculosis DNA using nested polymerase chain reaction.
2001 Feb
Sources of variation in studies of the early bactericidal activity of antituberculosis drugs.
2001 Feb
Antimycobacterial in vitro activity of cobalt(II) isonicotinoylhydrazone complexes. Part 10.
2001 Feb 12
Drug-resistant tuberculosis in foreign-born persons from Mexico, the Philippines, and Vietnam-United States, 1993-1997.
2001 Jan
Tuberculosis treatment: dangerous regimens?
2001 Jan
Therapeutic efficacy of Poly(DL-lactide-Co-Glycolide)-encapsulated antitubercular drugs against Mycobacterium tuberculosis infection induced in mice.
2001 Jan
Survey for tuberculosis in a tribal population in North Arcot District.
2001 Mar
Efficacy of chemotherapy for prostatic tuberculosis-a clinical and histologic follow-up study.
2001 May
Increasing resistance of M. tuberculosis to anti-TB drugs in Saudi Arabia.
2001 May
Substandard tuberculosis drugs on the global market and their simple detection.
2001 May
Influence of endothelium in dose-dependent inhibition and potentiation by isoniazid of isosorbide dinitrate relaxation of rat aorta.
2001 May
Patents

Sample Use Guides

Adults: 5 mg/kg up to 300 mg daily in a single dose; or 15 mg/kg up to 900 mg/day, two or three times/week
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment:: MIC90 (minimum inhibitory concentration at which 90% of the test strains were inhibited) of isoniazid for Mycobacterium tuberculosis is 1.56 μg/ml.
1.56 μg/ml
Substance Class Chemical
Created
by admin
on Fri Jun 25 20:57:22 UTC 2021
Edited
by admin
on Fri Jun 25 20:57:22 UTC 2021
Record UNII
V83O1VOZ8L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ISONIAZID
EP   HSDB   INN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INN  
Official Name English
HYDRAZID
Common Name English
ISONIAZID COMPONENT OF RIFATER
Common Name English
ISOBICINA
Common Name English
ERALON
Common Name English
4-PYRIDINECARBOXYLIC ACID, HYDRAZIDE
Common Name English
INH
Brand Name English
STANOZIDE
Brand Name English
ISONIAZID [USP MONOGRAPH]
Common Name English
HYZYD
Brand Name English
ISONICOTINIC ACID HYDRAZIDE
WHO-IP  
Systematic Name English
MYBASAN
Common Name English
NYDRAZID
Brand Name English
4-PYRIDINECARBOXYLIC ACID HYDRAZIDE [WHO-IP]
Common Name English
CEDIN
Common Name English
ISONIAZID [ORANGE BOOK]
Common Name English
ATCOTIBINE
Common Name English
ISONIAZID [JAN]
Common Name English
ISONIAZID [WHO-DD]
Common Name English
COTINAZIN
Common Name English
RIMIFON
Brand Name English
DITUBIN
Common Name English
ARMAZID
Common Name English
NEUMANDIN
Common Name English
IPCAZIDE
Common Name English
TEEBACONIN
Common Name English
ISONIAZID [EP MONOGRAPH]
Common Name English
ISONICOTINIC ACID HYDRAZIDE [WHO-IP]
Common Name English
ISONIAZID [USP-RS]
Common Name English
ISONIAZID COMPONENT OF RIFAMATE
Common Name English
HIDRASONIL
Common Name English
ISONIAZID [WHO-IP]
Common Name English
DINACRIN
Common Name English
ISONIAZID [MI]
Common Name English
ISONIAZID [INN]
Common Name English
RIFAMATE COMPONENT ISONIAZID
Common Name English
ISONIAZID [MART.]
Common Name English
ARMAZIDE
Common Name English
NSC-9659
Code English
ERTUBAN
Common Name English
ISONIAZIDUM [WHO-IP LATIN]
Common Name English
RIFATER COMPONENT ISONIAZID
Common Name English
ISONICOTINYLHYDRAZINE
Systematic Name English
TISIODRAZIDA
Common Name English
DIANICOTYL
Common Name English
DOW-ISONIAZID
Brand Name English
ISONICOTINIC ACID HYDRAZIDE [IARC]
Common Name English
ISONIAZID [EP]
Common Name English
ISONIAZID [HSDB]
Common Name English
ISONICOTAN
Common Name English
ISCOTIN
Brand Name English
ISONIAZID [VANDF]
Common Name English
ISIDRINA
Common Name English
Classification Tree Code System Code
NDF-RT N0000175483
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ESSENTIAL MEDICINES LIST 6.2.4 (ETH/ISO)
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ATC J04AM01
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ESSENTIAL MEDICINES LIST 6.2.4
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ATC J04AC01
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-VATC QJ04AC51
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ATC J04AM04
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ATC J04AM06
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-VATC QJ04AM01
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ATC J04AM05
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
NCI_THESAURUS C280
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ATC J04AM03
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ESSENTIAL MEDICINES LIST 6.2.4 (ETH/ISO/PYR/RIF)
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ESSENTIAL MEDICINES LIST 6.2.4 (ETH/ISO/RIF)
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-VATC QJ04AM02
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-VATC QJ04AM04
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
LIVERTOX 521
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-VATC QJ04AM03
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
FDA ORPHAN DRUG 6585
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ATC J04AM08
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-VATC QJ04AC01
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-VATC QJ04AM05
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ATC J04AM02
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ESSENTIAL MEDICINES LIST 6.2.4 (ISO/RIF)
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-VATC QJ04AM06
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ESSENTIAL MEDICINES LIST 6.2.4 (ISO/PYR/RIF)
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ATC J04AC51
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
WHO-ATC J04AM07
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
Code System Code Type Description
HSDB
1647
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY
FDA UNII
V83O1VOZ8L
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY
DRUG CENTRAL
1497
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY
RXCUI
6038
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY RxNorm
MERCK INDEX
M6502
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY Merck Index
EVMPD
SUB08326MIG
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY
LACTMED
Isoniazid
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY
ChEMBL
CHEMBL64
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY
INN
4188
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY
CAS
54-85-3
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-214-6
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY
USP_CATALOG
1349706
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY USP-RS
MESH
D007538
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY
PUBCHEM
3767
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY
DRUG BANK
DB00951
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY
EPA CompTox
54-85-3
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
ISONIAZID
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY Description: Colourless crystals or a white, crystalline powder; odourless. Solubility: Soluble in 8 parts of water and in 40 parts of ethanol (~750 g/l) TS; very slightly soluble in ether R. Category: Tuberculostatic. Storage: Isoniazid should be kept in a well-closed container, protected from light. Definition: Isoniazid contains not less than 98.0% and not more than 101.0% of C6H7N3O, calculated with reference to the dried substance.
NCI_THESAURUS
C600
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY
WIKIPEDIA
ISONIAZID
Created by admin on Fri Jun 25 20:57:22 UTC 2021 , Edited by admin on Fri Jun 25 20:57:22 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
MIC value of the in vitro growth of Mycobacterium Tuberculosis (H37RV strain) of the new anti-tuberculosis terpenoid derived agent tested was 0.02?0.04 ug/ml.
METABOLIC ENZYME -> INHIBITOR
POTENT
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> INDUCER
SALT/SOLVATE -> PARENT
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METABOLITE INACTIVE -> PARENT
METABOLITE -> PARENT
METABOLITE TOXIC -> PARENT
METABOLITE -> PARENT
METABOLITE ACTIVE -> PARENT
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IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
IMPURITY -> PARENT
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ACTIVE MOIETY