Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H9N3O2 |
| Molecular Weight | 179.176 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)NNC(=O)C1=CC=NC=C1
InChI
InChIKey=CVBGNAKQQUWBQV-UHFFFAOYSA-N
InChI=1S/C8H9N3O2/c1-6(12)10-11-8(13)7-2-4-9-5-3-7/h2-5H,1H3,(H,10,12)(H,11,13)
| Molecular Formula | C8H9N3O2 |
| Molecular Weight | 179.176 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Antituberculous compounds. 23. Alkyl- and acylisonicotinic acid hydrazides. | 1965 Nov |
|
| Increased urinary excretion of toxic hydrazino metabolites of isoniazid by slow acetylators. Effect of a slow-release preparation of isoniazid. | 1987 |
|
| Determination of antitubercular drugs in urine and pharmaceuticals by LC using a gradient flow combined with programmed diode array photometric detection. | 2002 Aug 23 |
|
| Determination of the acetylator phenotype in Moroccan tuberculosis patients using isoniazid as metabolic probe. | 2002 Dec |
|
| A simplified method for detecting isoniazid compliance in patients receiving antituberculosis chemotherapy. | 2002 Feb |
|
| Therapeutic isoniazid monitoring using a simple high-performance liquid chromatographic method with ultraviolet detection. | 2002 Jan 5 |
|
| Solid-phase extraction and HPTLC determination of isoniazid and acetylisoniazid in serum. Comparison with HPLC. | 2004 May-Jun |
|
| Unchanged acetylation of isoniazid by alcohol intake. | 2004 Nov |
|
| The effects of acute ethanol intake on isoniazid pharmacokinetics. | 2004 Nov |
|
| Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase. | 2005 Jan 15 |
|
| Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages. | 2005 Oct 3 |
|
| The influence of NAT2 genotypes on the plasma concentration of isoniazid and acetylisoniazid in Chinese pulmonary tuberculosis patients. | 2006 Mar |
|
| Tuberculosis chemotherapy: current drug delivery approaches. | 2006 Sep 19 |
|
| [Detection of mutation in NAT II gene as a method of determination of izoniazyd (INH) acetylation type in human population]. | 2007 |
|
| Simultaneous determination of first-line anti-tuberculosis drugs and their major metabolic ratios by liquid chromatography/tandem mass spectrometry. | 2007 |
|
| Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction. | 2007 Mar 1 |
|
| Low serum concentrations of anti-tuberculosis drugs and determinants of their serum levels. | 2007 Sep |
|
| The effect of pyrazinamide and rifampicin on isoniazid metabolism in rats. | 2007 Sep |
|
| Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients. | 2008 May |
|
| Estimating N-acetyltransferase metabolic activity and pharmacokinetic parameters of isoniazid from genotypes in Chinese subjects. | 2009 Jul |
|
| Simultaneous determination of isoniazid, pyrazinamide, rifampicin and acetylisoniazid in human plasma by high-performance liquid chromatography. | 2010 |
|
| Evaluation of hepatoprotective activity of Cissus quadrangularis stem extract against isoniazid-induced liver damage in rats. | 2010 Dec |
|
| [High-performance liquid chromatography for detecting the concentrations of isoniazid and acetylisoniazid in spinal tuberculosis]. | 2010 Feb |
|
| Is there any difference between acetylator phenotypes in tuberculosis patients and healthy subjects? | 2010 Mar |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:34:06 GMT 2023
by
admin
on
Fri Dec 15 17:34:06 GMT 2023
|
| Record UNII |
J42942UVUN
|
| Record Status |
Validated (UNII)
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| Record Version |
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C510884
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J42942UVUN
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1078-38-2
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7207
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