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Details

Stereochemistry ACHIRAL
Molecular Formula C18H19ClN3.C5H5.Fe
Molecular Weight 433.7557
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERROQUINE

SMILES

CN(C)Cc1ccc[c-]1CNc2ccnc3cc(ccc23)Cl.c1c[cH-]cc1.[Fe+2]

InChI

InChIKey=DDENDDKMBDTHAX-UHFFFAOYSA-N
InChI=1S/C18H19ClN3.C5H5.Fe/c1-22(2)12-14-5-3-4-13(14)11-21-17-8-9-20-18-10-15(19)6-7-16(17)18;1-2-4-5-3-1;/h3-10H,11-12H2,1-2H3,(H,20,21);1-5H;/q2*-1;+2

HIDE SMILES / InChI

Molecular Formula Fe
Molecular Weight 55.8451
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C18H19ClN3
Molecular Weight 312.8172
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C5H5
Molecular Weight 65.0934
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

FERROQUINE, a ferrocene-quinoline conjugate, is an antimalarial drug currently undergoing a clinical evaluation. It is also a promising candidate for repositioning as cancer therapeutics.

Approval Year

PubMed

PubMed

TitleDatePubMed
Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue.
1997 Nov 7
Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity.
2005 May-Jun
The antimalarial ferroquine: from bench to clinic.
2011 Aug
Phase I randomized dose-ascending placebo-controlled trials of ferroquine--a candidate anti-malarial drug--in adults with asymptomatic Plasmodium falciparum infection.
2011 Mar 1
Ferroquine and its derivatives: new generation of antimalarial agents.
2015 Aug 28
Ferroquine, the next generation antimalarial drug, has antitumor activity.
2017 Nov 21
Substance Class Chemical
Created
by admin
on Fri Jun 25 20:39:32 UTC 2021
Edited
by admin
on Fri Jun 25 20:39:32 UTC 2021
Record UNII
8D81JS19ET
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERROQUINE
INN   WHO-DD  
INN  
Official Name English
SSR-97193
Code English
FERROQUINE [WHO-DD]
Common Name English
FERROQUINE [INN]
Common Name English
SSR97193
Common Name English
7-CHLORO-4-(((2-((DIMETHYLAMINO)METHYL)FERROCENYL)METHYL)AMINO)QUINOLONE
Common Name English
FERROCHLOROQUINE
Common Name English
FERROCENE, 1-(((7-CHLORO-4-QUINOLINYL)AMINO)METHYL)-2-((DIMETHYLAMINO)METHYL)-
Systematic Name English
Code System Code Type Description
NCI_THESAURUS
C171721
Created by admin on Fri Jun 25 20:39:32 UTC 2021 , Edited by admin on Fri Jun 25 20:39:32 UTC 2021
PRIMARY
PUBCHEM
86574135
Created by admin on Fri Jun 25 20:39:32 UTC 2021 , Edited by admin on Fri Jun 25 20:39:32 UTC 2021
PRIMARY
INN
8774
Created by admin on Fri Jun 25 20:39:32 UTC 2021 , Edited by admin on Fri Jun 25 20:39:32 UTC 2021
PRIMARY
FDA UNII
8D81JS19ET
Created by admin on Fri Jun 25 20:39:32 UTC 2021 , Edited by admin on Fri Jun 25 20:39:32 UTC 2021
PRIMARY
CAS
185055-67-8
Created by admin on Fri Jun 25 20:39:32 UTC 2021 , Edited by admin on Fri Jun 25 20:39:32 UTC 2021
PRIMARY
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