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Details

Stereochemistry ACHIRAL
Molecular Formula C18H19ClN3.C5H5.Fe
Molecular Weight 433.755
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FERROQUINE

SMILES

[Fe++].[CH-]1C=CC=C1.CN(C)CC2=C[CH-]C=C2CNC3=CC=NC4=CC(Cl)=CC=C34

InChI

InChIKey=DDENDDKMBDTHAX-UHFFFAOYSA-N
InChI=1S/C18H19ClN3.C5H5.Fe/c1-22(2)12-14-5-3-4-13(14)11-21-17-8-9-20-18-10-15(19)6-7-16(17)18;1-2-4-5-3-1;/h3-10H,11-12H2,1-2H3,(H,20,21);1-5H;/q2*-1;+2

HIDE SMILES / InChI

Molecular Formula C5H5
Molecular Weight 65.0932
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Fe
Molecular Weight 55.845
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C18H19ClN3
Molecular Weight 312.817
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

FERROQUINE, a ferrocene-quinoline conjugate, is an antimalarial drug currently undergoing a clinical evaluation. It is also a promising candidate for repositioning as cancer therapeutics.

Approval Year

PubMed

PubMed

TitleDatePubMed
Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue.
1997 Nov 7
Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity.
2005 May-Jun
The antimalarial ferroquine: from bench to clinic.
2011 Aug
Phase I randomized dose-ascending placebo-controlled trials of ferroquine--a candidate anti-malarial drug--in adults with asymptomatic Plasmodium falciparum infection.
2011 Mar 1
Ferroquine and its derivatives: new generation of antimalarial agents.
2015 Aug 28
Ferroquine, the next generation antimalarial drug, has antitumor activity.
2017 Nov 21
Substance Class Chemical
Created
by admin
on Sun Dec 18 20:02:13 UTC 2022
Edited
by admin
on Sun Dec 18 20:02:13 UTC 2022
Record UNII
8D81JS19ET
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERROQUINE
INN   WHO-DD  
INN  
Official Name English
SSR-97193
Code English
ferroquine [INN]
Common Name English
SSR97193
Common Name English
7-CHLORO-4-(((2-((DIMETHYLAMINO)METHYL)FERROCENYL)METHYL)AMINO)QUINOLONE
Common Name English
Ferroquine [WHO-DD]
Common Name English
FERROCHLOROQUINE
Common Name English
FERROCENE, 1-(((7-CHLORO-4-QUINOLINYL)AMINO)METHYL)-2-((DIMETHYLAMINO)METHYL)-
Systematic Name English
Code System Code Type Description
NCI_THESAURUS
C171721
Created by admin on Sun Dec 18 20:02:15 UTC 2022 , Edited by admin on Sun Dec 18 20:02:15 UTC 2022
PRIMARY
PUBCHEM
86574135
Created by admin on Sun Dec 18 20:02:15 UTC 2022 , Edited by admin on Sun Dec 18 20:02:15 UTC 2022
PRIMARY
INN
8774
Created by admin on Sun Dec 18 20:02:15 UTC 2022 , Edited by admin on Sun Dec 18 20:02:15 UTC 2022
PRIMARY
EPA CompTox
DTXSID00939922
Created by admin on Sun Dec 18 20:02:15 UTC 2022 , Edited by admin on Sun Dec 18 20:02:15 UTC 2022
PRIMARY
FDA UNII
8D81JS19ET
Created by admin on Sun Dec 18 20:02:15 UTC 2022 , Edited by admin on Sun Dec 18 20:02:15 UTC 2022
PRIMARY
CAS
185055-67-8
Created by admin on Sun Dec 18 20:02:15 UTC 2022 , Edited by admin on Sun Dec 18 20:02:15 UTC 2022
PRIMARY
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