U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C13H16N4O
Molecular Weight 244.2923
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VELIPARIB

SMILES

C[C@@]1(CCCN1)C2=NC3=C(N2)C=CC=C3C(N)=O

InChI

InChIKey=JNAHVYVRKWKWKQ-CYBMUJFWSA-N
InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1

HIDE SMILES / InChI
Molecular Formula C13H16N4O
Molecular Weight 244.2923
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/17473206 | https://www.ncbi.nlm.nih.gov/pubmed/26251615

Veliparib (ABT-888) is a potent inhibitor of PARP, has good oral bioavailability, can cross the blood-brain barrier, and potentiates temozolomide, platinums, cyclophosphamide, and radiation in syngeneic and xenograft tumor models. AbbVie is developing veliparib for the treatment of cancers. Clinical trials are underway worldwide, investigating veliparib primarily as part of a combination therapy in oncology indications such as brain, colorectal, melanoma, ovarian, prostate and pancreatic cancers.

CNS Activity

CNS Penetrant
2554
Curator's Comment: Veliparib is brain penetrant in rodents. No human data available but the drug is studying for treatment of brain tumors https://www.ncbi.nlm.nih.gov/pubmed/24908656 | https://www.ncbi.nlm.nih.gov/pubmed/25682091

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
 5.2 nM [Ki]
Inhibitor
8297
 2.9 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Phase III
656
Unknown

Approved Use

Unknown
Primary
Phase III
656
Unknown

Approved Use

Unknown
Primary
Phase III
656
Unknown

Approved Use

Unknown
Primary
Phase III
656
Unknown

Approved Use

Unknown
Doses

Doses

DosePopulationAdverse events​
800 mg 1 times / day multiple, oral
Highest studied dose
Dose: 800 mg, 1 times / day
Route: oral
Route: multiple
Dose: 800 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
unhealthy, ADULT
n = 3
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Population Size: 3
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
DLT: Seizure...
Dose limiting toxicities:
Seizure (grade 3, 33.3%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
400 mg 2 times / day multiple, oral
MTD
Dose: 400 mg, 2 times / day
Route: oral
Route: multiple
Dose: 400 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
unhealthy, ADULT
n = 9
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Population Size: 9
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
400 mg 2 times / day multiple, oral
RP2D
Dose: 400 mg, 2 times / day
Route: oral
Route: multiple
Dose: 400 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
unhealthy, ADULT
n = 12
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Population Size: 12
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
DLT: Vomiting, Appetite decreased NOS...
Disc. AE: Fatigue, Vomiting...
Dose limiting toxicities:
Vomiting (grade 3, 8.3%)
Appetite decreased NOS (grade 3, 8.3%)
Fatigue (grade 3, 8.3%)
Nausea (grade 3, 8.3%)
AEs leading to
discontinuation/dose reduction:
Fatigue (25%)
Vomiting (16.7%)
Neutropenia (25%)
Nausea (25%)
Thrombocytopenia (25%)
Anemia (8.3%)
Essential tremor (8.3%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
600 mg 2 times / day multiple, oral
Studied dose
Dose: 600 mg, 2 times / day
Route: oral
Route: multiple
Dose: 600 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
unhealthy, ADULT
n = 5
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Population Size: 5
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
DLT: Asthenia, Nausea...
Dose limiting toxicities:
Asthenia (grade 2, 20%)
Nausea (grade 3, 20%)
Vomiting (grade 3, 20%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
AEs

AEs

AESignificanceDosePopulation
Seizure grade 3, 33.3%
DLT
800 mg 1 times / day multiple, oral
Highest studied dose
Dose: 800 mg, 1 times / day
Route: oral
Route: multiple
Dose: 800 mg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
unhealthy, ADULT
n = 3
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Population Size: 3
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
Vomiting 16.7%
Disc. AE
400 mg 2 times / day multiple, oral
RP2D
Dose: 400 mg, 2 times / day
Route: oral
Route: multiple
Dose: 400 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
unhealthy, ADULT
n = 12
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Population Size: 12
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
Fatigue 25%
Disc. AE
400 mg 2 times / day multiple, oral
RP2D
Dose: 400 mg, 2 times / day
Route: oral
Route: multiple
Dose: 400 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
unhealthy, ADULT
n = 12
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Population Size: 12
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
Nausea 25%
Disc. AE
400 mg 2 times / day multiple, oral
RP2D
Dose: 400 mg, 2 times / day
Route: oral
Route: multiple
Dose: 400 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
unhealthy, ADULT
n = 12
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Population Size: 12
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
Neutropenia 25%
Disc. AE
400 mg 2 times / day multiple, oral
RP2D
Dose: 400 mg, 2 times / day
Route: oral
Route: multiple
Dose: 400 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
unhealthy, ADULT
n = 12
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Population Size: 12
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
Thrombocytopenia 25%
Disc. AE
400 mg 2 times / day multiple, oral
RP2D
Dose: 400 mg, 2 times / day
Route: oral
Route: multiple
Dose: 400 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
unhealthy, ADULT
n = 12
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Population Size: 12
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
Anemia 8.3%
Disc. AE
400 mg 2 times / day multiple, oral
RP2D
Dose: 400 mg, 2 times / day
Route: oral
Route: multiple
Dose: 400 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
unhealthy, ADULT
n = 12
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Population Size: 12
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
Essential tremor 8.3%
Disc. AE
400 mg 2 times / day multiple, oral
RP2D
Dose: 400 mg, 2 times / day
Route: oral
Route: multiple
Dose: 400 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
unhealthy, ADULT
n = 12
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Population Size: 12
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
Fatigue grade 3, 8.3%
DLT
400 mg 2 times / day multiple, oral
RP2D
Dose: 400 mg, 2 times / day
Route: oral
Route: multiple
Dose: 400 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
unhealthy, ADULT
n = 12
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Population Size: 12
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
Nausea grade 3, 8.3%
DLT
400 mg 2 times / day multiple, oral
RP2D
Dose: 400 mg, 2 times / day
Route: oral
Route: multiple
Dose: 400 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
unhealthy, ADULT
n = 12
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Population Size: 12
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
Vomiting grade 3, 8.3%
DLT
400 mg 2 times / day multiple, oral
RP2D
Dose: 400 mg, 2 times / day
Route: oral
Route: multiple
Dose: 400 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
unhealthy, ADULT
n = 12
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Population Size: 12
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
Appetite decreased NOS grade 3, 8.3%
DLT, Disc. AE
400 mg 2 times / day multiple, oral
RP2D
Dose: 400 mg, 2 times / day
Route: oral
Route: multiple
Dose: 400 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
unhealthy, ADULT
n = 12
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: F
Food Status: UNKNOWN
Population Size: 12
Sources:
https://pubmed.ncbi.nlm.nih.gov/28665051
Page: p.1836
Asthenia grade 2, 20%
DLT
600 mg 2 times / day multiple, oral
Studied dose
Dose: 600 mg, 2 times / day
Route: oral
Route: multiple
Dose: 600 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
unhealthy, ADULT
n = 5
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Population Size: 5
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
Nausea grade 3, 20%
DLT
600 mg 2 times / day multiple, oral
Studied dose
Dose: 600 mg, 2 times / day
Route: oral
Route: multiple
Dose: 600 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
unhealthy, ADULT
n = 5
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Population Size: 5
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
Vomiting grade 3, 20%
DLT
600 mg 2 times / day multiple, oral
Studied dose
Dose: 600 mg, 2 times / day
Route: oral
Route: multiple
Dose: 600 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
unhealthy, ADULT
n = 5
Health Status: unhealthy
Condition: cancer
Age Group: ADULT
Sex: M+F
Food Status: UNKNOWN
Population Size: 5
Sources:
https://pubmed.ncbi.nlm.nih.gov/29733524
Page: p.2365
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY103035
https://www.001chemical.com/chem/search?q=DY103035
1PlusChem LLC
1P003A1L
https://www.1pchem.com/search?query=1P003A1L
1PlusChem LLC
1P006PW0
https://www.1pchem.com/search?query=1P006PW0
A2B Chem
AB52185
http://a2bchem.com/prod/AB52185
A2B Chem
AD12688
http://a2bchem.com/prod/AD12688
AChemBlock
10404
http://www.achemblock.com/catalogsearch/result/?q=10404
AChemBlock
Q70244
http://www.achemblock.com/catalogsearch/result/?q=Q70244
AK Scientific
SYN5722
https://aksci.com/item_detail.php?cat=SYN5722
AK Scientific
X7540
https://aksci.com/item_detail.php?cat=X7540
AK Scientific
Y0314
https://aksci.com/item_detail.php?cat=Y0314
AOBIOUS INC
AOB87114
http://aobious.com/aobious/search?search_query=AOB87114
Angene
AGN-PC-0VRX87
http://www.angenechemical.com/productshow/AGN-PC-0VRX87.html
ApexBio Technology
A3958
https://www.apexbt.com/catalogsearch/result/?q=A3958
AstaTech
41373
http://astatechinc.com/CPSResult.php?CRNO=41373
AstaTech
41382
http://astatechinc.com/CPSResult.php?CRNO=41382
Axon MedChem
1593
https://www.axonmedchem.com/product/1593
Axon MedChem
2888
https://www.axonmedchem.com/product/2888
BLD Pharm
BD160254
http://www.bldpharm.com/search/Search.html?keyword=BD160254
BOC Sciences
912444-00-9
http://www.bocsci.com/description.asp?cas=912444-00-9
Cayman Chemical
11505
http://www.caymanchem.com/app/template/Product.vm/catalog/11505
Chem Scene
CS-0076
http://www.chemscene.com/goproductList/searchProductList?productObj=CS-0076
Chem Scene
CS-0077
http://www.chemscene.com/goproductList/searchProductList?productObj=CS-0077
ChemShuttle
100936
https://www.chemshuttle.com/catalogsearch/result/?q=100936
ChemShuttle
133768
https://www.chemshuttle.com/catalogsearch/result/?q=133768
Debye Scientific
DB-078941
https://www.debyesci.com/index.php?id=product&ext[cno]=DB-078941
Fluorochem
519795
http://www.fluorochem.co.uk/Products/Product?code=519795
KeyOrganics
AS-17023
http://www.keyorganicsinc.com/bionet/catalogsearch/result?q=AS-17023
KeyOrganics
AS-19397
http://www.keyorganicsinc.com/bionet/catalogsearch/result?q=AS-19397
KeyOrganics
STR12090
http://www.keyorganicsinc.com/bionet/catalogsearch/result?q=STR12090
Lab Network
LN01270977
https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01270977
Lab Network
LN01325591
https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01325591
Matrix Scientific
120689
http://www.matrixscientific.com/120689.html
Matrix Scientific
153553
http://www.matrixscientific.com/153553.html
MedChem Express
HY-10129
https://www.medchemexpress.com/search.html?q=HY-10129&ft=&fa=&fp=
MedChem Express
HY-10130
https://www.medchemexpress.com/search.html?q=HY-10130&ft=&fa=&fp=
MolPort
MolPort-009-679-436
https://www.molport.com/shop/molecule-link/MolPort-009-679-436
MolPort
MolPort-016-631-859
https://www.molport.com/shop/molecule-link/MolPort-016-631-859
MolPort
MolPort-016-633-168
https://www.molport.com/shop/molecule-link/MolPort-016-633-168
MolPort
MolPort-021-804-902
https://www.molport.com/shop/molecule-link/MolPort-021-804-902
MolPort
MolPort-027-720-945
https://www.molport.com/shop/molecule-link/MolPort-027-720-945
Molcore
MC103035
http://www.molcore.com/CatMC103035.html
Molnova
M16548
https://www.molnova.com/en/serch-list.html?keywords=M16548
Molnova
M16549
https://www.molnova.com/en/serch-list.html?keywords=M16549
MuseChem
I005438
https://www.musechem.com/product/I005438.html
MuseChem
I005439
https://www.musechem.com/product/I005439.html
Ryan Scientific
ABT888_HCL
https://ryansci.com/products?q=ABT888_HCL&list_q=&search_type=exact
Ryan Scientific
Histone_Deacetylase_Inhibitor_III
https://ryansci.com/products?q=Histone_Deacetylase_Inhibitor_III&list_q=&search_type=exact
Selleck Chemicals
S1004
http://www.selleckchem.com/search.html?searchDTO.searchParam=S1004
ShangHai Biochempartner
BCP000074
http://www.biochempartner.com/search_BCP000074
ShangHai Biochempartner
BCP01727
http://www.biochempartner.com/search_BCP01727
ShangHai Biochempartner
BCP09427
http://www.biochempartner.com/search_BCP09427
Toronto Research Chemicals
A112580
https://www.trc-canada.com/product-detail/?CatNum=A112580
eMolecules
271447500
https://orderbb.emolecules.com/search/#?query=271447500
eMolecules
295311079
https://orderbb.emolecules.com/search/#?query=295311079
eMolecules
32278019
https://orderbb.emolecules.com/search/#?query=32278019
eMolecules
36788386
https://orderbb.emolecules.com/search/#?query=36788386
eMolecules
43473183
https://orderbb.emolecules.com/search/#?query=43473183
eNovation Chemicals
D210761
https://www.enovationchem.com/Products.asp?SEARCHTEXT=D210761&searchbtn.x=0&searchbtn.y=0
mcule
MCULE-1119640162
https://mcule.com/MCULE-1119640162/
mcule
MCULE-3543863580
https://mcule.com/MCULE-3543863580/
mcule
MCULE-3859998796
https://mcule.com/MCULE-3859998796/
mcule
MCULE-6745061181
https://mcule.com/MCULE-6745061181/
PubMed

PubMed

TitleDatePubMed
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models.
2007 May 1
A novel poly(ADP-ribose) polymerase inhibitor, ABT-888, radiosensitizes malignant human cell lines under hypoxia.
2008 Aug
Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaks.
2008 Oct
Liquid chromatography-mass spectrometric assay for the quantitation in human plasma of ABT-888, an orally available, small molecule inhibitor of poly(ADP-ribose) polymerase.
2008 Sep 1
Phase 0 trials: a platform for drug development?
2009 Jul 18
Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms.
2010
Simultaneous determination of ABT-888, a poly (ADP-ribose) polymerase inhibitor, and its metabolite in human plasma by liquid chromatography/tandem mass spectrometry.
2010 Feb 1
Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.
2010 Feb 16
PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.
2010 Jul 1
Poly(adp-ribose) polymerase inhibitors: a novel drug class with a promising future.
2010 Mar-Apr
A rapid and sensitive method for determination of veliparib (ABT-888), in human plasma, bone marrow cells and supernatant by using LC/MS/MS.
2010 May 1
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.
2011 Jul
N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide.
2011 May
Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage.
2014 Sep 16
Patents

Patents

20060229289
2
WO/2013/173428A1
1
WO/2016/044384A1
1

Sample Use Guides

In Vivo Use Guide
recommended Phase II dose of single-agent veliparib as 400 mg bid.
Route of Administration: Oral
In Vitro Use Guide
Using colon cancer cell lines significant synergy was observed between Veliparib (ABT-888) and irinotecan at concentrations of ABT-888 as low as 0.125 μM. The level of synergy observed correlated with the degree of PARP1 inhibition as measured biochemically in cell lysates. ABT-888 at concentrations of 0.5-4 μM resulted in synergy with oxaliplatin.
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:15:31 UTC 2023
Edited
by admin
on Fri Dec 15 17:15:31 UTC 2023
Record UNII
01O4K0631N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VELIPARIB
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
PARP-1 INHIBITOR ABT-888
Code English
veliparib [INN]
Common Name English
Veliparib [WHO-DD]
Common Name English
1H-BENZIMIDAZOLE-7-CARBOXAMIDE, 2-((2R)-2-METHYL-2-PYRROLIDINYL)-
Systematic Name English
VELIPARIB [JAN]
Common Name English
ABT-888
Code English
VELIPARIB [USAN]
Common Name English
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide
Systematic Name English
Classification Tree Code System Code
EU-Orphan Drug EU/3/10/830
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
FDA ORPHAN DRUG 542916
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
FDA ORPHAN DRUG 456514
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
NCI_THESAURUS C62554
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
FDA ORPHAN DRUG 257108
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
FDA ORPHAN DRUG 246607
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
FDA ORPHAN DRUG 295509
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
FDA ORPHAN DRUG 290209
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
Code System Code Type Description
PUBCHEM
11960529
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
PRIMARY
FDA UNII
01O4K0631N
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
PRIMARY
INN
9211
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
PRIMARY
ChEMBL
CHEMBL506871
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
PRIMARY
WIKIPEDIA
VELIPARIB
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
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NCI_THESAURUS
C60768
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
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CAS
912444-00-9
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
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CHEBI
62880
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
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DRUG BANK
DB07232
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
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SMS_ID
100000124275
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
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EPA CompTox
DTXSID90238456
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
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USAN
WW-28
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
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EVMPD
SUB32392
Created by admin on Fri Dec 15 17:15:31 UTC 2023 , Edited by admin on Fri Dec 15 17:15:31 UTC 2023
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Related Record Type Details
CYTOCHROME P450 2C19
METABOLIC ENZYME -> SUBSTRATE
POLY (ADP-RIBOSE) POLYMERASE 1
TARGET -> INHIBITOR
Ki
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> SUBSTRATE
Veliparib was a weak P-glycoprotein (P-gp) substrate.
Structure of VELIPARIB
EXCRETED UNCHANGED
URINE
Structure of VELIPARIB
EXCRETED UNCHANGED
POLY (ADP-RIBOSE) POLYMERASE 2
TARGET -> INHIBITOR
Ki
CYTOCHROME P450 2D6
METABOLIC ENZYME -> SUBSTRATE
MAJOR
CYTOCHROME P450 1A2
METABOLIC ENZYME -> SUBSTRATE
Related Record Type Details
Structure of Veliparib lactam metabolite
METABOLITE LESS ACTIVE -> PARENT
Related Record Type Details
Structure of VELIPARIB
ACTIVE MOIETY
NIH
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