Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 12:47:07 UTC 2023
by
admin
on
Sat Dec 16 12:47:07 UTC 2023
|
| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
U25G2OFC53
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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U25G2OFC53
Created by
admin on Sat Dec 16 12:47:08 UTC 2023 , Edited by admin on Sat Dec 16 12:47:08 UTC 2023
|
PRIMARY | |||
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P09874
Created by
admin on Sat Dec 16 12:47:08 UTC 2023 , Edited by admin on Sat Dec 16 12:47:08 UTC 2023
|
PRIMARY | |||
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PARP1
Created by
admin on Sat Dec 16 12:47:08 UTC 2023 , Edited by admin on Sat Dec 16 12:47:08 UTC 2023
|
PRIMARY |
| Linkage Type | Residue Index | |
|---|---|---|
| ZINC FINGER | 1_112 | 1_202 |
| ZINC FINGER | 1_8 | 1_92 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
INHIBITOR -> TARGET |
EC50 values determined
using the cell protection assay.
COMPETITIVE INHIBITOR
EC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
Fluzoparib was well ordered in the catalytic active site of PARP1 with the same binding mode as olaparib.
IC50
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INHIBITOR -> TARGET |
exceedingly selective PARP-1 inhibitor,
whose unprecedented selectivity might reside in its distinct
binding poses within the catalytic domains of PARP-1
Kd
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INHIBITOR -> TARGET |
BINDING
EC50
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
The selective inhibition of MPH against PARPs analyzed by biotinylated NAD+ -based luminescence assays
IC50
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INHIBITOR -> TARGET |
Selective for PARP-1 over PARP-2
IC50
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INHIBITOR -> TARGET |
Ki
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
INHIBITOR
IC50
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INHIBITOR -> TARGET |
DT40 cells cytotoxicity
BINDING
IC50
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RADIOLIGAND->TARGET |
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INHIBITOR -> TARGET |
BINDING
EC50
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INHIBITOR -> TARGET |
5 fold less active than Veliparib in-vitro and 14 fold less active it cell assay.
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
|