U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Jun 26 18:04:03 UTC 2021
Edited
by admin
on Sat Jun 26 18:04:03 UTC 2021
Protein Sub Type
Sequence Type COMPLETE
Record UNII
U25G2OFC53
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
POLY (ADP-RIBOSE) POLYMERASE 1
Common Name English
PARP-1
Common Name English
ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIKE 1
Common Name English
PARP1
Common Name English
NAD(+) ADP-RIBOSYLTRANSFERASE 1
Common Name English
POLY(ADP-RIBOSE) SYNTHASE 1
Common Name English
Code System Code Type Description
FDA UNII
U25G2OFC53
Created by admin on Sat Jun 26 18:04:05 UTC 2021 , Edited by admin on Sat Jun 26 18:04:05 UTC 2021
PRIMARY
UNIPROT
P09874
Created by admin on Sat Jun 26 18:04:05 UTC 2021 , Edited by admin on Sat Jun 26 18:04:05 UTC 2021
PRIMARY
WIKIPEDIA
PARP1
Created by admin on Sat Jun 26 18:04:05 UTC 2021 , Edited by admin on Sat Jun 26 18:04:05 UTC 2021
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
Fluzoparib was well ordered in the catalytic active site of PARP1 with the same binding mode as olaparib.
IC50
INHIBITOR -> TARGET
exceedingly selective PARP-1 inhibitor, whose unprecedented selectivity might reside in its distinct binding poses within the catalytic domains of PARP-1
Kd
INHIBITOR -> TARGET
INHIBITOR -> TARGET
The selective inhibition of MPH against PARPs analyzed by biotinylated NAD+ -based luminescence assays
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
BINDING
EC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
DT40 cells cytotoxicity
BINDING
IC50
RADIOLIGAND->TARGET
INHIBITOR -> TARGET
BINDING
EC50
INHIBITOR -> TARGET
INHIBITOR
IC50
INHIBITOR -> TARGET
EC50 values determined using the cell protection assay.
COMPETITIVE INHIBITOR
EC50
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL