SELICICLIB

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H26N6O
Molecular Weight	354.4493
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC[C@H](CO)NC1=NC2=C(N=CN2C(C)C)C(NCC3=CC=CC=C3)=N1

InChI

InChIKey=BTIHMVBBUGXLCJ-OAHLLOKOSA-N

InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C19H26N6O
Molecular Weight	354.4493
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15958589 | https://www.ncbi.nlm.nih.gov/pubmed/26987072 | https://www.ncbi.nlm.nih.gov/pubmed/19938906

Seliciclib (CYC202, R-roscovitine) is a second-generation orally available cyclin-dependent kinases (CDKs) inhibitor that competes for ATP binding sites on these kinases. It is a direct inhibitor of cyclin CDK2/E, CDK2/A and it has inhibitory effects on cyclin H/CDK7, CDK5, and CDK9. CDKs are enzymes that are central to the process of cell division and cell cycle control and play pivotal roles in cancer cell growth and DNA damage repair. Seliciclib exerts an anti-proliferative effect via several key mechanisms: selective downregulation of proliferative and survival proteins and upregulation of p53, leading to growth arrest or apoptosis. The second one is decreasing phosphorylation of Rb and modulating E2F transcriptional activity leading to growth arrest or apoptosis. Seliciclib is currently in phase II clinical trial as a drug candidate for the treatment of Cushing's disease and as a potential therapeutic agent for the treatment of cystic fibrosis (CF). In addition, it is in Phase II trials for non-small cell lung cancer and nasopharyngeal carcinoma.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Cyclin-dependent kinase 2 22 Target ID: CHEMBL301 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12432547	Inhibitor 8297	0.1 µM [IC50]
Cyclin-dependent kinase 9 19 Target ID: CHEMBL3116 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15958589	Inhibitor 8297	0.81 µM [IC50]
Cyclin-dependent kinase 7 5 Target ID: CHEMBL3055 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15958589	Inhibitor 8297	0.36 µM [IC50]
Cyclin-dependent kinase 5 8 Target ID: CHEMBL4036 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9030781	Inhibitor 8297	0.2 µM [IC50]

Conditions

Condition	Modality	Highest Phase	Product
Cushing’s disease 13 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25942479	Primary	Phase II 1132	Unknown Approved Use Unknown
Cystic fibrosis 120 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26987072	Primary	Phase II 1132	Unknown Approved Use Unknown
Non-small cell lung cancer 206 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19938906	Primary	Phase II 1132	Unknown Approved Use Unknown
Nasopharyngeal carcinoma 8 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19938906	Primary	Phase II 1132	Unknown Approved Use Unknown

Doses

Dose	Population	Adverse events
1800 mg 2 times / day multiple, oral Highest studied dose Dose: 1800 mg, 2 times / day Route: oral Route: multiple Dose: 1800 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3246, 3247	unhealthy, ADULT n = 6 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: UNKNOWN Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3246, 3247	DLT: Asthenia, Hypokalaemia... Dose limiting toxicities: Asthenia (33.3%) Hypokalaemia (33.3%) Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3246, 3247
1250 mg 2 times / day multiple, oral MTD Dose: 1250 mg, 2 times / day Route: oral Route: multiple Dose: 1250 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3245, 3246	unhealthy, ADULT n = 3 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: UNKNOWN Population Size: 3 Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3245, 3246	Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3245, 3246
1600 mg 2 times / day multiple, oral MTD Dose: 1600 mg, 2 times / day Route: oral Route: multiple Dose: 1600 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3246, 3247	unhealthy, ADULT n = 3 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: UNKNOWN Population Size: 3 Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3246, 3247	Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3246, 3247
1600 mg 2 times / day multiple, oral Studied dose Dose: 1600 mg, 2 times / day Route: oral Route: multiple Dose: 1600 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3245, 3246	unhealthy, ADULT n = 6 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: UNKNOWN Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3245, 3246	DLT: Hypokalaemia, Asthenia... Dose limiting toxicities: Hypokalaemia (33.3%) Asthenia (33.3%) Vomiting (33.3%) Nausea (33.3%) Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3245, 3246
800 mg 2 times / day multiple, oral Studied dose Dose: 800 mg, 2 times / day Route: oral Route: multiple Dose: 800 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32	unhealthy, ADULT n = 12 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: FASTED Population Size: 12 Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32	DLT: Hyperglycaemia, Fatigue... Dose limiting toxicities: Hyperglycaemia (8.3%) Fatigue (grade 3, 8.3%) Hyponatraemia (grade 3, 8.3%) Hypokalaemia (grade 4, 8.3%) Skin rash (grade 3, 8.3%) Glycosuria (8.3%) GGT increased (25%) Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32

AEs

AE	Significance	Dose	Population
Asthenia	33.3% DLT	1800 mg 2 times / day multiple, oral Highest studied dose Dose: 1800 mg, 2 times / day Route: oral Route: multiple Dose: 1800 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3246, 3247	unhealthy, ADULT n = 6 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: UNKNOWN Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3246, 3247
Hypokalaemia	33.3% DLT	1800 mg 2 times / day multiple, oral Highest studied dose Dose: 1800 mg, 2 times / day Route: oral Route: multiple Dose: 1800 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3246, 3247	unhealthy, ADULT n = 6 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: UNKNOWN Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3246, 3247
Asthenia	33.3% DLT	1600 mg 2 times / day multiple, oral Studied dose Dose: 1600 mg, 2 times / day Route: oral Route: multiple Dose: 1600 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3245, 3246	unhealthy, ADULT n = 6 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: UNKNOWN Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3245, 3246
Hypokalaemia	33.3% DLT	1600 mg 2 times / day multiple, oral Studied dose Dose: 1600 mg, 2 times / day Route: oral Route: multiple Dose: 1600 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3245, 3246	unhealthy, ADULT n = 6 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: UNKNOWN Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3245, 3246
Nausea	33.3% DLT	1600 mg 2 times / day multiple, oral Studied dose Dose: 1600 mg, 2 times / day Route: oral Route: multiple Dose: 1600 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3245, 3246	unhealthy, ADULT n = 6 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: UNKNOWN Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3245, 3246
Vomiting	33.3% DLT	1600 mg 2 times / day multiple, oral Studied dose Dose: 1600 mg, 2 times / day Route: oral Route: multiple Dose: 1600 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3245, 3246	unhealthy, ADULT n = 6 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: UNKNOWN Population Size: 6 Sources: https://pubmed.ncbi.nlm.nih.gov/20822897 Page: p.3245, 3246
GGT increased	25% DLT	800 mg 2 times / day multiple, oral Studied dose Dose: 800 mg, 2 times / day Route: oral Route: multiple Dose: 800 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32	unhealthy, ADULT n = 12 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: FASTED Population Size: 12 Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32
Glycosuria	8.3% DLT	800 mg 2 times / day multiple, oral Studied dose Dose: 800 mg, 2 times / day Route: oral Route: multiple Dose: 800 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32	unhealthy, ADULT n = 12 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: FASTED Population Size: 12 Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32
Hyperglycaemia	8.3% DLT	800 mg 2 times / day multiple, oral Studied dose Dose: 800 mg, 2 times / day Route: oral Route: multiple Dose: 800 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32	unhealthy, ADULT n = 12 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: FASTED Population Size: 12 Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32
Fatigue	grade 3, 8.3% DLT	800 mg 2 times / day multiple, oral Studied dose Dose: 800 mg, 2 times / day Route: oral Route: multiple Dose: 800 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32	unhealthy, ADULT n = 12 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: FASTED Population Size: 12 Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32
Hyponatraemia	grade 3, 8.3% DLT	800 mg 2 times / day multiple, oral Studied dose Dose: 800 mg, 2 times / day Route: oral Route: multiple Dose: 800 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32	unhealthy, ADULT n = 12 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: FASTED Population Size: 12 Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32
Skin rash	grade 3, 8.3% DLT	800 mg 2 times / day multiple, oral Studied dose Dose: 800 mg, 2 times / day Route: oral Route: multiple Dose: 800 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32	unhealthy, ADULT n = 12 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: FASTED Population Size: 12 Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32
Hypokalaemia	grade 4, 8.3% DLT	800 mg 2 times / day multiple, oral Studied dose Dose: 800 mg, 2 times / day Route: oral Route: multiple Dose: 800 mg, 2 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32	unhealthy, ADULT n = 12 Health Status: unhealthy Condition: cancer Age Group: ADULT Sex: M+F Food Status: FASTED Population Size: 12 Sources: https://pubmed.ncbi.nlm.nih.gov/17179992 Page: p.32

Sourcing

Vendor/Aggregator	ID	URL
1PlusChem LLC	1P003ULO	https://www.1pchem.com/search?query=1P003ULO
AChemBlock	M15131	http://www.achemblock.com/catalogsearch/result/?q=M15131
AK Scientific	X7381	https://aksci.com/item_detail.php?cat=X7381
AOBIOUS INC	AOB2095	http://aobious.com/aobious/search?search_query=AOB2095
Ambeed	A300507	http://www.ambeed.com/search/Search.html?keyword=A300507
Angene	AGN-PC-0QFT1T	http://www.angenechemical.com/productshow/AGN-PC-0QFT1T.html
AstaTech	40772	http://astatechinc.com/CPSResult.php?CRNO=40772
AstaTech	44091	http://astatechinc.com/CPSResult.php?CRNO=44091
BOC Sciences	186692-44-4	http://www.bocsci.com/description.asp?cas=186692-44-4
BOC Sciences	186692-46-6	http://www.bocsci.com/description.asp?cas=186692-46-6
Cayman Chemical	10009569	http://www.caymanchem.com/app/template/Product.vm/catalog/10009569
Chem Scene	CS-0016	http://www.chemscene.com/goproductList/searchProductList?productObj=CS-0016
ChemShuttle	109815	https://www.chemshuttle.com/catalogsearch/result/?q=109815
ChemShuttle	169545	https://www.chemshuttle.com/catalogsearch/result/?q=169545
Debye Scientific	DB-014986	https://www.debyesci.com/index.php?id=product&ext[cno]=DB-014986
Fluorochem	M02443	http://www.fluorochem.co.uk/Products/Product?code=M02443
Hairui	HR121539	http://www.hairuichem.com/en/product/search.do?q=HR121539
KeyOrganics	AS-56277	http://www.keyorganicsinc.com/bionet/catalogsearch/result?q=AS-56277
Lab Network	LN01309105	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01309105
Lab Network	LN01354423	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01354423
Lab Seeker	SC-85946	http://www.labseeker.com/search.php?keywords=SC-85946&category=0
LabSeeker	SC-85946	http://www.labseeker.com/search.php?keywords=SC-85946&category=0
Matrix Scientific	146699	http://www.matrixscientific.com/146699.html
MedChem Express	HY-30237	https://www.medchemexpress.com/search.html?q=HY-30237&ft=&fa=&fp=
MolPort	MolPort-003-959-463	https://www.molport.com/shop/molecule-link/MolPort-003-959-463
Molnova	M12883	https://www.molnova.com/en/serch-list.html?keywords=M12883
MuseChem	M039487	https://www.musechem.com/product/M039487.html
ShangHai Biochempartner	BCP000089	http://www.biochempartner.com/search_BCP000089
ShangHai Biochempartner	BCP01760	http://www.biochempartner.com/search_BCP01760
ShangHai Biochempartner	BCP19053	http://www.biochempartner.com/search_BCP19053
TargetMol	T2095	https://www.targetmol.com/search?keyword=T2095
Toronto Research Chemicals	R684000	https://www.trc-canada.com/product-detail/?CatNum=R684000
eMolecules	1988824	https://orderbb.emolecules.com/search/#?query=1988824
eMolecules	299993222	https://orderbb.emolecules.com/search/#?query=299993222
eMolecules	594108	https://orderbb.emolecules.com/search/#?query=594108
eNovation Chemicals	D572855	https://www.enovationchem.com/Products.asp?SEARCHTEXT=D572855&searchbtn.x=0&searchbtn.y=0
mcule	MCULE-7286831836	https://mcule.com/MCULE-7286831836/
mcule	MCULE-8307455670	https://mcule.com/MCULE-8307455670/
mcule	MCULE-9773570692	https://mcule.com/MCULE-9773570692/

PubMed

Title	Date	PubMed
Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors.	2001 Aug	11461999
Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins.	2002 Aug	12097601
TBP-associated factor 1 overexpression induces tolerance to Doxorubicin in confluent H9c2 cells by an increase in cdk2 activity and cyclin E expression.	2004 Apr	15124910
Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1).	2004 Dec	15317660
P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells.	2004 Sep 1	15342418
Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor.	2005 Aug	16003486
Indirubin-3'-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replication.	2005 Dec 2	16284457
Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R-roscovitine in the mouse.	2005 Jan	15657360
Antiviral activity of CYC202 in HIV-1-infected cells.	2005 Jan 28	15531588
Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1.	2005 Jun 15	15958589
Cyclin-dependent kinase inhibitor seliciclib shows in vitro activity in diffuse large B-cell lymphomas.	2007 Jan	17325859
Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex.	2007 Jul 11	17625008
Gateways to clinical trials.	2007 Jul-Aug	17922073
Gateways to clinical trials.	2007 Jun	17805439
'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.	2007 Jun 7	17173063
Cyclin-dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus.	2007 May	17469145
Crosstalk among Bcl-2 family members in B-CLL: seliciclib acts via the Mcl-1/Noxa axis and gradual exhaustion of Bcl-2 protection.	2007 Nov	17703234
You never know: Cdk inhibitors as anti-cancer drugs.	2008 Dec 15	19066455
Isothiocyanate NB7M causes selective cytotoxicity, pro-apoptotic signalling and cell-cycle regression in ovarian cancer cells.	2008 Dec 2	19002174
Synergistic inhibition of ErbB signaling by combined treatment with seliciclib and ErbB-targeting agents.	2008 Jul 1	18594016
Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR.	2008 May 22	18498648
Role of caspases, calpain and cdk5 in ammonia-induced cell death in developing brain cells.	2008 Nov	18722528
Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects.	2009	19591653
Seliciclib in malignancies.	2009 Dec	19938906
Seliciclib (CYC202, R-roscovitine) enhances the antitumor effect of doxorubicin in vivo in a breast cancer xenograft model.	2009 Jan 15	19003963
Cdk2 plays a critical role in hepatocyte cell cycle progression and survival in the setting of cyclin D1 expression in vivo.	2009 Sep 1	19652536
Healthy clocks, healthy body, healthy mind.	2010 Jan	19926479
Role of senescence and mitotic catastrophe in cancer therapy.	2010 Jan 21	20205872
Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells.	2010 May	20100483
Application of new drugs in chronic lymphocytic leukemia.	2010 May 10	21415964
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.	2013 Apr 15	23398362
Synergism of cyclin-dependent kinase inhibitors with camptothecin derivatives in small cell lung cancer cell lines.	2014 Feb 17	24549232
Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells.	2016 Jan 1	26621329

Sample Use Guides

In Vivo Use Guide

Cushing Disease: R-roscovitine 400 mg oral administration twice daily for 4 days every week for total of 4 weeks. cystic fibrosis: 200 or 400 mg roscovitine (8) or placebo (4) once daily for 4 cycles of 7 days (4 days "on" and 3 days "off")

Route of Administration: Oral

In Vitro Use Guide

CDK2 inhibitors have been proposed as effective anti-cancer therapeutics. It was shown that CYC202 (R-roscovitine) is a potent inhibitor of recombinant CDK2/cyclin E kinase activity (IC(50) = 0.10 microM) with an average cytotoxic IC(50) of 15.2 microM in a panel of 19 human tumour cell lines, and was also demonstrated selectivity for rapidly proliferating cells over non-proliferating cells. A study of the cell cycle effects of CYC202 in Lovo colorectal carcinoma cells showed that the major effect was not the predicted arrest in one part of the cycle, but rather an induction of cell death from all compartments of the cell cycle.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:27:26 GMT 2023` Edited by `admin` on `Sat Dec 16 17:27:26 GMT 2023`
Record UNII	0ES1C2KQ94
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SELICICLIB

Official Name

English

AL-39256

Code

English

SELICICLIB [MI]

Common Name

English

R-ROSCOVITINE

Common Name

English

Seliciclib [WHO-DD]

Common Name

English

CYC-202

Code

English

(2R)-2-((6-BENZYLAMINO-9-(PROPAN-2-YL)-9H-PURIN-2-YL)AMINO)BUTAN-1-OL

Systematic Name

English

seliciclib [INN]

Common Name

English

ROSCOVITINE

Common Name

English

NSC-701554

Code

English

ROSCOVITIN

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2185