PARATHION

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H14NO5PS
Molecular Weight	291.261
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+]([O-])=O

InChI

InChIKey=LCCNCVORNKJIRZ-UHFFFAOYSA-N

InChI=1S/C10H14NO5PS/c1-3-14-17(18,15-4-2)16-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C10H14NO5PS
Molecular Weight	291.261
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein.	1996 Nov	8917702
Oxime reactivation of RBC acetylcholinesterases for biomonitoring.	1999 Oct	10473783
Comparison of oxime-initiated reactivation of organophosphorous-inhibited acetylcholinesterase in brains of avian embryos.	2000 Jan 14	10681099
Optimizing microwave-assisted solvent extraction (MASE) of pesticides from soil.	2001 Jan	11281258
Association between human paraoxonase gene polymorphism and chronic symptoms in pesticide-exposed workers.	2003 Feb	12625227
Organophosphorous pesticides in breast cancer progression.	2003 Jan	12762645
Modeling of sorption and biodegradation of parathion and its metabolite paraoxon in soil.	2003 Nov-Dec	14674543
Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.	2003 Oct	14565775
Cardiac responses of Pacific oyster Crassostrea gigas to agents modulating cholinergic function.	2004 Dec	15683842
Methyl parathion interaction with human and bovine serum albumin.	2004 Feb 28	14700528
Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster populations.	2004 Feb 5	15018651
Acetylcholinesterase alterations reveal the fitness cost of mutations conferring insecticide resistance.	2004 Feb 6	15018650
Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition.	2005 Jan	15470232
Photodegradation of fenitrothion and parathion in tomato epicuticular waxes.	2006 Jan 25	16417307
A model for linking the effects of parathion in soil to its degradation and bioavailability kinetics.	2006 Jan-Feb	16397101
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.	2006 Nov	16497524
Paradoxical effect of salbutamol in a model of acute organophosphates intoxication in guinea pigs: role of substance P release.	2007 Apr	17158603
Gene expression signature of parathion-transformed human breast epithelial cells.	2007 May	17390078
Sorption of hydrophobic organic compounds (HOC) in rapeseed oil bodies.	2008 Feb	17942138
OpdA, a bacterial organophosphorus hydrolase, prevents lethality in rats after poisoning with highly toxic organophosphorus pesticides.	2008 May 21	18378376
Pesticide use and adult-onset asthma among male farmers in the Agricultural Health Study.	2009 Dec	19541724
Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions.	2009 Jun	19590683
Organophosphorous pesticides and estrogen induce transformation of breast cells affecting p53 and c-Ha-ras genes.	2009 Nov	19787260
Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion.	2010 Feb	20123610
Constitutive androstane receptor -null mice are sensitive to the toxic effects of parathion: association with reduced cytochrome p450-mediated parathion metabolism [corrected].	2010 Sep	20573718
Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons.	2011 Sep 1	21767560
Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity.	2012 Aug 16	22562034
Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity.	2013 Jun	22954530
Hypothyroidism and pesticide use among male private pesticide applicators in the agricultural health study.	2013 Oct	24064777
Pesticide use and incident diabetes among wives of farmers in the Agricultural Health Study.	2014 Sep	24727735

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:14:28 GMT 2023` Edited by `admin` on `Fri Dec 15 15:14:28 GMT 2023`
Record UNII	61G466064D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PARATHION

Common Name

English

E-605

Code

English

PARATHION [MI]

Common Name

English

PARATHION [IARC]

Common Name

English

NSC-8933

Code

English

O,O-DIETHYL O-4-NITROPHENYL PHOSPHOROTHIOATE

Systematic Name

English

Parathion [WHO-DD]

Common Name

English

DIETHYL-P-NITROPHENYL MONOTHIOPHOSPHATE

Common Name

English

PARATHION [MART.]

Common Name

English

THIOPHOS

Common Name

English

PARATHION [ISO]

Common Name

English

O,O-DIETHYL O-(4-NITROPHENYL) PHOSPHOROTHIOATE

Systematic Name

English

PARATHION [HSDB]

Common Name

English

PHOSPHOROTHIOIC ACID O,O-DIETHYL O-(4-NITROPHENYL) ESTER

Systematic Name

English

Classification Tree Code System Code

IARC

Parathion

EPA PESTICIDE CODE

57501