U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C10H14NO5PS
Molecular Weight 291.2621
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PARATHION

SMILES

CCOP(=S)(OCC)Oc1ccc(cc1)N(=O)=O

InChI

InChIKey=LCCNCVORNKJIRZ-UHFFFAOYSA-N
InChI=1S/C10H14NO5PS/c1-3-14-17(18,15-4-2)16-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C10H14NO5PS
Molecular Weight 291.2621
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Suxamethonium sensitivity.
1971 Jul 6
Interaction of dichlorvos and anticholinesterases on the in vitro inhibition of human blood cholinesterases.
1974 Feb
Effect of phenobarbitol pretreatment on regeneration of plasma cholinesterase activity inhibited by parathion or dichlorovos.
1982 Jan-Feb
Changes in toxicity of DDVP, DFP, and parathion in rats under cold environment.
1982 Nov
The effects of organophosphate-induced cholinergic stimulation on the antibody response to sheep erythrocytes in inbred mice.
1983 Apr
Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein.
1996 Nov
Foetal and adult human CYP3A isoforms in the bioactivation of organophosphorothionate insecticides.
2006 Dec 15
Pesticides and adult respiratory outcomes in the agricultural health study.
2006 Sep
Recent emergence of insensitive acetylcholinesterase in Chinese populations of the mosquito Culex pipiens (Diptera: Culicidae).
2006 Sep
Paradoxical effect of salbutamol in a model of acute organophosphates intoxication in guinea pigs: role of substance P release.
2007 Apr
Human drug metabolism genes in parathion-and estrogen-treated breast cells.
2007 Dec
Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos.
2007 Feb
Gene expression signature of parathion-transformed human breast epithelial cells.
2007 May
Gene and protein expressions induced by 17beta-estradiol and parathion in cultured breast epithelial cells.
2007 May-Jun
Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification.
2008 Apr 1
Gas-phase mechanisms of degradation of hazardous organophosphorus compounds: do they follow a common pattern of alkaline hydrolysis reaction as in phosphotriesterase?
2008 Aug 14
Cancer genes induced by malathion and parathion in the presence of estrogen in breast cells.
2008 Feb
Sorption of hydrophobic organic compounds (HOC) in rapeseed oil bodies.
2008 Feb
Pesticides and atopic and nonatopic asthma among farm women in the Agricultural Health Study.
2008 Jan 1
Evaluation of androgen receptor transcriptional activities of some pesticides in vitro.
2008 Jan 14
OpdA, a bacterial organophosphorus hydrolase, prevents lethality in rats after poisoning with highly toxic organophosphorus pesticides.
2008 May 21
Pesticide use and adult-onset asthma among male farmers in the Agricultural Health Study.
2009 Dec
Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions.
2009 Jun
Gene expression as a sensitive endpoint to evaluate cell differentiation and maturation of the developing central nervous system in primary cultures of rat cerebellar granule cells (CGCs) exposed to pesticides.
2009 Mar 15
Organophosphorous pesticides and estrogen induce transformation of breast cells affecting p53 and c-Ha-ras genes.
2009 Nov
Prior exposure to organophosphorus and organochlorine pesticides increases the allergic potential of environmental chemical allergens in a local lymph node assay.
2010 Dec 15
Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion.
2010 Feb
Blood gene expression markers to detect and distinguish target organ toxicity.
2010 Feb
Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study.
2010 Jun
A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay.
2010 Jun 1
Evidence that adaptation in Drosophila is not limited by mutation at single sites.
2010 Jun 17
Constitutive androstane receptor -null mice are sensitive to the toxic effects of parathion: association with reduced cytochrome p450-mediated parathion metabolism [corrected].
2010 Sep
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.
2011 Mar 28
Prior or coinstantaneous oral exposure to environmental immunosuppressive agents aggravates mite allergen-induced atopic dermatitis-like immunoreaction in NC/Nga mice.
2011 Nov 18
Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons.
2011 Sep 1
DNA methylation alterations in response to pesticide exposure in vitro.
2012 Aug
Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity.
2012 Aug 16
Genetic variation in nucleotide excision repair pathway genes, pesticide exposure and prostate cancer risk.
2012 Feb
Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran.
2012 Feb 5
Role of regulatory T cells in the induction of atopic dermatitis by immunosuppressive chemicals.
2012 Sep 18
Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs.
2013 Apr 15
Immunotoxicity in mice induced by short-term exposure to methoxychlor, parathion, or piperonyl butoxide.
2013 Apr-Jun
Chlorpyrifos-, diisopropylphosphorofluoridate-, and parathion-induced behavioral and oxidative stress effects: are they mediated by analogous mechanisms of action?
2013 Jan
Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity.
2013 Jun
Comparative effects of parathion and chlorpyrifos on extracellular endocannabinoid levels in rat hippocampus: influence on cholinergic toxicity.
2013 Nov 1
Comparative study on short- and long-term behavioral consequences of organophosphate exposure: relationship to AChE mRNA expression.
2014 Jan
Pesticide exposure and depression among male private pesticide applicators in the agricultural health study.
2014 Sep
Pesticide use and incident diabetes among wives of farmers in the Agricultural Health Study.
2014 Sep
Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes.
2015 Oct 1
Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum.
2015 Sep
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 09:07:28 UTC 2021
Edited
by admin
on Sat Jun 26 09:07:28 UTC 2021
Record UNII
61G466064D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PARATHION
HSDB   ISO   MART.   MI   WHO-DD  
Common Name English
E-605
Code English
PARATHION [MI]
Common Name English
PARATHION [IARC]
Common Name English
NSC-8933
Code English
O,O-DIETHYL O-4-NITROPHENYL PHOSPHOROTHIOATE
Systematic Name English
PARATHION [WHO-DD]
Common Name English
DIETHYL-P-NITROPHENYL MONOTHIOPHOSPHATE
Common Name English
PARATHION [MART.]
Common Name English
THIOPHOS
Common Name English
PARATHION [ISO]
Common Name English
O,O-DIETHYL O-(4-NITROPHENYL) PHOSPHOROTHIOATE
Systematic Name English
PARATHION [HSDB]
Common Name English
PHOSPHOROTHIOIC ACID O,O-DIETHYL O-(4-NITROPHENYL) ESTER
Systematic Name English
Classification Tree Code System Code
IARC Parathion
EPA PESTICIDE CODE 57501
Created by admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
Code System Code Type Description
MESH
D010278
Created by admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
PRIMARY
EVMPD
SUB14775MIG
Created by admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
PRIMARY
CAS
56-38-2
Created by admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
PRIMARY
EPA CompTox
56-38-2
Created by admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
PRIMARY
HSDB
197
Created by admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
PRIMARY
PUBCHEM
991
Created by admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
PRIMARY
MERCK INDEX
M8407
Created by admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
PRIMARY Merck Index
WIKIPEDIA
PARATHION
Created by admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
PRIMARY
FDA UNII
61G466064D
Created by admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-271-7
Created by admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
PRIMARY
Related Record Type Details
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
Related Record Type Details
METABOLITE -> PARENT