PARATHION

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H14NO5PS
Molecular Weight	291.261
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+]([O-])=O

InChI

InChIKey=LCCNCVORNKJIRZ-UHFFFAOYSA-N

InChI=1S/C10H14NO5PS/c1-3-14-17(18,15-4-2)16-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C10H14NO5PS
Molecular Weight	291.261
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Suxamethonium sensitivity.	1971 Jul 6	4998912
Interaction of dichlorvos and anticholinesterases on the in vitro inhibition of human blood cholinesterases.	1974 Feb	4859365
Pathways of microbial metabolism of parathion.	1976 Jan	8005
Effect of phenobarbitol pretreatment on regeneration of plasma cholinesterase activity inhibited by parathion or dichlorovos.	1982 Jan-Feb	7059232
Changes in toxicity of DDVP, DFP, and parathion in rats under cold environment.	1982 Nov	7150809
The effects of organophosphate-induced cholinergic stimulation on the antibody response to sheep erythrocytes in inbred mice.	1983 Apr	6857660
Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein.	1996 Nov	8917702
Foetal and adult human CYP3A isoforms in the bioactivation of organophosphorothionate insecticides.	2006 Dec 15	17110060
Pesticides and adult respiratory outcomes in the agricultural health study.	2006 Sep	17119214
Paradoxical effect of salbutamol in a model of acute organophosphates intoxication in guinea pigs: role of substance P release.	2007 Apr	17158603
Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos.	2007 Feb	17079358
Gene expression signature of parathion-transformed human breast epithelial cells.	2007 May	17390078
Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification.	2008 Apr 1	18164358
Cancer genes induced by malathion and parathion in the presence of estrogen in breast cells.	2008 Feb	18204794
Pesticides and atopic and nonatopic asthma among farm women in the Agricultural Health Study.	2008 Jan 1	17932376
OpdA, a bacterial organophosphorus hydrolase, prevents lethality in rats after poisoning with highly toxic organophosphorus pesticides.	2008 May 21	18378376
Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro.	2008 Sep 25	18617161
Pesticide use and adult-onset asthma among male farmers in the Agricultural Health Study.	2009 Dec	19541724
A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures.	2009 Jan	18832183
Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions.	2009 Jun	19590683
Gene expression as a sensitive endpoint to evaluate cell differentiation and maturation of the developing central nervous system in primary cultures of rat cerebellar granule cells (CGCs) exposed to pesticides.	2009 Mar 15	19146868
Organophosphorous pesticides and estrogen induce transformation of breast cells affecting p53 and c-Ha-ras genes.	2009 Nov	19787260
Prior exposure to organophosphorus and organochlorine pesticides increases the allergic potential of environmental chemical allergens in a local lymph node assay.	2010 Dec 15	20920556
Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion.	2010 Feb	20123610
Blood gene expression markers to detect and distinguish target organ toxicity.	2010 Feb	19784758
Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study.	2010 Jun	20164001
A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay.	2010 Jun 1	20206647
Evidence that adaptation in Drosophila is not limited by mutation at single sites.	2010 Jun 17	20585551
Constitutive androstane receptor -null mice are sensitive to the toxic effects of parathion: association with reduced cytochrome p450-mediated parathion metabolism [corrected].	2010 Sep	20573718
Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays.	2011 Feb 27	21115097
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.	2011 Mar 28	21251949
Prior or coinstantaneous oral exposure to environmental immunosuppressive agents aggravates mite allergen-induced atopic dermatitis-like immunoreaction in NC/Nga mice.	2011 Nov 18	21864637
Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons.	2011 Sep 1	21767560
DNA methylation alterations in response to pesticide exposure in vitro.	2012 Aug	22847954
Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity.	2012 Aug 16	22562034
Genetic variation in nucleotide excision repair pathway genes, pesticide exposure and prostate cancer risk.	2012 Feb	22102698
Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran.	2012 Feb 5	22209767
Role of regulatory T cells in the induction of atopic dermatitis by immunosuppressive chemicals.	2012 Sep 18	22842586
Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs.	2013 Apr 15	23377347
Immunotoxicity in mice induced by short-term exposure to methoxychlor, parathion, or piperonyl butoxide.	2013 Apr-Jun	22834942
Chlorpyrifos-, diisopropylphosphorofluoridate-, and parathion-induced behavioral and oxidative stress effects: are they mediated by analogous mechanisms of action?	2013 Jan	22986948
Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity.	2013 Jun	22954530
Comparative effects of parathion and chlorpyrifos on extracellular endocannabinoid levels in rat hippocampus: influence on cholinergic toxicity.	2013 Nov 1	23933531
Hypothyroidism and pesticide use among male private pesticide applicators in the agricultural health study.	2013 Oct	24064777
Pesticide exposure and inherited variants in vitamin d pathway genes in relation to prostate cancer.	2013 Sep	23833127
Comparative study on short- and long-term behavioral consequences of organophosphate exposure: relationship to AChE mRNA expression.	2014 Jan	24291005
Pesticide exposure and depression among male private pesticide applicators in the agricultural health study.	2014 Sep	24906048
Pesticide use and incident diabetes among wives of farmers in the Agricultural Health Study.	2014 Sep	24727735
Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes.	2015 Oct 1	26196221
Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum.	2015 Sep	26215119

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:51:22 GMT 2025` Edited by `admin` on `Mon Mar 31 17:51:22 GMT 2025`
Record UNII	61G466064D
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

E-605

Preferred Name

English

PARATHION

Common Name

English

PARATHION [MI]

Common Name

English

PARATHION [IARC]

Common Name

English

NSC-8933

Code

English

O,O-DIETHYL O-4-NITROPHENYL PHOSPHOROTHIOATE

Systematic Name

English

Parathion [WHO-DD]

Common Name

English

DIETHYL-P-NITROPHENYL MONOTHIOPHOSPHATE

Common Name

English

PARATHION [MART.]

Common Name

English

THIOPHOS

Common Name

English

PARATHION [ISO]

Common Name

English

O,O-DIETHYL O-(4-NITROPHENYL) PHOSPHOROTHIOATE

Systematic Name

English

PARATHION [HSDB]

Common Name

English

PHOSPHOROTHIOIC ACID O,O-DIETHYL O-(4-NITROPHENYL) ESTER

Systematic Name

English

Classification Tree Code System Code

IARC

Parathion

EPA PESTICIDE CODE

57501