PARATHION

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H14NO5PS
Molecular Weight	291.2621
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOP(=S)(OCC)Oc1ccc(cc1)N(=O)=O

InChI

InChIKey=LCCNCVORNKJIRZ-UHFFFAOYSA-N

InChI=1S/C10H14NO5PS/c1-3-14-17(18,15-4-2)16-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C10H14NO5PS
Molecular Weight	291.2621
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Suxamethonium sensitivity.	1971 Jul 6	4998912
Pathways of microbial metabolism of parathion.	1976 Jan	8005
Effect of phenobarbitol pretreatment on regeneration of plasma cholinesterase activity inhibited by parathion or dichlorovos.	1982 Jan-Feb	7059232
Changes in toxicity of DDVP, DFP, and parathion in rats under cold environment.	1982 Nov	7150809
The effects of organophosphate-induced cholinergic stimulation on the antibody response to sheep erythrocytes in inbred mice.	1983 Apr	6857660
Prolonged toxicity with intermediate syndrome after combined parathion and methyl parathion poisoning.	1992	1512808
Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein.	1996 Nov	8917702
Modeling of sorption and biodegradation of parathion and its metabolite paraoxon in soil.	2003 Nov-Dec	14674543
Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.	2003 Oct	14565775
Intraclonal variability in Daphnia acetylcholinesterase activity: the implications for its applicability as a biomarker.	2003 Sep	12959529
Determination of malathion and diazinon resistance by sequencing the Md alpha E7 gene from Guatemala, Colombia, Manhattan, and Thailand housefly (Musca domestica L.) strains.	2004 Apr	15174280
Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells.	2004 Apr	15064155
Cardiac responses of Pacific oyster Crassostrea gigas to agents modulating cholinergic function.	2004 Dec	15683842
Block of neuronal nicotinic acetylcholine receptors by organophosphate insecticides.	2004 Dec	15342957
Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster populations.	2004 Feb 5	15018651
Acetylcholinesterase alterations reveal the fitness cost of mutations conferring insecticide resistance.	2004 Feb 6	15018650
Time course of brain cholinesterase inhibition and recovery following acute and subacute azinphosmethyl, parathion and carbaryl exposure in the goldfish (Carassius auratus).	2004 Mar	15041264
Stress regulation of sulfotransferases in male rat liver.	2004 Oct 8	15351727
Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition.	2005 Jan	15470232
Malathion bioactivation in the human liver: the contribution of different cytochrome p450 isoforms.	2005 Mar	15557345
High-level expression of recombinant human paraoxonase 1 Q in silkworm larvae (Bombyx mori).	2006 Aug	16331452
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.	2006 Nov	16497524
Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition.	2006 Oct	17035140
Pesticides and adult respiratory outcomes in the agricultural health study.	2006 Sep	17119214
Recent emergence of insensitive acetylcholinesterase in Chinese populations of the mosquito Culex pipiens (Diptera: Culicidae).	2006 Sep	17017223
Enhanced nucleophilic reactivity of hydroxamate ions in some novel micellar systems for the cleavage of parathion.	2006 Sep 15	16797580
Paradoxical effect of salbutamol in a model of acute organophosphates intoxication in guinea pigs: role of substance P release.	2007 Apr	17158603
Gene expression signature of parathion-transformed human breast epithelial cells.	2007 May	17390078
Gene and protein expressions induced by 17beta-estradiol and parathion in cultured breast epithelial cells.	2007 May-Jun	17622325
Cancer genes induced by malathion and parathion in the presence of estrogen in breast cells.	2008 Feb	18204794
Sorption of hydrophobic organic compounds (HOC) in rapeseed oil bodies.	2008 Feb	17942138
Pesticide use and adult-onset asthma among male farmers in the Agricultural Health Study.	2009 Dec	19541724
A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures.	2009 Jan	18832183
Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions.	2009 Jun	19590683
A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay.	2010 Jun 1	20206647
Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays.	2011 Feb 27	21115097
Prior or coinstantaneous oral exposure to environmental immunosuppressive agents aggravates mite allergen-induced atopic dermatitis-like immunoreaction in NC/Nga mice.	2011 Nov 18	21864637
Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons.	2011 Sep 1	21767560
DNA methylation alterations in response to pesticide exposure in vitro.	2012 Aug	22847954
Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity.	2012 Aug 16	22562034
Genetic variation in nucleotide excision repair pathway genes, pesticide exposure and prostate cancer risk.	2012 Feb	22102698
Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran.	2012 Feb 5	22209767
Role of regulatory T cells in the induction of atopic dermatitis by immunosuppressive chemicals.	2012 Sep 18	22842586
Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs.	2013 Apr 15	23377347
Immunotoxicity in mice induced by short-term exposure to methoxychlor, parathion, or piperonyl butoxide.	2013 Apr-Jun	22834942
Chlorpyrifos-, diisopropylphosphorofluoridate-, and parathion-induced behavioral and oxidative stress effects: are they mediated by analogous mechanisms of action?	2013 Jan	22986948
Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity.	2013 Jun	22954530
Hypothyroidism and pesticide use among male private pesticide applicators in the agricultural health study.	2013 Oct	24064777
Pesticide exposure and inherited variants in vitamin d pathway genes in relation to prostate cancer.	2013 Sep	23833127
Comparative study on short- and long-term behavioral consequences of organophosphate exposure: relationship to AChE mRNA expression.	2014 Jan	24291005

Patents

Substance Class	Chemical Created by `admin` on `Sat Jun 26 09:07:28 UTC 2021` Edited by `admin` on `Sat Jun 26 09:07:28 UTC 2021`
Record UNII	61G466064D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PARATHION

Common Name

English

E-605

Code

English

PARATHION [MI]

Common Name

English

PARATHION [IARC]

Common Name

English

NSC-8933

Code

English

O,O-DIETHYL O-4-NITROPHENYL PHOSPHOROTHIOATE

Systematic Name

English

PARATHION [WHO-DD]

Common Name

English

DIETHYL-P-NITROPHENYL MONOTHIOPHOSPHATE

Common Name

English

PARATHION [MART.]

Common Name

English

THIOPHOS

Common Name

English

PARATHION [ISO]

Common Name

English

O,O-DIETHYL O-(4-NITROPHENYL) PHOSPHOROTHIOATE

Systematic Name

English

PARATHION [HSDB]

Common Name

English

PHOSPHOROTHIOIC ACID O,O-DIETHYL O-(4-NITROPHENYL) ESTER

Systematic Name

English

Classification Tree Code System Code

IARC

Parathion

EPA PESTICIDE CODE

57501