U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C10H14NO5PS
Molecular Weight 291.261
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PARATHION

SMILES

CCOP(=S)(OCC)OC1=CC=C(C=C1)[N+]([O-])=O

InChI

InChIKey=LCCNCVORNKJIRZ-UHFFFAOYSA-N
InChI=1S/C10H14NO5PS/c1-3-14-17(18,15-4-2)16-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C10H14NO5PS
Molecular Weight 291.261
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Suxamethonium sensitivity.
1971 Jul 6
Interaction of dichlorvos and anticholinesterases on the in vitro inhibition of human blood cholinesterases.
1974 Feb
[On the plurifactorial determinism of the organophosphorous-induced teratogenesis on bird embryos; trials of protection by various compounds: oximes, hydroxamic acids and nicotinamide analogs (author's transl)].
1979
Effect of phenobarbitol pretreatment on regeneration of plasma cholinesterase activity inhibited by parathion or dichlorovos.
1982 Jan-Feb
The effects of organophosphate-induced cholinergic stimulation on the antibody response to sheep erythrocytes in inbred mice.
1983 Apr
Comparative inhibition of inducible and constitutive CYPs in rat hepatic microsomes by parathion.
2004 Aug
Cardiac responses of Pacific oyster Crassostrea gigas to agents modulating cholinergic function.
2004 Dec
Biochemical stress indicators of greater wax moth exposure to organophosphorus insecticides.
2005 Apr
Role of metabolism in parathion-induced hepatotoxicity and immunotoxicity.
2005 Dec 10
Malathion bioactivation in the human liver: the contribution of different cytochrome p450 isoforms.
2005 Mar
The thermodynamics of phosphate versus phosphorothioate ester hydrolysis.
2005 Oct 14
High-level expression of recombinant human paraoxonase 1 Q in silkworm larvae (Bombyx mori).
2006 Aug
Foetal and adult human CYP3A isoforms in the bioactivation of organophosphorothionate insecticides.
2006 Dec 15
Photodegradation of fenitrothion and parathion in tomato epicuticular waxes.
2006 Jan 25
A model for linking the effects of parathion in soil to its degradation and bioavailability kinetics.
2006 Jan-Feb
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
2006 Nov
Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition.
2006 Oct
Pesticides and adult respiratory outcomes in the agricultural health study.
2006 Sep
Parathion effects on protein synthesis in the seminiferous tubules of mice.
2006 Sep
Enhanced nucleophilic reactivity of hydroxamate ions in some novel micellar systems for the cleavage of parathion.
2006 Sep 15
Paradoxical effect of salbutamol in a model of acute organophosphates intoxication in guinea pigs: role of substance P release.
2007 Apr
Gene expression signature of parathion-transformed human breast epithelial cells.
2007 May
Gene and protein expressions induced by 17beta-estradiol and parathion in cultured breast epithelial cells.
2007 May-Jun
Gas-phase mechanisms of degradation of hazardous organophosphorus compounds: do they follow a common pattern of alkaline hydrolysis reaction as in phosphotriesterase?
2008 Aug 14
Sorption of hydrophobic organic compounds (HOC) in rapeseed oil bodies.
2008 Feb
Pesticides and atopic and nonatopic asthma among farm women in the Agricultural Health Study.
2008 Jan 1
Evaluation of androgen receptor transcriptional activities of some pesticides in vitro.
2008 Jan 14
OpdA, a bacterial organophosphorus hydrolase, prevents lethality in rats after poisoning with highly toxic organophosphorus pesticides.
2008 May 21
Pesticide use and adult-onset asthma among male farmers in the Agricultural Health Study.
2009 Dec
Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions.
2009 Jun
Gene expression as a sensitive endpoint to evaluate cell differentiation and maturation of the developing central nervous system in primary cultures of rat cerebellar granule cells (CGCs) exposed to pesticides.
2009 Mar 15
Organophosphorous pesticides and estrogen induce transformation of breast cells affecting p53 and c-Ha-ras genes.
2009 Nov
Prior exposure to organophosphorus and organochlorine pesticides increases the allergic potential of environmental chemical allergens in a local lymph node assay.
2010 Dec 15
Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion.
2010 Feb
Blood gene expression markers to detect and distinguish target organ toxicity.
2010 Feb
Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study.
2010 Jun
A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay.
2010 Jun 1
Constitutive androstane receptor -null mice are sensitive to the toxic effects of parathion: association with reduced cytochrome p450-mediated parathion metabolism [corrected].
2010 Sep
Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays.
2011 Feb 27
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.
2011 Mar 28
Prior or coinstantaneous oral exposure to environmental immunosuppressive agents aggravates mite allergen-induced atopic dermatitis-like immunoreaction in NC/Nga mice.
2011 Nov 18
Genetic variation in nucleotide excision repair pathway genes, pesticide exposure and prostate cancer risk.
2012 Feb
Role of regulatory T cells in the induction of atopic dermatitis by immunosuppressive chemicals.
2012 Sep 18
Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs.
2013 Apr 15
Immunotoxicity in mice induced by short-term exposure to methoxychlor, parathion, or piperonyl butoxide.
2013 Apr-Jun
Chlorpyrifos-, diisopropylphosphorofluoridate-, and parathion-induced behavioral and oxidative stress effects: are they mediated by analogous mechanisms of action?
2013 Jan
Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity.
2013 Jun
Pesticide exposure and depression among male private pesticide applicators in the agricultural health study.
2014 Sep
Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes.
2015 Oct 1
Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum.
2015 Sep
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:14:28 GMT 2023
Edited
by admin
on Fri Dec 15 15:14:28 GMT 2023
Record UNII
61G466064D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PARATHION
HSDB   ISO   MART.   MI   WHO-DD  
Common Name English
E-605
Code English
PARATHION [MI]
Common Name English
PARATHION [IARC]
Common Name English
NSC-8933
Code English
O,O-DIETHYL O-4-NITROPHENYL PHOSPHOROTHIOATE
Systematic Name English
Parathion [WHO-DD]
Common Name English
DIETHYL-P-NITROPHENYL MONOTHIOPHOSPHATE
Common Name English
PARATHION [MART.]
Common Name English
THIOPHOS
Common Name English
PARATHION [ISO]
Common Name English
O,O-DIETHYL O-(4-NITROPHENYL) PHOSPHOROTHIOATE
Systematic Name English
PARATHION [HSDB]
Common Name English
PHOSPHOROTHIOIC ACID O,O-DIETHYL O-(4-NITROPHENYL) ESTER
Systematic Name English
Classification Tree Code System Code
IARC Parathion
EPA PESTICIDE CODE 57501
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
Code System Code Type Description
MESH
D010278
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
PRIMARY
EVMPD
SUB14775MIG
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
PRIMARY
CAS
56-38-2
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
PRIMARY
ALANWOOD
parathion
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
PRIMARY
EPA CompTox
DTXSID7021100
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
PRIMARY
NCI_THESAURUS
C163685
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
PRIMARY
HSDB
197
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
PRIMARY
PUBCHEM
991
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
PRIMARY
CHEBI
27928
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
PRIMARY
MERCK INDEX
m8407
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
PARATHION
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
PRIMARY
FDA UNII
61G466064D
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
PRIMARY
SMS_ID
100000079747
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
PRIMARY
NSC
8933
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-271-7
Created by admin on Fri Dec 15 15:14:28 GMT 2023 , Edited by admin on Fri Dec 15 15:14:28 GMT 2023
PRIMARY
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