Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H14NO5PS |
| Molecular Weight | 291.2621 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOP(=S)(OCC)Oc1ccc(cc1)N(=O)=O
InChI
InChIKey=LCCNCVORNKJIRZ-UHFFFAOYSA-N
InChI=1S/C10H14NO5PS/c1-3-14-17(18,15-4-2)16-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3
| Molecular Formula | C10H14NO5PS |
| Molecular Weight | 291.2621 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Suxamethonium sensitivity. | 1971 Jul 6 |
|
| Interaction of dichlorvos and anticholinesterases on the in vitro inhibition of human blood cholinesterases. | 1974 Feb |
|
| Pathways of microbial metabolism of parathion. | 1976 Jan |
|
| Effect of phenobarbitol pretreatment on regeneration of plasma cholinesterase activity inhibited by parathion or dichlorovos. | 1982 Jan-Feb |
|
| Changes in toxicity of DDVP, DFP, and parathion in rats under cold environment. | 1982 Nov |
|
| The effects of organophosphate-induced cholinergic stimulation on the antibody response to sheep erythrocytes in inbred mice. | 1983 Apr |
|
| Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein. | 1996 Nov |
|
| Human drug metabolism genes in parathion-and estrogen-treated breast cells. | 2007 Dec |
|
| Gene and protein expressions induced by 17beta-estradiol and parathion in cultured breast epithelial cells. | 2007 May-Jun |
|
| Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification. | 2008 Apr 1 |
|
| Gas-phase mechanisms of degradation of hazardous organophosphorus compounds: do they follow a common pattern of alkaline hydrolysis reaction as in phosphotriesterase? | 2008 Aug 14 |
|
| Cancer genes induced by malathion and parathion in the presence of estrogen in breast cells. | 2008 Feb |
|
| Sorption of hydrophobic organic compounds (HOC) in rapeseed oil bodies. | 2008 Feb |
|
| Pesticides and atopic and nonatopic asthma among farm women in the Agricultural Health Study. | 2008 Jan 1 |
|
| Evaluation of androgen receptor transcriptional activities of some pesticides in vitro. | 2008 Jan 14 |
|
| OpdA, a bacterial organophosphorus hydrolase, prevents lethality in rats after poisoning with highly toxic organophosphorus pesticides. | 2008 May 21 |
|
| Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro. | 2008 Sep 25 |
|
| Pesticide use and adult-onset asthma among male farmers in the Agricultural Health Study. | 2009 Dec |
|
| A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures. | 2009 Jan |
|
| Consumption of a high-fat diet in adulthood ameliorates the effects of neonatal parathion exposure on acetylcholine systems in rat brain regions. | 2009 Jun |
|
| Gene expression as a sensitive endpoint to evaluate cell differentiation and maturation of the developing central nervous system in primary cultures of rat cerebellar granule cells (CGCs) exposed to pesticides. | 2009 Mar 15 |
|
| Organophosphorous pesticides and estrogen induce transformation of breast cells affecting p53 and c-Ha-ras genes. | 2009 Nov |
|
| Prior exposure to organophosphorus and organochlorine pesticides increases the allergic potential of environmental chemical allergens in a local lymph node assay. | 2010 Dec 15 |
|
| Neonatal organophosphorus pesticide exposure alters the developmental trajectory of cell-signaling cascades controlling metabolism: differential effects of diazinon and parathion. | 2010 Feb |
|
| Blood gene expression markers to detect and distinguish target organ toxicity. | 2010 Feb |
|
| Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study. | 2010 Jun |
|
| A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay. | 2010 Jun 1 |
|
| Evidence that adaptation in Drosophila is not limited by mutation at single sites. | 2010 Jun 17 |
|
| Constitutive androstane receptor -null mice are sensitive to the toxic effects of parathion: association with reduced cytochrome p450-mediated parathion metabolism [corrected]. | 2010 Sep |
|
| Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. | 2011 Feb 27 |
|
| Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets. | 2011 Mar 28 |
|
| Prior or coinstantaneous oral exposure to environmental immunosuppressive agents aggravates mite allergen-induced atopic dermatitis-like immunoreaction in NC/Nga mice. | 2011 Nov 18 |
|
| Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons. | 2011 Sep 1 |
|
| DNA methylation alterations in response to pesticide exposure in vitro. | 2012 Aug |
|
| Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity. | 2012 Aug 16 |
|
| Genetic variation in nucleotide excision repair pathway genes, pesticide exposure and prostate cancer risk. | 2012 Feb |
|
| Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran. | 2012 Feb 5 |
|
| Role of regulatory T cells in the induction of atopic dermatitis by immunosuppressive chemicals. | 2012 Sep 18 |
|
| Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs. | 2013 Apr 15 |
|
| Immunotoxicity in mice induced by short-term exposure to methoxychlor, parathion, or piperonyl butoxide. | 2013 Apr-Jun |
|
| Chlorpyrifos-, diisopropylphosphorofluoridate-, and parathion-induced behavioral and oxidative stress effects: are they mediated by analogous mechanisms of action? | 2013 Jan |
|
| Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity. | 2013 Jun |
|
| Comparative effects of parathion and chlorpyrifos on extracellular endocannabinoid levels in rat hippocampus: influence on cholinergic toxicity. | 2013 Nov 1 |
|
| Hypothyroidism and pesticide use among male private pesticide applicators in the agricultural health study. | 2013 Oct |
|
| Pesticide exposure and inherited variants in vitamin d pathway genes in relation to prostate cancer. | 2013 Sep |
|
| Comparative study on short- and long-term behavioral consequences of organophosphate exposure: relationship to AChE mRNA expression. | 2014 Jan |
|
| Pesticide exposure and depression among male private pesticide applicators in the agricultural health study. | 2014 Sep |
|
| Pesticide use and incident diabetes among wives of farmers in the Agricultural Health Study. | 2014 Sep |
|
| Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes. | 2015 Oct 1 |
|
| Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum. | 2015 Sep |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 09:07:28 UTC 2021
by
admin
on
Sat Jun 26 09:07:28 UTC 2021
|
| Record UNII |
61G466064D
|
| Record Status |
Validated (UNII)
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| Record Version |
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| Classification Tree | Code System | Code | ||
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IARC | Parathion | ||
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EPA PESTICIDE CODE |
57501
Created by
admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
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| Code System | Code | Type | Description | ||
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D010278
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SUB14775MIG
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56-38-2
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56-38-2
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197
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991
Created by
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M8407
Created by
admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
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PRIMARY | Merck Index | ||
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PARATHION
Created by
admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
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61G466064D
Created by
admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
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200-271-7
Created by
admin on Sat Jun 26 09:07:28 UTC 2021 , Edited by admin on Sat Jun 26 09:07:28 UTC 2021
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| Related Record | Type | Details | ||
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METABOLIC ENZYME -> SUBSTRATE | |||
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METABOLIC ENZYME -> SUBSTRATE | |||
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METABOLIC ENZYME -> SUBSTRATE | |||
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METABOLIC ENZYME -> SUBSTRATE | |||
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METABOLIC ENZYME -> SUBSTRATE | |||
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METABOLIC ENZYME -> SUBSTRATE |
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METABOLITE -> PARENT |
