Details
Stereochemistry | RACEMIC |
Molecular Formula | C12H18IN |
Molecular Weight | 303.1825 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)NC(C)CC1=CC=C(I)C=C1
InChI
InChIKey=ISEHJSHTIVKELA-UHFFFAOYSA-N
InChI=1S/C12H18IN/c1-9(2)14-10(3)8-11-4-6-12(13)7-5-11/h4-7,9-10,14H,8H2,1-3H3
Molecular Formula | C12H18IN |
Molecular Weight | 303.1825 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
CNS Activity
Sources: http://www.ncbi.nlm.nih.gov/pubmed/3335919
Curator's Comment: Known to be CNS active in rodents.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
[Analysis of regional cerebral blood flow and distribution volume in Machado-Joseph disease by iodine-123I IMP single photon emission computed tomography]. | 2001 Sep |
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A simplified double-injection method to quantify cerebral blood flow and vascular reserve using iodine-123 IMP-SPECT. | 2002 Apr |
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Relationship between cognitive function and regional cerebral blood flow in Alzheimer's disease. | 2002 Aug |
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[Estimation and optimization of the use of standard arterial input function for split-dose administration of N-isopropyl-p[123I]iodoamphetamine]. | 2002 Feb |
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Which attenuation coefficient to use in combined attenuation and scatter corrections for quantitative brain SPET? | 2002 Jul |
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The effect of scatter correction on 123I-IMP brain perfusion SPET with the triple energy window method in normal subjects using SPM analysis. | 2002 Mar |
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Quantitative local cerebral blood flow change after cerebrospinal fluid removal in patients with normal pressure hydrocephalus measured by a double injection method with N-isopropyl-p-[(123)I] iodoamphetamine. | 2002 Mar |
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Quantitative measurement of regional cerebral blood flow with flow-sensitive alternating inversion recovery imaging: comparison with [iodine 123]-iodoamphetamin single photon emission CT. | 2002 Mar |
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Combined Analysis of CSF Tau Levels and [(123)I]Iodoamphetamine SPECT in Mild Cognitive Impairment: Implications for a Novel Predictor of Alzheimer's Disease. | 2002 Mar |
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[Estimation by static SPECT of the radioactivity remaining after the first dose of two-fractionated 123I-IMP administration: the rate of increase in cerebral blood flow by ARG and the rate of increase in SPECT count]. | 2002 May |
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Decreased cerebral blood flow in renal transplant recipients. | 2002 Sep |
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Use of cerebrovascular reactivity in patients with symptomatic major cerebral artery occlusion to predict 5-year outcome: comparison of xenon-133 and iodine-123-IMP single-photon emission computed tomography. | 2002 Sep |
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Detection of misery perfusion with split-dose 123I-iodoamphetamine single-photon emission computed tomography in patients with carotid occlusive diseases. | 2002 Sep |
|
[Regional cerebral blood flow measured by three-dimensional stereotactic surface projections (3D-SSP) of 123I-IMP SPECT in Parkinson disease patients with cognitive impairment]. | 2003 Apr |
|
Successful scintigraphic visualization of metastatic lesions of a hard palate melanoma with N-isopropyl-p-[123I]-iodoamphetamine. | 2003 Apr |
|
Regional cerebral blood flow in vascular depression assessed by 123I-IMP SPECT. | 2003 Aug |
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Comparison of I-123 IMP and Ga-67 citrate scintigraphy of malignant melanoma. | 2003 Aug |
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High 123I-IMP retention on SPECT image in primary central nervous system lymphoma. | 2003 Feb |
|
Validation of the dual-table autoradiographic method to quantify two sequential rCBFs in a single SPET session with N-isopropyl-[123I] p-iodoamphetamine. | 2003 Jul |
|
[The development of new method for the assessment of perfusion reserve using split dose iodine-123-IMP SPECT: one-day protocol by modified ARG method]. | 2003 May |
|
Quantitative imaging of cerebral blood flow using SPECT with 123I-iodoamphetamine in neuropsychiatric systemic lupus erythematosus. | 2003 Sep |
|
Cerebral hemodynamics and metabolism in adult moyamoya disease: comparison of angiographic collateral circulation. | 2004 Apr |
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Clinical efficacy of 123I-IMP SPECT for the diagnosis of malignant uveal melanoma. | 2004 Apr |
|
A case of intravascular lymphoma with increased regional cerebral blood flow in I-123 IMP single-photon emission CT. | 2004 Apr |
|
Availability of N-isopropyl-p-[125I]iodoamphetamine (IMP) as a practical cerebral blood flow (CBF) indicator in rats. | 2004 Aug |
|
Chronic subdural hematoma following dural metastasis of gastric cancer: measurement of pre- and postoperative cerebral blood flow with N-isopropyl-p-[123I]iodoamphetamine--case report. | 2004 Dec |
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Therapeutic effect and [123I]IMP SPECT findings of sodium dichloroacetate in a patient with MELAS. | 2004 Jan 27 |
|
The clinical role of N-isopropyl-p-[123I]-iodoamphetamine single photon emission computed tomography in the follow-up of choroidal melanoma after radiotherapy. | 2004 Jan-Feb |
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Comparison of FDG-PET and IMP-SPECT in patients with dementia with Lewy bodies. | 2004 Jul |
|
Error analysis of measured cerebral vascular response to acetazolamide stress by I-123-IMP autoradiographic method with single photon emission computed tomography: errors due to distribution volume of I-123-IMP. | 2004 May |
|
A simple method for the detection of abnormal brain regions in Alzheimer's disease patients using [11C]MP4A: comparison with [123I]IMP SPECT. | 2004 May |
|
Losartan, an angiotensin II (AT1) receptor antagonist, preserves cerebral blood flow in hypertensive patients with a history of stroke. | 2004 Oct |
|
Cerebral blood flow in Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease according to three-dimensional stereotactic surface projection imaging. | 2005 |
|
Diagnosis of Alzheimer's disease using brain perfusion SPECT and MR imaging: which modality achieves better diagnostic accuracy? | 2005 Apr |
|
[Two surgically treated cases with dural arteriovenous malformation in the anterior cranial fossa]. | 2005 Dec |
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Perfusion CT investigation of chronic internal carotid artery occlusion: comparison with SPECT. | 2005 Dec |
|
Effects of tissue heterogeneity on cerebral vascular response to acetazolamide stress measured by an I-123-IMP autoradiographic method with single-photon emission computed tomography. | 2005 Jun |
|
[Amnesia following left medial frontal subcortical hemorrhage: a case report]. | 2005 Mar |
|
Increased accumulations of N-isopropyl-p-[123I]-iodoamphetamine related to tumefactive multiple sclerosis. | 2005 Oct |
|
N-isopropyl-p- 123I iodoamphetamine single photon emission computed tomography study of Parkinson's disease with dementia. | 2005 Oct |
|
[SPECT for diagnosis of brain tumors]. | 2005 Sep |
|
[Single photon emission computed tomography findings in a case of alternating hemiplegia of childhood in relation to migraine]. | 2005 Sep |
|
Hypoperfusion of the auditory and prefrontal cortices in Parkinsonian patients with verbal hallucinations. | 2006 Dec |
|
Comparative study of cerebral blood flow in patients with normal-tension glaucoma and control subjects. | 2006 Feb |
|
[Correlation of the cognitive function and the duration of the illness with the regional cerebral blood flow in the patients with Parkinson's disease: objective evaluation using stereotactic extraction estimation analysis in 123I-IMP SPECT]. | 2006 Jan |
|
Wisconsin Card Sorting Test and brain perfusion imaging in Parkinson's disease. | 2006 Jun |
|
Comparative value of brain perfusion SPECT and [(123)I]MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and Alzheimer's disease. | 2006 Mar |
|
Diagnosis of atypical choroidal malignant melanoma using N-isopropyl-p-[123I]-iodoamphetamine single photon emission computed tomography. | 2006 Mar-Apr |
|
Measurement of regional cerebral blood flow with 123I-IMP using one-point venous blood sampling and causality analysis: evaluation by comparison with conventional continuous arterial blood sampling. | 2006 Nov |
|
Symptomatic hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in a child with moyamoya disease. | 2007 Oct |
Patents
Sample Use Guides
The recommended intravenous dose for SPECTAMINE (lofetamine HCI I-123 Injection) in the average adult patient (70 kg) is 111 to 222 megabecquerels (3 to 6 millicuries).
Route of Administration:
Intravenous
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2537215
Cerebral tissue was taken from six-day-old Wistar rat pups. Twenty-four explants were cut from the occipital cortex of a single animal and grown in pairs on polyamide carrier grids distributed over 12 petri. The cultures were incubated with iofetamine (5 uCi) and the drug uptake was tested.
Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Jul 05 23:17:47 UTC 2023
by
admin
on
Wed Jul 05 23:17:47 UTC 2023
|
Record UNII |
C2A5X08042
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Record Status |
Validated (UNII)
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Record Version |
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-
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Systematic Name | English |
Code System | Code | Type | Description | ||
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DTXSID3048443
Created by
admin on Wed Jul 05 23:17:47 UTC 2023 , Edited by admin on Wed Jul 05 23:17:47 UTC 2023
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C2A5X08042
Created by
admin on Wed Jul 05 23:17:47 UTC 2023 , Edited by admin on Wed Jul 05 23:17:47 UTC 2023
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82691-33-6
Created by
admin on Wed Jul 05 23:17:47 UTC 2023 , Edited by admin on Wed Jul 05 23:17:47 UTC 2023
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Iofetamine
Created by
admin on Wed Jul 05 23:17:47 UTC 2023 , Edited by admin on Wed Jul 05 23:17:47 UTC 2023
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3729
Created by
admin on Wed Jul 05 23:17:47 UTC 2023 , Edited by admin on Wed Jul 05 23:17:47 UTC 2023
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