Details
Stereochemistry | RACEMIC |
Molecular Formula | C12H18IN |
Molecular Weight | 303.1825 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)NC(C)CC1=CC=C(I)C=C1
InChI
InChIKey=ISEHJSHTIVKELA-UHFFFAOYSA-N
InChI=1S/C12H18IN/c1-9(2)14-10(3)8-11-4-6-12(13)7-5-11/h4-7,9-10,14H,8H2,1-3H3
Molecular Formula | C12H18IN |
Molecular Weight | 303.1825 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
CNS Activity
Sources: http://www.ncbi.nlm.nih.gov/pubmed/3335919
Curator's Comment: Known to be CNS active in rodents.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
[Development of quantification analysis software for measuring regional cerebral blood flow by the modified split-dose method with (123)I-IMP before and after acetazolamide loading]. | 2003 Dec |
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[Normalization of cerebral hemodynamics and metabolism after carotid stenting in patients unfit for major surgery]. | 2003 Dec |
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Cerebral hemodynamics and metabolism in adult moyamoya disease: comparison of angiographic collateral circulation. | 2004 Apr |
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Clinical efficacy of 123I-IMP SPECT for the diagnosis of malignant uveal melanoma. | 2004 Apr |
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A case of intravascular lymphoma with increased regional cerebral blood flow in I-123 IMP single-photon emission CT. | 2004 Apr |
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Availability of N-isopropyl-p-[125I]iodoamphetamine (IMP) as a practical cerebral blood flow (CBF) indicator in rats. | 2004 Aug |
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Chronic subdural hematoma following dural metastasis of gastric cancer: measurement of pre- and postoperative cerebral blood flow with N-isopropyl-p-[123I]iodoamphetamine--case report. | 2004 Dec |
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Crossed cerebellar diaschisis in patients with cortical infarction: logistic regression analysis to control for confounding effects. | 2004 Feb |
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[Changes in visual event-related potentials and SPECT in dissociative amnesia]. | 2004 Jan |
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Therapeutic effect and [123I]IMP SPECT findings of sodium dichloroacetate in a patient with MELAS. | 2004 Jan 27 |
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The clinical role of N-isopropyl-p-[123I]-iodoamphetamine single photon emission computed tomography in the follow-up of choroidal melanoma after radiotherapy. | 2004 Jan-Feb |
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Comparison of FDG-PET and IMP-SPECT in patients with dementia with Lewy bodies. | 2004 Jul |
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Assessment of cerebral hemodynamics in childhood moyamoya disease using a quantitative and a semiquantitative IMP-SPECT study. | 2004 Jun |
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[Diagnosis of dementia and neurodegenerative disorders by brain SPECT of three dimensional stereotactic surface projection method]. | 2004 Mar |
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Error analysis of measured cerebral vascular response to acetazolamide stress by I-123-IMP autoradiographic method with single photon emission computed tomography: errors due to distribution volume of I-123-IMP. | 2004 May |
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A simple method for the detection of abnormal brain regions in Alzheimer's disease patients using [11C]MP4A: comparison with [123I]IMP SPECT. | 2004 May |
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Losartan, an angiotensin II (AT1) receptor antagonist, preserves cerebral blood flow in hypertensive patients with a history of stroke. | 2004 Oct |
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Cerebral blood flow in Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease according to three-dimensional stereotactic surface projection imaging. | 2005 |
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Diagnosis of Alzheimer's disease using brain perfusion SPECT and MR imaging: which modality achieves better diagnostic accuracy? | 2005 Apr |
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Brain 3D-SSP SPECT analysis in dementia with Lewy bodies, Parkinson's disease with and without dementia, and Alzheimer's disease. | 2005 Aug |
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[Two surgically treated cases with dural arteriovenous malformation in the anterior cranial fossa]. | 2005 Dec |
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Perfusion CT investigation of chronic internal carotid artery occlusion: comparison with SPECT. | 2005 Dec |
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Incidentally detected parafalcine chondrosarcoma. | 2005 Jul |
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Effects of tissue heterogeneity on cerebral vascular response to acetazolamide stress measured by an I-123-IMP autoradiographic method with single-photon emission computed tomography. | 2005 Jun |
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[Amnesia following left medial frontal subcortical hemorrhage: a case report]. | 2005 Mar |
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Increased accumulations of N-isopropyl-p-[123I]-iodoamphetamine related to tumefactive multiple sclerosis. | 2005 Oct |
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N-isopropyl-p- 123I iodoamphetamine single photon emission computed tomography study of Parkinson's disease with dementia. | 2005 Oct |
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Three-dimensional stereotactic surface projection study of freezing of gait and brain perfusion image in Parkinson's disease. | 2005 Oct |
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[SPECT for diagnosis of brain tumors]. | 2005 Sep |
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[Single photon emission computed tomography findings in a case of alternating hemiplegia of childhood in relation to migraine]. | 2005 Sep |
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Diastolic blood pressure influences cerebrovascular reactivity measured by means of 123I-iodoamphetamine brain single photon emission computed tomography in medically treated patients with occlusive carotid or middle cerebral artery disease. | 2006 Apr |
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Brain and whole body distribution of N-isopropyl-4-iodoamphetamine (I-123) in humans: comparison of radiopharmaceuticals marketed by different companies in Japan. | 2006 Aug |
|
[Diagnostic value of perfusion-weighted MRI for evaluating postoperative alteration of cerebral hemodynamics following STA-MCA anastomosis in patients with moyamoya disease]. | 2006 Aug |
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Quantification of the regional cerebral blood flow and vascular reserve in moyamoya disease using split-dose iodoamphetamine I 123 single-photon emission computed tomography. | 2006 Aug |
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Hypoperfusion of the visual pathway in parkinsonian patients with visual hallucinations. | 2006 Dec |
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Hypoperfusion of the auditory and prefrontal cortices in Parkinsonian patients with verbal hallucinations. | 2006 Dec |
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Database of normal human cerebral blood flow measured by SPECT: II. Quantification of I-123-IMP studies with ARG method and effects of partial volume correction. | 2006 Feb |
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Database of normal human cerebral blood flow measured by SPECT: I. Comparison between I-123-IMP, Tc-99m-HMPAO, and Tc-99m-ECD as referred with O-15 labeled water PET and voxel-based morphometry. | 2006 Feb |
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Comparative study of cerebral blood flow in patients with normal-tension glaucoma and control subjects. | 2006 Feb |
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[Correlation of the cognitive function and the duration of the illness with the regional cerebral blood flow in the patients with Parkinson's disease: objective evaluation using stereotactic extraction estimation analysis in 123I-IMP SPECT]. | 2006 Jan |
|
Wisconsin Card Sorting Test and brain perfusion imaging in Parkinson's disease. | 2006 Jun |
|
Frontal assessment battery and brain perfusion image in Parkinson's disease. | 2006 Mar |
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Comparative value of brain perfusion SPECT and [(123)I]MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and Alzheimer's disease. | 2006 Mar |
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Diagnosis of atypical choroidal malignant melanoma using N-isopropyl-p-[123I]-iodoamphetamine single photon emission computed tomography. | 2006 Mar-Apr |
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Alteration of regional cerebral blood flow to thyrotropin-releasing hormone therapy in acute encephalitis and encephalopathy during childhood. | 2006 May |
|
Measurement of regional cerebral blood flow with 123I-IMP using one-point venous blood sampling and causality analysis: evaluation by comparison with conventional continuous arterial blood sampling. | 2006 Nov |
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Pre-surgical identification of epileptogenic areas in temporal lobe epilepsy by 123I-iomazenil SPECT: a comparison with IMP SPECT and FDG PET. | 2006 Nov |
|
[A case of ticlopidine-associated thrombotic thrombocytopenic purpura: special emphasis on diffusion weighted MRI]. | 2006 Oct |
|
Regional cerebral blood flow and developmental outcome in cryptogenic West syndrome. | 2007 Jan |
|
Symptomatic hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in a child with moyamoya disease. | 2007 Oct |
Patents
Sample Use Guides
The recommended intravenous dose for SPECTAMINE (lofetamine HCI I-123 Injection) in the average adult patient (70 kg) is 111 to 222 megabecquerels (3 to 6 millicuries).
Route of Administration:
Intravenous
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2537215
Cerebral tissue was taken from six-day-old Wistar rat pups. Twenty-four explants were cut from the occipital cortex of a single animal and grown in pairs on polyamide carrier grids distributed over 12 petri. The cultures were incubated with iofetamine (5 uCi) and the drug uptake was tested.
Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:09:54 GMT 2025
by
admin
on
Mon Mar 31 18:09:54 GMT 2025
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Record UNII |
C2A5X08042
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Record Status |
Validated (UNII)
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Record Version |
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-
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Preferred Name | English | ||
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Systematic Name | English |
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DTXSID3048443
Created by
admin on Mon Mar 31 18:09:54 GMT 2025 , Edited by admin on Mon Mar 31 18:09:54 GMT 2025
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C2A5X08042
Created by
admin on Mon Mar 31 18:09:54 GMT 2025 , Edited by admin on Mon Mar 31 18:09:54 GMT 2025
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82691-33-6
Created by
admin on Mon Mar 31 18:09:54 GMT 2025 , Edited by admin on Mon Mar 31 18:09:54 GMT 2025
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Iofetamine
Created by
admin on Mon Mar 31 18:09:54 GMT 2025 , Edited by admin on Mon Mar 31 18:09:54 GMT 2025
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3729
Created by
admin on Mon Mar 31 18:09:54 GMT 2025 , Edited by admin on Mon Mar 31 18:09:54 GMT 2025
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