IOFETAMINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C12H18IN
Molecular Weight	303.1825
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)NC(C)CC1=CC=C(I)C=C1

InChI

InChIKey=ISEHJSHTIVKELA-UHFFFAOYSA-N

InChI=1S/C12H18IN/c1-9(2)14-10(3)8-11-4-6-12(13)7-5-11/h4-7,9-10,14H,8H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C12H18IN
Molecular Weight	303.1825
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://jnm.snmjournals.org/content/29/7/local/advertising.pdf

Iofetamine is a diagnostic compound that was used for brain-imaging. Iofetamine may cause different adverse reactions such as increase in systolic blood pressure by about 10 mm Hg, dizziness, hearing loss and allergy.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Brain disease 7 Sources: http://jnm.snmjournals.org/content/29/7/local/advertising.pdf	Diagnostic		Approved 8583	SPECTAMINE Approved Use lofetamine is recommended for use as a lipid-soluble brain-imaging agent. Launch Date 1987

PubMed

Title	Date	PubMed
[Development of quantification analysis software for measuring regional cerebral blood flow by the modified split-dose method with (123)I-IMP before and after acetazolamide loading].	2003 Dec	15001874
[Normalization of cerebral hemodynamics and metabolism after carotid stenting in patients unfit for major surgery].	2003 Dec	14719446
Cerebral hemodynamics and metabolism in adult moyamoya disease: comparison of angiographic collateral circulation.	2004 Apr	15195758
Clinical efficacy of 123I-IMP SPECT for the diagnosis of malignant uveal melanoma.	2004 Apr	15108037
A case of intravascular lymphoma with increased regional cerebral blood flow in I-123 IMP single-photon emission CT.	2004 Apr	15090342
Availability of N-isopropyl-p-[125I]iodoamphetamine (IMP) as a practical cerebral blood flow (CBF) indicator in rats.	2004 Aug	15246373
Chronic subdural hematoma following dural metastasis of gastric cancer: measurement of pre- and postoperative cerebral blood flow with N-isopropyl-p-[123I]iodoamphetamine--case report.	2004 Dec	15684596
Crossed cerebellar diaschisis in patients with cortical infarction: logistic regression analysis to control for confounding effects.	2004 Feb	14739422
[Changes in visual event-related potentials and SPECT in dissociative amnesia].	2004 Jan	15199732
Therapeutic effect and [123I]IMP SPECT findings of sodium dichloroacetate in a patient with MELAS.	2004 Jan 27	14745089
The clinical role of N-isopropyl-p-[123I]-iodoamphetamine single photon emission computed tomography in the follow-up of choroidal melanoma after radiotherapy.	2004 Jan-Feb	14767652
Comparison of FDG-PET and IMP-SPECT in patients with dementia with Lewy bodies.	2004 Jul	15462408
Assessment of cerebral hemodynamics in childhood moyamoya disease using a quantitative and a semiquantitative IMP-SPECT study.	2004 Jun	15359926
[Diagnosis of dementia and neurodegenerative disorders by brain SPECT of three dimensional stereotactic surface projection method].	2004 Mar	15101187
Error analysis of measured cerebral vascular response to acetazolamide stress by I-123-IMP autoradiographic method with single photon emission computed tomography: errors due to distribution volume of I-123-IMP.	2004 May	15233283
A simple method for the detection of abnormal brain regions in Alzheimer's disease patients using [11C]MP4A: comparison with [123I]IMP SPECT.	2004 May	15233279
Losartan, an angiotensin II (AT1) receptor antagonist, preserves cerebral blood flow in hypertensive patients with a history of stroke.	2004 Oct	15129230
Cerebral blood flow in Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease according to three-dimensional stereotactic surface projection imaging.	2005	15775716
Diagnosis of Alzheimer's disease using brain perfusion SPECT and MR imaging: which modality achieves better diagnostic accuracy?	2005 Apr	15821961
Brain 3D-SSP SPECT analysis in dementia with Lewy bodies, Parkinson's disease with and without dementia, and Alzheimer's disease.	2005 Aug	16023534
[Two surgically treated cases with dural arteriovenous malformation in the anterior cranial fossa].	2005 Dec	16359034
Perfusion CT investigation of chronic internal carotid artery occlusion: comparison with SPECT.	2005 Dec	16098657
Incidentally detected parafalcine chondrosarcoma.	2005 Jul	15864410
Effects of tissue heterogeneity on cerebral vascular response to acetazolamide stress measured by an I-123-IMP autoradiographic method with single-photon emission computed tomography.	2005 Jun	16097633
[Amnesia following left medial frontal subcortical hemorrhage: a case report].	2005 Mar	15912758
Increased accumulations of N-isopropyl-p-[123I]-iodoamphetamine related to tumefactive multiple sclerosis.	2005 Oct	16363626
N-isopropyl-p- 123I iodoamphetamine single photon emission computed tomography study of Parkinson's disease with dementia.	2005 Oct	16293914
Three-dimensional stereotactic surface projection study of freezing of gait and brain perfusion image in Parkinson's disease.	2005 Oct	16007622
[SPECT for diagnosis of brain tumors].	2005 Sep	16201529
[Single photon emission computed tomography findings in a case of alternating hemiplegia of childhood in relation to migraine].	2005 Sep	16164248
Diastolic blood pressure influences cerebrovascular reactivity measured by means of 123I-iodoamphetamine brain single photon emission computed tomography in medically treated patients with occlusive carotid or middle cerebral artery disease.	2006 Apr	16715952
Brain and whole body distribution of N-isopropyl-4-iodoamphetamine (I-123) in humans: comparison of radiopharmaceuticals marketed by different companies in Japan.	2006 Aug	17037282
[Diagnostic value of perfusion-weighted MRI for evaluating postoperative alteration of cerebral hemodynamics following STA-MCA anastomosis in patients with moyamoya disease].	2006 Aug	16910493
Quantification of the regional cerebral blood flow and vascular reserve in moyamoya disease using split-dose iodoamphetamine I 123 single-photon emission computed tomography.	2006 Aug	16876609
Hypoperfusion of the visual pathway in parkinsonian patients with visual hallucinations.	2006 Dec	17029272
Hypoperfusion of the auditory and prefrontal cortices in Parkinsonian patients with verbal hallucinations.	2006 Dec	17029260
Database of normal human cerebral blood flow measured by SPECT: II. Quantification of I-123-IMP studies with ARG method and effects of partial volume correction.	2006 Feb	16615423
Database of normal human cerebral blood flow measured by SPECT: I. Comparison between I-123-IMP, Tc-99m-HMPAO, and Tc-99m-ECD as referred with O-15 labeled water PET and voxel-based morphometry.	2006 Feb	16615422
Comparative study of cerebral blood flow in patients with normal-tension glaucoma and control subjects.	2006 Feb	16458708
[Correlation of the cognitive function and the duration of the illness with the regional cerebral blood flow in the patients with Parkinson's disease: objective evaluation using stereotactic extraction estimation analysis in 123I-IMP SPECT].	2006 Jan	16482919
Wisconsin Card Sorting Test and brain perfusion imaging in Parkinson's disease.	2006 Jun	16551505
Frontal assessment battery and brain perfusion image in Parkinson's disease.	2006 Mar	16449760
Comparative value of brain perfusion SPECT and [(123)I]MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and Alzheimer's disease.	2006 Mar	16328506
Diagnosis of atypical choroidal malignant melanoma using N-isopropyl-p-[123I]-iodoamphetamine single photon emission computed tomography.	2006 Mar-Apr	16604400
Alteration of regional cerebral blood flow to thyrotropin-releasing hormone therapy in acute encephalitis and encephalopathy during childhood.	2006 May	16757195
Measurement of regional cerebral blood flow with 123I-IMP using one-point venous blood sampling and causality analysis: evaluation by comparison with conventional continuous arterial blood sampling.	2006 Nov	17294669
Pre-surgical identification of epileptogenic areas in temporal lobe epilepsy by 123I-iomazenil SPECT: a comparison with IMP SPECT and FDG PET.	2006 Nov	17021430
[A case of ticlopidine-associated thrombotic thrombocytopenic purpura: special emphasis on diffusion weighted MRI].	2006 Oct	17323777
Regional cerebral blood flow and developmental outcome in cryptogenic West syndrome.	2007 Jan	17241217
Symptomatic hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in a child with moyamoya disease.	2007 Oct	17486352

Patents

Sample Use Guides

In Vivo Use Guide

The recommended intravenous dose for SPECTAMINE (lofetamine HCI I-123 Injection) in the average adult patient (70 kg) is 111 to 222 megabecquerels (3 to 6 millicuries).

Route of Administration: Intravenous

In Vitro Use Guide

Cerebral tissue was taken from six-day-old Wistar rat pups. Twenty-four explants were cut from the occipital cortex of a single animal and grown in pairs on polyamide carrier grids distributed over 12 petri. The cultures were incubated with iofetamine (5 uCi) and the drug uptake was tested.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:09:54 GMT 2025` Edited by `admin` on `Mon Mar 31 18:09:54 GMT 2025`
Record UNII	C2A5X08042
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IOFETAMINE

Common Name

English

(±)-N-ISOPROPYL-4-IODOAMPHETAMINE

Preferred Name

English

BENZENEETHANAMINE, 4-IODO-.ALPHA.-METHYL-N-(1-METHYLETHYL)-, (±)-

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID3048443