U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C15H21NO2
Molecular Weight 247.3327
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEPERIDINE

SMILES

CCOC(=O)C1(CCN(C)CC1)C2=CC=CC=C2

InChI

InChIKey=XADCESSVHJOZHK-UHFFFAOYSA-N
InChI=1S/C15H21NO2/c1-3-18-14(17)15(9-11-16(2)12-10-15)13-7-5-4-6-8-13/h4-8H,3,9-12H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C15H21NO2
Molecular Weight 247.3327
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: http://www.pbm.va.gov/clinicalguidance/criteriaforuse/MeperidineCriteriaforUse.pdf | https://www.drugs.com/pro/meperidine.html

Pethidine, also known as meperidine and Demerol, a narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Meperidine is an opioid agonist with multiple actions qualitatively similar to those of morphine. Most common adverse reactions were lightheadedness, dizziness, sedation, nausea, vomiting, and sweating. Pethidine has serious interactions that can be dangerous with monoamine oxidase inhibitors (e.g., furazolidone, isocarboxazid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine). Pethidine can interact with muscle relaxants, some antidepressants, benzodiazepines, and ethanol.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
450.1 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DEMEROL

Approved Use

For the relief of moderate to severe pain. For preoperative medication. For support of anesthesia. For obstetrical analgesia.

Launch Date

1942
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
196 ng/mL
30 mg single, intravenous
dose: 30 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
MEPERIDINE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
19.6 μg × min/mL
30 mg single, intravenous
dose: 30 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
MEPERIDINE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
124 min
30 mg single, intravenous
dose: 30 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
MEPERIDINE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
10 g single, oral
Overdose
Dose: 10 g
Route: oral
Route: single
Dose: 10 g
Sources:
unknown, 17 years
Health Status: unknown
Age Group: 17 years
Sex: F
Sources:
Other AEs: Myoclonus, Hyperreflexia...
Other AEs:
Myoclonus (1 patient)
Hyperreflexia (1 patient)
Respiratory depression (1 patient)
Hypotension (1 patient)
Tremor (1 patient)
Sources:
50 mg single, intrathecal
Dose: 50 mg
Route: intrathecal
Route: single
Dose: 50 mg
Sources:
unknown, 24 - 81 years
Health Status: unknown
Age Group: 24 - 81 years
Sex: F
Sources:
Other AEs: Respiratory depression...
Other AEs:
Respiratory depression (2 patients)
Sources:
1000 mg 1 times / day multiple, intramuscular
Highest studied dose
Dose: 1000 mg, 1 times / day
Route: intramuscular
Route: multiple
Dose: 1000 mg, 1 times / day
Sources:
unhealthy, 37 years
n = 1
Health Status: unhealthy
Condition: pain
Age Group: 37 years
Sex: M
Population Size: 1
Sources:
Disc. AE: Muscle twitching, Tremor...
AEs leading to
discontinuation/dose reduction:
Muscle twitching (1 patient)
Tremor (1 patient)
Sources:
600 mg 1 times / day multiple, intravenous
Highest studied dose
Dose: 600 mg, 1 times / day
Route: intravenous
Route: multiple
Dose: 600 mg, 1 times / day
Sources:
unknown, 44 years
n = 7
Health Status: unknown
Age Group: 44 years
Sex: M+F
Population Size: 7
Sources:
Other AEs: Jitteriness, Hallucinations...
Other AEs:
Jitteriness (3 patients)
Hallucinations (3 patients)
Seizures (3 patients)
Sources:
50 mg 6 times / day multiple, intramuscular
Recommended
Dose: 50 mg, 6 times / day
Route: intramuscular
Route: multiple
Dose: 50 mg, 6 times / day
Sources:
pregnant, adult
Health Status: pregnant
Age Group: adult
Sex: F
Sources:
Other AEs: Withdrawal syndrome neonatal...
50 mg 6 times / day multiple, oral
Recommended
Dose: 50 mg, 6 times / day
Route: oral
Route: multiple
Dose: 50 mg, 6 times / day
Sources:
pregnant, adult
Health Status: pregnant
Condition: pain
Age Group: adult
Sex: F
Sources:
Other AEs: Withdrawal syndrome neonatal...
50 mg 6 times / day multiple, subcutaneous
Recommended
Dose: 50 mg, 6 times / day
Route: subcutaneous
Route: multiple
Dose: 50 mg, 6 times / day
Sources:
pregnant, adult
Health Status: pregnant
Age Group: adult
Sex: F
Sources:
Other AEs: Withdrawal syndrome neonatal...
50 mg 6 times / day multiple, intramuscular
Recommended
Dose: 50 mg, 6 times / day
Route: intramuscular
Route: multiple
Dose: 50 mg, 6 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Condition: pain
Age Group: adult
Sources:
Other AEs: Addiction, Respiratory depression...
Other AEs:
Addiction
Respiratory depression (serious|grade 5)
Sources:
50 mg 6 times / day multiple, oral
Recommended
Dose: 50 mg, 6 times / day
Route: oral
Route: multiple
Dose: 50 mg, 6 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Condition: pain
Age Group: adult
Sources:
Other AEs: Addiction, Respiratory depression...
Other AEs:
Addiction
Respiratory depression (serious|grade 5)
Sources:
50 mg 6 times / day multiple, subcutaneous
Recommended
Dose: 50 mg, 6 times / day
Route: subcutaneous
Route: multiple
Dose: 50 mg, 6 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Condition: pain
Age Group: adult
Sources:
Other AEs: Addiction, Respiratory depression...
Other AEs:
Addiction
Respiratory depression (serious|grade 5)
Sources:
10 mg/mL multiple, intravenous
Recommended
Dose: 10 mg/mL
Route: intravenous
Route: multiple
Dose: 10 mg/mL
Sources:
pregnant, adult
Health Status: pregnant
Age Group: adult
Sex: F
Sources:
Other AEs: Withdrawal syndrome neonatal...
10 mg/mL multiple, intravenous
Recommended
Dose: 10 mg/mL
Route: intravenous
Route: multiple
Dose: 10 mg/mL
Sources:
unhealthy, adult
Other AEs: Addiction, Respiratory depression...
Other AEs:
Addiction
Respiratory depression (serious|grade 5)
Sources:
AEs

AEs

AESignificanceDosePopulation
Hyperreflexia 1 patient
10 g single, oral
Overdose
Dose: 10 g
Route: oral
Route: single
Dose: 10 g
Sources:
unknown, 17 years
Health Status: unknown
Age Group: 17 years
Sex: F
Sources:
Hypotension 1 patient
10 g single, oral
Overdose
Dose: 10 g
Route: oral
Route: single
Dose: 10 g
Sources:
unknown, 17 years
Health Status: unknown
Age Group: 17 years
Sex: F
Sources:
Myoclonus 1 patient
10 g single, oral
Overdose
Dose: 10 g
Route: oral
Route: single
Dose: 10 g
Sources:
unknown, 17 years
Health Status: unknown
Age Group: 17 years
Sex: F
Sources:
Respiratory depression 1 patient
10 g single, oral
Overdose
Dose: 10 g
Route: oral
Route: single
Dose: 10 g
Sources:
unknown, 17 years
Health Status: unknown
Age Group: 17 years
Sex: F
Sources:
Tremor 1 patient
10 g single, oral
Overdose
Dose: 10 g
Route: oral
Route: single
Dose: 10 g
Sources:
unknown, 17 years
Health Status: unknown
Age Group: 17 years
Sex: F
Sources:
Respiratory depression 2 patients
50 mg single, intrathecal
Dose: 50 mg
Route: intrathecal
Route: single
Dose: 50 mg
Sources:
unknown, 24 - 81 years
Health Status: unknown
Age Group: 24 - 81 years
Sex: F
Sources:
Muscle twitching 1 patient
Disc. AE
1000 mg 1 times / day multiple, intramuscular
Highest studied dose
Dose: 1000 mg, 1 times / day
Route: intramuscular
Route: multiple
Dose: 1000 mg, 1 times / day
Sources:
unhealthy, 37 years
n = 1
Health Status: unhealthy
Condition: pain
Age Group: 37 years
Sex: M
Population Size: 1
Sources:
Tremor 1 patient
Disc. AE
1000 mg 1 times / day multiple, intramuscular
Highest studied dose
Dose: 1000 mg, 1 times / day
Route: intramuscular
Route: multiple
Dose: 1000 mg, 1 times / day
Sources:
unhealthy, 37 years
n = 1
Health Status: unhealthy
Condition: pain
Age Group: 37 years
Sex: M
Population Size: 1
Sources:
Hallucinations 3 patients
600 mg 1 times / day multiple, intravenous
Highest studied dose
Dose: 600 mg, 1 times / day
Route: intravenous
Route: multiple
Dose: 600 mg, 1 times / day
Sources:
unknown, 44 years
n = 7
Health Status: unknown
Age Group: 44 years
Sex: M+F
Population Size: 7
Sources:
Jitteriness 3 patients
600 mg 1 times / day multiple, intravenous
Highest studied dose
Dose: 600 mg, 1 times / day
Route: intravenous
Route: multiple
Dose: 600 mg, 1 times / day
Sources:
unknown, 44 years
n = 7
Health Status: unknown
Age Group: 44 years
Sex: M+F
Population Size: 7
Sources:
Seizures 3 patients
600 mg 1 times / day multiple, intravenous
Highest studied dose
Dose: 600 mg, 1 times / day
Route: intravenous
Route: multiple
Dose: 600 mg, 1 times / day
Sources:
unknown, 44 years
n = 7
Health Status: unknown
Age Group: 44 years
Sex: M+F
Population Size: 7
Sources:
Withdrawal syndrome neonatal
50 mg 6 times / day multiple, intramuscular
Recommended
Dose: 50 mg, 6 times / day
Route: intramuscular
Route: multiple
Dose: 50 mg, 6 times / day
Sources:
pregnant, adult
Health Status: pregnant
Age Group: adult
Sex: F
Sources:
Withdrawal syndrome neonatal
50 mg 6 times / day multiple, oral
Recommended
Dose: 50 mg, 6 times / day
Route: oral
Route: multiple
Dose: 50 mg, 6 times / day
Sources:
pregnant, adult
Health Status: pregnant
Condition: pain
Age Group: adult
Sex: F
Sources:
Withdrawal syndrome neonatal
50 mg 6 times / day multiple, subcutaneous
Recommended
Dose: 50 mg, 6 times / day
Route: subcutaneous
Route: multiple
Dose: 50 mg, 6 times / day
Sources:
pregnant, adult
Health Status: pregnant
Age Group: adult
Sex: F
Sources:
Addiction
50 mg 6 times / day multiple, intramuscular
Recommended
Dose: 50 mg, 6 times / day
Route: intramuscular
Route: multiple
Dose: 50 mg, 6 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Condition: pain
Age Group: adult
Sources:
Respiratory depression serious|grade 5
50 mg 6 times / day multiple, intramuscular
Recommended
Dose: 50 mg, 6 times / day
Route: intramuscular
Route: multiple
Dose: 50 mg, 6 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Condition: pain
Age Group: adult
Sources:
Addiction
50 mg 6 times / day multiple, oral
Recommended
Dose: 50 mg, 6 times / day
Route: oral
Route: multiple
Dose: 50 mg, 6 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Condition: pain
Age Group: adult
Sources:
Respiratory depression serious|grade 5
50 mg 6 times / day multiple, oral
Recommended
Dose: 50 mg, 6 times / day
Route: oral
Route: multiple
Dose: 50 mg, 6 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Condition: pain
Age Group: adult
Sources:
Addiction
50 mg 6 times / day multiple, subcutaneous
Recommended
Dose: 50 mg, 6 times / day
Route: subcutaneous
Route: multiple
Dose: 50 mg, 6 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Condition: pain
Age Group: adult
Sources:
Respiratory depression serious|grade 5
50 mg 6 times / day multiple, subcutaneous
Recommended
Dose: 50 mg, 6 times / day
Route: subcutaneous
Route: multiple
Dose: 50 mg, 6 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Condition: pain
Age Group: adult
Sources:
Withdrawal syndrome neonatal
10 mg/mL multiple, intravenous
Recommended
Dose: 10 mg/mL
Route: intravenous
Route: multiple
Dose: 10 mg/mL
Sources:
pregnant, adult
Health Status: pregnant
Age Group: adult
Sex: F
Sources:
Addiction
10 mg/mL multiple, intravenous
Recommended
Dose: 10 mg/mL
Route: intravenous
Route: multiple
Dose: 10 mg/mL
Sources:
unhealthy, adult
Respiratory depression serious|grade 5
10 mg/mL multiple, intravenous
Recommended
Dose: 10 mg/mL
Route: intravenous
Route: multiple
Dose: 10 mg/mL
Sources:
unhealthy, adult
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG


OverviewOther

Other InhibitorOther SubstrateOther Inducer


Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
yes
yes
likely (co-administration study)
Comment: The concomitant use of DEMEROL Injection and CYP3A4 or CYP2B6 inhibitors can increase the plasma concentration of meperidine, resulting in increased or prolonged opioid effects; The concomitant use of DEMEROL Injection and CYP3A4 inducers, or CYP2B6 inducers can decrease the plasma concentration of meperidine
Page: 20.0
yes
likely (co-administration study)
Comment: The concomitant use of DEMEROL Injection and CYP3A4 or CYP2B6 inhibitors can increase the plasma concentration of meperidine, resulting in increased or prolonged opioid effects; The concomitant use of DEMEROL Injection and CYP3A4 inducers, or CYP2B6 inducers can decrease the plasma concentration of meperidine
Page: 20.0
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1.
1999 Jul
Norpethidine accumulation and generalized seizure during pethidine patient-controlled analgesia.
1999 Jun
[Meperidine (pethidine) outdated as analgesic in acute pancreatitis].
2000 Apr 1
Successful treatment of normeperidine neurotoxicity by hemodialysis.
2000 Jan
Urticaria induced by meperidine allergy.
2000 Mar
[Condition of patients after surgical wisdom tooth extraction under general anesthesia with different premedication variants--a prospective study based on a post-anesthesia questionnaire].
2001
Single-dose dipyrone for acute postoperative pain.
2001
Tramadol for postoperative shivering: a double-blind comparison with pethidine.
2001 Apr
Co-administration of drugs and blood products.
2001 Apr
Analgesic effects in dogs of carprofen and pethidine together compared with the effects of either drug alone.
2001 Apr 7
Intrathecal pethidine as sole anaesthetic agent for operative procedures of the lower limb, inguinal area and perineum.
2001 Dec
Morphine, pethidine and buprenorphine disposition in the cat.
2001 Dec
Determination of pethidine in rabbit plasma by capillary gas chromatography.
2001 Dec
A randomized comparison of low-dose ketamine and lignocaine infiltration with ketamine-diazepam anaesthesia for post partum tubal ligation in Vanuatu.
2001 Feb
Renal colic and recurrent urinary calculi. Management and prevention.
2001 Jan
Meperidine--a liability.
2001 Jan
Tris(2,2'-bipyridine)ruthenium(II) electrogenerated chemiluminescence of alkaloid type drugs with solid phase extraction sample preparation.
2001 Jan
Serotonin syndrome: potential consequences of Meridia combined with Demerol or fentanyl.
2001 Jan
Preoperative rectal diclofenac versus paracetamol for tonsillectomy: effects on pain and blood loss.
2001 Jan
Randomized trial of needlescopic versus laparoscopic cholecystectomy.
2001 Jan
Remifentanil versus meperidine for monitored anesthesia care: a comparison study in older patients undergoing ambulatory colonoscopy.
2001 Jan
Opiate-sensitivity: clinical characteristics and the role of skin prick testing.
2001 Jul
Use of a new finger-mounted device to compare mechanical nociceptive thresholds in cats given pethidine or no medication after castration.
2001 Jun
Efficacy and safety of repeated postoperative administration of intramuscular diclofenac sodium in the treatment of post-cesarean section pain: a double-blind study.
2001 Mar-Apr
Prospective, randomized trial comparing diathermy and Harmonic Scalpel hemorrhoidectomy.
2001 May
Ipsilateral dislocation of the shoulder and elbow.
2001 Nov
Patient-controlled pethidine after major upper abdominal surgery: comparison of the epidural and intravenous routes.
2001 Nov
Iatrogenic cardiopulmonary arrest during pediatric sedation with meperidine, promethazine, and chlorpromazine.
2001 Oct
A novel approach to the prevention of postoperative delirium in the elderly after gastrointestinal surgery.
2002
A placebo-controlled, randomized trial of droperidol versus metoclopramide for outpatients undergoing gynecological laparoscopy under conscious sedation.
2002 Apr
Laparoscopic hysterectomy versus abdominal hysterectomy: a controlled study of clinical and functional outcomes.
2002 Aug
Upper gastrointestinal endoscopic ultrasound and its impact on patient management: 1990-2000.
2002 Aug
Vitamin K and childhood cancer: analysis of individual patient data from six case-control studies.
2002 Jan 7
Severe hypokalaemia secondary to dicloxacillin.
2002 Jul
A thermal threshold testing device for evaluation of analgesics in cats.
2002 Jun
Intra-arterial injection of metoclopramide, midazolam, propofol and pethidine.
2002 Jun
Double-blind, randomized trial comparing Harmonic Scalpel hemorrhoidectomy, bipolar scissors hemorrhoidectomy, and scissors excision: ligation technique.
2002 Jun
Anxiolytic premedication reduces preoperative anxiety and pain during oocyte retrieval. A randomized double-blinded placebo-controlled trial.
2002 May
The low normothermia concept--maintaining a core body temperature between 36 and 37 degrees C in acute stroke unit patients.
2002 Oct
Characterisation of silent and active genes for a variable large protein of Borrelia recurrentis.
2002 Oct 14
Two in one: patient-controlled epidural analgesia (PCEA) to prevent erection and control pain in adult hypospadias-surgery patients.
2002 Sep
Comparison of colonoscopies performed under sedation with propofol or with midazolam or without sedation.
2003
Patents

Sample Use Guides

Oral: 50 to 100 mg every 4 hours as needed. IV,IM,subcutaneously: 25 to 100 mg every 4 hours as needed. Continuous IV: 15 to 35 mg/hr.
Route of Administration: Other
In Vitro Use Guide
Pethidine's stimulant action on the 22-day pregnant rat isolated uterus does not involve receptors sensitive to methysergide and is unlikely to involve the synthesis and release of endogenous prostaglandins. Maximal stimulant response occurred with 40 ug/ml.
Substance Class Chemical
Created
by admin
on Sat Dec 16 18:05:36 GMT 2023
Edited
by admin
on Sat Dec 16 18:05:36 GMT 2023
Record UNII
9E338QE28F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MEPERIDINE
HSDB   MI   VANDF  
Common Name English
PETHIDINE
INN   WHO-DD  
INN  
Official Name English
IDS-NP-001
Code English
MEPERIDINE [MI]
Common Name English
RENAUDIN
Common Name English
PETHANOL
Common Name English
4-PIPERIDINECARBOXYLIC ACID, 1-METHYL-4-PHENYL-, ETHYL ESTER
Common Name English
ETHYL 1-METHYL-4-PHENYLISONIPECOTATE
Systematic Name English
ISONIPECAINE
Common Name English
PETHIDINETER
Common Name English
ISONIPECOTIC ACID, 1-METHYL-4-PHENYL-, ETHYL ESTER
Systematic Name English
1-METHYL-4-PHENYLPIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER
Systematic Name English
MEPERIDINE [HSDB]
Common Name English
MEPERIDINE [VANDF]
Common Name English
MEPERIDOL
Common Name English
PETHIDINE DBL
Brand Name English
ETHYL 1-METHYL-4-PHENYLPIPERIDINE-4-CARBOXYLATE
Systematic Name English
Pethidine [WHO-DD]
Common Name English
pethidine [INN]
Common Name English
Classification Tree Code System Code
WHO-VATC QN02AG03
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
NCI_THESAURUS C67413
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
WHO-ATC N02AB72
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
LIVERTOX NBK548764
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
NDF-RT N0000175690
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
DEA NO. 9230
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
WHO-ATC N02AB52
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
NDF-RT N0000175684
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
WHO-VATC QN02AB72
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
WHO-VATC QN02AB02
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
WHO-ATC N02AB02
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
WHO-VATC QN02AB52
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
WHO-ATC N02AG03
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID9023253
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
RXCUI
6754
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY RxNorm
CAS
57-42-1
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
SMS_ID
100000082223
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
IUPHAR
7221
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
INN
411
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-329-1
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
WIKIPEDIA
PETHIDINE
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
DRUG BANK
DB00454
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
LACTMED
Meperidine
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
PUBCHEM
4058
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
ChEMBL
CHEMBL607
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
MESH
D008614
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
NCI_THESAURUS
C71632
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
DAILYMED
9E338QE28F
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
FDA UNII
9E338QE28F
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
HSDB
3116
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
EVMPD
SUB09738MIG
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
MERCK INDEX
m7186
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY Merck Index
DRUG CENTRAL
1690
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
CHEBI
6754
Created by admin on Sat Dec 16 18:05:37 GMT 2023 , Edited by admin on Sat Dec 16 18:05:37 GMT 2023
PRIMARY
Related Record Type Details
METABOLIC ENZYME -> SUBSTRATE
MAJOR
SALT/SOLVATE -> PARENT
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
METABOLIC ENZYME -> SUBSTRATE
MINOR
BINDER->LIGAND
METABOLIC ENZYME -> SUBSTRATE
MAJOR
DERIVATIVE -> PARENT
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC Elimination
PHARMACOKINETIC
Elimination
PHARMACOKINETIC