U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Showing 1 - 10 of 66 results

Status:
US Approved Rx (1997)
First approved in 1978

Class (Stereo):
CHEMICAL (ABSOLUTE)



Timolol is the non-selective Beta antagonist used as eye drops to treat increased pressure inside the eye such as in ocular hypertension and glaucoma. Timolol is also used for high blood pressure, chest pain due to insufficient blood flow to the hear...
Status:
US Approved Rx (2023)
First approved in 1972

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Hydromorphone (also known as dihydromorphinone and the brand name Dilaudid among others) is a more potent opioid analgesic than morphine and is used for moderate to severe pain. It can be administered by injection, by infusion, by mouth, and rectally...
Status:
US Approved Rx (1997)
First approved in 1967

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Pentazocine is a synthetically prepared prototypical mixed agonist-antagonist narcotic (opioid analgesic) drug of the benzomorphan class of opioids used to treat moderate to moderately severe pain. Pentazocine is sold under several brand names, such ...
Status:
US Approved Rx (2008)
First approved in 1964

Class (Stereo):
CHEMICAL (ACHIRAL)



Valproic acid (VPA; valproate; di-n-propylacetic acid, DPA; 2-propylpentanoic acid, or 2-propylvaleric acid) was first synthesized in 1882, by Burton. FDA approved valproic acid for the treatment of manic episodes associated with bipolar disorder, fo...
Status:
US Approved Rx (2018)
First approved in 1959

Class (Stereo):
CHEMICAL (ABSOLUTE)



Oxymorphone is an analgesic that is FDA approved for the treatment of moderate to severe pain. It is also indicated for relief of anxiety in patients with dyspnea associated with pulmonary edema secondary to acute left ventricular dysfunction. Oxymor...
Status:
US Approved Rx (1999)
First approved in 1942

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Pethidine, also known as meperidine and Demerol, a narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Meperidine is an opioid agonist with multiple actions ...
Status:
US Approved Rx (2023)
First marketed in 1921

Class (Stereo):
CHEMICAL (ACHIRAL)



Since its discovery as component of the tea leaf by Albert Kossel in 1888, the history of theophylline (CAS 58-55-9) has been a long and successful one. At the turn of the century, theophylline became less expensive due to chemical synthesis and was ...
Status:
US Approved Rx (2004)
First marketed in 1880

Class (Stereo):
CHEMICAL (ABSOLUTE)



Apomorphine (brand names: Apokyn, Ixense, Spontane, Uprima) is indicated for the acute, intermittent treatment of hypomobility, “off” episodes (“end-of-dose wearing off” and unpredictable “on/off” episodes) in patients with advanced Parkinson’s disea...
Status:
US Previously Marketed
First approved in 1957

Class (Stereo):
CHEMICAL (RACEMIC)



Propoxyphene is a centrally acting opiate analgesic. Propoxyphene is an odorless, freely soluble in water, white crystalline powder with a bitter taste. In vitro studies demonstrated propoxyphene and the metabolite norpropoxyphene inhibit sodium chan...
Status:
US Previously Marketed
First approved in 1956

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Dihydrocodeine is an opioid analgesic used as an alternative or adjunct to codeine to treat moderate to severe pain, severe dyspnea, and cough. It is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more e...