U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C12H21NO8S
Molecular Weight 339.3636
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TOPIRAMATE

SMILES

CC1(C)O[C@]2([H])CO[C@]3(COS(=O)(=O)N)[C@]([H])([C@]2([H])O1)OC(C)(C)O3

InChI

InChIKey=KJADKKWYZYXHBB-XBWDGYHZSA-N
InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1

HIDE SMILES / InChI

Molecular Formula C12H21NO8S
Molecular Weight 339.3636
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment:: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020505s055,020844s046lbl.pdf

Topiramate is an anticonvulsant indicated in the treatment of epilepsy and migraine. Topiramate enhances GABA-activated chloride channels. In addition, topiramate inhibits excitatory neurotransmission, through actions on kainate and AMPA receptors. There is evidence that topiramate has a specific effect on GluR5 kainate receptors. It is also an inhibitor of carbonic anhydrase, particular subtypes II and IV, but this action is weak and unlikely to be related to its anticonvulsant actions, but may account for the bad taste and the development of renal stones seen during treatment. Its possible effect as a mood stabilizer seems to occur before anticonvulsant qualities at lower dosages. Topiramate inhibits maximal electroshock and pentylenetetrazol-induced seizures as well as partial and secundarily generalized tonic-clonic seizures in the kindling model, findings predective of a broad spectrum of antiseizure activities clinically. The precise mechanism of action of topiramate is not known. However, studies have shown that topiramate blocks the action potentials elicited repetitively by a sustained depolarization of the neurons in a time-dependent manner, suggesting a state-dependent sodium channel blocking action. Topiramate also augments the activity of the neurotransmitter gamma-aminobutyrate (GABA) at some subtypes of the GABAAreceptor (controls an integral chloride channel), indicating a possible mechanism through potentiation of the activity of GABA. Topiramate also demonstrates antagonism of the AMPA/kainate subtype of the glutamate excitatory amino acid receptor. It also inhibits carbonic anhydrase (particularly isozymes II and IV), but this action is weak and unlikely to be related to its anticonvulsant actions. Topiramate is used for the treatment and control of partial seizures and severe tonic-clonic (grand mal) seizures and also for the prevention of migraine headaches. In children it is also used for treatment of Lennox-Gastaut syndrome. Topiramate is sold under the brand name Topamax. A combination product containing phentermine and topiramate extended-release called QSYMIA® is indicated for the management of obesity.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
5 nM [Ki]
4.90000000000000036 µM [Ki]
0.900000000000000022 nM [Ki]
3.79999999999999982 nM [Ki]
63 nM [Ki]
30 nM [Ki]
47 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
TOPAMAX

Approved Use

TOPAMAX is indicated for: Monotherapy epilepsy: Initial monotherapy in patients > 2 years of age with partial onset or primary generalized tonic-clonic seizures Adjunctive therapy epilepsy: Adjunctive therapy for adults and pediatric patients (2 to 16 years of age) with partial onset seizures or primary generalized tonic-clonic seizures, and in patients >2 years of age with seizures associated with Lennox-Gastaut syndrome (LGS) Migraine: Treatment for adults and adolescents 12 years of age and older for prophylaxis of migraine headache

Launch Date

851299200000
Preventing
TOPAMAX

Approved Use

TOPAMAX is indicated for: Monotherapy epilepsy: Initial monotherapy in patients > 2 years of age with partial onset or primary generalized tonic-clonic seizures Adjunctive therapy epilepsy: Adjunctive therapy for adults and pediatric patients (2 to 16 years of age) with partial onset seizures or primary generalized tonic-clonic seizures, and in patients >2 years of age with seizures associated with Lennox-Gastaut syndrome (LGS) Migraine: Treatment for adults and adolescents 12 years of age and older for prophylaxis of migraine headache

Launch Date

851299200000
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
6.98 μg/mL
400 mg single, oral
dose: 400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: HIGH-FAT
8 μg/mL
400 mg single, oral
dose: 400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
1.46 μg/mL
100 mg single, oral
dose: 100 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: HIGH-FAT
1.63 μg/mL
100 mg single, oral
dose: 100 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
18.38 μg/mL
800 mg single, oral
dose: 800 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
28.73 μg/mL
1200 mg single, oral
dose: 1200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
3.68 μg/mL
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
350.3 mg × h/mL
400 mg single, oral
dose: 400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: HIGH-FAT
311.2 μg × h/mL
400 mg single, oral
dose: 400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
57.3 μg × h/mL
100 mg single, oral
dose: 100 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: HIGH-FAT
59.8 μg × h/mL
100 mg single, oral
dose: 100 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
23 h
400 mg single, oral
dose: 400 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
18.7 h
100 mg single, oral
dose: 100 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
22 h
800 mg single, oral
dose: 800 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
20 h
1200 mg single, oral
dose: 1200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
23 h
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
TOPIRAMATE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
59%
unknown, unknown
TOPIRAMATE plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
1200 mg 1 times / day steady, oral
MTD
Dose: 1200 mg, 1 times / day
Route: oral
Route: steady
Dose: 1200 mg, 1 times / day
Sources:
healthy, 23.3 years (range: 20–26 years)
Health Status: healthy
Age Group: 23.3 years (range: 20–26 years)
Sex: M+F
Sources:
4000 mg single, oral
Overdose
Dose: 4000 mg
Route: oral
Route: single
Dose: 4000 mg
Sources:
unknown, 24 years
Health Status: unknown
Age Group: 24 years
Sex: F
Sources:
400 mg 1 times / day steady, oral
Recommended
Dose: 400 mg, 1 times / day
Route: oral
Route: steady
Dose: 400 mg, 1 times / day
Sources:
unhealthy, 6-15 years
Disc. AE: Attention concentration difficulty, Fever...
AEs leading to
discontinuation/dose reduction:
Attention concentration difficulty (>=2)
Fever (>=2)
Flushing (>=2)
Confusion (>=2)
Sources:
400 mg 1 times / day steady, oral
Recommended
Dose: 400 mg, 1 times / day
Route: oral
Route: steady
Dose: 400 mg, 1 times / day
Sources:
unhealthy, >16 years
Disc. AE: Memory impairment, Fatigue...
AEs leading to
discontinuation/dose reduction:
Memory impairment (>=2)
Fatigue (>=2)
Asthenia (>=2)
Insomnia (>=2)
Somnolence (>=2)
Paresthesia (>=2)
Sources:
1400 mg 1 times / day steady, oral
Highest studied dose
Dose: 1400 mg, 1 times / day
Route: oral
Route: steady
Dose: 1400 mg, 1 times / day
Sources:
unhealthy, adult (>16 years)
Disc. AE: Psychomotor retardation, Memory impairment...
AEs leading to
discontinuation/dose reduction:
Psychomotor retardation (4%)
Memory impairment (3.2%)
Fatigue (3.2%)
Confusion (3.1%)
Somnolence (3.2%)
Attention concentration difficulty (2.9%)
Anorexia (2.7%)
Depression (2.6%)
Dizziness (2.5%)
Weight decrease (2.5%)
Nervousness (2.3%)
Ataxia (2.1%)
Paresthesia (2%)
Sources:
30 mg/kg 1 times / day steady, oral
Dose: 30 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 30 mg/kg, 1 times / day
Sources:
unhealthy, pediatric (<16 years)
Health Status: unhealthy
Age Group: pediatric (<16 years)
Sources:
Disc. AE: Convulsions aggravated, Attention concentration difficulty...
AEs leading to
discontinuation/dose reduction:
Convulsions aggravated (2.3%)
Attention concentration difficulty (1.6%)
Language disorder (1.3%)
Personality disorder (1.3%)
Somnolence (1.3%)
Sources:
96 g single, oral
Overdose
unknown
Other AEs: Coma...
AEs

AEs

AESignificanceDosePopulation
Attention concentration difficulty >=2
Disc. AE
400 mg 1 times / day steady, oral
Recommended
Dose: 400 mg, 1 times / day
Route: oral
Route: steady
Dose: 400 mg, 1 times / day
Sources:
unhealthy, 6-15 years
Confusion >=2
Disc. AE
400 mg 1 times / day steady, oral
Recommended
Dose: 400 mg, 1 times / day
Route: oral
Route: steady
Dose: 400 mg, 1 times / day
Sources:
unhealthy, 6-15 years
Fever >=2
Disc. AE
400 mg 1 times / day steady, oral
Recommended
Dose: 400 mg, 1 times / day
Route: oral
Route: steady
Dose: 400 mg, 1 times / day
Sources:
unhealthy, 6-15 years
Flushing >=2
Disc. AE
400 mg 1 times / day steady, oral
Recommended
Dose: 400 mg, 1 times / day
Route: oral
Route: steady
Dose: 400 mg, 1 times / day
Sources:
unhealthy, 6-15 years
Asthenia >=2
Disc. AE
400 mg 1 times / day steady, oral
Recommended
Dose: 400 mg, 1 times / day
Route: oral
Route: steady
Dose: 400 mg, 1 times / day
Sources:
unhealthy, >16 years
Fatigue >=2
Disc. AE
400 mg 1 times / day steady, oral
Recommended
Dose: 400 mg, 1 times / day
Route: oral
Route: steady
Dose: 400 mg, 1 times / day
Sources:
unhealthy, >16 years
Insomnia >=2
Disc. AE
400 mg 1 times / day steady, oral
Recommended
Dose: 400 mg, 1 times / day
Route: oral
Route: steady
Dose: 400 mg, 1 times / day
Sources:
unhealthy, >16 years
Memory impairment >=2
Disc. AE
400 mg 1 times / day steady, oral
Recommended
Dose: 400 mg, 1 times / day
Route: oral
Route: steady
Dose: 400 mg, 1 times / day
Sources:
unhealthy, >16 years
Paresthesia >=2
Disc. AE
400 mg 1 times / day steady, oral
Recommended
Dose: 400 mg, 1 times / day
Route: oral
Route: steady
Dose: 400 mg, 1 times / day
Sources:
unhealthy, >16 years
Somnolence >=2
Disc. AE
400 mg 1 times / day steady, oral
Recommended
Dose: 400 mg, 1 times / day
Route: oral
Route: steady
Dose: 400 mg, 1 times / day
Sources:
unhealthy, >16 years
Paresthesia 2%
Disc. AE
1400 mg 1 times / day steady, oral
Highest studied dose
Dose: 1400 mg, 1 times / day
Route: oral
Route: steady
Dose: 1400 mg, 1 times / day
Sources:
unhealthy, adult (>16 years)
Ataxia 2.1%
Disc. AE
1400 mg 1 times / day steady, oral
Highest studied dose
Dose: 1400 mg, 1 times / day
Route: oral
Route: steady
Dose: 1400 mg, 1 times / day
Sources:
unhealthy, adult (>16 years)
Nervousness 2.3%
Disc. AE
1400 mg 1 times / day steady, oral
Highest studied dose
Dose: 1400 mg, 1 times / day
Route: oral
Route: steady
Dose: 1400 mg, 1 times / day
Sources:
unhealthy, adult (>16 years)
Dizziness 2.5%
Disc. AE
1400 mg 1 times / day steady, oral
Highest studied dose
Dose: 1400 mg, 1 times / day
Route: oral
Route: steady
Dose: 1400 mg, 1 times / day
Sources:
unhealthy, adult (>16 years)
Weight decrease 2.5%
Disc. AE
1400 mg 1 times / day steady, oral
Highest studied dose
Dose: 1400 mg, 1 times / day
Route: oral
Route: steady
Dose: 1400 mg, 1 times / day
Sources:
unhealthy, adult (>16 years)
Depression 2.6%
Disc. AE
1400 mg 1 times / day steady, oral
Highest studied dose
Dose: 1400 mg, 1 times / day
Route: oral
Route: steady
Dose: 1400 mg, 1 times / day
Sources:
unhealthy, adult (>16 years)
Anorexia 2.7%
Disc. AE
1400 mg 1 times / day steady, oral
Highest studied dose
Dose: 1400 mg, 1 times / day
Route: oral
Route: steady
Dose: 1400 mg, 1 times / day
Sources:
unhealthy, adult (>16 years)
Attention concentration difficulty 2.9%
Disc. AE
1400 mg 1 times / day steady, oral
Highest studied dose
Dose: 1400 mg, 1 times / day
Route: oral
Route: steady
Dose: 1400 mg, 1 times / day
Sources:
unhealthy, adult (>16 years)
Confusion 3.1%
Disc. AE
1400 mg 1 times / day steady, oral
Highest studied dose
Dose: 1400 mg, 1 times / day
Route: oral
Route: steady
Dose: 1400 mg, 1 times / day
Sources:
unhealthy, adult (>16 years)
Fatigue 3.2%
Disc. AE
1400 mg 1 times / day steady, oral
Highest studied dose
Dose: 1400 mg, 1 times / day
Route: oral
Route: steady
Dose: 1400 mg, 1 times / day
Sources:
unhealthy, adult (>16 years)
Memory impairment 3.2%
Disc. AE
1400 mg 1 times / day steady, oral
Highest studied dose
Dose: 1400 mg, 1 times / day
Route: oral
Route: steady
Dose: 1400 mg, 1 times / day
Sources:
unhealthy, adult (>16 years)
Somnolence 3.2%
Disc. AE
1400 mg 1 times / day steady, oral
Highest studied dose
Dose: 1400 mg, 1 times / day
Route: oral
Route: steady
Dose: 1400 mg, 1 times / day
Sources:
unhealthy, adult (>16 years)
Psychomotor retardation 4%
Disc. AE
1400 mg 1 times / day steady, oral
Highest studied dose
Dose: 1400 mg, 1 times / day
Route: oral
Route: steady
Dose: 1400 mg, 1 times / day
Sources:
unhealthy, adult (>16 years)
Language disorder 1.3%
Disc. AE
30 mg/kg 1 times / day steady, oral
Dose: 30 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 30 mg/kg, 1 times / day
Sources:
unhealthy, pediatric (<16 years)
Health Status: unhealthy
Age Group: pediatric (<16 years)
Sources:
Personality disorder 1.3%
Disc. AE
30 mg/kg 1 times / day steady, oral
Dose: 30 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 30 mg/kg, 1 times / day
Sources:
unhealthy, pediatric (<16 years)
Health Status: unhealthy
Age Group: pediatric (<16 years)
Sources:
Somnolence 1.3%
Disc. AE
30 mg/kg 1 times / day steady, oral
Dose: 30 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 30 mg/kg, 1 times / day
Sources:
unhealthy, pediatric (<16 years)
Health Status: unhealthy
Age Group: pediatric (<16 years)
Sources:
Attention concentration difficulty 1.6%
Disc. AE
30 mg/kg 1 times / day steady, oral
Dose: 30 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 30 mg/kg, 1 times / day
Sources:
unhealthy, pediatric (<16 years)
Health Status: unhealthy
Age Group: pediatric (<16 years)
Sources:
Convulsions aggravated 2.3%
Disc. AE
30 mg/kg 1 times / day steady, oral
Dose: 30 mg/kg, 1 times / day
Route: oral
Route: steady
Dose: 30 mg/kg, 1 times / day
Sources:
unhealthy, pediatric (<16 years)
Health Status: unhealthy
Age Group: pediatric (<16 years)
Sources:
Coma 1 patient
96 g single, oral
Overdose
unknown
PubMed

PubMed

TitleDatePubMed
Topiramate increases brain GABA, homocarnosine, and pyrrolidinone in patients with epilepsy.
1999 Feb
Cerebral edema with herniation during acetaminophen-induced fulminant hepatic failure.
2000 Jul
A comparison of topiramate and acetazolamide on seizure duration and paired-pulse inhibition in the dentate gyrus of the rat.
2000 Jul
Psychiatric symptoms after therapy with new antiepileptic drugs: psychopathological and seizure related variables.
2000 Jun
Concerns with antiepileptic drug initiation: safety, tolerability, and efficacy.
2001
The management of refractory idiopathic epilepsies.
2001
Management strategies for refractory localization-related seizures.
2001
Cognitive side effects of anticonvulsants.
2001
Topiramate: a review of its use in childhood epilepsy.
2001
Validation of liquid-liquid extraction followed by flow-injection negative ion electrospray mass spectrometry assay to Topiramate in human plasma.
2001
Long-term effects of topiramate on bipolar mood instability, weight change and glycemic control: a case-series.
2001 Apr
Topiramate promotes neurite outgrowth and recovery of function after nerve injury.
2001 Apr 17
Topiramate in venlafaxine-induced visual hallucinations in an obese patient with a posterior cerebral artery infarction.
2001 Aug
Panic attacks associated with the use of topiramate.
2001 Aug
Intrinsic optical signals and electrographic seizures in the rat limbic system.
2001 Dec
Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy.
2001 Dec
Topiramate selectively attenuates nicotine-induced increases in monoamine release.
2001 Dec 1
Treatment and management of cluster headache.
2001 Feb
[Antiepileptic drugs and neuropathic pain].
2001 Feb 16-28
Evaluating the tolerability of the newer mood stabilizers.
2001 Jan
[Controversies about the new anti-epileptic drugs].
2001 Jan 16-31
Advances in the treatment of epilepsy.
2001 Jul 1
Topiramate in refractory partial-onset seizures in children, adolescents and young adults: a multicentric open trial.
2001 Mar
[Social and economic aspects of administration of new antiepileptic drugs].
2001 Mar-Apr
Drug-resistant cluster headache responding to gabapentin: a pilot study.
2001 Sep
[Topiramate: an experience in children with partial epilepsy].
2001 Sep
Re: Weight change with antipsychotic use.
2001 Sep
Postmarketing experience with topiramate and cognition.
2001 Sep
Weight loss with topiramate.
2001 Sep
Topiramate as a mood stabilizer.
2001 Sep
Topiramate improves deficit symptoms in a patient with schizophrenia when added to a stable regimen of antipsychotic medication.
2001 Sep-Oct
Treatment-resistant bipolar disorder.
2001 Winter
Patents

Sample Use Guides

Recommended dose: 400 mg orally per day in 2 divided doses of 200 mg each
Route of Administration: Oral
0.3 to 10 uM topiramate 1 inhibited ATPA-evoked postsynaptic currents recorded from rat basolateral amygdala (BLA) interneurons
Substance Class Chemical
Created
by admin
on Fri Jun 25 20:50:58 UTC 2021
Edited
by admin
on Fri Jun 25 20:50:58 UTC 2021
Record UNII
0H73WJJ391
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TOPIRAMATE
HSDB   INCI   INN   JAN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN   INCI  
Official Name English
TOPIRAMATE [USP-RS]
Common Name English
USL-255
Code English
TOPIRAMATE [USP MONOGRAPH]
Common Name English
TOPIRAMATE [WHO-DD]
Common Name English
TPM
Common Name English
TOPINA
Brand Name English
TOPOMAX
Brand Name English
TOPAMAX
Brand Name English
TOPIRAMATE [USAN]
Common Name English
TOPIRAMATE [JAN]
Common Name English
QUDEXY
Brand Name English
TOPIRAMATE [EP MONOGRAPH]
Common Name English
EPITOMA
Brand Name English
TOPIRAMATE [VANDF]
Common Name English
TOPIMAX
Brand Name English
EPITOMAX
Brand Name English
SINCRONIL
Brand Name English
TOPIRAMATE [USP]
Common Name English
TOPIRAMATE [MART.]
Common Name English
TOPIRAMATE COMPONENT OF QSYMIA
Brand Name English
TOPIRAMATE [INCI]
Common Name English
TOPIRAMATE [MI]
Common Name English
USL255
Code English
.BETA.-D-FRUCTOPYRANOSE, 2,3:4,5-BIS-O-(1-METHYLETHYLIDENE)-, SULFAMATE
Common Name English
TOPIRAMATE [HSDB]
Common Name English
TOPIRAMATE [INN]
Common Name English
RWJ-17021-000
Code English
MCN-4853
Code English
RWJ-17021
Code English
QSYMIA COMPONENT TOPIRAMATE
Brand Name English
TOPIRAMATE [ORANGE BOOK]
Common Name English
(-)-TOPIRAMATE
Common Name English
2,3:4,5-DI-O-ISOPROPYLIDENE-.BETA.-D-FRUCTOPYRANOSE SULFAMATE
Common Name English
TOPAMAC
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C264
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
WHO-ATC N03AX11
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
FDA ORPHAN DRUG 283909
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
NDF-RT N0000008486
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
NDF-RT N0000175753
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
WHO-VATC QN03AX11
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
LIVERTOX 981
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
FDA ORPHAN DRUG 70792
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
EMA ASSESSMENT REPORTS QSIVA (REFUSED: OBESITY)
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
Code System Code Type Description
NDF-RT
N0000182140
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY Cytochrome P450 2C19 Inhibitors [MoA]
CAS
97240-79-4
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY
HSDB
7531
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY
DRUG CENTRAL
2706
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY
USP_CATALOG
1672206
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY USP-RS
FDA UNII
0H73WJJ391
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY
WIKIPEDIA
TOPIRAMATE
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY
LACTMED
Topiramate
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY
ChEMBL
CHEMBL220492
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY
MERCK INDEX
M10976
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY Merck Index
IUPHAR
6849
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY
NDF-RT
N0000185506
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY Cytochrome P450 3A4 Inducers [MoA]
INN
6099
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY
EPA CompTox
97240-79-4
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY
PUBCHEM
5284627
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY
NCI_THESAURUS
C47764
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY
MESH
C052342
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY
RXCUI
38404
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY RxNorm
EVMPD
SUB11190MIG
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY
DRUG BANK
DB00273
Created by admin on Fri Jun 25 20:50:58 UTC 2021 , Edited by admin on Fri Jun 25 20:50:58 UTC 2021
PRIMARY
Related Record Type Details
METABOLIC ENZYME -> INHIBITOR
BINDER->LIGAND
decreases as concentration increases
BINDING
TARGET -> AGONIST
TARGET -> INHIBITOR
TARGET -> INHIBITOR
TARGET -> INHIBITOR
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
EXCRETED UNCHANGED
URINE
Related Record Type Details
METABOLITE -> PARENT
MINOR
URINE
Related Record Type Details
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Tmax PHARMACOKINETIC