PARATHION-METHYL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H10NO5PS
Molecular Weight	263.207
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COP(=S)(OC)OC1=CC=C(C=C1)[N+]([O-])=O

InChI

InChIKey=RLBIQVVOMOPOHC-UHFFFAOYSA-N

InChI=1S/C8H10NO5PS/c1-12-15(16,13-2)14-8-5-3-7(4-6-8)9(10)11/h3-6H,1-2H3

HIDE SMILES / InChI

Molecular Formula	C8H10NO5PS
Molecular Weight	263.207
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Inhibition of acetylcholinesterase and butyrylcholinesterase by the organophosphorus insecticide methylparathion in the central nervous system of the golden hamster (Mesocricetus auratus).	1991	1801511
Prolonged toxicity with intermediate syndrome after combined parathion and methyl parathion poisoning.	1992	1512808
Acetylcholinesterase (AChE) electrodes based on gelatin and chitosan matrices for the pesticide detection.	2004	15508279
Determination of impurities in pesticides and their degradation products formed during the wine-making process by solid-phase extraction and gas chromatography with detection by electron ionization mass spectrometry. II. Bromopropylate, trichlorphon, parathion-methyl and tebuconazole.	2004	15481093
Block of neuronal nicotinic acetylcholine receptors by organophosphate insecticides.	2004 Dec	15342957
Metabolical effects of Folidol 600 on the neotropical freshwater fish matrinxã, Brycon cephalus.	2004 Jun	15147928
Determination of organophosphorus pesticides using membrane-assisted solvent extraction combined with large volume injection-gas chromatography-mass spectrometric detection.	2004 Jun 25	15230532
Pesticide volatilization from plants: improvement of the PEC model PELMO based on a boundary-layer concept.	2004 May 15	15212264
Methyl parathion increases neuronal activities in the rat locus coeruleus.	2004 Nov-Dec	15591769
Sorption and detoxification of toxic compounds by a bifunctional organoclay.	2004 Sep-Oct	15356256
Assessment of pesticide residues in two arable soils from the semi-arid and subtropical regions of China.	2005 Oct	16240205
Evaluation of sublethal biomarkers in Litopenaeus vannamei on foodborne exposure to methyl parathion.	2005 Sep	15978292
An organophosphate insecticide methyl parathion (o- o- dimethyl o-4-nitrophenyl phosphorothioate) induces cytotoxic damage and tubular atrophy in the testis despite elevated testosterone level in the rat.	2006 Aug	16960428
Evaluation of performance of a commercial monoclonal antibody-based fenitrothion immunoassay and application to residual analysis in fruit samples.	2006 Jan	16416918
Motor functions but not learning and memory are impaired upon repeated exposure to sub-lethal doses of methyl parathion.	2006 Jul	16645783
[Isolation and identification of a bacterial strain JS018 capable of degrading several kinds of organophosphate pesticides].	2006 Jun	16933622
Oxidative stress biomarkers in the freshwater characid fish, Brycon cephalus, exposed to organophosphorus insecticide Folisuper 600 (methyl parathion).	2006 Jun	16546452
Modulation of aromatase activity and mRNA by various selected pesticides in the human choriocarcinoma JEG-3 cell line.	2006 Nov 10	16996190
Nucleophilic substitution of phosphorothionate ester pesticides with bisulfide (HS-) and polysulfides (S(n)2-).	2006 Sep 1	16999121
Effects of seed coatings with thiamethoxam on germination and flea beetle control in flax.	2007	18399492
Acute organophosphate poisoning in university hospital emergency room patients.	2007	17603234
Alteration of neurotrophins in the hippocampus and cerebral cortex of young rats exposed to chlorpyrifos and methyl parathion.	2007 Dec	17893397
Multienzyme inhibition assay for residue analysis of insecticidal organophosphates and carbamates.	2007 Dec 26	18052096
Interaction of insecticides with mammalian P-glycoprotein and their effect on its transport function.	2007 Jul	17490606
[Determination of organic phosphorus pesticide residues in scallion by gas chromatography coupled with microwave clean-up].	2007 May	17679438
Effects of methyl parathion on Chasmagnathus granulatus hepatopancreas: protective role of sesamol.	2007 May	16675014
Enzyme-linked immunosorbent assays for the insecticide fenitrothion. Influence of hapten conformation and sample matrix on assay performance.	2007 May 22	17481406
Altered muscarinic acetylcholine receptor subtype binding in neonatal rat brain following exposure to chlorpyrifos or methyl parathion.	2007 Nov	17666426
Cutinase inhibition by means of insecticidal organophosphates and carbamates. 3. Oxidation of phosphorothionates by chloroperoxidase from Caldariomyces fumago.	2007 Oct 3	17824663
Multi-residue determination of pesticides in water using multi-walled carbon nanotubes solid-phase extraction and gas chromatography-mass spectrometry.	2007 Sep 21	17697685
The effect of parathion-methyl and antidotes on parotid and pancreatic glands: a pilot experimental study.	2007 Sep-Oct	17963125
Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.	2008 Apr	18324785
Subacute effects of methyl parathion on antioxidant defense systems and lipid peroxidation in rats.	2008 Aug	18571824
Effects of model organophosphorous pesticides on DNA damage and proliferation of HepG2 cells.	2008 Jun	18418871
Volatilisation and competing processes computed for a pesticide applied to plants in a wind tunnel system.	2008 Jun	18213615
Optimization of separation and detection conditions for the multiresidue analysis of pesticides in grapes by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry.	2008 May 9	18371973
Monitoring of organophosphorus pesticide residues in vegetables of agricultural area in Venezuela.	2008 Oct	18766290
High-performance thin-layer chromatographic analysis of selected organophosphorous pesticide residues in tea.	2008 Sep-Oct	18980143
Organophosphorus pesticides enhance the genotoxicity of benzo(a)pyrene by modulating its metabolism.	2009 Dec 1	19800895
Mercaptobenzothiazole-on-gold organic phase biosensor systems: 1. Enhanced organosphosphate pesticide determination.	2009 Feb	19130375
The effects of selenium on oxidative stress biomarkers in the freshwater characid fish matrinxã, Brycon cephalus (Günther, 1869) exposed to organophosphate insecticide Folisuper 600 BR (methyl parathion).	2009 Jan	18655848
Identification and characterization of chlorpyrifos-methyl and 3,5,6-trichloro-2-pyridinol degrading Burkholderia sp. strain KR100.	2009 Jul	19082866
Methyl-parathion decreases sperm function and fertilization capacity after targeting spermatocytes and maturing spermatozoa.	2009 Jul 15	19442678
Organophosphorus pesticide residues in milled rice (Oryza sativa) on the Chinese market and dietary risk assessment.	2009 Mar	19680907
A transposable class I composite transposon carrying mph (methyl parathion hydrolase) from Pseudomonas sp. strain WBC-3.	2009 Mar	19222584
Repeated developmental exposure to chlorpyrifos and methyl parathion causes persistent alterations in nicotinic acetylcholine subunit mRNA expression with chlorpyrifos altering dopamine metabolite levels.	2009 Mar-Apr	18977431
The potential role of cAMP as a pollution biomarker of terrestrial environments using the land snail Eobania vermiculata: correlation with lysosomal membrane stability.	2009 Sep	19631962
Development of square wave voltammetry method for the assessment of organophosphorus compound impact on the cholinesterase of Pheretima with 2,6-dichloroindophenol as a redox indicator.	2009 Sep	19487014
Comparing the inhibitory effects of five protoxicant organophosphates (azinphos-methyl, parathion-methyl, chlorpyriphos-methyl, methamidophos and diazinon) on the spontaneously beating auricle of Sparus aurata: an in vitro study.	2009 Sep 14	19674799
Blood gene expression markers to detect and distinguish target organ toxicity.	2010 Feb	19784758

Patents

Substance Class	Chemical Created by `admin` on `Thu Jul 06 07:49:33 UTC 2023` Edited by `admin` on `Thu Jul 06 07:49:33 UTC 2023`
Record UNII	41BCL2O91D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PARATHION-METHYL

Common Name

English

GEARPHOS

Brand Name

English

BAY E 601

Brand Name

English

DIMETHYL P-NITROPHENYL THIONOPHOSPHATE

Common Name

English

O,O-DIMETHYL O-(4-NITROPHENYL) PHOSPHOROTHIOATE

Systematic Name

English

PHOSPHOROTHIOIC ACID, O,O-DIMETHYL O-(4-NITROPHENYL) ESTER

Common Name

English

PARATHION-METHYL [ISO]

Common Name

English

METHYL PARATHION [MI]

Common Name

English

FOLIDOL M

Brand Name

English

DIMETHYL 4-NITROPHENYL PHOSPHOROTHIONATE

Common Name

English

BAY-11405

Code

English

METACIDE

Brand Name

English

PARATHION-METHYL [HSDB]

Common Name

English

METHYL PARATHION

Common Name

English

METAFOS

Brand Name

English

METACID

Brand Name

English

O,O-DIMETHYL O-(4-NITROPHENYL) THIOPHOSPHATE

Systematic Name

English

METHYL PARATHION [IARC]

Common Name

English

METRON

Brand Name

English

DIMETHYL PARATHION

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

53501