ANETHOLTRITHION

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H8OS3
Molecular Weight	240.365
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)C2=CC(=S)SS2

InChI

InChIKey=KYLIZBIRMBGUOP-UHFFFAOYSA-N

InChI=1S/C10H8OS3/c1-11-8-4-2-7(3-5-8)9-6-10(12)14-13-9/h2-6H,1H3

HIDE SMILES / InChI

Molecular Formula	C10H8OS3
Molecular Weight	240.365
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/1327842
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/19957670

Anethole trithione or anetholtrithione is a drug used in the treatment of dry mouth. Anethole trithione is a bile secretion-stimulating drug that restores salivation. It is listed in the U.S. National Cancer Institute's Dictionary of Cancer Terms as being studied in the treatment of cancer. Anethol has also been identified as a treatment for improving medium and severe dry eye symptoms. The mechanism of action for the chemopreventive and xerostomia properties have not been fully elucidated.

CNS Activity

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Dry eye syndrome 21 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19957670	Primary	Basic research	Unknown Approved Use Unknown
Drug-induced xerostomia 1 Sources: http://www.ncbi.nlm.nih.gov/pubmed/1327842	Primary	Basic research	Unknown Approved Use Unknown
Lung cancer 69 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12096085	Preventing	Phase III 656	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Chemoprotective effects of two dithiolthiones and of butylhydroxyanisole against carbon tetrachloride and acetaminophen toxicity.	1983 Nov-Dec	6629324
Systemic therapy of salivary gland hypofunction.	1987 Feb	3476633
Pharmacological studies on anethole trithione.	1988 Oct	3196385
Effects of chronic anethole trithione and amitriptyline treatment on rat parotid gland signalling.	1992 May 12	1327842
Protective effects of anethole dithiolethione against oxidative stress-induced cytotoxicity in human Jurkat T cells.	1998 Jul 1	9698089
A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia.	2002 Jul 3	12096085
The neuroprotective antioxidant alpha-lipoic acid induces detoxication enzymes in cultured astroglial cells.	2002 Jun	12180195
[Radiation protectants of the crystalline lens].	2003 Nov	15124544
Seizures in the developing brain.	2004	15610187
[Anethole dithiolethione: an antioxidant agent against tenotoxicity induced by fluoroquinolones].	2004 Jul	15261372
The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes.	2006 May	16252076

Patents

Sample Use Guides

In Vivo Use Guide

was administered 6 tablets per day

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:04:10 GMT 2023` Edited by `admin` on `Fri Dec 15 15:04:10 GMT 2023`
Record UNII	QUY32964DJ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ANETHOLTRITHION

Common Name

English

OP2113

Code

English

Anethole trithione [WHO-DD]

Common Name

English

ANETHOLE TRITHIONE [MART.]

Common Name

English

OP-2113

Code

English

ANETHOLE TRITHIONE [MI]

Common Name

English

5-(P-METHOXYPHENYL)-3H-1,2-DITHIOLE-3-THIONE

Common Name

English

ANETHOLTRITHION [JAN]

Common Name

English

ANETHOLE TRITHIONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C54630