Details
Stereochemistry | ACHIRAL |
Molecular Formula | C10H8OS3 |
Molecular Weight | 240.3685 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COc1ccc(cc1)-c2cc(=S)ss2
InChI
InChIKey=KYLIZBIRMBGUOP-UHFFFAOYSA-N
InChI=1S/C10H8OS3/c1-11-8-4-2-7(3-5-8)9-6-10(12)14-13-9/h2-6H,1H3
Molecular Formula | C10H8OS3 |
Molecular Weight | 240.3685 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://www.ncbi.nlm.nih.gov/pubmed/1327842Curator's Comment:: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19957670
Sources: http://www.ncbi.nlm.nih.gov/pubmed/1327842
Curator's Comment:: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19957670
Anethole trithione or anetholtrithione is a drug used in the treatment of dry mouth. Anethole trithione is a bile secretion-stimulating drug that restores salivation. It is listed in the U.S. National Cancer Institute's Dictionary of Cancer Terms as being studied in the treatment of cancer. Anethol has also been identified as a treatment for improving medium and severe dry eye symptoms. The mechanism of action for the chemopreventive and xerostomia properties have not been fully elucidated.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3196385
Curator's Comment:: Known to be CNS NON-penetrant in mouse. Human data not available.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Effects of anethole dithiolthione and 2(3)-tert-butyl-4-hydroxyanisole on schistosome granuloma formation. | 1985 Nov |
|
[Protective effect of malotilate (diisopropyl 1,3-dithiol-2-ylidenemalonate) on chemical-induced hepatotoxicity]. | 1986 Aug |
|
Pharmacological studies on anethole trithione. | 1988 Oct |
|
Chemoprevention of colon carcinogenesis by organosulfur compounds. | 1993 Aug 1 |
|
Inhibition of NF-kappa B activation in human T-cell lines by anetholdithiolthione. | 1996 Jan 5 |
|
Protective effects of anethole dithiolethione against oxidative stress-induced cytotoxicity in human Jurkat T cells. | 1998 Jul 1 |
|
Lens epithelial cell protection by aminothiol WR-1065 and anetholedithiolethione from ionizing radiation. | 2001 |
|
A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia. | 2002 Jul 3 |
|
The neuroprotective antioxidant alpha-lipoic acid induces detoxication enzymes in cultured astroglial cells. | 2002 Jun |
|
[Radiation protectants of the crystalline lens]. | 2003 Nov |
|
[Anethole dithiolethione: an antioxidant agent against tenotoxicity induced by fluoroquinolones]. | 2004 Jul |
|
HPLC determination of 4-hydroxy-anethole trithione in plasma via enzymatic hydrolysis and its application to bioequivalence study. | 2008 Jul 15 |
|
Cancer is a preventable disease that requires major lifestyle changes. | 2008 Sep |
|
[The clinical therapic efficiency of anethol trithione on dry eye]. | 2009 Jun |
|
Lipid-based formulations to enhance oral bioavailability of the poorly water-soluble drug anethol trithione: effects of lipid composition and formulation. | 2009 Sep 8 |
|
Design, synthesis, and pharmacological evaluation of the aqueous prodrugs of desmethyl anethole trithione with hepatoprotective activity. | 2010 Jul |
|
Quantitative morphometry of respiratory tract epithelial cells as a tool for testing chemopreventive agent efficacy. | 2010 Mar |
|
Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells. | 2010 May |
|
Modulation of thiol homeostasis induced by H2S-releasing aspirin. | 2010 May 1 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10487404
was administered 6 tablets per day
Route of Administration:
Oral
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/11213483
Unknown
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 09:12:59 UTC 2021
by
admin
on
Sat Jun 26 09:12:59 UTC 2021
|
Record UNII |
QUY32964DJ
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C54630
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
||
|
WHO-ATC |
A16AX02
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
||
|
WHO-VATC |
QA16AX02
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
2194
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
PRIMARY | |||
|
M1907
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
PRIMARY | Merck Index | ||
|
CHEMBL178862
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
PRIMARY | |||
|
208-528-5
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
PRIMARY | |||
|
QUY32964DJ
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
PRIMARY | |||
|
532-11-6
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
PRIMARY | |||
|
532-11-6
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
PRIMARY | |||
|
DB13853
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
PRIMARY | |||
|
D000781
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
PRIMARY | |||
|
820
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
PRIMARY | RxNorm | ||
|
C246
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
PRIMARY | |||
|
SUB12902MIG
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
PRIMARY | |||
|
218
Created by
admin on Sat Jun 26 09:12:59 UTC 2021 , Edited by admin on Sat Jun 26 09:12:59 UTC 2021
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
METABOLIC ENZYME -> SUBSTRATE | |||
|
METABOLIC ENZYME -> SUBSTRATE | |||
|
METABOLIC ENZYME -> SUBSTRATE | |||
|
METABOLIC ENZYME -> SUBSTRATE | |||
|
METABOLIC ENZYME -> SUBSTRATE | |||
|
METABOLIC ENZYME -> SUBSTRATE | |||
|
METABOLIC ENZYME -> SUBSTRATE | |||
|
METABOLIC ENZYME -> SUBSTRATE | |||
|
METABOLIC ENZYME -> SUBSTRATE |
MINOR
|
Related Record | Type | Details | ||
---|---|---|---|---|
|
METABOLITE -> PARENT | |||
|
METABOLITE -> PARENT | |||
|
METABOLITE -> PARENT | |||
|
METABOLITE -> PARENT | |||
|
METABOLITE -> PARENT | |||
|
METABOLITE -> PARENT |
MAJOR
|
||
|
METABOLITE -> PARENT |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |