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Approval Year

Substance Class Protein
Created
by admin
on Fri Jun 25 21:21:53 UTC 2021
Edited
by admin
on Fri Jun 25 21:21:53 UTC 2021
Protein Type ENZYME
Protein Sub Type CYTOCHROME P450
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
9DX651UO0D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYTOCHROME P450 1A1
Common Name English
CYTOCHROME P450 FORM 6
Common Name English
CYTOCHROME P450-P1
Common Name English
HUMAN CYTOCHROME P450 1A1
Common Name English
CYP1A1
Common Name English
CYTOCHROME P 450 1A1
Common Name English
0P16S00R2H
Common Name English
Code System Code Type Description
UNIPROT
P04798
Created by admin on Fri Jun 25 21:21:53 UTC 2021 , Edited by admin on Fri Jun 25 21:21:53 UTC 2021
PRIMARY
CAS
329764-85-4
Created by admin on Fri Jun 25 21:21:53 UTC 2021 , Edited by admin on Fri Jun 25 21:21:53 UTC 2021
PRIMARY
FDA UNII
9DX651UO0D
Created by admin on Fri Jun 25 21:21:53 UTC 2021 , Edited by admin on Fri Jun 25 21:21:53 UTC 2021
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
O 1_67
Related Record Type Details
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
INDUCER -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
MINOR
SUBSTRATE -> METABOLIC ENZYME
MINOR
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
MINOR
INHIBITOR -> METABOLIC ENZYME
Profenofos inhibited CYP1A1/2 activities more than 90%.
SUBSTRATE -> METABOLIC ENZYME
???????????????????????????? expressed in extrahepatic tissues such as the lung and intestine, it is unlikely that this isoform would be extensively involved in generating the metabolites observed following incubations with human liver microsomes.
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> METABOLIC ENZYME
Chlorpyrifos inhibited CYP1A1/2 activities more than 90%.
INHIBITOR -> METABOLIC ENZYME
WEAK
IC50
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
In vitro metabolism studies involving recombinant enzymes indicated that CYP3A4, CYP1A1, CYP3A5, CYP2C9, CYP2C19 and CYP2B6 were responsible for the oxidative metabolism of voxelotor.
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> METABOLIC ENZYME
Phenthoate inhibited CYP1A1/2 activities more than 90%.
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> METABOLIC ENZYME
Fenitrothion inhibited CYP1A1/2 activities more than 90%.
SUBSTRATE -> METABOLIC ENZYME
TISSUE EXPRESSION -> PARENT
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
MINOR
SUBSTRATE -> METABOLIC ENZYME
MINOR
SUBSTRATE -> METABOLIC ENZYME
TISSUE EXPRESSION -> PARENT
SUBSTRATE -> METABOLIC ENZYME
MAJOR
INHIBITOR -> TARGET
MINOR
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> METABOLIC ENZYME
Malathion inhibited CYP1A1/2 activities more than 90%.
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL