Approval Year
Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 11:03:59 GMT 2023
by
admin
on
Sat Dec 16 11:03:59 GMT 2023
|
Protein Type | ENZYME |
Protein Sub Type | CYTOCHROME P450 |
Sequence Origin | HUMAN |
Sequence Type | COMPLETE |
Record UNII |
9DX651UO0D
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Record Status |
Validated (UNII)
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Record Version |
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-
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
Code System | Code | Type | Description | ||
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P04798
Created by
admin on Sat Dec 16 11:04:02 GMT 2023 , Edited by admin on Sat Dec 16 11:04:02 GMT 2023
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PRIMARY | |||
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329764-85-4
Created by
admin on Sat Dec 16 11:04:02 GMT 2023 , Edited by admin on Sat Dec 16 11:04:02 GMT 2023
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PRIMARY | |||
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9DX651UO0D
Created by
admin on Sat Dec 16 11:04:02 GMT 2023 , Edited by admin on Sat Dec 16 11:04:02 GMT 2023
|
PRIMARY | |||
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P04798
Created by
admin on Sat Dec 16 11:04:02 GMT 2023 , Edited by admin on Sat Dec 16 11:04:02 GMT 2023
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PRIMARY |
Glycosylation Type | HUMAN |
Glycosylation Link Type | Site |
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O | 1_67 |
Related Record | Type | Details | ||
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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INDUCER -> METABOLIC ENZYME |
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INHIBITOR -> METABOLIC ENZYME |
Ki
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SUBSTRATE -> METABOLIC ENZYME |
NINGETINIB M1 FORMATION
MAJOR
Vmax
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SUBSTRATE -> METABOLIC ENZYME |
MINOR
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SUBSTRATE -> METABOLIC ENZYME |
MINOR
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
MINOR
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INHIBITOR -> METABOLIC ENZYME |
Profenofos inhibited CYP1A1/2 activities more than 90%.
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SUBSTRATE -> METABOLIC ENZYME |
expressed in extrahepatic tissues such as the lung and intestine, it is unlikely that this isoform
would be extensively involved in generating the metabolites observed following incubations
with human liver microsomes.
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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INHIBITOR -> METABOLIC ENZYME |
Chlorpyrifos inhibited CYP1A1/2 activities more than 90%.
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INHIBITOR -> METABOLIC ENZYME |
WEAK
IC50
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INDUCER -> METABOLIC ENZYME |
Modulation of CYP1A1/CYP1A2 levels markedly
reduced parent drug concentrations, significantly altering metabolite pharmacokinetics (PK) in humanized mice in vivo. Produces three hydroxy impurities where site is not specified.
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
In vitro metabolism studies involving recombinant enzymes indicated that CYP3A4, CYP1A1, CYP3A5, CYP2C9, CYP2C19 and CYP2B6 were responsible for the oxidative metabolism of voxelotor.
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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INHIBITOR -> METABOLIC ENZYME |
Phenthoate inhibited CYP1A1/2 activities more than 90%.
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SUBSTRATE -> METABOLIC ENZYME |
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INHIBITOR -> METABOLIC ENZYME |
Fenitrothion inhibited CYP1A1/2 activities more than 90%
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SUBSTRATE -> METABOLIC ENZYME |
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INDUCER -> METABOLIC ENZYME |
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TISSUE EXPRESSION -> PARENT |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
MINOR
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SUBSTRATE -> METABOLIC ENZYME |
MINOR
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SUBSTRATE -> METABOLIC ENZYME |
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TISSUE EXPRESSION -> PARENT |
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SUBSTRATE -> METABOLIC ENZYME |
MAJOR
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INHIBITOR -> TARGET |
MINOR
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SUBSTRATE -> METABOLIC ENZYME |
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ACTIVATOR OF EXPRESSION->TARGET |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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INHIBITOR -> METABOLIC ENZYME |
Malathion inhibited CYP1A1/2 activities more than 90%.
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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SUBSTRATE -> METABOLIC ENZYME |
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Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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Molecular Formula | CHEMICAL |
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