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Details

Stereochemistry RACEMIC
Molecular Formula C10H19O6PS2
Molecular Weight 330.358
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MALATHION

SMILES

CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC

InChI

InChIKey=JXSJBGJIGXNWCI-UHFFFAOYSA-N
InChI=1S/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3

HIDE SMILES / InChI
Molecular Formula C10H19O6PS2
Molecular Weight 330.358
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Malathion is an organophosphate insecticide, an inhibitor of cholinesterase. In low doses (0.5%) malathion is used for treatment of pediculosis and scabies.

Originator

Approval Year

1982
105
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8504
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8583
OVIDE

Approved Use

Malathion lotion is indicated for patients infected with Pediculus humanus capitis (head lice and their ova) of the scalp hair.

Launch Date

1982
Curative
Approved
8583
DERBAC M

Approved Use

Malathion is used for topical treatment of scabies, usually as an aqueous lotion.
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2.89 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/3612901
1.8 g single, intravenous
dose: 1.8 g
route of administration: Intravenous
experiment type: SINGLE
co-administered:
MALATHION serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
15 mg/kg single, oral
Highest studied dose
Dose: 15 mg/kg
Route: oral
Route: single
Dose: 15 mg/kg
Sources:
https://www.epa.gov/sites/production/files/2017-01/documents/ache_white_paper_for_hsrb_122016.pdf
healthy, 18-50 years
Health Status: healthy
Age Group: 18-50 years
Sex: M+F
Sources:
https://www.epa.gov/sites/production/files/2017-01/documents/ache_white_paper_for_hsrb_122016.pdf
Sources:
https://www.epa.gov/sites/production/files/2017-01/documents/ache_white_paper_for_hsrb_122016.pdf
1.8 g single, intravenous
Dose: 1.8 g
Route: intravenous
Route: single
Dose: 1.8 g
Sources:
https://pubmed.ncbi.nlm.nih.gov/3612901
healthy, 24 years
Health Status: healthy
Age Group: 24 years
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/3612901
DLT: Headache, Nausea...
Dose limiting toxicities:
Headache
Nausea
Urination abnormal NOS
Sources:
https://pubmed.ncbi.nlm.nih.gov/3612901
85 mg/m3 single, respiratory
Highest studied dose
Dose: 85 mg/m3
Route: respiratory
Route: single
Dose: 85 mg/m3
Sources:
https://www.fs.fed.us/foresthealth/pesticide/pdfs/0520202c_Malathion.pdf
healthy
Health Status: healthy
Sources:
https://www.fs.fed.us/foresthealth/pesticide/pdfs/0520202c_Malathion.pdf
Sources:
https://www.fs.fed.us/foresthealth/pesticide/pdfs/0520202c_Malathion.pdf
1000 mg/kg single, oral
Lethal dose
Dose: 1000 mg/kg
Route: oral
Route: single
Dose: 1000 mg/kg
Sources:
https://www.fs.fed.us/foresthealth/pesticide/pdfs/0520202c_Malathion.pdf
healthy
Health Status: healthy
Sources:
https://www.fs.fed.us/foresthealth/pesticide/pdfs/0520202c_Malathion.pdf
DLT: Death...
Dose limiting toxicities:
Death
Sources:
https://www.fs.fed.us/foresthealth/pesticide/pdfs/0520202c_Malathion.pdf
AEs

AEs

AESignificanceDosePopulation
Headache DLT
1.8 g single, intravenous
Dose: 1.8 g
Route: intravenous
Route: single
Dose: 1.8 g
Sources:
https://pubmed.ncbi.nlm.nih.gov/3612901
healthy, 24 years
Health Status: healthy
Age Group: 24 years
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/3612901
Nausea DLT
1.8 g single, intravenous
Dose: 1.8 g
Route: intravenous
Route: single
Dose: 1.8 g
Sources:
https://pubmed.ncbi.nlm.nih.gov/3612901
healthy, 24 years
Health Status: healthy
Age Group: 24 years
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/3612901
Urination abnormal NOS DLT
1.8 g single, intravenous
Dose: 1.8 g
Route: intravenous
Route: single
Dose: 1.8 g
Sources:
https://pubmed.ncbi.nlm.nih.gov/3612901
healthy, 24 years
Health Status: healthy
Age Group: 24 years
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/3612901
Death DLT
1000 mg/kg single, oral
Lethal dose
Dose: 1000 mg/kg
Route: oral
Route: single
Dose: 1000 mg/kg
Sources:
https://www.fs.fed.us/foresthealth/pesticide/pdfs/0520202c_Malathion.pdf
healthy
Health Status: healthy
Sources:
https://www.fs.fed.us/foresthealth/pesticide/pdfs/0520202c_Malathion.pdf
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
substrate
1946
inhibitor
2438

OverviewOther

Other InhibitorOther SubstrateOther Inducer
OAT1
725
CYP1A2
1197

CYP2B6
776

P-gp
2052

carboxylesterase
4
CYP1A1
151
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
CYP1A1
272
 no
CYP2C9
2497
 strong [IC50 2.5 uM]
OAT1
730
 yes [IC50 114.2 uM]
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
P-gp
2052
 no
CYP1A2
1197
 yes
CYP2B6
776
 yes
CYP3A4
1946
 yes
carboxylesterase
4
 yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
3B Scientific (Wuhan) Corp
3B2-2211
http://www.3bsc.com/index/pro_info.php?id=70763
AA Blocks
AA009NX0
https://www.aablocks.com/goods/Goods/detail?id=AA009NX0
abcr GmbH
AB506770
http://www.abcr.de/shop/en/AB506770
AbMole Bioscience
M5760
http://www.abmole.com/products/malathion.html
Achemica
ACMC-20n0ay
http://www.achemica.com/prodinfo/?id=227917
Achemtek
0104-021283
http://www.achemtek.com/121-75-5
Achemtek
1ST20168
http://achemtek.com/121-75-5-5
AHH Chemical co.,ltd
MT-53410
http://www.ahhchemical.com/product/MT-53410.html
AK Scientific, Inc. (AKSCI)
J10314
http://www.aksci.com/item_detail.php?cat=J10314
AK Scientific, Inc. (AKSCI)
R319
http://www.aksci.com/item_detail.php?cat=R319
Angene
AGN-PC-07A21X
http://www.angenechemical.com/productshow/AGN-PC-07A21X.html
Aurora Fine Chemicals LLC
A17.894.697
http://online.aurorafinechemicals.com/info?ID=A17.894.697
Aurum Pharmatech LLC
K-1631
http://www.Aurumpharmatech.com/Product/ProductDetails/K_1631
Avantor Inc
100201-486
https://us.vwr.com/store/catalog/product.jsp?catalog_number=100201-486
Avantor Inc
100573-634
https://us.vwr.com/store/catalog/product.jsp?catalog_number=100573-634
Avantor Inc
101095-370
https://us.vwr.com/store/catalog/product.jsp?catalog_number=101095-370
Avantor Inc
76196-246
https://us.vwr.com/store/product/23882803/malathion-1-2-bis-ethoxycarbonyl-ethyl-o-o-dimethyl-phosphorodithioate-96-yellow-liquid
BioSynth
J-004630
https://www.biosynth.com/en/products/all-products/products/J-004630.html
Boerchem
BC203973
http://www.boerchem.com/?product_34271.html
Chem Scene
CS-4416
http://www.chemscene.com/121-75-5.html
ChemMol
44001648
http://www.chemmol.com/chemmol/44001648.html
ChemMol
49415632
http://www.chemmol.com/chemmol/49415632.html
Chemspace
CSSB00000038524
https://chem-space.com/CSSB00000038524
Clearsynth
CS-EB-01254
https://www.clearsynth.com/en/CSEB01254.html
Clearsynth
CS-ER-01252
https://www.clearsynth.com/en/CSER01252.html
Clearsynth
CS-O-03439
http://www.clearsynth.com/en/CSO03439.html
Debye Scientific
DB-041629
http://www.debyesci.com/cas_121-75-5.html
Finetech
FT-0701077
http://www.finetechnology-ind.com/prod/detail/pub/347841-48-9.html
Glentham Life Sciences
GK1583
http://www.glentham.com/products/product/GK1583/
iChemical
EBD2199090
http://www.ichemical.com/products/121-75-5.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
LGC Standards
DRE-A14710000TO-1000
https://www.lgcstandards.com/US/en/p/DRE-A14710000TO-1000
LGC Standards
DRE-C14710000
https://www.lgcstandards.com/US/en/p/DRE-C14710000
LGC Standards
DRE-CR14710000
https://www.lgcstandards.com/US/en/p/DRE-CR14710000
LGC Standards
DRE-L14710000CY
https://www.lgcstandards.com/US/en/p/DRE-L14710000CY
LGC Standards
DRE-XA14710000CY
https://www.lgcstandards.com/US/en/p/DRE-XA14710000CY
MedChem Express
HY-B0943
https://www.medchemexpress.com/Malathion.html
MolPort
MolPort-003-665-439
https://www.molport.com/shop/molecule-link/MolPort-003-665-439
MuseChem
I000828
https://www.musechem.com/product/I000828.html
OChem
2921
http://www.ocheminc.com/index.php?act=psearch&pid=121M755
Sigma-Aldrich
1374408_USP
https://www.sigmaaldrich.com/catalog/product/usp/1374408?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
31558_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/31558?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
36143_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/36143?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
91481_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/91481?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
M0120000_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/m0120000?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule
S534425
http://www.smolecule.com/products/s534425
THE BioTek
bt-274850
https://www.thebiotek.com/product/inhibitors/bt-274850
Yuhao Chemical
RT19782
http://www.chemyuhao.com/121-75-5.html
PubMed

PubMed

TitleDatePubMed
Comparative sensitivity of embryo-larval toxicity assays with African catfish (Clarias gariepinus) and zebra fish (Danio rerio).
2001
Concentrations of pesticide residues in tissues of fish from Kolleru Lake in India.
2001
Organ procurement and successful transplantation after malathion poisoning.
2001
Malathion resistance and prevalence of the malathion carboxylesterase mechanism in populations of mosquito vectors of disease in Sri Lanka.
2001
Comparative residual toxicities of pesticides to the predator Agistemus industani (Acari: Stigmaeidae) on citrus in Florida.
2001
Interventions for treating headlice.
2001
Highly-substrate active isoenzyme acetylcholinesterase-II, in rosy eye mutant of Aedes aegypti mosquito.
2001 Aug
Case of the month. Suspicion--an important EMS asset.
2001 Dec
Chemomorphic analysis of malathion in skin layers of the rat: implications for the use of dermatopharmacokinetic tape stripping in exposure assessment to pesticides.
2001 Dec
Gas chromatographic-tandem mass spectrometric analytical method for the study of inhalation, potential dermal and actual exposure of agricultural workers to the pesticide malathion.
2001 Dec 21
[Biologic effect of diflubenzuron on Blattella germanica (Dictyoptera: Blattellidae)].
2001 Jan-Apr
An outbreak of Plasmodium falciparum malaria due to Anopheles minimus in central Assam, India.
2001 Mar-Jun
Non-Hodgkin's lymphoma and specific pesticide exposures in men: cross-Canada study of pesticides and health.
2001 Nov
Mechanism of inhibition of lysyl hydroxylase activity by the organophosphates malathion and malaoxon.
2001 Nov 1
Toxicological studies of organophosphate and pyrethroid insecticides for controlling the fruit fly Dacus ciliatus (Diptera: Tephritidae).
2001 Oct
Identification of butyrylcholinesterase adducts after inhibition with isomalathion using mass spectrometry: difference in mechanism between (1R)- and (1S)-stereoisomers.
2001 Oct 15
Protective effect of vitamin E in dimethoate and malathion induced oxidative stress in rat erythrocytes.
2001 Sep
Organic pollutants in surface waters from Portugal using chemometric interpretation.
2001 Sep
Designing safer (soft) drugs by avoiding the formation of toxic and oxidative metabolites.
2002
Esterase patterns and phylogenetic relationships of Drosophila species in the saltans subgroup (saltans group).
2002
Age-related alteration in hepatic disposition of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and pesticides.
2002 Apr
Field studies on the susceptibility of housefly to certain insecticides in nine Egyptian governorates.
2002 Apr
Solid-phase microextraction coupled to gas chromatography-mass spectrometry for the study of soil adsorption coefficients of organophosphorus pesticides.
2002 Aug
Monitoring of pesticide applicators for potential dermal exposure to malathion and biomarkers in urine.
2002 Aug 5
Biological monitoring of exposure to organophosphate pesticides.
2002 Aug 5
General anaesthesia for emergency surgery during acute organophosphate poisoning.
2002 Feb
Comparative in vitro pediculicidal efficacy of treatments in a resistant head lice population in the United States.
2002 Feb
Embryo-larval toxicity tests with the African catfish (Clarias gariepinus): comparative sensitivity of endpoints.
2002 Feb
Educational campaign versus malathion spraying for the control of Aedes aegypti in Colima, Mexico.
2002 Feb
Genotoxic effects of malathion: an organophosphorus insecticide, using three mammalian bioassays in vivo.
2002 Feb 15
Residues of methamidofos, malathion, and methiocarb in greenhouse crops.
2002 Feb 27
[Insecticide resistance of different populations of white-backed planthopper, Sogatella furcifera (Horváth) (Homoptera:Delphacidae)].
2002 Jan
Simple determination of 22 organophosphorous pesticides in human blood using headspace solid-phase microextraction and gas chromatography with mass spectrometric detection.
2002 Jan
Widespread insecticide resistance in head lice to the over-the-counter pediculocides in England, and the emergence of carbaryl resistance.
2002 Jan
Sister chromatid exchange and proliferative rate index in the longitudinal risk assessment of occupational exposure to pesticides.
2002 Jan
Transformation of Enterobacter gergoviae isolated from pink bollworm (Lepidoptera: Gelechiidae) gut with Bacillus thuringiensis toxin.
2002 Jan
Increased T-lymphocyte dependent antibody production in female SJL/J mice following exposure to commercial grade malathion.
2002 Jan 15
Cytogenetic studies on the effect of feeding mice with stored wheat grains treated with malathion.
2002 Jan 15
Size exclusion chromatographic cleanup for GC/MS determination of organophosphorus pesticide residues in household and vehicle dust.
2002 Jan-Feb
Determination of insecticides in honey by matrix solid-phase dispersion and gas chromatography with nitrogen-phosphorus detection and mass spectrometric confirmation.
2002 Jan-Feb
Assessment of organophosphorous pesticide exposures in the diets of preschool children in Washington State.
2002 Jan-Feb
Factors influencing nominal effective concentrations of chemical compounds in vitro: medium protein concentration.
2002 Jun
Observations on the domestic ecology of Rhodnius ecuadoriensis (Triatominae).
2002 Mar
Chemical predictors of wheeze among farmer pesticide applicators in the Agricultural Health Study.
2002 Mar 1
Human blood and environmental media screening method for pesticides and polychlorinated biphenyl compounds using liquid extraction and gas chromatography-mass spectrometry analysis.
2002 Mar 25
Removal of lindane and malathion from wastewater using bagasse fly ash--a sugar industry waste.
2002 May
Controversies concerning the treatment of lice and scabies.
2002 May
Clinical practice. Head lice.
2002 May 23
Determination of pesticide residues in coconut water by liquid-liquid extraction and gas chromatography with electron-capture plus thermionic specific detection and solid-phase extraction and high-performance liquid chromatography with ultraviolet detection.
2002 May 31
Development of an in vitro test battery for the estimation of acute human systemic toxicity: An outline of the EDIT project. Evaluation-guided Development of New In Vitro Test Batteries.
2002 May-Jun
Patents

Patents

JP2003513892A
12
JP2007501208A
1
JPH02138104A
1
JPH08231322A
1
JPS63170326A
4
US3097128
1

Sample Use Guides

In Vivo Use Guide
Malathion lotion should be applied on dry hair in amount just sufficient to thoroughly wet the hair and scalp. After 8 to 12 hours, the hair should be shampooed and rinsed.
Route of Administration: Topical
In Vitro Use Guide
The activity of acetylcholinesterase was measured by the colorimetric method using acetylthiocholine iodide (ASChl) as the substrate and 5,5 dithiobis(2-nitrobenzoicacid) (DTNB), as the reagent. The enzyme activity was measured by following the increase in absorbance at 412 nm arising from the formation of the thionitrobenzoate anion in the enzyme catalysed reaction.
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:11:46 GMT 2025
Edited
by admin
on Mon Mar 31 19:11:46 GMT 2025
Record UNII
U5N7SU872W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MALATHION
EP   HSDB   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD  
Common Name English
DIETHYL (DIMETHOXYPHOSPHINOTHIOYLTHIO)SUCCINATE
Preferred Name English
MALATHION [MART.]
Common Name English
ENT-17034
Code English
MALATHION [VANDF]
Common Name English
MALATHION [ORANGE BOOK]
Common Name English
MALATHION [MI]
Common Name English
MALATHION [IARC]
Common Name English
Malathion [WHO-DD]
Common Name English
MALATHION [EP MONOGRAPH]
Common Name English
DIETHYL 2-((DIMETHOXYPHOSPHINOTHIOYL)THIO)BUTANEDIOATE
Systematic Name English
DIETHYL (±)-MERCAPTOSUCCINATE, S-ESTER WITH O,O-DIMETHYL PHOSPHORODITHIOATE
Common Name English
MALATHION [USP MONOGRAPH]
Common Name English
8059HC
Code English
BUTANEDIOIC ACID, ((DIMETHOXYPHOSPHINOTHIOYL)-THIO)-, DIETHYL ESTER, (±)-
Common Name English
MALATHION [HSDB]
Common Name English
ENT 17,034
Code English
NSC-6524
Code English
BUTANEDIOIC ACID, ((DIMETHOXYPHOSPHINOTHIOYL)THIO)-, DIETHYL ESTER
Common Name English
SUCCINIC ACID, MERCAPTO-, DIETHYL ESTER, S-ESTER WITH O,O-DIMETHYLPHOSPHORODITHIOATE
Common Name English
MALATHION [USP-RS]
Common Name English
OVIDE
Code English
Classification Tree Code System Code
NDF-RT N0000175723
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
NCI_THESAURUS C29727
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
EPA PESTICIDE CODE 57701
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
WHO-ATC P03AX03
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
WHO-VATC QP53AF12
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
NDF-RT N0000000177
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
Code System Code Type Description
NSC
6524
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
CAS
121-75-5
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
ChEMBL
CHEMBL1200468
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
HSDB
665
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
ALANWOOD
malathion
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
EVMPD
SUB14453MIG
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
EPA CompTox
DTXSID4020791
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
LACTMED
Malathion
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
ECHA (EC/EINECS)
204-497-7
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
CHEBI
6651
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
NCI_THESAURUS
C47593
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
MERCK INDEX
m7034
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY Merck Index
RXCUI
6606
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY RxNorm
DAILYMED
U5N7SU872W
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
SMS_ID
100000076812
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
PUBCHEM
4004
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
DRUG BANK
DB00772
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
FDA UNII
U5N7SU872W
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
RS_ITEM_NUM
1374408
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
WIKIPEDIA
MALATHION
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
MESH
D008294
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
DRUG CENTRAL
1626
Created by admin on Mon Mar 31 19:11:46 GMT 2025 , Edited by admin on Mon Mar 31 19:11:46 GMT 2025
PRIMARY
Related Record Type Details
CYTOCHROME P450 1A1
METABOLIC ENZYME -> INHIBITOR
Malathion inhibited CYP1A1/2 activities more than 90%.
CYTOCHROME P450 1A2
METABOLIC ENZYME -> INHIBITOR
Malathion inhibited CYP1A1/2 activities more than 90%.
CYTOCHROME P450 2C8
METABOLIC ENZYME -> INHIBITOR
Human hepatic CYP2C8 activities after incubation with different pesticides showed that CYP2C8 activities were inhibited extensively by malathion (100,90%).
CYTOCHROME P450 2A6
METABOLIC ENZYME -> INHIBITOR
Extensive inhibitions of CYP2A6-associated activity (94–98%) were observed with malathion
CYTOCHROME P450 2C9
METABOLIC ENZYME -> INHIBITOR
CYP2C9 activity was extensively inhibited (more than 90% inhibition) by organophosphorus insecticides malathion
CYTOCHROME P450 2B6
METABOLIC ENZYME -> INHIBITOR
Screening of potential CYP2B6 inhibitions illustrates that CYP2B6 activity was extensively inhibited by all tested organophosphate pesticides. Malathion and phenthoate resulted in 91% inhibition.
Related Record Type Details
Structure of MALAOXON
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of BUTANEDIOIC ACID, 2-((DIMETHOXYPHOSPHINOTHIOYL)THIO)-, 4-ETHYL 1-METHYL ESTER
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of ISOMALATHION
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of MALATHION
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