U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
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Approval Year

Substance Class Protein
Created
by admin
on Mon Mar 31 23:34:00 GMT 2025
Edited
by admin
on Mon Mar 31 23:34:00 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
246D9TQ2XG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYTOCHROME P450 2A6
Common Name English
1,4-CINEOLE 2-EXO-MONOOXYGENASE (CYP2A6)
Preferred Name English
CYP2A6
Common Name English
CYTOCHROME P 450 2A6
Common Name English
COUMARIN 7-HYDROXYLASE
Common Name English
HUMAN CYTOCHROME P450 2A6
Common Name English
Code System Code Type Description
FDA UNII
246D9TQ2XG
Created by admin on Mon Mar 31 23:34:00 GMT 2025 , Edited by admin on Mon Mar 31 23:34:00 GMT 2025
PRIMARY
CAS
165885-36-9
Created by admin on Mon Mar 31 23:34:00 GMT 2025 , Edited by admin on Mon Mar 31 23:34:00 GMT 2025
ALTERNATIVE
UNIPROT
P11509
Created by admin on Mon Mar 31 23:34:00 GMT 2025 , Edited by admin on Mon Mar 31 23:34:00 GMT 2025
PRIMARY
CAS
331827-06-6
Created by admin on Mon Mar 31 23:34:00 GMT 2025 , Edited by admin on Mon Mar 31 23:34:00 GMT 2025
PRIMARY
Related Record Type Details
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
MINOR
TISSUE EXPRESSION -> PARENT
INHIBITOR -> TARGET
MINOR
INHIBITOR -> METABOLIC ENZYME
IC50
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
METABOLIC ENZYME -> INDUCER
NON-SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
NON-SUBSTRATE -> METABOLIC ENZYME
TISSUE EXPRESSION -> PARENT
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
INDUCER -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> METABOLIC ENZYME
Extensive inhibitions of CYP2A6-associated activity (94–98%) were observed with phenthoate
INHIBITOR -> METABOLIC ENZYME
MODERATE
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Extensive inhibitions of CYP2A6-associated activity (94–98%) were observed with malathion
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
NON-SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
MINOR
INHIBITOR -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> METABOLIC ENZYME
Extensive inhibitions of CYP2A6-associated activity (94–98%) were observed with fenitrothion,
SUBSTRATE -> METABOLIC ENZYME
IN VITRO
INHIBITOR -> METABOLIC ENZYME
IC50
SUBSTRATE -> METABOLIC ENZYME
INHIBITOR -> METABOLIC ENZYME
REVERSIBLE INHIBITION
IC50
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
Activates to genotoxic metabolite
SUBSTRATE -> METABOLIC ENZYME
SUBSTRATE -> METABOLIC ENZYME
MINOR
SUBSTRATE -> METABOLIC ENZYME

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_439] SITE_SPECIFIC CYSTEINE Amount: HEME CYSTEINE COMPLEX XW1PA2GTW0
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL