Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C12H17O4PS2 |
| Molecular Weight | 320.365 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC(=O)C(SP(=S)(OC)OC)C1=CC=CC=C1
InChI
InChIKey=XAMUDJHXFNRLCY-UHFFFAOYSA-N
InChI=1S/C12H17O4PS2/c1-4-16-12(13)11(10-8-6-5-7-9-10)19-17(18,14-2)15-3/h5-9,11H,4H2,1-3H3
| Molecular Formula | C12H17O4PS2 |
| Molecular Weight | 320.365 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Detection of O,O,S-trimethyl phosphorodithioate, an impurity in phenthoate (PAP), in komatsuna]. | 2001 Jun |
|
| Fast and precise determination of phenthoate and its enantiomeric ratio in soil by the matrix solid-phase dispersion method and liquid chromatography. | 2002 Nov 15 |
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| Stereo- and enantioselective determination of pesticides in soil by using achiral and chiral liquid chromatography in combination with matrix solid-phase dispersion. | 2003 May-Jun |
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| Adsorption of phenthoate and acetochlor from water by clays and organoclays. | 2004 |
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| Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. | 2004 Apr |
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| Cardiac responses of Pacific oyster Crassostrea gigas to agents modulating cholinergic function. | 2004 Dec |
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| Comparison of solid-phase microextraction and stir bar sorptive extraction for determining six organophosphorus insecticides in honey by liquid chromatography-mass spectrometry. | 2004 Mar 19 |
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| Distribution and dissipation of phenthoate insecticide following aerial application. | 2004 Nov |
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| Rapid report acetamiprid resistance and cross-resistance in the diamondback moth, Plutella xylostella. | 2004 Sep |
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| Application of hollow fiber liquid phase microextraction for the determination of insecticides in water. | 2005 Apr 22 |
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| Effects of organophosphate compounds on a soil protist, Colpoda inflata (Ciliophora, Colpodidae). | 2006 Dec |
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| The stability of organophosphorus insecticides in fresh blood. | 2006 May |
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| Acetylcholinesterase inhibition and gill lesions in Rasbora caverii, an indigenous fish inhabiting rice field associated waterbodies in Sri Lanka. | 2006 Oct |
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| Enantioselective degradation and chiral stability of phenthoate in soil. | 2007 Aug |
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| Toxicity of insecticides to the sweetpotato whitefly (Hemiptera: Aleyrodidae) and its natural enemies. | 2007 Jul |
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| Rapid simultaneous determination for organophosphorus pesticides in human serum by LC-MS. | 2007 May 9 |
|
| Multi-residue determination of pesticides in water using multi-walled carbon nanotubes solid-phase extraction and gas chromatography-mass spectrometry. | 2007 Sep 21 |
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| Solid-phase microextraction-liquid chromatography-mass spectrometry applied to the analysis of insecticides in honey. | 2008 Jan |
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| Synthesis of three haptens for the class-specific immunoassay of O,O-dimethyl organophosphorus pesticides and effect of hapten heterology on immunoassay sensitivity. | 2008 May 19 |
|
| Longitudinal trends in organophosphate incidents reported to the National Pesticide Information Center, 1995-2007. | 2009 Apr 20 |
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| An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes. | 2009 Aug |
|
| A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning. | 2009 Aug 20 |
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| Factors for determining survival in acute organophosphate poisoning. | 2009 Dec |
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| Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial. | 2009 Jun 30 |
|
| Determination of 23 organophosphorous pesticides in surface water using SPME followed by GC-MS. | 2010 Mar |
|
| Characterization of racemization of chiral pesticides in organic solvents and water. | 2010 Sep 3 |
|
| Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. | 2011 Feb 27 |
|
| Characterization of human cytochrome P450 induction by pesticides. | 2012 Mar 29 |
|
| The inhibition of major human hepatic cytochrome P450 enzymes by 18 pesticides: comparison of the N-in-one and single substrate approaches. | 2013 Aug |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:21:23 GMT 2023
by
admin
on
Sat Dec 16 01:21:23 GMT 2023
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| Record UNII |
J96Q7F091K
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| Record Status |
Validated (UNII)
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C163686
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C008838
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phenthoate
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219-997-0
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1708
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DTXSID6042280
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17435
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J96Q7F091K
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PHENTHOATE
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2597-03-7
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34917
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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METABOLIC ENZYME -> INHIBITOR |
CYP2C9 activity was extensively inhibited (more than 90% inhibition) by organophosphorus insecticides phenthoate
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METABOLIC ENZYME -> INHIBITOR |
Extensive inhibitions of CYP2A6-associated activity (94–98%) were observed with phenthoate
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METABOLIC ENZYME -> INHIBITOR |
Phenthoate inhibited CYP1A1/2 activities more than 90%.
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METABOLIC ENZYME -> INHIBITOR |
Screening of potential CYP2B6 inhibitions illustrates that CYP2B6 activity was extensively inhibited by all tested organophosphate pesticides. Phenthoate resulted in 91% inhibition.
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METABOLIC ENZYME -> INHIBITOR |
Phenthoate inhibited CYP1A1/2 activities more than 90%.
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METABOLIC ENZYME -> INHIBITOR |
Human hepatic CYP2C8 activities after incubation with different pesticides showed that CYP2C8 activities were inhibited extensively by phenthoate (100,90%).
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