U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ABSOLUTE
Molecular Formula C20H24O2
Molecular Weight 296.4034
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETHINYL ESTRADIOL

SMILES

C[C@]12CC[C@H]3[C@@H](CCC4=CC(O)=CC=C34)[C@@H]1CC[C@@]2(O)C#C

InChI

InChIKey=BFPYWIDHMRZLRN-SLHNCBLASA-N
InChI=1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1

HIDE SMILES / InChI

Molecular Formula C20H24O2
Molecular Weight 296.4034
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 5 / 5
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/dosage/ethinyl-estradiol-levonorgestrel.html

Ethinyl estradiol is a synthetic derivative of the natural estrogen estradiol. It is one of two estrogens currently used in oral contraceptive pills. The other, mestranol, is converted to ethinyl estradiol before it is biologically active. Ethinyl estradiol and norethindrone are used together as an oral contraceptive agent. Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH). Used for treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.

Originator

Curator's Comment: Introduced as Estinyl by Schering, US, in 1944

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
LESSINA-21

Approved Use

Indicated for the prevention of pregnancy in women who elect to use oral contraceptives as a method of contraception.

Launch Date

2002
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
122.8 pg/mL
0.06 mg single, oral
dose: 0.06 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ETHINYL ESTRADIOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1335.8 pg × h/mL
0.06 mg single, oral
dose: 0.06 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ETHINYL ESTRADIOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
17.5 h
0.06 mg single, oral
dose: 0.06 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ETHINYL ESTRADIOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
5 mg 1 times / day multiple, oral
Highest studied dose
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources:
healthy, 14-54
Health Status: healthy
Age Group: 14-54
Sex: F
Sources:
Other AEs: Vomiting...
Other AEs:
Vomiting (23%)
Sources:
5 mg 1 times / day multiple, oral
Highest studied dose
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources:
healthy, 14-54
Health Status: healthy
Age Group: 14-54
Sex: F
Sources:
Other AEs: Nausea...
Other AEs:
Nausea (48%)
Sources:
5 mg 1 times / day multiple, oral
Highest studied dose
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources:
healthy, 14-54
Health Status: healthy
Age Group: 14-54
Sex: F
Sources:
Other AEs: Mastalgia...
Other AEs:
Mastalgia (32%)
Sources:
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Sources:
healthy, 18-41
Health Status: healthy
Age Group: 18-41
Sex: F
Sources:
Disc. AE: Dysfunctional uterine bleeding, Uterine bleeding...
AEs leading to
discontinuation/dose reduction:
Dysfunctional uterine bleeding
Uterine bleeding
Headache
Mood change
Nausea
Acne
Weight gain
Sources:
0.595 mg single, oral
Overdose
Dose: 0.595 mg
Route: oral
Route: single
Dose: 0.595 mg
Sources:
healthy, 29
Health Status: healthy
Age Group: 29
Sex: F
Sources:
Disc. AE: Pulmonary embolism...
AEs leading to
discontinuation/dose reduction:
Pulmonary embolism
Sources:
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Sources:
healthy
Disc. AE: Thromboembolic event, Hepatic disease...
AEs leading to
discontinuation/dose reduction:
Thromboembolic event
Hepatic disease
Headache
Hypertension
Uterine bleeding
Sources:
AEs

AEs

AESignificanceDosePopulation
Vomiting 23%
5 mg 1 times / day multiple, oral
Highest studied dose
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources:
healthy, 14-54
Health Status: healthy
Age Group: 14-54
Sex: F
Sources:
Nausea 48%
5 mg 1 times / day multiple, oral
Highest studied dose
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources:
healthy, 14-54
Health Status: healthy
Age Group: 14-54
Sex: F
Sources:
Mastalgia 32%
5 mg 1 times / day multiple, oral
Highest studied dose
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources:
healthy, 14-54
Health Status: healthy
Age Group: 14-54
Sex: F
Sources:
Acne Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Sources:
healthy, 18-41
Health Status: healthy
Age Group: 18-41
Sex: F
Sources:
Dysfunctional uterine bleeding Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Sources:
healthy, 18-41
Health Status: healthy
Age Group: 18-41
Sex: F
Sources:
Headache Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Sources:
healthy, 18-41
Health Status: healthy
Age Group: 18-41
Sex: F
Sources:
Mood change Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Sources:
healthy, 18-41
Health Status: healthy
Age Group: 18-41
Sex: F
Sources:
Nausea Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Sources:
healthy, 18-41
Health Status: healthy
Age Group: 18-41
Sex: F
Sources:
Uterine bleeding Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Sources:
healthy, 18-41
Health Status: healthy
Age Group: 18-41
Sex: F
Sources:
Weight gain Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Sources:
healthy, 18-41
Health Status: healthy
Age Group: 18-41
Sex: F
Sources:
Pulmonary embolism Disc. AE
0.595 mg single, oral
Overdose
Dose: 0.595 mg
Route: oral
Route: single
Dose: 0.595 mg
Sources:
healthy, 29
Health Status: healthy
Age Group: 29
Sex: F
Sources:
Headache Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Sources:
healthy
Hepatic disease Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Sources:
healthy
Hypertension Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Sources:
healthy
Thromboembolic event Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Sources:
healthy
Uterine bleeding Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Sources:
healthy
OverviewDrug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes [IC50 1.5 uM]
yes [IC50 14 uM]
yes (co-administration study)
Comment: No Preincubation; see https://pubmed.ncbi.nlm.nih.gov/17253885/ for list of DDI
Page: 4.0
yes [IC50 15 uM]
yes [IC50 19 uM]
yes (co-administration study)
Comment: No Preincubation; see https://pubmed.ncbi.nlm.nih.gov/17253885/ for list of DDI
Page: 4.0
yes [IC50 2.1 uM]
yes [IC50 2.8 uM]
yes (co-administration study)
Comment: No Preincubation; see https://pubmed.ncbi.nlm.nih.gov/17253885/ for list of DDI
Page: 4.0
yes [IC50 24 uM]
yes [IC50 3.3 uM]
yes [IC50 8.3 uM]
yes [IC50 9.2 uM]
yes [IC50 9.2 uM]
yes
weak (co-administration study)
Comment: ~22% increase in clerance of nicotine
Page: 12.0
yes
yes (co-administration study)
Comment: Coadministration with propranolol: ~70% increase in glucuronidation; Coadministration with lamotrigine: ~64% increase in glucuronidation
Drug as victim
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
A 1-year pharmacokinetic investigation of a novel oral contraceptive containing drospirenone in healthy female volunteers.
2000 Dec
Dramatic suppression of plasma and urinary prostate specific antigen and human glandular kallikrein by antiandrogens in male-to-female transsexuals.
2000 Mar
Ability of xeno- and phytoestrogens to modulate expression of estrogen-sensitive genes in rat uterus: estrogenicity profiles and uterotropic activity.
2000 May
Low dose of ethinyl estradiol can reverse the antiestrogenic effects of clomiphene citrate on endometrium.
2001
Synthetic estrogens-mediated activation of JNK intracellular signaling molecule.
2001 Apr
Metabolism of chylomicron cholesterol is delayed by estrogen. An in vivo study in the rat.
2001 Feb
Oral contraceptives in the treatment of acne.
2001 Feb
Choosing an oestrogen replacement therapy in young adult women with Turner syndrome.
2001 Feb
Anatomical and histological changes in the oviducts of Japanese quail, Coturnix japonica, after embryonic exposure to ethynyloestradiol.
2001 Jan
Differential response of immature rat uterine tissue to ethinylestradiol and the red wine constituent resveratrol.
2001 Jan
Charcoal treatment and risk of escape ovulation in oral contraceptive users.
2001 Jan
Effects of the synthetic estrogen 17 alpha-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas).
2001 Jun
Effects of estrogens in vitro and in vivo on cartilage growth in the tilapia (Oreochromis mossambicus).
2001 Mar
Induction of gene expression in sheepshead minnows (Cyprinodon variegatus) treated with 17beta-estradiol, diethylstilbestrol, or ethinylestradiol: the use of mRNA fingerprints as an indicator of gene regulation.
2001 Mar
Diane 35 and spironolactone combination in the treatment of hirsutism.
2001 May
Patents

Sample Use Guides

Usual Adult Dose for Endometriosis Ethinyl estradiol-levonorgestrel products are packaged in 21 or 28 day dosage preparations. The last seven tablets in 28 day dosage preparations are hormonally inert. Regardless of the number of tablets in a package, the cycle length for oral contraceptives is generally considered to be 28 days.
Route of Administration: Oral
EE (
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:54:27 GMT 2025
Edited
by admin
on Mon Mar 31 17:54:27 GMT 2025
Record UNII
423D2T571U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ETHINYL ESTRADIOL
EMA EPAR   HSDB   MI   ORANGE BOOK   USP   USP-RS   VANDF  
Common Name English
ETHINYLESTRADIOL
EP   INCI   INN   MART.   WHO-DD   WHO-IP  
INCI   INN  
Preferred Name English
ORSYTHIA COMPONENT ETHINYL ESTRADIOL
Common Name English
OVRAL COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL [VANDF]
Common Name English
FEMCON FE COMPONENT ETHINYL ESTRADIOL
Common Name English
MINASTRIN 24 FE COMPONENT ETHINYL ESTRADIOL
Brand Name English
MARLISSA COMPONENT ETHINYL ESTRADIOL
Brand Name English
ISIBLOOM COMPONENT ETHINYL ESTRADIOL
Brand Name English
KELNOR COMPONENT ETHINYL ESTRADIOL
Common Name English
ZOVIA COMPONENT ETHINYL ESTRADIOL
Brand Name English
AVIANE COMPONENT ETHINYL ESTRADIOL
Brand Name English
QUARTETTE COMPONENT ETHINYL ESTRADIOL
Brand Name English
ETHINYL ESTRADIOL [HSDB]
Common Name English
ETHINYL ESTRADIOL [USP-RS]
Common Name English
NSC-10973
Code English
ELIFEMME COMPONENT ETHINYL ESTRADIOL
Brand Name English
LYNORAL
Brand Name English
KURVELO COMPONENT ETHINYL ESTRADIOL
Common Name English
SEASONIQUE COMPONENT ETHINYL ESTRADIOL
Common Name English
ORTHO TRI-CYCLEN COMPONENT ETHINYL ESTRADIOL
Common Name English
NORQUEST FE COMPONENT ETHINYL ESTRADIOL
Common Name English
PREVIFEM COMPONENT ETHINYL ESTRADIOL
Common Name English
YAZ COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL [MI]
Common Name English
LYBREL COMPONENT ETHINYL ESTRADIOL
Common Name English
BEYAZ COMPONENT ETHINYL ESTRADIOL
Common Name English
TRI-SPRINTEC COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL [EMA EPAR]
Common Name English
SPRINTEC COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYLESTRADIOLUM [WHO-IP LATIN]
Common Name English
CYCLESSA COMPONENT ETHINYL ESTRADIOL
Common Name English
ESTROSTEP FE COMPONENT ETHINYL ESTRADIOL
Common Name English
PORTIA COMPONENT ETHINYL ESTRADIOL
Brand Name English
ETHINYLESTRADIOL [EP MONOGRAPH]
Common Name English
LEVORA COMPONENT ETHINYL ESTRADIOL
Brand Name English
ENSKYCE COMPONENT ETHINYL ESTRADIOL
Brand Name English
TWIRLA COMPONENT ETHINYL ESTRADIOL
Brand Name English
17-ETHINYLESTRADIOL
Common Name English
ARANELLE COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYLESTRADIOL [MART.]
Common Name English
NORDETTE COMPONENT ETHINYL ESTRADIOL
Brand Name English
XULANE COMPONENT ETHINYL ESTRADIOL
Brand Name English
ESTINYL
Brand Name English
ETHINYLESTRADIOL [JAN]
Common Name English
QUASENSE COMPONENT ETHINYL ESTRADIOL
Common Name English
TAYTULLA COMPONENT ETHINYL ESTRADIOL
Brand Name English
ethinylestradiol [INN]
Common Name English
ETHINYLOESTRADIOL
Common Name English
PIMTREA COMPONENT ETHINYL ESTRADIOL
Brand Name English
SAFYRAL COMPONENT ETHINYL ESTRADIOL
Common Name English
INTROVALE COMPONENT ETHINYL ESTRADIOL
Common Name English
TRIVORA COMPONENT ETHINYL ESTRADIOL
Brand Name English
KARIVA COMPONENT ETHINYL ESTRADIOL
Common Name English
ORTHO-CEPT COMPONENT ETHINYL ESTRADIOL
Common Name English
LO MINASTRIN FE COMPONENT ETHINYL ESTRADIOL
Brand Name English
FEMINONE
Brand Name English
TRI-PREVIFEM COMPONENT ETHINYL ESTRADIOL
Common Name English
YASMIN COMPONENT ETHINYL ESTRADIOL
Common Name English
NUVARING COMPONENT ETHINYL ESTRADIOL
Common Name English
TRI LO SPRINTEC COMPONENT ETHINYL ESTRADIOL
Common Name English
ANNOVERA COMPONENT ETHINYL ESTRADIOL
Brand Name English
ALTAVERA COMPONENT ETHINYL ESTRADIOL
Common Name English
MIRCETTE COMPONENT ETHINYL ESTRADIOL
Common Name English
VYFEMLA COMPONENT ETHINYL ESTRADIOL
Brand Name English
LO LOESTRIN FE COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL [ORANGE BOOK]
Common Name English
ENPRESSE COMPONENT ETHINYL ESTRADIOL
Brand Name English
ALESSE COMPONENT ETHINYL ESTRADIOL
Common Name English
CRYSELLE COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYLESTRADIOL [WHO-IP]
Common Name English
LEVLITE COMPONENT ETHINYL ESTRADIOL
Common Name English
SETLAKIN COMPONENT ETHINYL ESTRADIOL
Brand Name English
VOLNEA COMPONENT ETHINYL ESTRADIOL
Brand Name English
DESOGEN COMPONENT ETHINYL ESTRADIOL
Common Name English
VELIVET COMPONENT ETHINYL ESTRADIOL
Common Name English
17ALPHA-ETHINYLESTRADIOL
Common Name English
PREVEN COMPONENT ETHINYL ESTRADIOL
Common Name English
LOSEASONIQUE COMPONENT ETHINYL ESTRADIOL
Common Name English
VIENVA COMPONENT ETHINYL ESTRADIOL
Brand Name English
19-Nor-17?-pregna-1,3,5(10)-trien-20-yne-3,17-diol
Common Name English
Ethinylestradiol [WHO-DD]
Common Name English
TRI-LEGEST FE COMPONENT ETHINYL ESTRADIOL
Common Name English
FEMHRT COMPONENT ETHINYL ESTRADIOL
Common Name English
LESSINA COMPONENT ETHINYL ESTRADIOL
Brand Name English
BEKYREE COMPONENT ETHINYL ESTRADIOL
Brand Name English
SEASONALE COMPONENT ETHINYL ESTRADIOL
Common Name English
TRIPHASIL COMPONENT ETHINYL ESTRADIOL
Brand Name English
VIORELE COMPONENT ETHINYL ESTRADIOL
Brand Name English
NORINYL COMPONENT ETHINYL ESTRADIOL
Brand Name English
19-NORPREGNA-1,3,5(10)-TRIEN-20-YNE-3,17-DIOL, (17.ALPHA.)-
Common Name English
BREVICON COMPONENT ETHINYL ESTRADIOL
Brand Name English
FEMLYV COMPONENT ETHINYL ESTRADIOL
Brand Name English
LEVONEST COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL [USP MONOGRAPH]
Common Name English
Classification Tree Code System Code
WHO-VATC QG03AA06
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
NDF-RT N0000000100
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ESSENTIAL MEDICINES LIST 18.3.1 (ETH/LEV)
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AB03
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AA02
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AB05
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AA07
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AA13
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AB07
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AA10
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AB01
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03CA01
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AA07
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QL02AA03
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
NDF-RT N0000175825
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AA03
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AA15
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AA04
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ESSENTIAL MEDICINES LIST 18.3.1 (ETH/NOR)
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AB01
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
NCI_THESAURUS C478
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AA12
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AA16
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AA12
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AA05
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AA08
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AA04
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03CA01
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AB04
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AB06
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AA05
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AA01
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AA09
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AA06
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AA10
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AB03
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AA02
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
FDA ORPHAN DRUG 28788
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AA08
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AB05
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AB07
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
LIVERTOX 382
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AB04
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AA11
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AA13
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AA16
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AA15
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AA03
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AA09
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AB02
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AA01
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AB06
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
EMA ASSESSMENT REPORTS EVRA (AUTHORIZED: CONTRACEPTION)
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-VATC QG03AA11
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC G03AB02
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
WHO-ATC L02AA03
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
Code System Code Type Description
EVMPD
SUB07277MIG
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
DAILYMED
423D2T571U
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
FDA UNII
423D2T571U
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
PUBCHEM
5991
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
RS_ITEM_NUM
1260001
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
NCI_THESAURUS
C486
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
ETHINYL ESTRADIOL
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY Description: A white to slightly yellowish white, crystalline powder; odourless.Solubility: Practically insoluble in water; freely soluble in ethanol (~750 g/l) TS; soluble in acetone R and dioxan R.Category: Estrogen.Storage: Ethinylestradiol should be kept in a well-closed container, protected from light.Additional information: Ethinylestradiol may exist in 2 polymorphic forms one of which melts at about 183?C, the other, metastable, at about 143?C.RequirementsDefinition: Ethinylestradiol contains not less than 97.0% and not more than 102.0% of C20H24O2, calculated with reference to the dried substance.
CHEBI
4903
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
NSC
10973
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
SMS_ID
100000091721
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
ChEMBL
CHEMBL691
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
DRUG BANK
DB00977
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
MERCK INDEX
m5058
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY Merck Index
MESH
D004997
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
LACTMED
Ethinyl Estradiol
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
EPA CompTox
DTXSID5020576
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
ECHA (EC/EINECS)
200-342-2
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
RXCUI
4124
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY RxNorm
INN
437
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
IUPHAR
7071
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
DRUG CENTRAL
1082
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
CAS
57-63-6
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
HSDB
3587
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
WIKIPEDIA
ETHINYL ESTRADIOL
Created by admin on Mon Mar 31 17:54:27 GMT 2025 , Edited by admin on Mon Mar 31 17:54:27 GMT 2025
PRIMARY
Related Record Type Details
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
METABOLIC ENZYME -> SUBSTRATE
MAJOR
METABOLIC ENZYME -> INHIBITOR
IC50
METABOLIC ENZYME -> SUBSTRATE
DERIVATIVE -> PARENT
METABOLIC ENZYME -> SUBSTRATE
MAJOR
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
EP
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
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METABOLITE -> PARENT
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METABOLITE -> PARENT
METABOLITE -> PARENT
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PRODRUG -> METABOLITE ACTIVE
Related Record Type Details
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 0.7
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
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EP
IMPURITY -> PARENT
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IMPURITY -> PARENT
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CHROMATOGRAPHIC PURITY (HPLC/UV)
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EP
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 0.4
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
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CHROMATOGRAPHIC PURITY (HPLC/UV)
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IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
ACTIVE MOIETY