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Possibly Marketed Outside US

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Estrogen receptor alpha

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1943

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Estrogens

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Natural and semisynthetic estrogens, plain

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ETHINYL ESTRADIOL

423D2T571U

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Status:

US Approved Rx (1992)

First approved in 1943

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Estrogen receptor alpha

Conditions:

Ethinyl estradiol is a synthetic derivative of the natural estrogen estradiol. It is one of two estrogens currently used in oral contraceptive pills. The other, mestranol, is converted to ethinyl estradiol before it is biologically active. Ethinyl es...

tradiol and norethindrone are used together as an oral contraceptive agent. Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH). Used for treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.

SOLKETAL

3XK098O8ZW

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Status:

Possibly Marketed Outside US

First approved in 2017

Class (Stereo):

CHEMICAL (RACEMIC)

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