Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C20H24O2 |
Molecular Weight | 296.4034 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)CC[C@]3([H])C4=C(CC[C@@]23[H])C=C(O)C=C4
InChI
InChIKey=BFPYWIDHMRZLRN-SLHNCBLASA-N
InChI=1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1
DescriptionSources: http://www.drugbank.ca/drugs/DB00977Curator's Comment: Description was created based on several sources, including
https://www.drugs.com/dosage/ethinyl-estradiol-levonorgestrel.html
Sources: http://www.drugbank.ca/drugs/DB00977
Curator's Comment: Description was created based on several sources, including
https://www.drugs.com/dosage/ethinyl-estradiol-levonorgestrel.html
Ethinyl estradiol is a synthetic derivative of the natural estrogen estradiol. It is one of two estrogens currently used in oral contraceptive pills. The other, mestranol, is converted to ethinyl estradiol before it is biologically active. Ethinyl estradiol and norethindrone are used together as an oral contraceptive agent. Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH). Used for treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL206 Sources: http://www.drugbank.ca/drugs/DB00977 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Preventing | LESSINA-21 Approved UseIndicated for the prevention of pregnancy in women who elect to use oral contraceptives as a method of contraception. Launch Date2002 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
122.8 pg/mL |
0.06 mg single, oral dose: 0.06 mg route of administration: Oral experiment type: SINGLE co-administered: |
ETHINYL ESTRADIOL plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
1335.8 pg × h/mL |
0.06 mg single, oral dose: 0.06 mg route of administration: Oral experiment type: SINGLE co-administered: |
ETHINYL ESTRADIOL plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
17.5 h |
0.06 mg single, oral dose: 0.06 mg route of administration: Oral experiment type: SINGLE co-administered: |
ETHINYL ESTRADIOL plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
Doses
Dose | Population | Adverse events |
---|---|---|
5 mg 1 times / day multiple, oral Highest studied dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.209 |
healthy, 14-54 n = 172 Health Status: healthy Condition: Pregnancy prevention Age Group: 14-54 Sex: F Population Size: 172 Sources: Page: p.209 |
Other AEs: Nausea... |
5 mg 1 times / day multiple, oral Highest studied dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.209 |
healthy, 14-54 n = 222 Health Status: healthy Condition: Pregnancy prevention Age Group: 14-54 Sex: F Population Size: 222 Sources: Page: p.209 |
Other AEs: Vomiting... |
5 mg 1 times / day multiple, oral Highest studied dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.211 |
healthy, 14-54 n = 222 Health Status: healthy Condition: Pregnancy prevention Age Group: 14-54 Sex: F Population Size: 222 Sources: Page: p.211 |
Other AEs: Mastalgia... |
0.02 mg 1 times / day multiple, oral Recommended Dose: 0.02 mg, 1 times / day Route: oral Route: multiple Dose: 0.02 mg, 1 times / day Co-administed with:: levonorgestrel, p.o(0.1 mg; q.d) Sources: Page: p.4 |
healthy, 18-41 n = 2185 Health Status: healthy Condition: Pregnancy prevention Age Group: 18-41 Sex: F Population Size: 2185 Sources: Page: p.4 |
Disc. AE: Dysfunctional uterine bleeding, Uterine bleeding... AEs leading to discontinuation/dose reduction: Dysfunctional uterine bleeding Sources: Page: p.4Uterine bleeding Headache Mood change Nausea Acne Weight gain |
0.595 mg single, oral Overdose Dose: 0.595 mg Route: oral Route: single Dose: 0.595 mg Co-administed with:: cyproterone acetate, p.o(34 mg, single) Sources: |
healthy, 29 n = 1 Health Status: healthy Age Group: 29 Sex: F Population Size: 1 Sources: |
Disc. AE: Pulmonary embolism... AEs leading to discontinuation/dose reduction: Pulmonary embolism Sources: |
0.02 mg 1 times / day multiple, oral Recommended Dose: 0.02 mg, 1 times / day Route: oral Route: multiple Dose: 0.02 mg, 1 times / day Co-administed with:: levonorgestrel, p.o(0.1 mg; q.d) Sources: Page: p.1 |
healthy Health Status: healthy Condition: Pregnancy prevention Sources: Page: p.1 |
Disc. AE: Thromboembolic event, Hepatic disease... AEs leading to discontinuation/dose reduction: Thromboembolic event Sources: Page: p.1Hepatic disease Headache Hypertension Uterine bleeding |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Nausea | 48% | 5 mg 1 times / day multiple, oral Highest studied dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.209 |
healthy, 14-54 n = 172 Health Status: healthy Condition: Pregnancy prevention Age Group: 14-54 Sex: F Population Size: 172 Sources: Page: p.209 |
Vomiting | 23% | 5 mg 1 times / day multiple, oral Highest studied dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.209 |
healthy, 14-54 n = 222 Health Status: healthy Condition: Pregnancy prevention Age Group: 14-54 Sex: F Population Size: 222 Sources: Page: p.209 |
Mastalgia | 32% | 5 mg 1 times / day multiple, oral Highest studied dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: Page: p.211 |
healthy, 14-54 n = 222 Health Status: healthy Condition: Pregnancy prevention Age Group: 14-54 Sex: F Population Size: 222 Sources: Page: p.211 |
Acne | Disc. AE | 0.02 mg 1 times / day multiple, oral Recommended Dose: 0.02 mg, 1 times / day Route: oral Route: multiple Dose: 0.02 mg, 1 times / day Co-administed with:: levonorgestrel, p.o(0.1 mg; q.d) Sources: Page: p.4 |
healthy, 18-41 n = 2185 Health Status: healthy Condition: Pregnancy prevention Age Group: 18-41 Sex: F Population Size: 2185 Sources: Page: p.4 |
Dysfunctional uterine bleeding | Disc. AE | 0.02 mg 1 times / day multiple, oral Recommended Dose: 0.02 mg, 1 times / day Route: oral Route: multiple Dose: 0.02 mg, 1 times / day Co-administed with:: levonorgestrel, p.o(0.1 mg; q.d) Sources: Page: p.4 |
healthy, 18-41 n = 2185 Health Status: healthy Condition: Pregnancy prevention Age Group: 18-41 Sex: F Population Size: 2185 Sources: Page: p.4 |
Headache | Disc. AE | 0.02 mg 1 times / day multiple, oral Recommended Dose: 0.02 mg, 1 times / day Route: oral Route: multiple Dose: 0.02 mg, 1 times / day Co-administed with:: levonorgestrel, p.o(0.1 mg; q.d) Sources: Page: p.4 |
healthy, 18-41 n = 2185 Health Status: healthy Condition: Pregnancy prevention Age Group: 18-41 Sex: F Population Size: 2185 Sources: Page: p.4 |
Mood change | Disc. AE | 0.02 mg 1 times / day multiple, oral Recommended Dose: 0.02 mg, 1 times / day Route: oral Route: multiple Dose: 0.02 mg, 1 times / day Co-administed with:: levonorgestrel, p.o(0.1 mg; q.d) Sources: Page: p.4 |
healthy, 18-41 n = 2185 Health Status: healthy Condition: Pregnancy prevention Age Group: 18-41 Sex: F Population Size: 2185 Sources: Page: p.4 |
Nausea | Disc. AE | 0.02 mg 1 times / day multiple, oral Recommended Dose: 0.02 mg, 1 times / day Route: oral Route: multiple Dose: 0.02 mg, 1 times / day Co-administed with:: levonorgestrel, p.o(0.1 mg; q.d) Sources: Page: p.4 |
healthy, 18-41 n = 2185 Health Status: healthy Condition: Pregnancy prevention Age Group: 18-41 Sex: F Population Size: 2185 Sources: Page: p.4 |
Uterine bleeding | Disc. AE | 0.02 mg 1 times / day multiple, oral Recommended Dose: 0.02 mg, 1 times / day Route: oral Route: multiple Dose: 0.02 mg, 1 times / day Co-administed with:: levonorgestrel, p.o(0.1 mg; q.d) Sources: Page: p.4 |
healthy, 18-41 n = 2185 Health Status: healthy Condition: Pregnancy prevention Age Group: 18-41 Sex: F Population Size: 2185 Sources: Page: p.4 |
Weight gain | Disc. AE | 0.02 mg 1 times / day multiple, oral Recommended Dose: 0.02 mg, 1 times / day Route: oral Route: multiple Dose: 0.02 mg, 1 times / day Co-administed with:: levonorgestrel, p.o(0.1 mg; q.d) Sources: Page: p.4 |
healthy, 18-41 n = 2185 Health Status: healthy Condition: Pregnancy prevention Age Group: 18-41 Sex: F Population Size: 2185 Sources: Page: p.4 |
Pulmonary embolism | Disc. AE | 0.595 mg single, oral Overdose Dose: 0.595 mg Route: oral Route: single Dose: 0.595 mg Co-administed with:: cyproterone acetate, p.o(34 mg, single) Sources: |
healthy, 29 n = 1 Health Status: healthy Age Group: 29 Sex: F Population Size: 1 Sources: |
Headache | Disc. AE | 0.02 mg 1 times / day multiple, oral Recommended Dose: 0.02 mg, 1 times / day Route: oral Route: multiple Dose: 0.02 mg, 1 times / day Co-administed with:: levonorgestrel, p.o(0.1 mg; q.d) Sources: Page: p.1 |
healthy Health Status: healthy Condition: Pregnancy prevention Sources: Page: p.1 |
Hepatic disease | Disc. AE | 0.02 mg 1 times / day multiple, oral Recommended Dose: 0.02 mg, 1 times / day Route: oral Route: multiple Dose: 0.02 mg, 1 times / day Co-administed with:: levonorgestrel, p.o(0.1 mg; q.d) Sources: Page: p.1 |
healthy Health Status: healthy Condition: Pregnancy prevention Sources: Page: p.1 |
Hypertension | Disc. AE | 0.02 mg 1 times / day multiple, oral Recommended Dose: 0.02 mg, 1 times / day Route: oral Route: multiple Dose: 0.02 mg, 1 times / day Co-administed with:: levonorgestrel, p.o(0.1 mg; q.d) Sources: Page: p.1 |
healthy Health Status: healthy Condition: Pregnancy prevention Sources: Page: p.1 |
Thromboembolic event | Disc. AE | 0.02 mg 1 times / day multiple, oral Recommended Dose: 0.02 mg, 1 times / day Route: oral Route: multiple Dose: 0.02 mg, 1 times / day Co-administed with:: levonorgestrel, p.o(0.1 mg; q.d) Sources: Page: p.1 |
healthy Health Status: healthy Condition: Pregnancy prevention Sources: Page: p.1 |
Uterine bleeding | Disc. AE | 0.02 mg 1 times / day multiple, oral Recommended Dose: 0.02 mg, 1 times / day Route: oral Route: multiple Dose: 0.02 mg, 1 times / day Co-administed with:: levonorgestrel, p.o(0.1 mg; q.d) Sources: Page: p.1 |
healthy Health Status: healthy Condition: Pregnancy prevention Sources: Page: p.1 |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Drug as perpetrator
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/19454483/ Page: 4.0 |
yes [IC50 1.5 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/19454483/ Page: 4.0 |
yes [IC50 14 uM] | yes (co-administration study) Comment: No Preincubation; see https://pubmed.ncbi.nlm.nih.gov/17253885/ for list of DDI Sources: https://pubmed.ncbi.nlm.nih.gov/19454483/ Page: 4.0 |
||
Sources: https://pubmed.ncbi.nlm.nih.gov/19454483/ Page: 4.0 |
yes [IC50 15 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/19454483/ Page: 4.0 |
yes [IC50 19 uM] | yes (co-administration study) Comment: No Preincubation; see https://pubmed.ncbi.nlm.nih.gov/17253885/ for list of DDI Sources: https://pubmed.ncbi.nlm.nih.gov/19454483/ Page: 4.0 |
||
Sources: https://pubmed.ncbi.nlm.nih.gov/19454483/ Page: 4.0 |
yes [IC50 2.1 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/19454483/ Page: 4.0 |
yes [IC50 2.8 uM] | yes (co-administration study) Comment: No Preincubation; see https://pubmed.ncbi.nlm.nih.gov/17253885/ for list of DDI Sources: https://pubmed.ncbi.nlm.nih.gov/19454483/ Page: 4.0 |
||
Sources: https://pubmed.ncbi.nlm.nih.gov/19454483/ Page: 4.0 |
yes [IC50 24 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/19454483/ Page: 4.0 |
yes [IC50 3.3 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/19454483/ Page: 4.0 |
yes [IC50 8.3 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/19454483/ Page: 4.0 |
yes [IC50 9.2 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/19454483/ Page: 4.0 |
yes [IC50 9.2 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/17253885/ Page: 12.0 |
yes | weak (co-administration study) Comment: ~22% increase in clerance of nicotine Sources: https://pubmed.ncbi.nlm.nih.gov/17253885/ Page: 12.0 |
||
Sources: https://pubmed.ncbi.nlm.nih.gov/17253885/ |
yes | yes (co-administration study) Comment: Coadministration with propranolol: ~70% increase in glucuronidation; Coadministration with lamotrigine: ~64% increase in glucuronidation Sources: https://pubmed.ncbi.nlm.nih.gov/17253885/ |
Drug as victim
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
major | ||||
major | yes (co-administration study) Comment: see https://pubmed.ncbi.nlm.nih.gov/17253885/ for list of DDI |
|||
minor | ||||
minor | ||||
minor | ||||
yes | ||||
yes | ||||
yes | ||||
yes | yes (co-administration study) Comment: see https://pubmed.ncbi.nlm.nih.gov/17253885/ for list of DDI |
PubMed
Title | Date | PubMed |
---|---|---|
The effect of therapeutic drugs and other pharmacologic agents on activity of porphobilinogen deaminase, the enzyme that is deficient in intermittent acute porphyria. | 1999 |
|
The efficacy and tolerability of Valette: a postmarketing surveillance study. | 1999 Sep |
|
In vivo effects of sex steroids on lymphocyte responsiveness and immunoglobulin levels in humans. | 2000 Apr |
|
Oral ethinyl estradiol, but not transdermal 17beta-estradiol, increases plasma C-reactive protein levels in men. | 2000 Aug |
|
Effects of two oral contraceptives on plasma levels of insulin-like growth factor I (IGF-I) and growth hormone (hGH). | 2000 Nov |
|
Influence of the M235T polymorphism of human angiotensinogen (AGT) on plasma AGT and renin concentrations after ethinylestradiol administration. | 2000 Nov |
|
17-alpha-ethinylestradiol affects reproduction, sexual differentiation and aromatase gene expression of the medaka (Oryzias latipes). | 2000 Oct 1 |
|
Method for non-invasively recording electrocardiograms in conscious mice. | 2001 |
|
Biphasic versus monophasic oral contraceptives for contraception. | 2001 |
|
Synthetic estrogens-mediated activation of JNK intracellular signaling molecule. | 2001 Apr |
|
Effect of epomediol on ethinyloestradiol-induced changes in bile acid and cholesterol metabolism in rats. | 2001 Aug |
|
Regulation of sex hormone-binding globulin secretion in human hepatoma G2 cells. | 2001 Aug |
|
Fine structure of prolactin cell of female albino rat as affected by some antifertility drugs--a comparative electron microscopic study. | 2001 Feb |
|
Minimal androgenic activity of a new oral contraceptive containing norethindrone acetate and graduated doses of ethinyl estradiol. | 2001 Feb |
|
Insulin action and insulin secretion in polycystic ovary syndrome treated with ethinyl oestradiol/cyproterone acetate. | 2001 Jan |
|
Effects of LY117018 and the estrogen analogue, 17alpha-ethinylestradiol, on vascular reactivity, platelet aggregation, and lipid metabolism in the insulin-resistant JCR:LA-cp male rat: role of nitric oxide. | 2001 Jan |
|
Dose-response relationships and pharmacokinetics of vitellogenin in rainbow trout after intravascular administration of 17alpha-ethynylestradiol. | 2001 Jan |
|
Induction of granulin precursor gene expression by estrogen treatment in neonatal rat hypothalamus. | 2001 Jan 19 |
|
Development and validation of a homologous zebrafish (Danio rerio Hamilton-Buchanan) vitellogenin enzyme-linked immunosorbent assay (ELISA) and its application for studies on estrogenic chemicals. | 2001 Jul |
|
Effect of a combined oral contraceptive containing 3 mg of drospirenone and 30 microg of ethinyl estradiol on the human endometrium. | 2001 Jul |
|
Molecular basis of perinatal changes in UDP-glucuronosyltransferase activity in maternal rat liver. | 2001 Jul |
|
Estrogen-derived steroidal metal complexes: agents for cellular delivery of metal centers to estrogen receptor-positive cells. | 2001 Jul 30 |
|
Protein S levels are lower in women receiving desogestrel-containing combined oral contraceptives (COCs) than in women receiving levonorgestrel-containing COCs at steady state and on cross-over. | 2001 Jun |
|
Clinical recommendations for oxcarbazepine. | 2001 Mar |
|
Mechanism of action of hormonal preparations used for emergency contraception: a review of the literature. | 2001 Mar |
|
Comparison of the effect on acne with a combiphasic desogestrel-containing oral contraceptive and a preparation containing cyproterone acetate. | 2001 Mar |
|
Practices of prescribing oral contraceptives in Poland. | 2001 Mar |
|
Induction of gene expression in sheepshead minnows (Cyprinodon variegatus) treated with 17beta-estradiol, diethylstilbestrol, or ethinylestradiol: the use of mRNA fingerprints as an indicator of gene regulation. | 2001 Mar |
|
Efficacy, tolerability and acceptability of a novel contraceptive vaginal ring releasing etonogestrel and ethinyl oestradiol. | 2001 Mar |
|
Exposure of Chironomus riparius larvae to 17alpha-ethynylestradiol: effects on survival and mouthpart deformities. | 2001 Mar 26 |
|
Altered prostate growth and daily sperm production in male mice exposed prenatally to subclinical doses of 17alpha-ethinyl oestradiol. | 2001 May |
|
Comparison of the antiatherosclerotic effect of tibolone with that of estradiol and ethinyl estradiol in cholesterol-fed, ovariectomized rabbits. | 2001 Summer |
Sample Use Guides
Usual Adult Dose for Endometriosis
Ethinyl estradiol-levonorgestrel products are packaged in 21 or 28 day dosage preparations. The last seven tablets in 28 day dosage preparations are hormonally inert.
Regardless of the number of tablets in a package, the cycle length for oral contraceptives is generally considered to be 28 days.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10837011
EE (=3 uM) completely inhibited TGF-beta-induced apoptosis in cut rat liver slices and hepatocytes
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Classification Tree | Code System | Code | ||
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WHO-VATC |
QG03AA06
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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NDF-RT |
N0000000100
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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|
WHO-ESSENTIAL MEDICINES LIST |
18.3.1 (ETH/LEV)
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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|
WHO-VATC |
QG03AB03
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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||
|
WHO-ATC |
G03AA02
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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|
WHO-ATC |
G03AB05
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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|
WHO-VATC |
QG03AA07
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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|
WHO-ATC |
G03AA13
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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|
WHO-VATC |
QG03AB07
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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|
WHO-ATC |
G03AA10
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AB01
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03CA01
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AA07
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QL02AA03
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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NDF-RT |
N0000175825
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AA03
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AA15
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AA04
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ESSENTIAL MEDICINES LIST |
18.3.1 (ETH/NOR)
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AB01
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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NCI_THESAURUS |
C478
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AA12
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AA16
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AA12
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AA05
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AA08
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AA04
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03CA01
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AB04
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AB06
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AA05
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AA01
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AA09
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AA06
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AA10
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AB03
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AA02
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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FDA ORPHAN DRUG |
28788
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AA08
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AB05
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AB07
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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LIVERTOX |
382
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AB04
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AA11
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AA13
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AA16
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AA15
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AA03
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AA09
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AB02
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AA01
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AB06
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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EMA ASSESSMENT REPORTS |
EVRA (AUTHORIZED: CONTRACEPTION)
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-VATC |
QG03AA11
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
G03AB02
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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WHO-ATC |
L02AA03
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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Code System | Code | Type | Description | ||
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SUB07277MIG
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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423D2T571U
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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423D2T571U
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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5991
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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1260001
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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C486
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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ETHINYL ESTRADIOL
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | Description: A white to slightly yellowish white, crystalline powder; odourless.Solubility: Practically insoluble in water; freely soluble in ethanol (~750 g/l) TS; soluble in acetone R and dioxan R.Category: Estrogen.Storage: Ethinylestradiol should be kept in a well-closed container, protected from light.Additional information: Ethinylestradiol may exist in 2 polymorphic forms one of which melts at about 183?C, the other, metastable, at about 143?C.RequirementsDefinition: Ethinylestradiol contains not less than 97.0% and not more than 102.0% of C20H24O2, calculated with reference to the dried substance. | ||
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4903
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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10973
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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100000091721
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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CHEMBL691
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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DB00977
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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m5058
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | Merck Index | ||
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D004997
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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Ethinyl Estradiol
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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DTXSID5020576
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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200-342-2
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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4124
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | RxNorm | ||
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437
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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7071
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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1082
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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57-63-6
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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3587
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY | |||
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ETHINYL ESTRADIOL
Created by
admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
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PRIMARY |
ACTIVE MOIETY
METABOLITE (PARENT)
METABOLITE (PARENT)
METABOLITE (PARENT)
METABOLITE (PARENT)
PRODRUG (METABOLITE ACTIVE)