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Details

Stereochemistry ABSOLUTE
Molecular Formula C20H24O2
Molecular Weight 296.4034
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETHINYL ESTRADIOL

SMILES

[H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)CC[C@]3([H])C4=C(CC[C@@]23[H])C=C(O)C=C4

InChI

InChIKey=BFPYWIDHMRZLRN-SLHNCBLASA-N
InChI=1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/dosage/ethinyl-estradiol-levonorgestrel.html

Ethinyl estradiol is a synthetic derivative of the natural estrogen estradiol. It is one of two estrogens currently used in oral contraceptive pills. The other, mestranol, is converted to ethinyl estradiol before it is biologically active. Ethinyl estradiol and norethindrone are used together as an oral contraceptive agent. Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH). Used for treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.

Originator

Curator's Comment: Introduced as Estinyl by Schering, US, in 1944

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
LESSINA-21

Approved Use

Indicated for the prevention of pregnancy in women who elect to use oral contraceptives as a method of contraception.

Launch Date

2002
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
122.8 pg/mL
0.06 mg single, oral
dose: 0.06 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ETHINYL ESTRADIOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1335.8 pg × h/mL
0.06 mg single, oral
dose: 0.06 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ETHINYL ESTRADIOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
17.5 h
0.06 mg single, oral
dose: 0.06 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ETHINYL ESTRADIOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
5 mg 1 times / day multiple, oral
Highest studied dose
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources: Page: p.209
healthy, 14-54
n = 172
Health Status: healthy
Condition: Pregnancy prevention
Age Group: 14-54
Sex: F
Population Size: 172
Sources: Page: p.209
Other AEs: Nausea...
Other AEs:
Nausea (48%)
Sources: Page: p.209
5 mg 1 times / day multiple, oral
Highest studied dose
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources: Page: p.209
healthy, 14-54
n = 222
Health Status: healthy
Condition: Pregnancy prevention
Age Group: 14-54
Sex: F
Population Size: 222
Sources: Page: p.209
Other AEs: Vomiting...
Other AEs:
Vomiting (23%)
Sources: Page: p.209
5 mg 1 times / day multiple, oral
Highest studied dose
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources: Page: p.211
healthy, 14-54
n = 222
Health Status: healthy
Condition: Pregnancy prevention
Age Group: 14-54
Sex: F
Population Size: 222
Sources: Page: p.211
Other AEs: Mastalgia...
Other AEs:
Mastalgia (32%)
Sources: Page: p.211
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Co-administed with::
levonorgestrel, p.o(0.1 mg; q.d)
Sources: Page: p.4
healthy, 18-41
n = 2185
Health Status: healthy
Condition: Pregnancy prevention
Age Group: 18-41
Sex: F
Population Size: 2185
Sources: Page: p.4
Disc. AE: Dysfunctional uterine bleeding, Uterine bleeding...
AEs leading to
discontinuation/dose reduction:
Dysfunctional uterine bleeding
Uterine bleeding
Headache
Mood change
Nausea
Acne
Weight gain
Sources: Page: p.4
0.595 mg single, oral
Overdose
Dose: 0.595 mg
Route: oral
Route: single
Dose: 0.595 mg
Co-administed with::
cyproterone acetate, p.o(34 mg, single)
Sources:
healthy, 29
n = 1
Health Status: healthy
Age Group: 29
Sex: F
Population Size: 1
Sources:
Disc. AE: Pulmonary embolism...
AEs leading to
discontinuation/dose reduction:
Pulmonary embolism
Sources:
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Co-administed with::
levonorgestrel, p.o(0.1 mg; q.d)
Sources: Page: p.1
healthy
Health Status: healthy
Condition: Pregnancy prevention
Sources: Page: p.1
Disc. AE: Thromboembolic event, Hepatic disease...
AEs leading to
discontinuation/dose reduction:
Thromboembolic event
Hepatic disease
Headache
Hypertension
Uterine bleeding
Sources: Page: p.1
AEs

AEs

AESignificanceDosePopulation
Nausea 48%
5 mg 1 times / day multiple, oral
Highest studied dose
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources: Page: p.209
healthy, 14-54
n = 172
Health Status: healthy
Condition: Pregnancy prevention
Age Group: 14-54
Sex: F
Population Size: 172
Sources: Page: p.209
Vomiting 23%
5 mg 1 times / day multiple, oral
Highest studied dose
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources: Page: p.209
healthy, 14-54
n = 222
Health Status: healthy
Condition: Pregnancy prevention
Age Group: 14-54
Sex: F
Population Size: 222
Sources: Page: p.209
Mastalgia 32%
5 mg 1 times / day multiple, oral
Highest studied dose
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources: Page: p.211
healthy, 14-54
n = 222
Health Status: healthy
Condition: Pregnancy prevention
Age Group: 14-54
Sex: F
Population Size: 222
Sources: Page: p.211
Acne Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Co-administed with::
levonorgestrel, p.o(0.1 mg; q.d)
Sources: Page: p.4
healthy, 18-41
n = 2185
Health Status: healthy
Condition: Pregnancy prevention
Age Group: 18-41
Sex: F
Population Size: 2185
Sources: Page: p.4
Dysfunctional uterine bleeding Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Co-administed with::
levonorgestrel, p.o(0.1 mg; q.d)
Sources: Page: p.4
healthy, 18-41
n = 2185
Health Status: healthy
Condition: Pregnancy prevention
Age Group: 18-41
Sex: F
Population Size: 2185
Sources: Page: p.4
Headache Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Co-administed with::
levonorgestrel, p.o(0.1 mg; q.d)
Sources: Page: p.4
healthy, 18-41
n = 2185
Health Status: healthy
Condition: Pregnancy prevention
Age Group: 18-41
Sex: F
Population Size: 2185
Sources: Page: p.4
Mood change Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Co-administed with::
levonorgestrel, p.o(0.1 mg; q.d)
Sources: Page: p.4
healthy, 18-41
n = 2185
Health Status: healthy
Condition: Pregnancy prevention
Age Group: 18-41
Sex: F
Population Size: 2185
Sources: Page: p.4
Nausea Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Co-administed with::
levonorgestrel, p.o(0.1 mg; q.d)
Sources: Page: p.4
healthy, 18-41
n = 2185
Health Status: healthy
Condition: Pregnancy prevention
Age Group: 18-41
Sex: F
Population Size: 2185
Sources: Page: p.4
Uterine bleeding Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Co-administed with::
levonorgestrel, p.o(0.1 mg; q.d)
Sources: Page: p.4
healthy, 18-41
n = 2185
Health Status: healthy
Condition: Pregnancy prevention
Age Group: 18-41
Sex: F
Population Size: 2185
Sources: Page: p.4
Weight gain Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Co-administed with::
levonorgestrel, p.o(0.1 mg; q.d)
Sources: Page: p.4
healthy, 18-41
n = 2185
Health Status: healthy
Condition: Pregnancy prevention
Age Group: 18-41
Sex: F
Population Size: 2185
Sources: Page: p.4
Pulmonary embolism Disc. AE
0.595 mg single, oral
Overdose
Dose: 0.595 mg
Route: oral
Route: single
Dose: 0.595 mg
Co-administed with::
cyproterone acetate, p.o(34 mg, single)
Sources:
healthy, 29
n = 1
Health Status: healthy
Age Group: 29
Sex: F
Population Size: 1
Sources:
Headache Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Co-administed with::
levonorgestrel, p.o(0.1 mg; q.d)
Sources: Page: p.1
healthy
Health Status: healthy
Condition: Pregnancy prevention
Sources: Page: p.1
Hepatic disease Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Co-administed with::
levonorgestrel, p.o(0.1 mg; q.d)
Sources: Page: p.1
healthy
Health Status: healthy
Condition: Pregnancy prevention
Sources: Page: p.1
Hypertension Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Co-administed with::
levonorgestrel, p.o(0.1 mg; q.d)
Sources: Page: p.1
healthy
Health Status: healthy
Condition: Pregnancy prevention
Sources: Page: p.1
Thromboembolic event Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Co-administed with::
levonorgestrel, p.o(0.1 mg; q.d)
Sources: Page: p.1
healthy
Health Status: healthy
Condition: Pregnancy prevention
Sources: Page: p.1
Uterine bleeding Disc. AE
0.02 mg 1 times / day multiple, oral
Recommended
Dose: 0.02 mg, 1 times / day
Route: oral
Route: multiple
Dose: 0.02 mg, 1 times / day
Co-administed with::
levonorgestrel, p.o(0.1 mg; q.d)
Sources: Page: p.1
healthy
Health Status: healthy
Condition: Pregnancy prevention
Sources: Page: p.1
OverviewDrug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes [IC50 1.5 uM]
yes [IC50 14 uM]
yes (co-administration study)
Comment: No Preincubation; see https://pubmed.ncbi.nlm.nih.gov/17253885/ for list of DDI
Page: 4.0
yes [IC50 15 uM]
yes [IC50 19 uM]
yes (co-administration study)
Comment: No Preincubation; see https://pubmed.ncbi.nlm.nih.gov/17253885/ for list of DDI
Page: 4.0
yes [IC50 2.1 uM]
yes [IC50 2.8 uM]
yes (co-administration study)
Comment: No Preincubation; see https://pubmed.ncbi.nlm.nih.gov/17253885/ for list of DDI
Page: 4.0
yes [IC50 24 uM]
yes [IC50 3.3 uM]
yes [IC50 8.3 uM]
yes [IC50 9.2 uM]
yes [IC50 9.2 uM]
yes
weak (co-administration study)
Comment: ~22% increase in clerance of nicotine
Page: 12.0
yes
yes (co-administration study)
Comment: Coadministration with propranolol: ~70% increase in glucuronidation; Coadministration with lamotrigine: ~64% increase in glucuronidation
Drug as victim
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
The effect of therapeutic drugs and other pharmacologic agents on activity of porphobilinogen deaminase, the enzyme that is deficient in intermittent acute porphyria.
1999
The efficacy and tolerability of Valette: a postmarketing surveillance study.
1999 Sep
In vivo effects of sex steroids on lymphocyte responsiveness and immunoglobulin levels in humans.
2000 Apr
Oral ethinyl estradiol, but not transdermal 17beta-estradiol, increases plasma C-reactive protein levels in men.
2000 Aug
Effects of two oral contraceptives on plasma levels of insulin-like growth factor I (IGF-I) and growth hormone (hGH).
2000 Nov
Influence of the M235T polymorphism of human angiotensinogen (AGT) on plasma AGT and renin concentrations after ethinylestradiol administration.
2000 Nov
17-alpha-ethinylestradiol affects reproduction, sexual differentiation and aromatase gene expression of the medaka (Oryzias latipes).
2000 Oct 1
Method for non-invasively recording electrocardiograms in conscious mice.
2001
Biphasic versus monophasic oral contraceptives for contraception.
2001
Synthetic estrogens-mediated activation of JNK intracellular signaling molecule.
2001 Apr
Effect of epomediol on ethinyloestradiol-induced changes in bile acid and cholesterol metabolism in rats.
2001 Aug
Regulation of sex hormone-binding globulin secretion in human hepatoma G2 cells.
2001 Aug
Fine structure of prolactin cell of female albino rat as affected by some antifertility drugs--a comparative electron microscopic study.
2001 Feb
Minimal androgenic activity of a new oral contraceptive containing norethindrone acetate and graduated doses of ethinyl estradiol.
2001 Feb
Insulin action and insulin secretion in polycystic ovary syndrome treated with ethinyl oestradiol/cyproterone acetate.
2001 Jan
Effects of LY117018 and the estrogen analogue, 17alpha-ethinylestradiol, on vascular reactivity, platelet aggregation, and lipid metabolism in the insulin-resistant JCR:LA-cp male rat: role of nitric oxide.
2001 Jan
Dose-response relationships and pharmacokinetics of vitellogenin in rainbow trout after intravascular administration of 17alpha-ethynylestradiol.
2001 Jan
Induction of granulin precursor gene expression by estrogen treatment in neonatal rat hypothalamus.
2001 Jan 19
Development and validation of a homologous zebrafish (Danio rerio Hamilton-Buchanan) vitellogenin enzyme-linked immunosorbent assay (ELISA) and its application for studies on estrogenic chemicals.
2001 Jul
Effect of a combined oral contraceptive containing 3 mg of drospirenone and 30 microg of ethinyl estradiol on the human endometrium.
2001 Jul
Molecular basis of perinatal changes in UDP-glucuronosyltransferase activity in maternal rat liver.
2001 Jul
Estrogen-derived steroidal metal complexes: agents for cellular delivery of metal centers to estrogen receptor-positive cells.
2001 Jul 30
Protein S levels are lower in women receiving desogestrel-containing combined oral contraceptives (COCs) than in women receiving levonorgestrel-containing COCs at steady state and on cross-over.
2001 Jun
Clinical recommendations for oxcarbazepine.
2001 Mar
Mechanism of action of hormonal preparations used for emergency contraception: a review of the literature.
2001 Mar
Comparison of the effect on acne with a combiphasic desogestrel-containing oral contraceptive and a preparation containing cyproterone acetate.
2001 Mar
Practices of prescribing oral contraceptives in Poland.
2001 Mar
Induction of gene expression in sheepshead minnows (Cyprinodon variegatus) treated with 17beta-estradiol, diethylstilbestrol, or ethinylestradiol: the use of mRNA fingerprints as an indicator of gene regulation.
2001 Mar
Efficacy, tolerability and acceptability of a novel contraceptive vaginal ring releasing etonogestrel and ethinyl oestradiol.
2001 Mar
Exposure of Chironomus riparius larvae to 17alpha-ethynylestradiol: effects on survival and mouthpart deformities.
2001 Mar 26
Altered prostate growth and daily sperm production in male mice exposed prenatally to subclinical doses of 17alpha-ethinyl oestradiol.
2001 May
Comparison of the antiatherosclerotic effect of tibolone with that of estradiol and ethinyl estradiol in cholesterol-fed, ovariectomized rabbits.
2001 Summer
Patents

Sample Use Guides

Usual Adult Dose for Endometriosis Ethinyl estradiol-levonorgestrel products are packaged in 21 or 28 day dosage preparations. The last seven tablets in 28 day dosage preparations are hormonally inert. Regardless of the number of tablets in a package, the cycle length for oral contraceptives is generally considered to be 28 days.
Route of Administration: Oral
EE (
Name Type Language
ETHINYL ESTRADIOL
EMA EPAR   HSDB   MI   ORANGE BOOK   USP   USP-RS   VANDF  
Common Name English
ORSYTHIA COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL COMPONENT OF ORTHO-CEPT
Common Name English
OVRAL COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL COMPONENT OF PREVIFEM
Common Name English
ETHINYL ESTRADIOL COMPONENT OF SEASONIQUE
Common Name English
ETHINYL ESTRADIOL [VANDF]
Common Name English
ETHINYL ESTRADIOL COMPONENT OF ALESSE
Common Name English
FEMCON FE COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL COMPONENT OF ESTROSTEP FE
Common Name English
MINASTRIN 24 FE COMPONENT ETHINYL ESTRADIOL
Brand Name English
ETHINYL ESTRADIOL COMPONENT OF TRI LO SPRINTEC
Common Name English
ETHINYL ESTRADIOL COMPONENT OF SEASONALE
Common Name English
MARLISSA COMPONENT ETHINYL ESTRADIOL
Brand Name English
ISIBLOOM COMPONENT ETHINYL ESTRADIOL
Brand Name English
ETHINYL ESTRADIOL COMPONENT OF DESOGEN
Common Name English
KELNOR COMPONENT ETHINYL ESTRADIOL
Common Name English
ZOVIA COMPONENT ETHINYL ESTRADIOL
Brand Name English
AVIANE COMPONENT ETHINYL ESTRADIOL
Brand Name English
QUARTETTE COMPONENT ETHINYL ESTRADIOL
Brand Name English
ETHINYL ESTRADIOL [HSDB]
Common Name English
ETHINYL ESTRADIOL [USP-RS]
Common Name English
NSC-10973
Code English
ETHINYL ESTRADIOL COMPONENT OF INTROVALE
Common Name English
ETHINYL ESTRADIOL COMPONENT OF KELNOR
Common Name English
ELIFEMME COMPONENT ETHINYL ESTRADIOL
Brand Name English
LYNORAL
Brand Name English
KURVELO COMPONENT ETHINYL ESTRADIOL
Common Name English
SEASONIQUE COMPONENT ETHINYL ESTRADIOL
Common Name English
ORTHO TRI-CYCLEN COMPONENT ETHINYL ESTRADIOL
Common Name English
NORQUEST FE COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL COMPONENT OF VELIVET
Common Name English
PREVIFEM COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL COMPONENT OF MIRCETTE
Common Name English
YAZ COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL COMPONENT OF ORTHO TRI-CYCLEN
Common Name English
ETHINYL ESTRADIOL [MI]
Common Name English
LYBREL COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL COMPONENT OF TWIRLA
Brand Name English
ETHINYL ESTRADIOL COMPONENT OF LEVONEST
Common Name English
BEYAZ COMPONENT ETHINYL ESTRADIOL
Common Name English
TRI-SPRINTEC COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL [EMA EPAR]
Common Name English
ETHINYL ESTRADIOL COMPONENT OF YAZ
Common Name English
ETHINYL ESTRADIOL COMPONENT OF ALTAVERA
Common Name English
SPRINTEC COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYLESTRADIOLUM [WHO-IP LATIN]
Common Name English
CYCLESSA COMPONENT ETHINYL ESTRADIOL
Common Name English
ESTROSTEP FE COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYLESTRADIOL
EP   INCI   INN   MART.   WHO-DD   WHO-IP  
INCI   INN  
Official Name English
ETHINYLESTRADIOL [INCI]
Common Name English
PORTIA COMPONENT ETHINYL ESTRADIOL
Brand Name English
ETHINYLESTRADIOL [EP MONOGRAPH]
Common Name English
LEVORA COMPONENT ETHINYL ESTRADIOL
Brand Name English
ETHINYL ESTRADIOL COMPONENT OF BEYAZ
Common Name English
ENSKYCE COMPONENT ETHINYL ESTRADIOL
Brand Name English
TWIRLA COMPONENT ETHINYL ESTRADIOL
Brand Name English
17-ETHINYLESTRADIOL
Common Name English
ETHINYL ESTRADIOL COMPONENT OF TRI-SPRINTEC
Common Name English
ARANELLE COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL COMPONENT OF SAFYRAL
Common Name English
ETHINYLESTRADIOL [MART.]
Common Name English
ETHINYL ESTRADIOL COMPONENT OF YASMIN
Common Name English
NORDETTE COMPONENT ETHINYL ESTRADIOL
Brand Name English
XULANE COMPONENT ETHINYL ESTRADIOL
Brand Name English
ESTINYL
Brand Name English
ETHINYLESTRADIOL [JAN]
Common Name English
QUASENSE COMPONENT ETHINYL ESTRADIOL
Common Name English
TAYTULLA COMPONENT ETHINYL ESTRADIOL
Brand Name English
ethinylestradiol [INN]
Common Name English
ETHINYLOESTRADIOL
Common Name English
ETHINYL ESTRADIOL COMPONENT OF TRI-PREVIFEM
Common Name English
ETHINYL ESTRADIOL COMPONENT OF OVRAL
Common Name English
PIMTREA COMPONENT ETHINYL ESTRADIOL
Brand Name English
SAFYRAL COMPONENT ETHINYL ESTRADIOL
Common Name English
INTROVALE COMPONENT ETHINYL ESTRADIOL
Common Name English
TRIVORA COMPONENT ETHINYL ESTRADIOL
Brand Name English
ETHINYL ESTRADIOL COMPONENT OF LOSEASONIQUE
Common Name English
ETHINYL ESTRADIOL COMPONENT OF QUASENSE
Common Name English
ETHINYL ESTRADIOL COMPONENT OF CRYSELLE
Common Name English
KARIVA COMPONENT ETHINYL ESTRADIOL
Common Name English
ORTHO-CEPT COMPONENT ETHINYL ESTRADIOL
Common Name English
LO MINASTRIN FE COMPONENT ETHINYL ESTRADIOL
Brand Name English
FEMINONE
Brand Name English
TRI-PREVIFEM COMPONENT ETHINYL ESTRADIOL
Common Name English
YASMIN COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL COMPONENT OF LEVLITE
Common Name English
NUVARING COMPONENT ETHINYL ESTRADIOL
Common Name English
TRI LO SPRINTEC COMPONENT ETHINYL ESTRADIOL
Common Name English
ANNOVERA COMPONENT ETHINYL ESTRADIOL
Brand Name English
ETHINYL ESTRADIOL COMPONENT OF KARIVA
Common Name English
ALTAVERA COMPONENT ETHINYL ESTRADIOL
Common Name English
MIRCETTE COMPONENT ETHINYL ESTRADIOL
Common Name English
VYFEMLA COMPONENT ETHINYL ESTRADIOL
Brand Name English
ETHINYL ESTRADIOL COMPONENT OF ARANELLE
Common Name English
LO LOESTRIN FE COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL [ORANGE BOOK]
Common Name English
ETHINYL ESTRADIOL COMPONENT OF PREVEN
Common Name English
ENPRESSE COMPONENT ETHINYL ESTRADIOL
Brand Name English
ALESSE COMPONENT ETHINYL ESTRADIOL
Common Name English
CRYSELLE COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYLESTRADIOL [WHO-IP]
Common Name English
LEVLITE COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL COMPONENT OF LO LOESTRIN FE
Common Name English
SETLAKIN COMPONENT ETHINYL ESTRADIOL
Brand Name English
ETHINYL ESTRADIOL COMPONENT OF NUVARING
Common Name English
VOLNEA COMPONENT ETHINYL ESTRADIOL
Brand Name English
DESOGEN COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL COMPONENT OF SETLAKIN
Brand Name English
ETHINYL ESTRADIOL COMPONENT OF SPRINTEC
Common Name English
VELIVET COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL COMPONENT OF TRI-LEGEST FE
Common Name English
ETHINYL ESTRADIOL COMPONENT OF CYCLESSA
Common Name English
17ALPHA-ETHINYLESTRADIOL
Common Name English
PREVEN COMPONENT ETHINYL ESTRADIOL
Common Name English
LOSEASONIQUE COMPONENT ETHINYL ESTRADIOL
Common Name English
VIENVA COMPONENT ETHINYL ESTRADIOL
Brand Name English
19-Nor-17α-pregna-1,3,5(10)-trien-20-yne-3,17-diol
Common Name English
Ethinylestradiol [WHO-DD]
Common Name English
TRI-LEGEST FE COMPONENT ETHINYL ESTRADIOL
Common Name English
FEMHRT COMPONENT ETHINYL ESTRADIOL
Common Name English
LESSINA COMPONENT ETHINYL ESTRADIOL
Brand Name English
ETHINYL ESTRADIOL COMPONENT OF ANNOVERA
Brand Name English
BEKYREE COMPONENT ETHINYL ESTRADIOL
Brand Name English
ETHINYL ESTRADIOL COMPONENT OF FEMHRT
Common Name English
ETHINYL ESTRADIOL COMPONENT OF LYBREL
Common Name English
ETHINYL ESTRADIOL COMPONENT OF FEMCON FE
Common Name English
SEASONALE COMPONENT ETHINYL ESTRADIOL
Common Name English
TRIPHASIL COMPONENT ETHINYL ESTRADIOL
Brand Name English
ETHINYL ESTRADIOL COMPONENT OF NORQUEST FE
Common Name English
VIORELE COMPONENT ETHINYL ESTRADIOL
Brand Name English
NORINYL COMPONENT ETHINYL ESTRADIOL
Brand Name English
19-NORPREGNA-1,3,5(10)-TRIEN-20-YNE-3,17-DIOL, (17.ALPHA.)-
Common Name English
BREVICON COMPONENT ETHINYL ESTRADIOL
Brand Name English
LEVONEST COMPONENT ETHINYL ESTRADIOL
Common Name English
ETHINYL ESTRADIOL [USP MONOGRAPH]
Common Name English
Classification Tree Code System Code
WHO-VATC QG03AA06
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
NDF-RT N0000000100
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ESSENTIAL MEDICINES LIST 18.3.1 (ETH/LEV)
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AB03
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AA02
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AB05
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AA07
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AA13
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AB07
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AA10
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AB01
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03CA01
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AA07
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QL02AA03
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
NDF-RT N0000175825
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AA03
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AA15
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AA04
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ESSENTIAL MEDICINES LIST 18.3.1 (ETH/NOR)
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AB01
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
NCI_THESAURUS C478
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AA12
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AA16
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AA12
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AA05
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AA08
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AA04
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03CA01
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AB04
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AB06
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AA05
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AA01
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AA09
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AA06
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AA10
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AB03
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AA02
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
FDA ORPHAN DRUG 28788
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AA08
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AB05
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AB07
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
LIVERTOX 382
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AB04
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AA11
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AA13
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AA16
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AA15
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AA03
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AA09
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AB02
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AA01
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AB06
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
EMA ASSESSMENT REPORTS EVRA (AUTHORIZED: CONTRACEPTION)
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-VATC QG03AA11
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC G03AB02
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
WHO-ATC L02AA03
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
Code System Code Type Description
EVMPD
SUB07277MIG
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
DAILYMED
423D2T571U
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
FDA UNII
423D2T571U
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
PUBCHEM
5991
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
RS_ITEM_NUM
1260001
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
NCI_THESAURUS
C486
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
ETHINYL ESTRADIOL
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY Description: A white to slightly yellowish white, crystalline powder; odourless.Solubility: Practically insoluble in water; freely soluble in ethanol (~750 g/l) TS; soluble in acetone R and dioxan R.Category: Estrogen.Storage: Ethinylestradiol should be kept in a well-closed container, protected from light.Additional information: Ethinylestradiol may exist in 2 polymorphic forms one of which melts at about 183?C, the other, metastable, at about 143?C.RequirementsDefinition: Ethinylestradiol contains not less than 97.0% and not more than 102.0% of C20H24O2, calculated with reference to the dried substance.
CHEBI
4903
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
NSC
10973
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
SMS_ID
100000091721
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
ChEMBL
CHEMBL691
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
DRUG BANK
DB00977
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
MERCK INDEX
m5058
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY Merck Index
MESH
D004997
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
LACTMED
Ethinyl Estradiol
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
EPA CompTox
DTXSID5020576
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
ECHA (EC/EINECS)
200-342-2
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
RXCUI
4124
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY RxNorm
INN
437
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
IUPHAR
7071
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
DRUG CENTRAL
1082
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
CAS
57-63-6
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
HSDB
3587
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY
WIKIPEDIA
ETHINYL ESTRADIOL
Created by admin on Fri Dec 15 15:20:20 GMT 2023 , Edited by admin on Fri Dec 15 15:20:20 GMT 2023
PRIMARY