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Details

Stereochemistry ABSOLUTE
Molecular Formula C32H48N4O8
Molecular Weight 616.7468
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 6
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALVESPIMYCIN

SMILES

C[C@]1([H])CC2=C(C(=O)C=C(C2=O)N=C(/C(=C(\[H])/C(/[H])=C(/[H])\[C@@]([H])([C@]([H])(/C(=C(\[H])/[C@]([H])(C)[C@]([H])([C@]([H])(C1)OC)O)/C)OC(=N)O)OC)/C)O)NCCN(C)C

InChI

InChIKey=KUFRQPKVAWMTJO-LMZWQJSESA-N
InChI=1S/C32H48N4O8/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40)/b11-9-,19-10+,21-16+/t18-,20+,25+,26+,28-,30+/m1/s1

HIDE SMILES / InChI

Molecular Formula C32H48N4O8
Molecular Weight 616.7468
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 6 / 6
E/Z Centers 0
Optical Activity UNSPECIFIED

Alvespimycin (17-desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin) (17-DMAG; NSC 707545) is an inhibitor of the molecular chaperone heat shock protein HSP90. Alvespimycin is a derivative of antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Alvespimycin was studied in clinical trials for the treatment of solid tumors and hematologic malignancies however its development was discontinued.

CNS Activity

Curator's Comment:: Alvespimycin (17-DMAG) is brain penetrant and CNS active in animals. No human data available.

Approval Year

PubMed

PubMed

TitleDatePubMed
Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines.
2006 Nov 1
The bioreduction of a series of benzoquinone ansamycins by NAD(P)H:quinone oxidoreductase 1 to more potent heat shock protein 90 inhibitors, the hydroquinone ansamycins.
2006 Oct
Heat shock protein inhibitors, 17-DMAG and KNK437, enhance arsenic trioxide-induced mitotic apoptosis.
2009 Apr 15
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.
2011 Jul
Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants.
2012 Sep 1
Patents

Patents

Sample Use Guides

Phase 1 study. Patients with advanced acute myeloid leukemia (AML) received escalating doses of intravenous alvespimycin (8-32 mg/m(2)), twice weekly, for 2 of 3 weeks. Alvespimycin was well tolerated; the maximum-tolerated dose was 24 mg/m(2) twice weekly. Common toxicities included neutropenic fever, fatigue, nausea and diarrhea. Cardiac DLTs occurred at 32 mg/m(2) (elevated troponin and myocardial infarction). Pharmacokinetics revealed linear increases in C(max) and area under the curve (AUC) from 8 to 32 mg/m(2) and minor accumulation upon repeated doses. Recommended phase 2 dose is 24 mg/m(2).
Route of Administration: Intravenous
One hepatic cell line (L02) and two HCC cell lines (Huh7 and HepG2) were heated at 42 °C for 0, 0.5 or 4 h with or without 100 nM alvespimycin (17-DMAG).
Substance Class Chemical
Created
by admin
on Sat Jun 26 09:20:59 UTC 2021
Edited
by admin
on Sat Jun 26 09:20:59 UTC 2021
Record UNII
001L2FE0M3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ALVESPIMYCIN
INN   WHO-DD  
INN  
Official Name English
ALVESPIMYCIN [INN]
Common Name English
ALVESPIMYCIN [WHO-DD]
Common Name English
(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-((2-(DIMETHYLAMINO)ETHYL)AMINO)-13-HYDROXY-8,14-DIMETHOXY-4,10,12,16-TETRAMETHYL-3,20,22-TRIOXO-2-AZABICYCLO(16.3.1)DOCOSA-1(21),4,6,10,18-PENTAEN-9-YL CARBAMATE
Common Name English
GELDANAMYCIN, 17-DEMETHOXY-17-((2-(DIMETHYLAMINO)ETHYL)AMINO)-
Common Name English
NSC-707545
Code English
DMAG
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C2516
Created by admin on Sat Jun 26 09:21:00 UTC 2021 , Edited by admin on Sat Jun 26 09:21:00 UTC 2021
Code System Code Type Description
NCI_THESAURUS
C38142
Created by admin on Sat Jun 26 09:21:00 UTC 2021 , Edited by admin on Sat Jun 26 09:21:00 UTC 2021
PRIMARY
INN
8811
Created by admin on Sat Jun 26 09:21:00 UTC 2021 , Edited by admin on Sat Jun 26 09:21:00 UTC 2021
PRIMARY
PUBCHEM
5288674
Created by admin on Sat Jun 26 09:21:00 UTC 2021 , Edited by admin on Sat Jun 26 09:21:00 UTC 2021
PRIMARY
FDA UNII
001L2FE0M3
Created by admin on Sat Jun 26 09:21:00 UTC 2021 , Edited by admin on Sat Jun 26 09:21:00 UTC 2021
PRIMARY
MESH
C448659
Created by admin on Sat Jun 26 09:21:00 UTC 2021 , Edited by admin on Sat Jun 26 09:21:00 UTC 2021
PRIMARY
DRUG BANK
DB12442
Created by admin on Sat Jun 26 09:21:00 UTC 2021 , Edited by admin on Sat Jun 26 09:21:00 UTC 2021
PRIMARY
CAS
467214-20-6
Created by admin on Sat Jun 26 09:21:00 UTC 2021 , Edited by admin on Sat Jun 26 09:21:00 UTC 2021
PRIMARY
ChEMBL
CHEMBL383824
Created by admin on Sat Jun 26 09:21:00 UTC 2021 , Edited by admin on Sat Jun 26 09:21:00 UTC 2021
PRIMARY
EVMPD
SUB33529
Created by admin on Sat Jun 26 09:21:00 UTC 2021 , Edited by admin on Sat Jun 26 09:21:00 UTC 2021
PRIMARY
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