U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class
Concept
Record UNII
4JEH3BL51N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PF-5212377
Code English
1H-BENZIMIDAZOLE, 2-METHYL-1-(PHENYLSULFONYL)-4-(1-PIPERAZINYL)-
Systematic Name English
PF-05212377
Code English
Code System Code Type Description
CAS
1226793-34-5
Created by admin on Sat Jun 26 08:26:14 UTC 2021 , Edited by admin on Sat Jun 26 08:26:14 UTC 2021
PRIMARY
ChEMBL
CHEMBL3545344
Created by admin on Sat Jun 26 08:26:14 UTC 2021 , Edited by admin on Sat Jun 26 08:26:14 UTC 2021
PRIMARY
PUBCHEM
46203710
Created by admin on Sat Jun 26 08:26:14 UTC 2021 , Edited by admin on Sat Jun 26 08:26:14 UTC 2021
PRIMARY
FDA UNII
4JEH3BL51N
Created by admin on Sat Jun 26 08:26:14 UTC 2021 , Edited by admin on Sat Jun 26 08:26:14 UTC 2021
PRIMARY
This is a non-substance concept
Related Record Type Details
METABOLIC ENZYME -> SUBSTRATE
MINOR
METABOLIC ENZYME -> SUBSTRATE
MINOR
METABOLIC ENZYME -> SUBSTRATE
MAJOR
TARGET -> INHIBITOR
Full antagonist SAM-760 completed phase I trials with no adverse effects at doses of up to 50 mg daily. Pfizer terminated a phase II trial after SAM-760 30 mg/day failed to produce an improvement in cognition in patients already taking a stable dose of donepezil.
Related Record Type Details
ACTIVE MOIETY
This is a non-substance concept