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Details

Stereochemistry RACEMIC
Molecular Formula C17H18F3NO
Molecular Weight 309.3268
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLUOXETINE

SMILES

CNCCC(c1ccccc1)Oc2ccc(cc2)C(F)(F)F

InChI

InChIKey=RTHCYVBBDHJXIQ-UHFFFAOYSA-N
InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3

HIDE SMILES / InChI

Molecular Formula C17H18F3NO
Molecular Weight 309.3268
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

other membrane receptors from brain tissue much less potently in vitro than do the tricyclic drugs.

Originator

Curator's Comment:: # Eli Lilly

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PROZAC

Approved Use

Fluoxetine is a selective serotonin reuptake inhibitor indicated for: Acute and maintenance treatment of Major Depressive Disorder (MDD) in adult and pediatric patients aged 8 to 18 years (1.1) Acute and maintenance treatment of Obsessive Compulsive Disorder (OCD) in adult and pediatric patients aged 7 to 17 years (1.2) Acute and maintenance treatment of Bulimia Nervosa in adult patients (1.3) Acute treatment of Panic Disorder, with or without agoraphobia, in adult patients (1.4) Fluoxetine and olanzapine in combination for: Acute treatment of Depressive Episodes Associated with Bipolar I Disorder in adults (1.5) 1.1 Major Depressive Disorder Fluoxetine hydrochloride is indicated for the acute and maintenance treatment of Major Depressive Disorder in adult patients and in pediatric patients aged 8 to18 years [see CLINICAL STUDIES (14.1)

Launch Date

567734400000
Primary
PROZAC

Approved Use

Fluoxetine is a selective serotonin reuptake inhibitor indicated for: Acute and maintenance treatment of Major Depressive Disorder (MDD) in adult and pediatric patients aged 8 to 18 years (1.1) Acute and maintenance treatment of Obsessive Compulsive Disorder (OCD) in adult and pediatric patients aged 7 to 17 years (1.2) Acute and maintenance treatment of Bulimia Nervosa in adult patients (1.3) Acute treatment of Panic Disorder, with or without agoraphobia, in adult patients (1.4) Fluoxetine and olanzapine in combination for: Acute treatment of Depressive Episodes Associated with Bipolar I Disorder in adults (1.5) 1.1 Major Depressive Disorder Fluoxetine hydrochloride is indicated for the acute and maintenance treatment of Major Depressive Disorder in adult patients and in pediatric patients aged 8 to18 years [see CLINICAL STUDIES (14.1)

Launch Date

567734400000
Primary
PROZAC

Approved Use

Fluoxetine is a selective serotonin reuptake inhibitor indicated for: Acute and maintenance treatment of Major Depressive Disorder (MDD) in adult and pediatric patients aged 8 to 18 years (1.1) Acute and maintenance treatment of Obsessive Compulsive Disorder (OCD) in adult and pediatric patients aged 7 to 17 years (1.2) Acute and maintenance treatment of Bulimia Nervosa in adult patients (1.3) Acute treatment of Panic Disorder, with or without agoraphobia, in adult patients (1.4) Fluoxetine and olanzapine in combination for: Acute treatment of Depressive Episodes Associated with Bipolar I Disorder in adults (1.5) 1.1 Major Depressive Disorder Fluoxetine hydrochloride is indicated for the acute and maintenance treatment of Major Depressive Disorder in adult patients and in pediatric patients aged 8 to18 years [see CLINICAL STUDIES (14.1)

Launch Date

567734400000
Primary
PROZAC

Approved Use

Fluoxetine is a selective serotonin reuptake inhibitor indicated for: Acute and maintenance treatment of Major Depressive Disorder (MDD) in adult and pediatric patients aged 8 to 18 years (1.1) Acute and maintenance treatment of Obsessive Compulsive Disorder (OCD) in adult and pediatric patients aged 7 to 17 years (1.2) Acute and maintenance treatment of Bulimia Nervosa in adult patients (1.3) Acute treatment of Panic Disorder, with or without agoraphobia, in adult patients (1.4) Fluoxetine and olanzapine in combination for: Acute treatment of Depressive Episodes Associated with Bipolar I Disorder in adults (1.5) 1.1 Major Depressive Disorder Fluoxetine hydrochloride is indicated for the acute and maintenance treatment of Major Depressive Disorder in adult patients and in pediatric patients aged 8 to18 years [see CLINICAL STUDIES (14.1)

Launch Date

567734400000
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
22.56 ng/mL
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FLUOXETINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
13576.38 pg/mL
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FLUOXETINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1101.46 ng × h/mL
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FLUOXETINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
788626.72 pg × h/mL
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FLUOXETINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
46.39 h
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FLUOXETINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
49.7 h
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FLUOXETINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
5.5%
FLUOXETINE plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
240 mg single, oral
Overdose
Dose: 240 mg
Route: oral
Route: single
Dose: 240 mg
Sources:
unhealthy, 12 - 19 years
Health Status: unhealthy
Age Group: 12 - 19 years
Sex: unknown
Sources:
280 mg single, oral
Overdose
Dose: 280 mg
Route: oral
Route: single
Dose: 280 mg
Sources:
unhealthy, 14 - 19 years
Health Status: unhealthy
Age Group: 14 - 19 years
Sex: unknown
Sources:
Disc. AE: Sleepy, Tremor...
AEs leading to
discontinuation/dose reduction:
Sleepy (1 patient)
Tremor (1 patient)
Sources:
260 mg single, oral
Overdose
Dose: 260 mg
Route: oral
Route: single
Dose: 260 mg
Sources:
unhealthy, 15 - 25 years
Health Status: unhealthy
Age Group: 15 - 25 years
Sex: unknown
Sources:
Disc. AE: Sleepy...
AEs leading to
discontinuation/dose reduction:
Sleepy (1 patient)
Sources:
200 mg single, oral
Overdose
Dose: 200 mg
Route: oral
Route: single
Dose: 200 mg
Sources:
unhealthy, 15 - 40 years
Health Status: unhealthy
Age Group: 15 - 40 years
Sex: unknown
Sources:
Disc. AE: Insomnia...
AEs leading to
discontinuation/dose reduction:
Insomnia (1 patient)
Sources:
320 mg single, oral
Overdose
Dose: 320 mg
Route: oral
Route: single
Dose: 320 mg
Sources:
unhealthy, 15 years
Health Status: unhealthy
Age Group: 15 years
Sex: unknown
Sources:
340 mg single, oral
Overdose
Dose: 340 mg
Route: oral
Route: single
Dose: 340 mg
Sources:
unhealthy, 18 - 22 years
Health Status: unhealthy
Age Group: 18 - 22 years
Sex: unknown
Sources:
Disc. AE: Hypertension...
AEs leading to
discontinuation/dose reduction:
Hypertension (grade 1, 1 patient)
Sources:
140 mg single, oral
Overdose
Dose: 140 mg
Route: oral
Route: single
Dose: 140 mg
Sources:
unhealthy, 18 - 42 years
Health Status: unhealthy
Age Group: 18 - 42 years
Sex: unknown
Sources:
Disc. AE: Sleepy...
AEs leading to
discontinuation/dose reduction:
Sleepy (1 patient)
Sources:
800 mg single, oral
Overdose
Dose: 800 mg
Route: oral
Route: single
Dose: 800 mg
Sources:
unhealthy, 18 years
Health Status: unhealthy
Age Group: 18 years
Sex: unknown
Sources:
Disc. AE: Hypertension...
AEs leading to
discontinuation/dose reduction:
Hypertension (grade 2, 1 patient)
Sources:
600 mg single, oral
Overdose
Dose: 600 mg
Route: oral
Route: single
Dose: 600 mg
Sources:
unhealthy, 20 - 45 years
Health Status: unhealthy
Age Group: 20 - 45 years
Sex: unknown
Sources:
Disc. AE: Hypertension, Sleepy...
AEs leading to
discontinuation/dose reduction:
Hypertension (grade 3, 1 patient)
Sleepy (1 patient)
Sources:
1000 mg single, oral
Overdose
Dose: 1000 mg
Route: oral
Route: single
Dose: 1000 mg
Sources:
unhealthy, 21 years
Health Status: unhealthy
Age Group: 21 years
Sex: unknown
Sources:
1500 mg single, oral
Overdose
Dose: 1500 mg
Route: oral
Route: single
Dose: 1500 mg
Sources:
unhealthy, 21 years
Health Status: unhealthy
Age Group: 21 years
Sex: unknown
Sources:
500 mg single, oral
Overdose
Dose: 500 mg
Route: oral
Route: single
Dose: 500 mg
Sources:
unhealthy, 28 years
Health Status: unhealthy
Age Group: 28 years
Sex: unknown
Sources:
Disc. AE: Sore throat...
AEs leading to
discontinuation/dose reduction:
Sore throat (1 patient)
Sources:
1200 mg single, oral
Overdose
Dose: 1200 mg
Route: oral
Route: single
Dose: 1200 mg
Sources:
unhealthy, 29 - 46 years
Health Status: unhealthy
Age Group: 29 - 46 years
Sex: unknown
Sources:
Disc. AE: Ataxic, Sleepy...
AEs leading to
discontinuation/dose reduction:
Ataxic (1 patient)
Sleepy (1 patient)
Sources:
400 mg single, oral
Overdose
Dose: 400 mg
Route: oral
Route: single
Dose: 400 mg
Sources:
unhealthy, 31 years
Health Status: unhealthy
Age Group: 31 years
Sex: unknown
Sources:
700 mg single, oral
Overdose
Dose: 700 mg
Route: oral
Route: single
Dose: 700 mg
Sources:
unhealthy, 36 years
Health Status: unhealthy
Age Group: 36 years
Sex: unknown
Sources:
Disc. AE: GI pain...
AEs leading to
discontinuation/dose reduction:
GI pain (1 patient)
Sources:
120 mg single, oral
Overdose
Dose: 120 mg
Route: oral
Route: single
Dose: 120 mg
Sources:
unhealthy, 42 years
Health Status: unhealthy
Age Group: 42 years
Sex: unknown
Sources:
640 mg single, oral
Overdose
Dose: 640 mg
Route: oral
Route: single
Dose: 640 mg
Sources:
unhealthy, 50 years
Health Status: unhealthy
Age Group: 50 years
Sex: unknown
Sources:
Disc. AE: Sleepy...
AEs leading to
discontinuation/dose reduction:
Sleepy (1 patient)
Sources:
1120 mg single, oral
Overdose
Dose: 1120 mg
Route: oral
Route: single
Dose: 1120 mg
Sources:
unhealthy, 51 years
Health Status: unhealthy
Age Group: 51 years
Sex: unknown
Sources:
Disc. AE: Nausea...
AEs leading to
discontinuation/dose reduction:
Nausea (1 patient)
Sources:
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adolescent
Health Status: unhealthy
Age Group: adolescent
Sources:
Other AEs: Intentional overdose, Suicide attempt...
Other AEs:
Intentional overdose (serious, 1 patient)
Suicide attempt (serious, 1 patient)
Suicidal ideation (serious, 1 patient)
Faecaloma (serious, 1 patient)
Tachycardia (below serious, 5 patients)
Vomiting (below serious, 4 patients)
Nasopharyngitis (below serious, 7 patients)
Decreased appetite (below serious, 10 patients)
Sources:
80 mg 1 times / day steady, oral
Dose: 80 mg, 1 times / day
Route: oral
Route: steady
Dose: 80 mg, 1 times / day
Sources:
unhealthy, adolescent
Health Status: unhealthy
Age Group: adolescent
Sources:
Other AEs: Suicidal behavior, Pain stomach...
Other AEs:
Suicidal behavior (serious, 1 patient)
Pain stomach (below serious, 2 patients)
Insomnia (below serious, 1 patient)
Fatigue (below serious, 1 patient)
Sources:
544 mg single, oral
Overdose
Dose: 544 mg
Route: oral
Route: single
Dose: 544 mg
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Disc. AE: Tachycardia, Drowsiness...
AEs leading to
discontinuation/dose reduction:
Tachycardia (15 patients)
Drowsiness (14 patients)
Tremor (5 patients)
Vomited (4 patients)
Nausea (4 patients)
Sources:
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Other AEs: Asthenia, Vasodilatation...
Other AEs:
Asthenia (7%)
Vasodilatation (1%)
Nausea (12%)
Diarrhea (9%)
Anorexia (5%)
Dry mouth (5%)
Dyspepsia (6%)
Insomnia (10%)
Anxiety (6%)
Nervousness (8%)
Somnolence (5%)
Tremor (3%)
Libido decreased (1%)
Abnormal dreams (1%)
Yawn (1%)
Sweating (2%)
Rash (2%)
Sources:
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Other AEs: Asthenia, Vasodilatation...
Other AEs:
Asthenia (15%)
Vasodilatation (5%)
Nausea (26%)
Diarrhea (18%)
Anorexia (17%)
Dry mouth (12%)
Dyspepsia (10%)
Insomnia (28%)
Anxiety (14%)
Nervousness (14%)
Somnolence (17%)
Tremor (9%)
Libido decreased (11%)
Abnormal dreams (5%)
Yawn (7%)
Sweating (7%)
Rash (6%)
Sources:
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Other AEs: Asthenia, Vasodilatation...
Other AEs:
Asthenia (9%)
Vasodilatation (3%)
Nausea (21%)
Diarrhea (12%)
Anorexia (11%)
Dry mouth (10%)
Dyspepsia (7%)
Insomnia (16%)
Anxiety (12%)
Nervousness (14%)
Somnolence (13%)
Tremor (10%)
Libido decreased (3%)
Abnormal dreams (1%)
Sweating (8%)
Rash (4%)
Sources:
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Other AEs: Headache, Asthenia...
Other AEs:
Headache (22%)
Asthenia (18%)
Nausea (18%)
Rhinitis (17%)
Diarrhoea (15%)
Somnolence (13%)
Insomnia (12%)
Nervousness (10%)
Sweating (9%)
Flu syndrome (8%)
Pain (7%)
Anxiety (7%)
Dizziness (6%)
Tremor (6%)
Pharyngitis (5%)
Sources:
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Other AEs: Asthenia, Vasodilatation...
Other AEs:
Asthenia (21%)
Vasodilatation (2%)
Nausea (29%)
Diarrhea (8%)
Anorexia (8%)
Dry mouth (9%)
Dyspepsia (10%)
Insomnia (33%)
Anxiety (15%)
Nervousness (11%)
Somnolence (13%)
Tremor (13%)
Libido decreased (5%)
Abnormal dreams (5%)
Yawn (11%)
Sweating (8%)
Rash (4%)
Sources:
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, children
Health Status: unhealthy
Age Group: children
Sex: unknown
Sources:
Other AEs: Hypomania...
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescent
Health Status: unhealthy
Age Group: children|adolescent
Sources:
Other AEs: Depressive symptom, Hallucination, auditory...
Other AEs:
Depressive symptom (serious, 1 patient)
Hallucination, auditory (serious, 1 patient)
Overdose (serious, 1 patient)
Suicidal ideation (serious, 3 patients)
Abdominal pain upper (below serious, 4 patients)
Upper respiratory tract infection (below serious, 5 patients)
Insomnia (below serious, 6 patients)
Sources:
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Other AEs: Suicidal ideation, Suicide attempt...
Other AEs:
Suicidal ideation (serious, 1 patient)
Suicide attempt (serious, 1 patient)
Abdominal pain upper (below serious, 9 patients)
Nausea (below serious, 13 patients)
Vomiting (below serious, 7 patients)
Fatigue (below serious, 6 patients)
Influenza (below serious, 2 patients)
Sources:
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Other AEs: Lymphadenitis, Gastritis...
Other AEs:
Lymphadenitis (serious, 1 patient)
Gastritis (serious, 1 patient)
Ulna fracture (serious, 1 patient)
Nausea (below serious, 15 patients)
Vomiting (below serious, 6 patients)
Upper respiratory tract infection (below serious, 3 patients)
Incorrect dose administered (below serious, 4 patients)
Decreased appetite (below serious, 10 patients)
Dizziness (below serious, 4 patients)
Headache (below serious, 18 patients)
Insomnia (below serious, 6 patients)
Sources:
20 mg single, oral
Dose: 20 mg
Route: oral
Route: single
Dose: 20 mg
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Other AEs: Blood triglycerides increased...
Other AEs:
Blood triglycerides increased (below serious, 1 patient)
Sources:
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Other AEs: Diarrhoea, Stomatitis...
Other AEs:
Diarrhoea (below serious, 1 patient)
Stomatitis (below serious, 1 patient)
Alanine aminotransferase increased (below serious, 2 patients)
Aspartate aminotransferase increased (below serious, 1 patient)
Sources:
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: F
Sources:
Other AEs: Headache, Anxiety...
Other AEs:
Headache (below serious, 6 patients)
Anxiety (below serious, 8 patients)
Dizziness (below serious, 5 patients)
Sources:
40 mg single, oral
Dose: 40 mg
Route: oral
Route: single
Dose: 40 mg
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Other AEs: White blood cell count decreased...
Other AEs:
White blood cell count decreased (below serious, 2 patients)
Sources:
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Other AEs: Atrioventricular block first degree, Conjunctivitis allergic...
Other AEs:
Atrioventricular block first degree (below serious, 2 patients)
Conjunctivitis allergic (below serious, 1 patient)
Haemorrhoids (below serious, 1 patient)
Proctalgia (below serious, 1 patient)
Excoriation (below serious, 1 patient)
Alanine aminotransferase increased (below serious, 1 patient)
Aspartate aminotransferase increased (below serious, 1 patient)
Blood triglycerides increased (below serious, 1 patient)
White blood cell count decreased (below serious, 1 patient)
White blood cell count increased (below serious, 1 patient)
Dizziness (below serious, 1 patient)
Anxiety (below serious, 1 patient)
Sources:
80 mg 1 times / day steady, oral
Dose: 80 mg, 1 times / day
Route: oral
Route: steady
Dose: 80 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: F
Sources:
Other AEs: Suicide attempt...
Other AEs:
Suicide attempt (serious, 1 patient)
Sources:
AEs

AEs

AESignificanceDosePopulation
Sleepy 1 patient
Disc. AE
280 mg single, oral
Overdose
Dose: 280 mg
Route: oral
Route: single
Dose: 280 mg
Sources:
unhealthy, 14 - 19 years
Health Status: unhealthy
Age Group: 14 - 19 years
Sex: unknown
Sources:
Tremor 1 patient
Disc. AE
280 mg single, oral
Overdose
Dose: 280 mg
Route: oral
Route: single
Dose: 280 mg
Sources:
unhealthy, 14 - 19 years
Health Status: unhealthy
Age Group: 14 - 19 years
Sex: unknown
Sources:
Sleepy 1 patient
Disc. AE
260 mg single, oral
Overdose
Dose: 260 mg
Route: oral
Route: single
Dose: 260 mg
Sources:
unhealthy, 15 - 25 years
Health Status: unhealthy
Age Group: 15 - 25 years
Sex: unknown
Sources:
Insomnia 1 patient
Disc. AE
200 mg single, oral
Overdose
Dose: 200 mg
Route: oral
Route: single
Dose: 200 mg
Sources:
unhealthy, 15 - 40 years
Health Status: unhealthy
Age Group: 15 - 40 years
Sex: unknown
Sources:
Hypertension grade 1, 1 patient
Disc. AE
340 mg single, oral
Overdose
Dose: 340 mg
Route: oral
Route: single
Dose: 340 mg
Sources:
unhealthy, 18 - 22 years
Health Status: unhealthy
Age Group: 18 - 22 years
Sex: unknown
Sources:
Sleepy 1 patient
Disc. AE
140 mg single, oral
Overdose
Dose: 140 mg
Route: oral
Route: single
Dose: 140 mg
Sources:
unhealthy, 18 - 42 years
Health Status: unhealthy
Age Group: 18 - 42 years
Sex: unknown
Sources:
Hypertension grade 2, 1 patient
Disc. AE
800 mg single, oral
Overdose
Dose: 800 mg
Route: oral
Route: single
Dose: 800 mg
Sources:
unhealthy, 18 years
Health Status: unhealthy
Age Group: 18 years
Sex: unknown
Sources:
Sleepy 1 patient
Disc. AE
600 mg single, oral
Overdose
Dose: 600 mg
Route: oral
Route: single
Dose: 600 mg
Sources:
unhealthy, 20 - 45 years
Health Status: unhealthy
Age Group: 20 - 45 years
Sex: unknown
Sources:
Hypertension grade 3, 1 patient
Disc. AE
600 mg single, oral
Overdose
Dose: 600 mg
Route: oral
Route: single
Dose: 600 mg
Sources:
unhealthy, 20 - 45 years
Health Status: unhealthy
Age Group: 20 - 45 years
Sex: unknown
Sources:
Sore throat 1 patient
Disc. AE
500 mg single, oral
Overdose
Dose: 500 mg
Route: oral
Route: single
Dose: 500 mg
Sources:
unhealthy, 28 years
Health Status: unhealthy
Age Group: 28 years
Sex: unknown
Sources:
Ataxic 1 patient
Disc. AE
1200 mg single, oral
Overdose
Dose: 1200 mg
Route: oral
Route: single
Dose: 1200 mg
Sources:
unhealthy, 29 - 46 years
Health Status: unhealthy
Age Group: 29 - 46 years
Sex: unknown
Sources:
Sleepy 1 patient
Disc. AE
1200 mg single, oral
Overdose
Dose: 1200 mg
Route: oral
Route: single
Dose: 1200 mg
Sources:
unhealthy, 29 - 46 years
Health Status: unhealthy
Age Group: 29 - 46 years
Sex: unknown
Sources:
GI pain 1 patient
Disc. AE
700 mg single, oral
Overdose
Dose: 700 mg
Route: oral
Route: single
Dose: 700 mg
Sources:
unhealthy, 36 years
Health Status: unhealthy
Age Group: 36 years
Sex: unknown
Sources:
Sleepy 1 patient
Disc. AE
640 mg single, oral
Overdose
Dose: 640 mg
Route: oral
Route: single
Dose: 640 mg
Sources:
unhealthy, 50 years
Health Status: unhealthy
Age Group: 50 years
Sex: unknown
Sources:
Nausea 1 patient
Disc. AE
1120 mg single, oral
Overdose
Dose: 1120 mg
Route: oral
Route: single
Dose: 1120 mg
Sources:
unhealthy, 51 years
Health Status: unhealthy
Age Group: 51 years
Sex: unknown
Sources:
Decreased appetite below serious, 10 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adolescent
Health Status: unhealthy
Age Group: adolescent
Sources:
Vomiting below serious, 4 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adolescent
Health Status: unhealthy
Age Group: adolescent
Sources:
Tachycardia below serious, 5 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adolescent
Health Status: unhealthy
Age Group: adolescent
Sources:
Nasopharyngitis below serious, 7 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adolescent
Health Status: unhealthy
Age Group: adolescent
Sources:
Faecaloma serious, 1 patient
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adolescent
Health Status: unhealthy
Age Group: adolescent
Sources:
Intentional overdose serious, 1 patient
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adolescent
Health Status: unhealthy
Age Group: adolescent
Sources:
Suicidal ideation serious, 1 patient
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adolescent
Health Status: unhealthy
Age Group: adolescent
Sources:
Suicide attempt serious, 1 patient
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adolescent
Health Status: unhealthy
Age Group: adolescent
Sources:
Fatigue below serious, 1 patient
80 mg 1 times / day steady, oral
Dose: 80 mg, 1 times / day
Route: oral
Route: steady
Dose: 80 mg, 1 times / day
Sources:
unhealthy, adolescent
Health Status: unhealthy
Age Group: adolescent
Sources:
Insomnia below serious, 1 patient
80 mg 1 times / day steady, oral
Dose: 80 mg, 1 times / day
Route: oral
Route: steady
Dose: 80 mg, 1 times / day
Sources:
unhealthy, adolescent
Health Status: unhealthy
Age Group: adolescent
Sources:
Pain stomach below serious, 2 patients
80 mg 1 times / day steady, oral
Dose: 80 mg, 1 times / day
Route: oral
Route: steady
Dose: 80 mg, 1 times / day
Sources:
unhealthy, adolescent
Health Status: unhealthy
Age Group: adolescent
Sources:
Suicidal behavior serious, 1 patient
80 mg 1 times / day steady, oral
Dose: 80 mg, 1 times / day
Route: oral
Route: steady
Dose: 80 mg, 1 times / day
Sources:
unhealthy, adolescent
Health Status: unhealthy
Age Group: adolescent
Sources:
Drowsiness 14 patients
Disc. AE
544 mg single, oral
Overdose
Dose: 544 mg
Route: oral
Route: single
Dose: 544 mg
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Tachycardia 15 patients
Disc. AE
544 mg single, oral
Overdose
Dose: 544 mg
Route: oral
Route: single
Dose: 544 mg
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Nausea 4 patients
Disc. AE
544 mg single, oral
Overdose
Dose: 544 mg
Route: oral
Route: single
Dose: 544 mg
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Vomited 4 patients
Disc. AE
544 mg single, oral
Overdose
Dose: 544 mg
Route: oral
Route: single
Dose: 544 mg
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Tremor 5 patients
Disc. AE
544 mg single, oral
Overdose
Dose: 544 mg
Route: oral
Route: single
Dose: 544 mg
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Abnormal dreams 1%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Libido decreased 1%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Vasodilatation 1%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Yawn 1%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Insomnia 10%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Nausea 12%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Rash 2%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Sweating 2%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Tremor 3%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Anorexia 5%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Dry mouth 5%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Somnolence 5%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Anxiety 6%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Dyspepsia 6%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Asthenia 7%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Nervousness 8%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Diarrhea 9%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Dyspepsia 10%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Libido decreased 11%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Dry mouth 12%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Anxiety 14%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Nervousness 14%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Asthenia 15%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Anorexia 17%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Somnolence 17%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Diarrhea 18%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Nausea 26%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Insomnia 28%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Abnormal dreams 5%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Vasodilatation 5%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Rash 6%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Sweating 7%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Yawn 7%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Tremor 9%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Abnormal dreams 1%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Dry mouth 10%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Tremor 10%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Anorexia 11%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Anxiety 12%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Diarrhea 12%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Somnolence 13%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Nervousness 14%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Insomnia 16%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Nausea 21%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Libido decreased 3%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Vasodilatation 3%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Rash 4%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Dyspepsia 7%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Sweating 8%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Asthenia 9%
20 mg 1 times / day steady, oral
Recommended
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Nervousness 10%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Insomnia 12%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Somnolence 13%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Diarrhoea 15%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Rhinitis 17%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Asthenia 18%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Nausea 18%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Headache 22%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Pharyngitis 5%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Dizziness 6%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Tremor 6%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Anxiety 7%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Pain 7%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Flu syndrome 8%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Sweating 9%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Dyspepsia 10%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Nervousness 11%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Yawn 11%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Somnolence 13%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Tremor 13%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Anxiety 15%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Vasodilatation 2%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Asthenia 21%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Nausea 29%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Insomnia 33%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Rash 4%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Abnormal dreams 5%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Libido decreased 5%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Anorexia 8%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Diarrhea 8%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Sweating 8%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Dry mouth 9%
60 mg 1 times / day steady, oral
Recommended
Dose: 60 mg, 1 times / day
Route: oral
Route: steady
Dose: 60 mg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sex: unknown
Sources:
Hypomania 1.8%
10 mg 1 times / day steady, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: steady
Dose: 10 mg, 1 times / day
Sources:
unhealthy, children
Health Status: unhealthy
Age Group: children
Sex: unknown
Sources:
Abdominal pain upper below serious, 4 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescent
Health Status: unhealthy
Age Group: children|adolescent
Sources:
Upper respiratory tract infection below serious, 5 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescent
Health Status: unhealthy
Age Group: children|adolescent
Sources:
Insomnia below serious, 6 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescent
Health Status: unhealthy
Age Group: children|adolescent
Sources:
Depressive symptom serious, 1 patient
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescent
Health Status: unhealthy
Age Group: children|adolescent
Sources:
Hallucination, auditory serious, 1 patient
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescent
Health Status: unhealthy
Age Group: children|adolescent
Sources:
Overdose serious, 1 patient
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescent
Health Status: unhealthy
Age Group: children|adolescent
Sources:
Suicidal ideation serious, 3 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescent
Health Status: unhealthy
Age Group: children|adolescent
Sources:
Nausea below serious, 13 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Influenza below serious, 2 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Fatigue below serious, 6 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Vomiting below serious, 7 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Abdominal pain upper below serious, 9 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Suicidal ideation serious, 1 patient
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Suicide attempt serious, 1 patient
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Decreased appetite below serious, 10 patients
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Nausea below serious, 15 patients
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Headache below serious, 18 patients
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Upper respiratory tract infection below serious, 3 patients
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Dizziness below serious, 4 patients
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Incorrect dose administered below serious, 4 patients
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Insomnia below serious, 6 patients
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Vomiting below serious, 6 patients
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Gastritis serious, 1 patient
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Lymphadenitis serious, 1 patient
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Ulna fracture serious, 1 patient
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
unhealthy, children|adolescents
Health Status: unhealthy
Age Group: children|adolescents
Sources:
Blood triglycerides increased below serious, 1 patient
20 mg single, oral
Dose: 20 mg
Route: oral
Route: single
Dose: 20 mg
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Aspartate aminotransferase increased below serious, 1 patient
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Diarrhoea below serious, 1 patient
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Stomatitis below serious, 1 patient
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Alanine aminotransferase increased below serious, 2 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Dizziness below serious, 5 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: F
Sources:
Headache below serious, 6 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: F
Sources:
Anxiety below serious, 8 patients
20 mg 1 times / day steady, oral
Dose: 20 mg, 1 times / day
Route: oral
Route: steady
Dose: 20 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: F
Sources:
White blood cell count decreased below serious, 2 patients
40 mg single, oral
Dose: 40 mg
Route: oral
Route: single
Dose: 40 mg
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Alanine aminotransferase increased below serious, 1 patient
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Anxiety below serious, 1 patient
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Aspartate aminotransferase increased below serious, 1 patient
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Blood triglycerides increased below serious, 1 patient
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Conjunctivitis allergic below serious, 1 patient
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Dizziness below serious, 1 patient
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Excoriation below serious, 1 patient
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Haemorrhoids below serious, 1 patient
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Proctalgia below serious, 1 patient
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
White blood cell count decreased below serious, 1 patient
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
White blood cell count increased below serious, 1 patient
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Atrioventricular block first degree below serious, 2 patients
40 mg 1 times / day steady, oral
Dose: 40 mg, 1 times / day
Route: oral
Route: steady
Dose: 40 mg, 1 times / day
Sources:
healthy
Health Status: healthy
Sex: M
Sources:
Suicide attempt serious, 1 patient
80 mg 1 times / day steady, oral
Dose: 80 mg, 1 times / day
Route: oral
Route: steady
Dose: 80 mg, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sex: F
Sources:
OverviewDrug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
moderate [IC50 31 uM]
moderate
moderate
moderate
yes (co-administration study)
Comment: addition of fluoxetine 20 mg/day to pre-existing risperidone therapy produced a mean 4- fold increase in plasma risperidone concentration, with some patients exhibiting an increase as large as 10-fold
no
strong [IC50 1.05 uM]
yes (co-administration study)
Comment: Coadministration of fluoxetine with other drugs that are metabolized by CYP2D6, including certain antidepressants (e.g., TCAs), antipsychotics (e.g., phenothiazines and most atypicals), and antiarrhythmics (e.g., propafenone, flecainide, and others) should be approached with caution
yes [IC50 14 uM]
yes [IC50 16 uM]
yes [IC50 3.32 uM]
yes [IC50 30 uM]
yes [IC50 5 uM]
yes [IC50 6.2 uM]
yes
yes
yes (co-administration study)
Comment: Fluoxetine dosing inhibited CYP2C19 activity in both age groups, increasing the (S)- to (R)-mephenytoin ratio 3- to 4-fold
Drug as victimTox targets
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
The emergence of social phobia during clozapine treatment and its response to fluoxetine augmentation.
1999 Dec
Focal necrotising vasculitis with secondary myositis following fluoxetine administration.
1999 Jun
Fluoxetine inhibits the metabolism of tolterodine-pharmacokinetic implications and proposed clinical relevance.
1999 Oct
[Fluoxetine (FX) efficacy in the treatment of cocaine dependence methadone maintenance patients. Interaction with plasma levels].
1999 Sep-Oct
Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine.
2000
Benztropine for venlafaxine-induced night sweats.
2000 Apr
Molecular serotonergic mechanisms appear to mediate genetic sensitivity to cocaine-induced convulsions.
2000 Apr 28
Methadone, ciprofloxacin, and adverse drug reactions.
2000 Dec 16
Antidepressant drugs appear to enhance cocaine-induced toxicity.
2000 Feb
Female sexual dysfunction associated with antidepressant administration: a randomized, placebo-controlled study of pharmacologic intervention.
2000 Feb
[SIADH with epileptic seizures and coma in fluoxetine therapy].
2000 Mar 2
Fluoxetine-induced sexual dysfunction reversed by trazodone.
2000 Nov
Evidence of early onset of antidepressant effect in randomized controlled trials.
2001
The effects of antidepressants on sexual functioning in depressed patients: a review.
2001
Dopaminergic activity in transgenic mice underexpressing glucocorticoid receptors: effect of antidepressants.
2001
Effects of selective serotonin reuptake inhibitors on sexual function.
2001 Apr
Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin.
2001 Apr
Effect of chronic and acute administration of fluoxetine and its additive effect with morphine on the behavioural response in the formalin test in rats.
2001 Feb
Characterization of 5-HT receptors in the parasitic nematode, Ascaris suum.
2001 Feb
Evaluation of the potential pharmacokinetic interaction between almotriptan and fluoxetine in healthy volunteers.
2001 Feb
The economic consequences of a drug-drug interaction.
2001 Feb
Citalopram-induced bruxism.
2001 Feb
Female sexual dysfunction and antidepressant use.
2001 Feb
Fluoxetine and side effects in the geriatric population.
2001 Feb 1
Inhibition of shock-induced foot tapping behaviour in the gerbil by a tachykinin NK1 receptor antagonist.
2001 Feb 2
Transient ST segment elevation in right precordial leads induced by psychotropic drugs: relationship to the Brugada syndrome.
2001 Jan
Treatment of bipolar depression with twice-weekly fluoxetine: management of antidepressant-induced mania.
2001 Jan
Effects of serotonin and fluoxetine on blood glucose regulation in two decapod species.
2001 Jan
Atrial arrhythmia in a woman treated with fluoxetine: is there a causal relationship?
2001 Jan
A novel augmentation strategy for treating resistant major depression.
2001 Jan
Depression among pregnant adolescents: an integrated treatment approach.
2001 Jan
In vitro study on fluoxetine adsorption onto charcoal using potentiometry.
2001 Jan
Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study.
2001 Jan
No gender differences in placebo responses of patients with major depressive disorder.
2001 Jan 15
Plasticity in serotonin uptake in primary neuronal cultures of serotonin transporter knockout mice.
2001 Jan 31
Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro.
2001 Jan 5
Role of serotonin and noradrenaline in social dysfunction: a review of data on reboxetine and the Social Adaptation Self-evaluation Scale (SASS).
2001 Jan-Feb
Mutism: elective or selective, and acquired.
2001 Mar
Regulation of the vesicular monoamine transporter-2: a novel mechanism for cocaine and other psychostimulants.
2001 Mar
Patents

Sample Use Guides

Usual Adult Dose for Bulimia
Route of Administration: Oral
Caco-2 SERT was also shown to be a high affinity (Kt=0.216 uM) saturable, Na(+) -dependent transporter that was inhibited by fluoxetine (IC(50)=17.6 nM).
Substance Class Chemical
Created
by admin
on Fri Jun 25 22:11:01 UTC 2021
Edited
by admin
on Fri Jun 25 22:11:01 UTC 2021
Record UNII
01K63SUP8D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FLUOXETINE
INN   MI   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
FLUOXETINE [INN]
Common Name English
(+/-)-N-METHYL-3-PHENYL-3-((.ALPHA.,ALPHA.,.ALPHA.-TRIFLUORO-P-TOLYL)OXY)PROPYLAMINE
Common Name English
FLUOXETIN RATIOPHARM
Common Name English
DL-N-METHYL-3-(P-TRIFLUOROMETHYLPHENOXY)-3-PHENYLPROPYLAMINE
Common Name English
FLUOXETINE [USAN]
Common Name English
NSC-283480
Code English
NSC-758685
Code English
FLUOXETINE [EMA EPAR VETERINARY]
Common Name English
FLUOXETINE [WHO-DD]
Common Name English
FLUOXETINE [VANDF]
Common Name English
N-METHYL-.GAMMA.-(4-(TRIFLUOROMETHYL)PHENOXY)BENZENEPROPANAMINE
Systematic Name English
FLUOXETINE [MI]
Common Name English
FLUVAL
Common Name English
BENZENEPROPANAMINE, N-METHYL-G-(4-(TRIFLUOROMETHYL)PHENOXY)-, (+/-)-
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 183504
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
NDF-RT N0000000109
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
WHO-ATC N06AB03
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
EMA VETERINARY ASSESSMENT REPORTS RECONCILE [AUTHORIZED]
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
FDA ORPHAN DRUG 123199
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
LIVERTOX 424
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
WHO-ATC N06CA03
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
WHO-VATC QN06AB03
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
WHO-ESSENTIAL MEDICINES LIST 24.2.1
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
WHO-ESSENTIAL MEDICINES LIST 8.4
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
NCI_THESAURUS C94725
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
CFR 21 CFR 520.980
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
NCI_THESAURUS C265
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
NDF-RT N0000175696
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
WHO-VATC QN06CA03
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
Code System Code Type Description
WIKIPEDIA
FLUOXETINE
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY
MERCK INDEX
M5487
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY Merck Index
CAS
54910-89-3
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY
ChEMBL
CHEMBL41
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY
EVMPD
SUB07723MIG
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY
FDA UNII
01K63SUP8D
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY
DRUG CENTRAL
1209
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY
RXCUI
4493
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY RxNorm
NCI_THESAURUS
C506
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY
EPA CompTox
54910-89-3
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY
IUPHAR
203
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY
PUBCHEM
3386
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY
INN
3883
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY
DRUG BANK
DB00472
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY
MESH
D005473
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY
LACTMED
Fluoxetine
Created by admin on Fri Jun 25 22:11:01 UTC 2021 , Edited by admin on Fri Jun 25 22:11:01 UTC 2021
PRIMARY
Related Record Type Details
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> INHIBITOR
TARGET -> INHIBITOR
METABOLIC ENZYME -> INHIBITOR
SALT/SOLVATE -> PARENT
METABOLIC ENZYME -> SUBSTRATE
SALT/SOLVATE -> PARENT
Related Record Type Details
METABOLITE -> PARENT
METABOLITE ACTIVE -> PARENT
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MAXIMUM TOLERATED DOSE TOXICITY RAPID METABOLIZERS OR THOSE WITH INADEQUATE RESPONSE AFTER 8 WEEKS

Tmax PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC NORFLUOXETINE
PHARMACOKINETIC
NORFLUOXETINE, LIVER CIRRHOSIS
PHARMACOKINETIC
LIVER CIRRHOSIS
PHARMACOKINETIC