U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Jun 26 16:51:35 UTC 2021
Edited
by admin
on Sat Jun 26 16:51:35 UTC 2021
Protein Type RECEPTOR
Protein Sub Type REUPTAKE RECEPTOR
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
CJZ26L1EGI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM-DEPENDENT SEROTONIN TRANSPORTER
Common Name English
5HTT
Common Name English
SERT
Common Name English
SOLUTE CARRIER FAMILY 6 MEMBER 4
Common Name English
SLC6A4
Common Name English
HTT
Common Name English
SEROTONIN REUPTAKE TRANSPORTER
Common Name English
5HT TRANSPORTER
Common Name English
Code System Code Type Description
FDA UNII
CJZ26L1EGI
Created by admin on Sat Jun 26 16:51:39 UTC 2021 , Edited by admin on Sat Jun 26 16:51:39 UTC 2021
PRIMARY
From To
1_200 1_209
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_208
N 1_217
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
LIGAND->TRANSPORTER
INHIBITOR -> TARGET
IN-VITRO
IC50
ANTAGONIST->TARGET
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
(+)-Tramadol inhibits serotonin reuptake
SUBSTRATE -> TRANSPORTER
STIMULATES SEROTONIN RELEASE.
SUBSTRATE -> TRANSPORTER
Our data show that drugs known or suspected to increase the risk of PPH (eg, aminorex, fenfluramine, and chlorphentermine) are 5-HT transporter substrates, whereas drugs that have not been shown to increase the risk of PPH are less potent in this regard.
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TRANSPORTER
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TRANSPORTER
INHIBITOR -> TARGET
Kd
INHIBITOR -> TARGET
INHIBITOR -> TARGET
LIGAND->BINDER
INHIBITOR -> TARGET
TARGET->RADIOLIGAND
INHIBITOR -> TRANSPORTER
IN-VITRO
RADIOLIGAND->TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL