Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 13:30:45 GMT 2023
by
admin
on
Sat Dec 16 13:30:45 GMT 2023
|
| Protein Type | RECEPTOR |
| Protein Sub Type | REUPTAKE RECEPTOR |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
CJZ26L1EGI
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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| Code System | Code | Type | Description | ||
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CJZ26L1EGI
Created by
admin on Sat Dec 16 13:30:50 GMT 2023 , Edited by admin on Sat Dec 16 13:30:50 GMT 2023
|
PRIMARY |
| From | To |
|---|---|
| 1_200 | 1_209 |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_208 |
| N | 1_217 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR -> TARGET |
Rat
Ki
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
BINDING
IC50
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INHIBITOR -> TRANSPORTER |
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INHIBITOR -> TRANSPORTER |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TRANSPORTER |
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LIGAND->TRANSPORTER |
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INHIBITOR -> TARGET |
IN-VITRO
IC50
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ANTAGONIST->TARGET |
Ki
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
IC50
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SUBSTRATE -> TARGET |
INDUCES SEROTONIN RELEASE; NOT A DAT SUBSTRATE
EC50
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LIGAND->TRANSPORTER |
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INHIBITOR -> TARGET |
nhibition of [3H]neurotransmitter uptake IC50 ± sem (μΜ).
IC50
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
(+)-Tramadol inhibits serotonin reuptake
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INHIBITOR -> TARGET |
Ki
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LIGAND->TRANSPORTER |
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SUBSTRATE -> TRANSPORTER |
STIMULATES SEROTONIN RELEASE.
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SUBSTRATE -> TRANSPORTER |
Our data show that drugs known or suspected to increase the risk of PPH (eg, aminorex, fenfluramine, and chlorphentermine) are 5-HT transporter substrates, whereas drugs that have not been shown to increase the risk of PPH are less potent in this regard.
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INHIBITOR -> TRANSPORTER |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TRANSPORTER |
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INHIBITOR -> TARGET |
From Rat Membrane Studies
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INHIBITOR -> TARGET |
BINDING
IC50
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INHIBITOR -> TARGET | |||
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WEAK INHIBITOR->TARGET |
IC50
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TRANSPORTER | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR->OFF-TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
BINDING
IC50
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INHIBITOR -> TRANSPORTER |
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INHIBITOR -> TARGET |
Kd
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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LIGAND->BINDER | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
Ki
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RADIOLIGAND->TARGET |
Kd
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TARGET->RADIOLIGAND |
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INHIBITOR -> TRANSPORTER |
IN-VITRO
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INHIBITOR -> TRANSPORTER |
IN RAT
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RADIOLIGAND->TARGET |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
|