UK-390957

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H20N2O3S2
Molecular Weight	352.472
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CSC1=CC=C(OC2=CC=C(C=C2CN(C)C)S(N)(=O)=O)C=C1

InChI

InChIKey=VCNSPGHSQPMCFF-UHFFFAOYSA-N

InChI=1S/C16H20N2O3S2/c1-18(2)11-12-10-15(23(17,19)20)8-9-16(12)21-13-4-6-14(22-3)7-5-13/h4-10H,11H2,1-3H3,(H2,17,19,20)

HIDE SMILES / InChI

Molecular Formula	C16H20N2O3S2
Molecular Weight	352.472
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800017934 | https://www.ncbi.nlm.nih.gov/pubmed/19412497

UK-390957 is a selective serotonin reuptake inhibitor (SSRI) that was in phase II/III development in the USA, European Union and other territories with Pfizer, for the treatment of Premature ejaculation. UK-390957 represented a major development in sexual medicine, and offered patients the convenience of on-demand dosing, significant improvements in IELT, ejaculatory control, and sexual satisfaction with minimal adverse effects. However development of UK-390957 was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

UK-390957 inhibited [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cells with IC50 value of 4 nM.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:22:07 GMT 2023` Edited by `admin` on `Fri Dec 15 15:22:07 GMT 2023`
Record UNII	W26I0D1D6J
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

UK-390957

Common Name

English

3-DIMETHYLAMINOMETHYL-4-(4-METHYLSULFANYL-PHENOXY)-BENZENESULFONAMIDE

Systematic Name

English

UK-390,957

Code

English

Code System Code Type Description

PUBCHEM

9884876