DASB

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H17N3S
Molecular Weight	283.391
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CC1=CC=CC=C1SC2=CC=C(C=C2N)C#N

InChI

InChIKey=UVWLEPXXYOYDGR-UHFFFAOYSA-N

InChI=1S/C16H17N3S/c1-19(2)11-13-5-3-4-6-15(13)20-16-8-7-12(10-17)9-14(16)18/h3-9H,11,18H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C16H17N3S
Molecular Weight	283.391
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Positron emission tomography quantification of [(11)C]-DASB binding to the human serotonin transporter: modeling strategies.	2001 Nov	11702049
In vitro and in vivo characterisation of [11C]-DASB: a probe for in vivo measurements of the serotonin transporter by positron emission tomography.	2002 Jul	12088720
Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes.	2004 Dec	15583118
Pharmacological and genetic characterization of two selective serotonin transporter ligands: 2-[2-(dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB).	2004 Feb	14610240
Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study.	2004 May	15121647
Biodistribution and radiation dosimetry of [11C]DASB in baboons.	2004 Nov	15607492
Biodistribution and radiation dosimetry of the serotonin transporter ligand 11C-DASB determined from human whole-body PET.	2004 Sep	15347724
DASB -in vitro binding characteristics on human recombinant monoamine transporters with regard to its potential as positron emission tomography (PET) tracer.	2004 Sep	15312176
Distinct effects of sleep deprivation on binding to norepinephrine and serotonin transporters in rat brain.	2005 Feb	15694238
Serotonin transporter availability in patients with schizophrenia: a positron emission tomography imaging study with [11C]DASB.	2005 Jun 15	15953487
Quantitative PET studies of the serotonin transporter in MDMA users and controls using [11C]McN5652 and [11C]DASB.	2005 Sep	15841106
Time course of in vivo 5-HTT transporter occupancy by fluvoxamine.	2006 Apr	16633150
Effects of early life stress on [11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer- and mother-reared rhesus monkeys.	2006 Apr 26	16641244
PET imaging of serotonin transporters with [11C]DASB: test-retest reproducibility using a multilinear reference tissue parametric imaging method.	2006 Feb	16455625
The serotonin transporter in rhesus monkey brain: comparison of DASB and citalopram binding sites.	2006 May	16720249
Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods.	2006 May	16644752
Reduced availability of serotonin transporters in obsessive-compulsive disorder correlates with symptom severity - a [11C]DASB PET study.	2007	17713719
Midbrain serotonin transporter binding potential measured with [11C]DASB is affected by serotonin transporter genotype.	2007	17225932
Human 5-HT transporter availability predicts amygdala reactivity in vivo.	2007 Aug 22	17715358
In vivo quantification of serotonin transporters using [(11)C]DASB and positron emission tomography in humans: modeling considerations.	2007 Jan	16736050
Effect on [11C]DASB binding after tranylcypromine-induced increase in serotonin concentration: positron emission tomography studies in monkeys and rats.	2007 Jun	17372973
Misunderstandings about how to choose a reference region.	2007 Jun 1	16989780
Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder.	2007 Oct 15	17678634
Effects of citalopram infusion on the serotonin transporter binding of [11C]DASB in healthy controls.	2008 Aug	18478022
Metabolism and autoradiographic evaluation of [(18)F]FE@CIT: a Comparison with [(123)I]beta-CIT and [(123)I]FP-CIT.	2008 May	18482685
Seasonal variation in human brain serotonin transporter binding.	2008 Sep	18762593
Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASB.	2008 Sep 15	18661545
Serotonin transporter availability in the amygdala and bed nucleus of the stria terminalis predicts anxious temperament and brain glucose metabolic activity.	2009 Aug 12	19675230
Behavioral and neurobiological characteristics influencing social hierarchy formation in female cynomolgus monkeys.	2009 Feb 18	19059311
High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding.	2009 Jun	19233297
Mapping of serotonin transporters by positron emission tomography with [11C]DASB in conscious common marmosets: comparison with rhesus monkeys.	2010 Aug	20340166
Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging study.	2010 Jun	20483717

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:55:23 GMT 2023` Edited by `admin` on `Sat Dec 16 10:55:23 GMT 2023`
Record UNII	PP549Z0645
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DASB

Common Name

English

BENZONITRILE, 3-AMINO-4-((2-((DIMETHYLAMINO)METHYL)PHENYL)THIO)-

Systematic Name

English

Code System Code Type Description

FDA UNII

PP549Z0645