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Details

Stereochemistry ACHIRAL
Molecular Formula C16H17N3S
Molecular Weight 283.393
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DASB

SMILES

CN(C)Cc1ccccc1Sc2ccc(cc2N)C#N

InChI

InChIKey=UVWLEPXXYOYDGR-UHFFFAOYSA-N
InChI=1S/C16H17N3S/c1-19(2)11-13-5-3-4-6-15(13)20-16-8-7-12(10-17)9-14(16)18/h3-9H,11,18H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C16H17N3S
Molecular Weight 283.393
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Positron emission tomography quantification of [(11)C]-DASB binding to the human serotonin transporter: modeling strategies.
2001 Nov
Linearized reference tissue parametric imaging methods: application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain.
2003 Sep
Pharmacological and genetic characterization of two selective serotonin transporter ligands: 2-[2-(dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB).
2004 Feb
Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study.
2004 May
DASB -in vitro binding characteristics on human recombinant monoamine transporters with regard to its potential as positron emission tomography (PET) tracer.
2004 Sep
Time course of in vivo 5-HTT transporter occupancy by fluvoxamine.
2006 Apr
Effects of early life stress on [11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer- and mother-reared rhesus monkeys.
2006 Apr 26
Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography.
2006 Aug 1
The serotonin transporter in rhesus monkey brain: comparison of DASB and citalopram binding sites.
2006 May
Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods.
2006 May
Midbrain serotonin transporter binding potential measured with [11C]DASB is affected by serotonin transporter genotype.
2007
Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: a [(11)C] DASB positron emission tomography study.
2007 Aug 15
5-HTT binding in recovered depressed patients and healthy volunteers: a positron emission tomography study with [11C]DASB.
2007 Dec
PET [11C]DASB imaging of serotonin transporters in patients with alcoholism.
2007 Jan
In vivo quantification of serotonin transporters using [(11)C]DASB and positron emission tomography in humans: modeling considerations.
2007 Jan
Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder.
2007 Oct 15
Effects of citalopram infusion on the serotonin transporter binding of [11C]DASB in healthy controls.
2008 Aug
Evaluation of non-uniform weighting in non-linear regression for pharmacokinetic neuroreceptor modelling.
2008 Feb
Anxiety is associated with reduced central serotonin transporter availability in unmedicated patients with unipolar major depression: a [11C]DASB PET study.
2008 Jun
Metabolism and autoradiographic evaluation of [(18)F]FE@CIT: a Comparison with [(123)I]beta-CIT and [(123)I]FP-CIT.
2008 May
Seasonal variation in human brain serotonin transporter binding.
2008 Sep
A probabilistic approach to delineating functional brain regions.
2009 Jun
Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain.
2010 Aug 1
Cerebral serotonin transporter binding is inversely related to body mass index.
2010 Aug 1
Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging study.
2010 Jun
Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels.
2010 Nov
Depressive symptoms in PD correlate with higher 5-HTT binding in raphe and limbic structures.
2010 Nov 23
Patents

Patents

Substance Class Chemical
Created
by admin
on Sat Jun 26 02:04:30 UTC 2021
Edited
by admin
on Sat Jun 26 02:04:30 UTC 2021
Record UNII
PP549Z0645
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DASB
Common Name English
BENZONITRILE, 3-AMINO-4-((2-((DIMETHYLAMINO)METHYL)PHENYL)THIO)-
Systematic Name English
Code System Code Type Description
FDA UNII
PP549Z0645
Created by admin on Sat Jun 26 02:04:30 UTC 2021 , Edited by admin on Sat Jun 26 02:04:30 UTC 2021
PRIMARY
CAS
627490-01-1
Created by admin on Sat Jun 26 02:04:30 UTC 2021 , Edited by admin on Sat Jun 26 02:04:30 UTC 2021
PRIMARY
PUBCHEM
10446567
Created by admin on Sat Jun 26 02:04:30 UTC 2021 , Edited by admin on Sat Jun 26 02:04:30 UTC 2021
PRIMARY
WIKIPEDIA
DASB
Created by admin on Sat Jun 26 02:04:30 UTC 2021 , Edited by admin on Sat Jun 26 02:04:30 UTC 2021
PRIMARY
Related Record Type Details
BINDER->LIGAND
SALT/SOLVATE -> PARENT