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Details

Stereochemistry ACHIRAL
Molecular Formula C16H17N3S
Molecular Weight 282.3937
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DASB C-11

SMILES

CN(C)Cc1ccccc1Sc2ccc(cc2N)C#N

InChI

InChIKey=UVWLEPXXYOYDGR-BJUDXGSMSA-N
InChI=1S/C16H17N3S/c1-19(2)11-13-5-3-4-6-15(13)20-16-8-7-12(10-17)9-14(16)18/h3-9H,11,18H2,1-2H3/i1-1

HIDE SMILES / InChI

Molecular Formula C16H17N3S
Molecular Weight 282.3937
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

3-amino-4-(2[11C]methylaminomethylphenylsulfanyl)benzonitrile (DASB C-11) exhibits excellent in vitro and in vivo properties toward the serotonin transporter. Parametric imaging of serotonin transporters (SERT) with DASB C-11 PET is a useful data analysis tool. DASB C-11 is a suitable PET radioligand for measuring drug occupancy of the SERT in vivo and has potential for monitoring in vivo changes in serotonin levels. Studies in humans showed that the regional distribution of DASB C-11 uptake was concordant with the known densities of SERT sites in the brain. The highest levels of radioactivity were observed in the hypothalamus, intermediate levels were observed in the thalamus and striatum, whereas modest to low levels of radioactivity were observed in the cortical regions and cerebellum, respectively.

Approval Year

PubMed

PubMed

TitleDatePubMed
[11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats.
2003 Feb
PET imaging of serotonin transporters with [11C]DASB: test-retest reproducibility using a multilinear reference tissue parametric imaging method.
2006 Feb
3-Amino-4-(2-((4-[18F]fluorobenzyl)methylamino)methylphenylsulfanyl)benzonitrile, an F-18 fluorobenzyl analogue of DASB: synthesis, in vitro binding, and in vivo biodistribution studies.
2007 Sep-Oct
Substance Class Chemical
Created
by admin
on Sat Jun 26 02:04:32 UTC 2021
Edited
by admin
on Sat Jun 26 02:04:32 UTC 2021
Record UNII
FJU46Q2BPU
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DASB C-11
Common Name English
BENZONITRILE, 3-AMINO-4-((2-((METHYLMETHYL-11C-AMINO)METHYL)PHENYL)THIO)-
Systematic Name English
11C DASB
Common Name English
Code System Code Type Description
PUBCHEM
656408
Created by admin on Sat Jun 26 02:04:32 UTC 2021 , Edited by admin on Sat Jun 26 02:04:32 UTC 2021
PRIMARY
FDA UNII
FJU46Q2BPU
Created by admin on Sat Jun 26 02:04:32 UTC 2021 , Edited by admin on Sat Jun 26 02:04:32 UTC 2021
PRIMARY
CAS
296774-13-5
Created by admin on Sat Jun 26 02:04:32 UTC 2021 , Edited by admin on Sat Jun 26 02:04:32 UTC 2021
PRIMARY
Related Record Type Details
BINDER->LIGAND
BINDING
RADIOLIGAND->TARGET
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
VOLUME OF DISTRIBUTION PHARMACOKINETIC