Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H17N3S |
| Molecular Weight | 282.392 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN([11CH3])CC1=CC=CC=C1SC2=C(N)C=C(C=C2)C#N
InChI
InChIKey=UVWLEPXXYOYDGR-BJUDXGSMSA-N
InChI=1S/C16H17N3S/c1-19(2)11-13-5-3-4-6-15(13)20-16-8-7-12(10-17)9-14(16)18/h3-9H,11,18H2,1-2H3/i1-1
| Molecular Formula | C16H17N3S |
| Molecular Weight | 282.392 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
3-amino-4-(2[11C]methylaminomethylphenylsulfanyl)benzonitrile (DASB C-11) exhibits excellent in vitro and in vivo properties toward the serotonin transporter. Parametric imaging of serotonin transporters (SERT) with DASB C-11 PET is a useful data analysis tool. DASB C-11 is a suitable PET radioligand for measuring drug occupancy of the SERT in vivo and has potential for monitoring in vivo changes in serotonin levels. Studies in humans showed that the regional distribution of DASB C-11 uptake was concordant with the known densities of SERT sites in the brain. The highest levels of radioactivity were observed in the hypothalamus, intermediate levels were observed in the thalamus and striatum, whereas modest to low levels of radioactivity were observed in the cortical regions and cerebellum, respectively.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats. | 2003 Feb |
|
| PET imaging of serotonin transporters with [11C]DASB: test-retest reproducibility using a multilinear reference tissue parametric imaging method. | 2006 Feb |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:45:45 GMT 2023
by
admin
on
Fri Dec 15 15:45:45 GMT 2023
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| Record UNII |
FJU46Q2BPU
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| Record Status |
Validated (UNII)
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656408
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FJU46Q2BPU
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296774-13-5
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DTXSID601319129
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admin on Fri Dec 15 15:45:45 GMT 2023 , Edited by admin on Fri Dec 15 15:45:45 GMT 2023
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BINDER->LIGAND |
BINDING
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RADIOLIGAND->TARGET |
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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| VOLUME OF DISTRIBUTION | PHARMACOKINETIC |
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